Clinical trials: Vasopressor
Transversus Abdominis Plane Block
Plasma Concentrations of Levobupivacaine With and Without Epinephrine in Transversus Abdominis Plane Blocks
The aim of this study is to determine the effect of the addition of vasoconstrictor in the plasma concentrations achieved and the extent of the transversus abdominis plane block in healthy male volunteers.
- Trial name
- NCT01596998
- Testing
- Levobupivacaine with epinephrine, Levobupivacaine without epinephrine, Monitoring
- Where
- Chile
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Vasoplegia
Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)
Vasopressors are medications that are given intravenously to increase the blood pressure of patients with illnesses that cause dangerous blood pressure drops.
- Trial name
- NCT05058612
- Testing
- Midodrine
- Where
- Canada
- Volunteers
- 870 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Pain, Trismus
2%-Mepivacaine With Two Different Vasoconstrictors Solutions in Third Molar Surgery a Comparative Study
Dental treatments, particularly third molars extraction, can become extremely uncomfortable and painful. They are associated to anxiety, fear and many other unpleasant sensations.
- Conditions
- Pain, Trismus, Edema
- Trial name
- NCT02603198
- Testing
- mepivacaine chloridrato epinephrine, mepivacaine chloridrato levonordefrin
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Methamphetamine Use Disorder
Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine]
This study will evaluate the behavioral effects of methamphetamine during maintenance on placebo, duloxetine, methylphenidate and duloxetine combined with methylphenidate using sophisticated human laboratory methods.
- Trial name
- NCT04178993
- Testing
- Methamphetamine, Methylphenidate, Duloxetine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Craig Rush
LOCAL ANESTHESIA
To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor
As vasoconstrictors adversely affect pulpal hemodynamics, this study compared the pulpal oxygen saturation levels after employing inferior alveolar nerve block with 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest…
- Trial name
- NCT04947267
- Testing
- 3% Mepivacaine Hydrochloride, 2% Mepivacaine with 1:100,000 epinephrine
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Afshan Amjad Ali
Healthy
Comparison of Intranasal Oxytocin Effects Using Co-administration With a Vasoconstrictor
This study aims to dissociate direct from indirectly mediated effects of intranasal oxytocin administration by using treatment with or without prior intranasal administration of a vasoconstrictor to reduce peripheral increases in…
- Trial name
- NCT04134663
- Testing
- vasoconstrictor and oxytocin treatment
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Acute Allergic Reaction, Anaphylaxis
Phase 1 Crossover Study Evaluating the Safety, Tolerability, and Pharmacokinetics of KP001 in Healthy Adult Volunteers
The goal of this clinical trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of several KP001 dose regimens to identify a treatment regimen with a PK profile that safely meets or exceeds the PK profile of…
- Trial name
- NCT06963411
- Testing
- KP001
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kokua Pharma Inc.
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cesarean Section, Cardiac Output
Best Regimen for Phenylephrine Administration During Cesarean Section
During Cesarean delivery, phenylephrine is used to maintain the patient's blood pressure. Low blood pressure is the most common side effect of the spinal medication used to anesthetize the patient prior to the start of surgery.
- Conditions
- Cesarean Section, Cardiac Output, Hypotension
- Trial name
- NCT00996190
- Testing
- Phenylephrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cardiac Output, Low
Cardiac Index Changes With Ephedrine, Phenylephrine, Ondansetron and Norepinephrine During Spinal Anesthesia
The purpose of the study is to evaluate the cardiac output changes after an intravenous bolus of ephedrine, phenylephrine, ondansetron or norepinephrine during a spinal anesthetic for a cesarean delivery.
- Trial name
- EPhON (NCT03421860)
- Testing
- cardiac output changes with "ephedrine", cardiac output changes with "phenylephrine", cardiac output changes with "ondansetron"
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Healthy
A Randomized, Double-Blind, Trial Comparing Epinephrine Versus Phenylephrine as a Vasoconstrictor in Regional Anesthesia for Upper Extremity Surgery
The study involves research, the purpose of which is to compare three different drug mixtures (Epinephrine, Phenylephrine 25 µg, or Phenylephrine 50 µg). Specifically, how long each medicine lasts will be studied.
- Trial name
- NCT00225043
- Testing
- Epinephrine/phenylephrine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Hemodynamics, Pain
Hemodynamic Effects of Different Vasoconstrictors in Mandibular Exodontia
Title of Study: The Effect of Different Vasoconstrictive Agents on Hemodynamics Among Patients Undergoing Simple Mandibular Exodontia: A Triple-Blind Randomized Controlled Trial Location: King Abdulaziz University Dental Hospital…
- Conditions
- Hemodynamics, Pain, ASA I-II Requiring Simple Dental Extraction of a Mandibular Tooth
- Trial name
- NCT07013071
- Testing
- 2% Mepivacaine with 1:100,000 epinephrine, 2% Mepivacaine with 1:55,000 Epinephrine Bitartrate
- Where
- Saudi Arabia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Migraine With Aura
Endothelin-1 as a Potential Trigger of Migraine Aura
One third of migraine patients experience aura, i.e. dramatic, transient neurological symptoms, most often in the form of visual disturbances, that usually appear before the onset of migraine headache.
- Trial name
- NCT02906085
- Testing
- Endothelin-1
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen