Clinical trials: Vascular Reactivity
Cancer
Bevacizumab Treatment and Retinal Vessel Monitoring
Bevacizumab might influence the dynamic vessel function after being administered intravenously.
- Trial name
- BevaRet (NCT00740168)
- Testing
- bevacizumab treatment
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technische Universität Dresden
Subarachnoid Hemorrhage, Aneurysmal
Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx).
- Trial name
- NCT06932640
- Testing
- - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Measurement of the Eye's Blood Vessels Using the Dynamic Vessel Analyzer (DVA)
The purpose of this research study is examine the response of the blood vessels in the eye to a light flicker stimulus using the Dynamic Vessel Analyzer (DVA) on two separate days in healthy individuals.
- Trial name
- NCT00783029
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hyperlipidemias, Metabolic Syndrome X
Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory Markers
The aim of this study is to explore the significance of the Lys:Arg ratio on responses of lipids and lipoprotein concentrations to dietary proteins and to evaluate the effects of dietary Lys:Arg on cardiovascular disease risk…
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175084
- Testing
- Comparison of dietary protein amino acid profile
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Protamine Allergy, Protamine Adverse Reaction
Serum Tryptase Levels During Cardiac Surgery, Diagnosis and Treatment Decisions for Allergic Reactions
The investigators aim to assess tryptase test efficacy for measuring the allergic response to protamine during cardiac bypass surgery.
- Trial name
- NCT02644785
- Testing
- protamine
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Mustafa Kemal University
Acute Coronary Syndrome
African-American Pharmacogenetics
This is a genetic and platelet reactivity study of African-American versus Caucasian patients undergoing percutaneous coronary intervention and receiving clopidogrel or prasugrel.
- Trial name
- AA Genetic (NCT01408121)
- Testing
- Genotyping and platelet reactivity testing with the VerifyNow P2Y12 assay
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Medstar Health Research Institute
Cardiovascular Diseases, Glucose Metabolism Disorders
Effects of Hazelnuts and Cocoa on Metabolic Parameters and Vascular Reactivity
This study aims to assess the effects of hazelnuts, cocoa, and the combination of both on vascular reactivity and metabolic profile.
- Trial name
- NCT02845622
- Testing
- Hazelnut, Cocoa, No hazelnuts / No cocoa
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Ospedale San Donato
Acute Coronary Syndrome, Adverse Reaction to Antiplatelet Agent
Mojito Study (Mashed Or Just Integral Pill of TicagrelOr ? )
The aim of the Mashed Or Just Integral pill of TicagrelOr (MOJITO) study is to evaluate the superiority of Ticagrelor 180 mg LD mashed pill versus Ticagrelor 180 mg LD integral pill both orally administrated in decreasing…
- Trial name
- NCT01992523
- Testing
- Ticagrelor mashed pills, Ticagrelor integral pills
- Where
- 2 sites in Greece, Italy
- Volunteers
- 82 people
- Sponsor
- David Antoniucci
Drug-eluting Stents, Percutaneous Coronary Intervention
In-stent Repair and Vessel Reaction of STEMI Patients With OCT
This study is a prospective, multi-center, non-inferior, randomized controlled clinical trial, aims to use optical Coherence tomography to observe the the early- and mid-stage vessel repair and neointimal proliferation.
- Conditions
- Drug-eluting Stents, Percutaneous Coronary Intervention, Optical Coherence Tomography, ST-Elevation Myocardial Infarction
- Trial name
- NCT04150016
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Xijing Hospital
Cardiovascular Diseases, Heart Diseases
Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension
To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005208
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Vascular Reactivity, Serum Biomarkers
MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers
To examine vascular reactivity and inflammatory biomarkers via quantitative magnetic resonance imaging (MRI) and blood serum, respectively, in a crossover study where active vapers (electronic cigarette users) and smokers will…
- Trial name
- AeCE (NCT05271578)
- Testing
- Standardized Electronic Research Cigarette, Nicotine Research Cigarette
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Peripheral Arterial Disease
TiVi Evaluation of Microcirculatory Reactivity of the Skin to Galvanic Stimulation: Effect of Aspirin
Prospective interventional study. The aim is to analyze the effect of usual ongoing treatments over microvascular cutaneous response to galvanic current applications (CIV: current induced vasodilatation) with tissue vitality…
- Trial name
- PIRAAT (NCT03357367)
- Testing
- TiVi system
- Where
- France
- Volunteers
- 830 people
- Sponsor
- University Hospital, Angers
Coronary Artery Disease
Evaluation of an Ayurvedic Herbal Compound Compared to Vitamins C+E and Placebo on Vascular Function in High-Risk Subjects
This was a randomized controlled trial aimed to evaluate the effects of an herbal Ayurvedic herbal supplement in comparison to a Vitamin C/E supplement and an inert placebo on heart health.
- Trial name
- NCT07206901
- Testing
- Maharishi Amrit Kalash, vitamin C + E
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Maharishi International University
Cerebral Hemorrhage
Multimodal Monitoring in Patients With Spontaneous Intracerebral Hemorrhage
Spontaneous intracerebral bleeding also known as spontaneous intracerebral hemorrhage (sICH) constitute 10-15 % of all apoplexies.
- Trial name
- NCT02326571
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- Christian Kærsmose Friberg
Sickle Cell Disease, Cerebral Stroke
Cerebral Oxygen Metabolism in Children
The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life.
- Trial name
- COMIC (NCT04157179)
- Testing
- Carbon Dioxide
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Coronary Artery Disease
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
Despite the relative safety of PCI with new generation stents, peri-PCI thrombotic complications, including myocardial infarction and myocardial injury, are common in elective PCI, occurring in up to 30% of patients.
- Trial name
- NCT05332262
- Testing
- Assessment of platelet reactivity, Troponin measurement
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Florida
Heart Attack, Cardioplegia Solution Adverse Reaction
Combined Use of a Novel Cardioplegic Formula With MPS® Versus Cardioplexol ® in Urgent Isolated CABG Using MiECC in Patients With Recent Acute Myocardial Infarction
The goal of this study is to compare the two cardioplegia solutions (blood cardioplegia by means of MPS ® vs. Cardioplexol ®) regarding perioperative outcome and with special attention to cardiac markers in patients with a recent…
- Conditions
- Heart Attack, Cardioplegia Solution Adverse Reaction, Coronary Artery Bypass Grafting (CABG)
- Trial name
- NCT04309994
- Testing
- Myocardial protection system (MPS), Cardioplexol
- Where
- Switzerland
- Volunteers
- 307 people
- Sponsor
- University Hospital, Basel, Switzerland
Psoriasis Vulgaris
Low-Salt Diet Effect on Th17-Mediated Inflammation and Vascular Reactivity in Psoriasis
Psoriasis presents an independent cardiovascular risk factor characterized by chronic low-grade systemic inflammation and oxidative stress which altogether might lead to endothelial dysfunction.
- Trial name
- NCT05892640
- Testing
- Low-Salt Diet
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Diabetes, Hypertension
Effects of Quinapril 40 mg With Alpha Lipoic Acid or Placebo on Diabetes and Hypertension
We will evaluate the combination of quinapril and alpha lipoic acid in patients with diabetes mellitus and hypertension. We will determine whether the combination of quinapril and lipoic acid as compared to quinapril and placebo…
- Trial name
- QUALITY (NCT00795262)
- Testing
- Quinapril (Accupril) plus Alpha Lipoic Acid, accupril, alpha lipoic acid
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- InVasc Therapeutics, Inc.
Coronary Artery Disease, Platelet Reactivity
Body Weight Adjusted Clopidogrel Treatment in Patients With CORonary Artery Disease
Extreme body weights (BW) or body mass index (BMI) affect the pharmacokinetics of antithrombotic drugs and consequently may affect cardiovascular risk during treatment.
- Trial name
- BW-ACCORD (NCT05657041)
- Testing
- Clopidogrel
- Where
- 2 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- St. Antonius Hospital