Clinical trials: Vascular Occlusive Disease
Coronary Artery Disease
Cangrelor Prasugrel Transition Study
To demonstrate that patients treated with cangrelor can be directly switched to oral prasugrel and that patients treated with prasugrel can be switched to cangrelor without a significant decrease in the extent of inhibition of…
- Trial name
- NCT01852019
- Testing
- Cangrelor, Prasugrel
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Medicines Company
Coronary Arteriosclerosis, Non ST Segment Elevation Acute Coronary Syndrome
HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt
This is a multi-center, single-blind, randomized, active-controlled, clinical trial in Percutaneous Coronary Intervention (PCI) subjects.
- Trial name
- HARMONEE (NCT02073565)
- Testing
- OrbusNeich Combo stent™, Everolimus Eluting Stent (EES)
- Where
- 50 sites in United States, Japan
- Volunteers
- 572 people
- Sponsor
- OrbusNeich
Coronary Artery Disease
Computed Tomography as the First-Choice Diagnostics in High Pre-Test Probability of Coronary Artery Disease
To evaluate the safety and effectiveness of computed tomography angiography in the diagnostic and therapeutic cycle as the first-choice method of imaging in the diagnosis of patients with a high probability of stable coronary…
- Trial name
- CAT-CAD (NCT02591992)
- Testing
- Cardiac CT as the first diagnostic modality in suspected CAD, Invasive coronary angiography as indicated by the guidelines
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Anaemia, Myocardial Ischaemia, Fractured Neck of Femur
Cardiac Injury and Anaemia Following Surgery for Fractured Neck of Femur: An Observational Study Study Protocol: Cardiac Injury and Anaemia Following Surgery for Fractured Neck of Femur
Blood transfusion is an expensive and finite resource and optimum transfusion threshold in surgical patients is yet to be defined.
- Trial name
- NCT02969811
- Volunteers
- 47 people
- Sponsor
- NHS Lothian
Coronary Artery Disease, CT Angiography
Further Lipid-Lowering With PCSK9 Inhibitors for Cardiovascular Outcomes in High-Risk Coronary Plaques Assessed by CT Angiography
The primary objective was to evaluate the effect of PCSK9 inhibitors in addition to the background lipid-modifying therapy (LMT), compared with standard LMT in terms of clinical outcomes in patients with coronary CT angiography…
- Conditions
- Coronary Artery Disease, CT Angiography, PCSK9, Cardiovascular Events
- Trial name
- FLAVOUR IV (NCT06863545)
- Testing
- PCSK9 inhibitors and background lipid-modifying therapy, Standard lipid-modifying therapy
- Where
- 6 sites in China, South Korea
- Volunteers
- 3,596 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bleeding Disorder, Ischemic Stroke
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR)…
- Conditions
- Bleeding Disorder, Ischemic Stroke, Hemorrhagic Stroke, Hematological Diseases
- Trial name
- NCT03815175
- Testing
- XIENCE, DAPT (aspirin and/or P2Y12 receptor inhibitor)
- Where
- 111 sites in United States, Austria and 13 more
- Volunteers
- 1,605 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
The Relationship Between Cognitive Status and Exercise Capacity, Fatigue Perception in Coronary Artery Patients
The study aimed to examine the relationship between cognitive status, exercise capacity, and fatigue perception in coronary artery disease patients.
- Trial name
- NCT06246201
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Heart Diseases, Cardiovascular Diseases
Genetics of Coronary Artery Disease in Alaskan Natives (GOCADAN)
To document cardiovascular disease and cardiovascular disease risk factors among 1,200 Native Alaskans who are members of approximately 40 families.
- Conditions
- Heart Diseases, Cardiovascular Diseases, Atherosclerosis, Hypertension
- Trial name
- NCT00006192
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Moyamoya Disease
Neurocognitive and Radiological Assessments in Adult Moyamoya Undergoing Surgery
Adult patients with moyamoya disease (MMD) are reported to suffer from considerable impairment of executive function/attention. Although reduced cerebrovascular reserve (CVR) in frontal areas has been detected by perfusion MRI…
- Trial name
- NRAAMUS (NCT02305407)
- Testing
- Surgical Revascularization, Conservative treatment
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Cardiovascular Disease, Cerebrovascular Disease
The Evening Versus Morning Polypill Utilization Study
Background and rationale: In clinical practice, antihypertensives are generally prescribed for use in the morning, whereas some statins are recommended for use in the evening.
- Conditions
- Cardiovascular Disease, Cerebrovascular Disease, Peripheral Arterial Disease
- Trial name
- TEMPUS (NCT01506505)
- Testing
- Cardiovascular Agents
- Where
- Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Clopidogrel and Response Variability Investigation Study 2
To evaluate the role of the genetic variant 2C19*2 on the pharmacodynamic response as assessed by optical aggregometry and on the pharmacokinetic response as assessed by measuring active metabolites following an oral…
- Trial name
- CLOVIS2 (NCT00822666)
- Testing
- clopidogrel
- Where
- France
- Volunteers
- 109 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Peripheral Artery Disease
Effects of Pulse Varieties on Blood Vessel Function in Peripheral Artery Disease
Consumption of a diet containing pulse crops provides flavonoid compounds that will improve vascular function and glycemic control in individuals with Peripheral Artery Disease.
- Trial name
- PULV-2011 (NCT01382056)
- Testing
- control foods, Mixed bean (higher amount), Mixed beans (lower amount)
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Peripheral Arterial Disease
Multi-Center Registry for Peripheral Arterial Disease Interventions and Outcomes
XLPAD is an observational study designed to evaluate the effectiveness and use of stent and non-stent based therapies among PAD patients.
- Trial name
- XLPAD (NCT01904851)
- Where
- 24 sites in United States
- Volunteers
- 14,000 people
- Sponsor
- Baylor Research Institute
Peripheral Arterial Disease, Peripheral Artery Disease
Implementation of Telemedicine for Patient With Lower Extremity Wounds
The objective of this study is to determine if patients with lower extremity wounds in rural communities who undergo specialty referral through telemedicine have expedited care compared to patients who are treated through…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Peripheral Vascular Diseases, Diabetic Foot
- Trial name
- NCT04440839
- Testing
- Telemedicine specialty consultation
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of California, Davis
Epicardial Fat, Visceral Fat
Epicardial Fat, Visceral Fat and Coronary Atherosclerosis
Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease.
- Conditions
- Epicardial Fat, Visceral Fat, Atherosclerosis
- Trial name
- NCT01344694
- Testing
- patient with liver fat, pts. with excess of visceral fat, control
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Atherosclerosis, Ischemic Stroke
A Phase I Study to Evaluate Safety and Pharmacokinetics of Escalating Single Doses and Multiple Doses of SP-8356
This is a 2-part, single-centre, randomised study in healthy males. Part 1 is a double-blind, randomised, placebo-controlled, single ascending dose (SAD) study in healthy males.
- Trial name
- NCT05574166
- Testing
- SP-8356
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Coronary Artery Disease, Percutaneous Coronary Intervention
Naples PCI Registry
The aim of the Naples PCI registry is to collect prospective data on baseline clinical, laboratory, and angiographic characteristics of patients undergoing PCI for acute or chronic coronary artery disease.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Myocardial Ischemia, Myocardial Infarction
- Trial name
- NCT05248165
- Testing
- PCI
- Where
- Italy
- Volunteers
- 5,000 people
- Sponsor
- Federico II University
Coronary Artery Disease
Technical Performance of a New Cardiac Technology "IQ-SPECT" Applied to SCINTI-CT Myocardial Imaging With 99mTc-Sestamibi in Coronary Patients
Cardiological examination is one of the major directions in nuclear medicine for detection of myocardial ischemia in patients with suspected coronary artery disease.
- Trial name
- IQSCINTIMYOC (NCT02524600)
- Testing
- myocardial IQ-SPECT imaging applied to scintigraphic imaging, scintigraphic imaging
- Where
- France
- Volunteers
- 103 people
- Sponsor
- University Hospital, Caen
Coronary Artery Disease
Feasibility and Diagnostic Accuracy of Myocardial Perfusion Imaging Using Early Imaging Protocol
The current protocol for myocardial perfusion imaging (MPI) entails imaging within 30-45 minutes after radiotracer injection, for both rest and stress studies.
- Trial name
- NCT01700972
- Testing
- Myocardial perfusion imaging
- Where
- United States
- Sponsor
- St. Louis University
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