Clinical trials: Vascular Neurocognitive Disorder
Cardiovascular Diseases, Coronary Disease
Honolulu Heart Program
To investigate coronary heart disease and stroke among American men of Japanese ancestry who were living on the island of Oahu in 1965. Morbidity and mortality surveillance of the original cohort is continuing.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Cerebrovascular Accident, Heart Diseases
- Trial name
- NCT00005123
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Atrial Fibrillation, Heart Failure
Akershus Cardiac Examination (ACE) 1950 Study
Akershus Cardiac Examination (ACE) 1950 Study is a large, observational, prospective, longitudinal, population-based cohort study.
- Conditions
- Atrial Fibrillation, Heart Failure, Mild Cognitive Impairment, Cardiovascular Diseases
- Trial name
- ACE1950 (NCT01555411)
- Where
- 2 sites in Norway
- Volunteers
- 3,706 people, healthy volunteers welcome
- Sponsor
- Vestre Viken Hospital Trust
Postoperative Cognitive Dysfunction
The Effect of Intraoperative Hypotension on Postoperative Cognitive Functions in Cesarean Section Operations
The aim of the study is to see whether the hypotension that develops during spinal anesthesia in cesarean section patients causes a decrease in the postoperative cognitive functions of the patient.
- Trial name
- NCT05843838
- Testing
- Hypotension during spinal anesthesia for cesarean section, Mini-mental test, Spinal anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Dementia, Alzheimer Disease
Care Ecosystem: Navigating Patients and Families Through Stages of Care, Extension Trial
This is an extension trial of a prior trial (NCT02213458). Both persons with dementia (PWD) and their caregivers were enrolled as dyads.
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT04287738
- Testing
- Navigated Care
- Volunteers
- 912 people
- Sponsor
- University of California, San Francisco
Stroke, Acute Ischemic Stroke
Mobilisation After Endovascular Stroke Treatment
The goal of this observational study is to learn how the timing of mobilisation after endovascular thrombectomy (EVT) affects complications in patients with acute ischaemic stroke.
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Ischemic Stroke AIS, Endovascular Thrombectomy
- Trial name
- MAESTRO (NCT07860333)
- Testing
- Mobilisation
- Where
- 2 sites in Finland, Sweden
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Cognitive Decline, Hypertension
MIND Foods and Aerobic Training in Black Adults With HTN
The goal of this randomized controlled trial is to determine the impact of Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet and aerobic training on cognition in Black adults with high systolic blood…
- Conditions
- Cognitive Decline, Hypertension, Diet, Aerobic Exercise
- Trial name
- MAT (NCT06152614)
- Testing
- Enhanced Usual Care (EUC), Food Delivery and Cooking PLUS Aerobic Training (FoRKS+)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Indiana University
Hypertension, Mild Cognitive Impairment
Retina Microvascular Remodeling and Cognitive Function In Hypertension
This study aims to determine the relationships between retina micro-vascular remodeling and cognitive function in hypertensive patients.
- Trial name
- EYEBRAIN (NCT02701855)
- Testing
- Cognitive tests, Blood test, Brain and aorta RMI
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Institute of Cardiometabolism and Nutrition, France
Hypertension, Elderly
Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population
Introduction: High blood pressure especially systolic hypertension is a common condition in the elderly and is considered as a major determinant not only of cardiovascular (CV) morbidity and mortality, but also of several other…
- Conditions
- Hypertension, Elderly, Cardiovascular Mortality, Cognitive Impairment
- Trial name
- PARTAGE (NCT00901355)
- Where
- 6 sites in France, Italy
- Volunteers
- 1,130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Parkinson Disease, Parkinsonism
More Than a Movement Disorder: Applying Palliative Care to Parkinson's Disease
This is a two-center (University of Colorado, University of California San Francisco) community-based comparative effectiveness study of outpatient palliative care for Parkinson's disease (PD) and related disorders (progressive…
- Conditions
- Parkinson Disease, Parkinsonism, Lewy Body Disease, Supranuclear Palsy, Progressive
- Trial name
- MTMD (NCT03076671)
- Testing
- Palliative Care
- Where
- 2 sites in United States
- Volunteers
- 783 people
- Sponsor
- University of Colorado, Denver
Cerebral Small Vessel Diseases, Stroke
Stopping Cognitive Decline and Dementia by Fighting Covert Cerebral Small Vessel Disease
Cerebral small Vessel Disease (cSVD), characterized by an alteration of the structure and function of small penetrating brain arteries, is highly prevalent in older persons from the general population and represents a leading…
- Conditions
- Cerebral Small Vessel Diseases, Stroke, Dementia
- Trial name
- SHIVA (NCT05306834)
- Testing
- Retinal Imaging, Blood sample, Evaluation of cardiovascular risks
- Where
- 2 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Bordeaux
Traumatic Brain Injury, Cognitive Decline
Cognitive and Vascular Functioning Following TBI
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia.
- Conditions
- Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
- Trial name
- NCT06034509
- Testing
- No intervention. This is an observational study.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Walter Reed National Military Medical Center
Diabetes, Alzheimer Disease
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for…
- Conditions
- Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia
- Trial name
- DPPOS-4 (NCT05704309)
- Where
- 27 sites in United States
- Volunteers
- 1,976 people, healthy volunteers welcome
- Sponsor
- Marinella Temprosa
Stroke, Cognitive Deficit
Transcranial Direct Current Stimulation (tDCS) in Post-Stroke Working Memory Deficits
The purpose of this study is to test the effects of tDCS (Transcranial Direct Current Stimulation) on stroke patients with working memory problems.
- Conditions
- Stroke, Cognitive Deficit, Cognitive Impairment, Short-Term Memory Impairment
- Trial name
- TDCS-PSMWD (NCT03034109)
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stony Brook University
Alzheimer's Disease, Cerebrovascular Disease
Co-LEsions in Alzheimer Disease and Related Disorders
One of the crucial challenges for the future of Alzheimer's disease (AD) therapeutic approaches in elderly is to target the main pathological process responsible for disability and dependency.
- Conditions
- Alzheimer's Disease, Cerebrovascular Disease, Lewy Body Disease
- Trial name
- CLEM (NCT02052947)
- Testing
- SPECT-DaTscan
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Hospices Civils de Lyon
Multiple Myeloma
A Safety and Efficacy of Pomalyst® Capsules Under the Actual Use in All Patients Who Are Treated With Pomalyst at a Dose of 1 mg, 2 mg, 3 mg, or 4 mg
1. Planned enrollment period One year (The planned number of patients to be enrolled is set to 400 patients.) Since all patients who are prescribed with Pomalyst are registered in RevMate®, enrollment using the Registration Form…
- Trial name
- NCT02921828
- Where
- 2 sites in United States, Japan
- Volunteers
- 1,149 people
- Sponsor
- Celgene
Delirium, Acute Coronary Syndrome
Incidence and Prognostic Value of DELIRIUM in Patients With Acute CORonary synDrome: an observatIonal Study
to evaluate the incidence of delirium in patients with acute coronary syndrome and its correlation with adverse events
- Trial name
- NCT02004665
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Ospedale San Donato
Ischemia, Cerebrovascular Ischemia
LA Improves the Prognosis of Patients With ICVD
Ischemic cerebrovascular disease will cause serious harm to the life and safety of patients, and the treatment prognosis is poor.
- Conditions
- Ischemia, Cerebrovascular Ischemia, Cognitive Impairment
- Trial name
- NCT05845983
- Testing
- Lactobacillus acidophilus, Maltodextrin
- Volunteers
- 236 people
- Sponsor
- Huaqiu Zhang
Brain Injury Traumatic Severe (Diagnosis), Coma
Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness
Phase 1 of the STIMPACT trial is an open label,dose-escalation,safety study of intravenous (IV) methylphenidate (MPH) therapy in patients with disorders of consciousness (DoC) caused by severe brain injuries.
- Conditions
- Brain Injury Traumatic Severe (Diagnosis), Coma, Consciousness, Level Altered, Anoxic Brain Injury
- Trial name
- STIMPACT (NCT03814356)
- Testing
- Methylphenidate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Dementia, Dementia, Vascular
Advanced Cognitive Stimulation Therapy Hong Kong (ACST-HK)
This study is a feasibility randomized controlled trial (RCT) for an evidence-based intervention for people with moderate to severe dementia in Hong Kong.
- Conditions
- Dementia, Dementia, Vascular, Dementia, Mixed, Dementia With Lewy Bodies
- Trial name
- NCT04555629
- Testing
- Advanced Cognitive Stimulation Therapy Hong Kong
- Volunteers
- 32 people
- Sponsor
- University College, London