Clinical trials: Vascular Occlusive Disease
Atherosclerosis, Ischemia
Clinical Of Chocolate Balloon Dilatation Versus Plain Balloon Dilatation to Treat Arteriosclerosis Occlusive Disease of Lower Extremity
This is a Prospective randomized controlled study to evaluate the difference of safety，effectiveness between chocolate balloon and plain balloon dilatation in treatment of infrapopliteal artery lesions.
- Trial name
- NCT05158283
- Testing
- chocolate balloon, plain balloon
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Xuanwu Hospital, Beijing
Coronary Artery Disease (CAD), ST-elevation Myocardial Infarction (STEMI)
Drug-coatEd Balloon Multicentric Registry in Spain and PORTugal
Drug-eluting stents (DES) have been the main treatment option for coronary angioplasty (PCI) for many years. The antiproliferative drug in DES has the effect of preventing in-stent restenosis, which is typically a consequence of…
- Trial name
- DESPORT (NCT07477405)
- Volunteers
- 1,200 people
- Sponsor
- Portuguese Association of Interventional Cardiology
Coronary Artery Disease
Angiography-derived FFR GPS in Predicting Post-PCI Physiological and Clinical Outcomes
To investigate the feasibility of physiological map generated from angiography-derived fractional flow reserve (FFR) (angio-FFR) pullback and its value in predicting physiological and clinical outcomes after stenting.
- Trial name
- Angio-GPS (NCT05496023)
- Testing
- Percutaneous coronary intervention
- Where
- China
- Volunteers
- 329 people
- Sponsor
- Shanghai Zhongshan Hospital
Peripheral Arterial Disease
Investigating Efficacy and Safety of JETi® in Arterial Occlusions in FEM-POP and Prox BTK-Lesions (JETART)
To demonstrate the efficacy and safety of the mechanical thrombectomy device (JETi 6F and 8F) for treatment of patients with symptomatic peripheral artery disease (PAD) due to acute or acute on chronic occlusions of the femoral…
- Trial name
- JETART (NCT06434779)
- Testing
- JETi 6F and 8F Thrombectomy system
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vascular Science LP GmbH
Coronary Artery Disease
EDUCATE: The MEDTRONIC Endeavor Drug Eluting Stenting: Understanding Care, Antiplatelet Agents and Thrombotic Events
EDUCATE is a prospective, multi-center study designed to collect real-world safety and clinical outcomes in subjects receiving one or more Endeavor Zotarolimus-Eluting Stents and either clopidogrel and aspirin or prasugrel and…
- Trial name
- EDUCATE (NCT01069003)
- Testing
- Thienopyridine Therapy, Surveillance Arm
- Where
- United States
- Volunteers
- 2,272 people
- Sponsor
- Medtronic Vascular
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Diabetic Foot Ulcers (DFU), Lower Extremity Arterial Occlusion
Efficacy and Safety of Cold Atmospheric Plasma Combined With Endovascular Intervention for Diabetic Foot Ulcers With Lower Extremity Arterial Occlusion
The goal of this clinical trial is to evaluate whether cold atmospheric plasma (CAP) combined with endovascular intervention can accelerate wound healing and improve safety outcomes in patients aged 18 to 80 years with diabetic…
- Trial name
- NCT07198061
- Testing
- Cold Atmospheric Plasma (CAP), Infrapopliteal Endovascular Revascularisation, Guideline-Based Standard DFU Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenyang Medical College
Atherosclerotic Vascular Disease
Evaluate the Utility of 18FDG-PET as a Tool to Quantify Atherosclerotic Plaque (MK-0000-081 AM3)(COMPLETED)
The purpose of this study is to evaluate the utility of 18Fluorine Fluorodeoxyglucose Positron Emission Tomography (18FDG-PET) as a tool to quantify atherosclerotic plaque.
- Trial name
- NCT00703261
- Testing
- atorvastatin
- Volunteers
- 83 people
- Sponsor
- Merck Sharp & Dohme LLC
Sinusoidal Obstruction Syndrome, Veno-occlusive Disease
5-day Defibrotide Treatment for Hepatic SOS/VOD
Sinusoidal Obstruction Syndrome (SOS), also referred to as hepatic veno-occlusive disease (VOD), is rare but serious complication of allogeneic stem cell transplantation (allo-SCT).
- Conditions
- Sinusoidal Obstruction Syndrome, Veno-occlusive Disease, Bone Marrow Transplant Complications
- Trial name
- NCT04313036
- Testing
- Defibrotide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Loyola University
Acute Ischemic Stroke
Albumin for Patients With Acute Large Vessel Occlusive Stroke Undergoing Endovascular Reperfusion Therapy
The objective of this study is to evaluate the effectiveness and safety of endovascular therapy combined with 25% human albumin in the treatment of acute large vessel occlusive stroke.
- Trial name
- NCT06538844
- Testing
- Intravenous infusion of human albumin, Saline
- Where
- 8 sites in China
- Volunteers
- 134 people
- Sponsor
- Capital Medical University
Peripheral Artery Disease
Campania Registry On Peripheral Artery Disease
The CAmpania REgistry on Peripheral Artery Disease (CARE-PAD) is a single-center observational study which has the purpose to collect clinical, laboratory, instrumental, procedural and follow-up data and to evaluate the outcome…
- Trial name
- CARE-PAD (NCT04903912)
- Testing
- Vascular ultrasound or other imaging methods according to current guidelines, Laboratory tests, Medical treatment according to current guidelines
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Federico II University
Carotid Artery Diseases
Study of Carotid Occlusion and Neurocognition
To determine the relationship between cognitive functioning and blood flow in the brain among patients randomized to either extracranial-intracranial (EC-IC) bypass or medical therapy alone in the Carotid Occlusion Surgery Study…
- Trial name
- NCT00390481
- Testing
- EC-IC Bypass in the COSS study
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Columbia University
Coronary Artery Disease, Myocardial Infarction
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe
The "EUropean Comparative Effectiveness Research to assess the use of primary prophylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD)" is a modular research project to study the effectiveness of prophylactic ICDs in a…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Dilated Cardiomyopathy, Implantable Defibrillator User
- Trial name
- EU-CERT-ICD (NCT02064192)
- Where
- 42 sites in Belgium, Bulgaria and 14 more
- Volunteers
- 2,285 people
- Sponsor
- University Medical Center Goettingen
Stable Coronary Artery Disease
A Study of the Antiplatelet Effects Comparing Ticagrelor (Ticag. - AZD6140) With Clopidogrel (Clop.) Responder and Non-responders
The purpose of this study is to see how Ticagrelor, a new oral reversible anti-platelet medication, affects platelets. Anti-platelet agents are medications that block the formation of blood clots by preventing the clumping of…
- Trial name
- RESPOND (NCT00642811)
- Testing
- Ticagrelor, Clopidogrel, Aspirin
- Where
- 10 sites in United States, Canada and 2 more
- Volunteers
- 98 people
- Sponsor
- AstraZeneca
Coronary Artery Disease
The Cardiac Benefit of Testosterone Replacement in Men With Low Testosterone Levels With Coronary Artery Disease After Successful Intervention of the Blockage or Narrowed Heart Artery
The purpose of the study is to find out if giving the study drug, Androgel (testosterone) as a testosterone replacement help bring the testosterone to an acceptable level and to find out if it will help improve heart condition in…
- Trial name
- NCT00413244
- Testing
- AndroGel 5 Grams
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Atherosclerosis, Adipokines
Adipokines of Epicardial Adipose Tissue and Atherosclerosis of Coronary Arteries
The aim of the study is to investigate whether the expression and production of adipokines secreted by the epicardial adipose tissue correlate with the degree of coronary atherosclerosis.
- Trial name
- NCT03322332
- Where
- Greece
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Peripheral Arterial Disease
Effect of Polyphenols on Peripheral Vascular Disease.
Peripheral arterial disease (PAD) is a clinical setting characterized by an exceptionally high risk for cardiovascular events. Oxidative stress seems to play a role in impairing flow-mediated dilation (FMD) and contributing to…
- Trial name
- NCT01947712
- Testing
- dark chocolate with crossover to milk chocolate, milk chocolate with crossover to dark chocolate
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Roma La Sapienza
Peripheral Arterial Disease
The AbsorbaSeal Vascular Closure Device Trial
This study investigates the efficacy and safety of the AbsorbaSeal 6Fr Vascular Closure device (VCD) for the closure of access site of patients requiring percutaneous diagnostic or interventional procedures.
- Trial name
- NCT03730571
- Testing
- AbsorbaSeal 6Fr Vascular Closure Device
- Where
- 3 sites in Belgium
- Volunteers
- 9 people
- Sponsor
- ID3 Medical
Coronary Artery Disease, Coronary Disease
Fractional Flow Reserve Versus Angiography Randomization for Graft Optimization Trial
The FARGO trial is a prospective, randomized (1:1), multicenter study. The aim of the study is to assess the importance of fractional flow reserve (FFR) assessment prior to coronary artery bypass grafting (CABG) with respect to…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Arteriosclerosis
- Trial name
- FARGO (NCT02477371)
- Testing
- Fractional flow reserve-guided CABG, Angiography-guided CABG
- Where
- 3 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Odense University Hospital
Central Retinal Artery Occlusion
The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform
The purpose of this study is to describe the effect of transcorneal electrical stimulation (TES) with a non conventional biphasic bipolar waveform in central retinal artery occlusion
- Trial name
- NCT00802698
- Testing
- Transcorneal electric stimulation, Transcorneal stimulation
- Where
- Mexico
- Volunteers
- 5 people
- Sponsor
- Asociación para Evitar la Ceguera en México
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