Clinical trials: Vasospasm, Cerebral
Subarachnoid Hemorrhage, Aneurysmal
Shuxuening Injection for the Prevention of CVS in Patients With aSAH(SXN-CVS)
Aneurysmal subarachnoid hemorrhage (SAH) is a frequent worldwide cause for stroke with a mortality of around 30%. Worldwide, almost 500 000 patients have aneurysmal SAH annually.An incidence of 2-16 cases of spontaneous SAH per…
- Trial name
- SXN-CVS (NCT06138353)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Xiaolin Chen, MD
Subarachnoid Hemorrhage, Aneurysmal
Angiotensin Metabolite Profile After Subarachnoid Hemorrhage
The outcome of subarchnoid hemorrhage depends on the severity of the bleeding and the development of secondary neurologic deficits caused by cerebral vasospasm.
- Trial name
- NCT05222542
- Testing
- Sampling of plasma and cerebrospinal fluid at specified time points
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Dr. Roman Ullrich
Subarachnoid Hemorrhage, Cerebral Vasospasm
Sildenafil for DCI
Each year, approximately 30,000 people in the United States suffer an intra-cranial hemorrhage due to aneurysmal rupture. Of those surviving the initial event, up to 40% will go on to have further neurological injury secondary to…
- Trial name
- NCT03028298
- Testing
- Low dose sildenafil citrate, High dose sildenafil citrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Mississippi Medical Center
Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal
Prevention of Vasospasm in SAH Through CSF Treatment
The pathophysiological mechanisms of aneurysmal subarachnoid haemorrhage (aSAH) involve early brain injury (EBI) and delayed cerebral ischemia (DCI).
- Conditions
- Subarachnoid Hemorrhage, Subarachnoid Hemorrhage, Aneurysmal, Vasospasm, Cerebral, Aneurysmal Subarachnoid Hemorrhage
- Trial name
- PREVAIL (NCT04490161)
- Testing
- intravenous reinstallation of cerebrospinal fluid
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University Innsbruck
Intracranial Vasospasm
Mechanical Intracranial Artery DilAtation Using Stent-retriever for Cerebral Vasospasm
Solitaire-x is a stent-retriever that is currently world-widely used, but is currently FDA-approved only as a revascularization device indicated for use to restore blood flow in the neurovasculature by removing thrombus for the…
- Trial name
- NCT06615882
- Testing
- stent-angioplasty & nimodipine infusion (During the stent (Solitaire-X) -angioplasty, IA nimodipine was also infused)
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Yonsei University
Subarachnoid Hemorrhage
Contrast Enhanced Ultrasound Imaging for Cerebral Perfusion Measurement in Cerebral Vasospasm After SAH
The objective of the study is to assess brain tissue perfusion by ultrasound perfusion imaging. Specifically to diagnose brain tissue hypoperfusion due to CVS with contrast enhanced UPI and to assess specificity and sensitivity…
- Trial name
- NCT02907879
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Subarachnoid Hemorrhage, Cerebral Vasospasm
Safety Study of Dantrolene in Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating acute brain injury due to bleeding onto the brain surface from a ruptured aneurysm.
- Trial name
- NCT01024972
- Testing
- Dantrolene
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Massachusetts, Worcester
Cerebral Vasospasm After Subarachnoid Hemorrhage
Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating acute brain injury due to bleeding onto the brain surface from a ruptured aneurysm.
- Trial name
- NCT00964548
- Testing
- Dantrolene
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
Metabolomic Profile and Proteasic Activity as Biomarkers for Early Detection of Arterial Vasospas in Arterial Vasospasm After Aneurysmal Subarachnoid Hemorrhage
The subarachnoid hemorrhage (SAH) from ruptured aneurysm is a situation that is life-threatening, which is largely dependent on the occurrence of vasospasm from the 4th day after the bleeding.
- Trial name
- NCT02397759
- Testing
- Blood draw and cerebrospinal fluid draw
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Subarachnoid Hemorrhage, Cerebral Vasospasm
Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage
The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage
- Conditions
- Subarachnoid Hemorrhage, Cerebral Vasospasm, Hydrocephalus
- Trial name
- NCT01799018
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- State University of New York - Upstate Medical University
Aneurysmal Subarachnoid Hemorrhage
Transdermal Nicotine Replacement in Smokers With Acute Aneurysmal Subarachnoid Hemorrhage
All patients with acute aneurysmal hemorrhage are treated in accordance with our institutional protocol. After securing of the aneurysm, some smokers with acute aneurysmal hemorrhage are randomly assigned to transdermal nicotine…
- Trial name
- NRT-SAH (NCT02350335)
- Testing
- Nicotine (transdermal)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Aneurysmal Subarachnoid Hemorrhage
Erythropoietin Therapy for Subarachnoid Hemorrhage
ABSTRACT: Delayed ischemic deficits (DID) and strokes caused by low cerebral blood flow (CBF) are major sources of poor outcome following aneurysmal subarachnoid hemorrhage (SAH).
- Trial name
- NCT00140010
- Testing
- erythropoietin beta
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Cambridge
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
CT Perfusion Imaging to Predict Vasospasm in Subarachnoid Hemorrhage
Patients with brain hemorrhage resulting from a ruptured aneurysm (SAH) are at risk of developing a condition called vasospasm, one or two weeks after their hemorrhage. This is a major cause of stroke and death following SAH.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Cerebral Vasospasm, CT Perfusion
- Trial name
- CT-PIPS (NCT02056769)
- Testing
- CT Perfusion
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Nova Scotia Health Authority
Subarachnoid Hemorrhage, Vasospasm, Intracranial
The Factors Cause Vasospasm After Aneurysmal Subarachnoid Hemorrhage
Extensive research has shown that the big event that leads to the initiation of vasospasm is the release of oxyhemoglobin (blood breakdown product).Depletion of NO synthase (19,20,21) was also noted after SAH.CSF is produced from…
- Trial name
- NCT00745758
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Subarachnoid Hemorrhage
Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage
The purpose of this study is to determine the effectiveness of prophylactic administration of intra-thecal nicardipine though lumbar cerebrospinal fluid drain in prevention of symptomatic vasospasm in patients with subarachnoid…
- Trial name
- NCT07246629
- Testing
- Normal Saline, Nicardipine
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- Wake Forest University Health Sciences
Cerebral Vasospasm After Subarachnoid Hemorrhage
Invasive Diagnostic and Therapeutic Management of Cerebral Vasospasm After Aneurysmatic Subarachnoid Hemorrhage
Cerebral vasospasm(CVS) after subarachnoid hemorrhage (SAH) results in a considerable amount of transient or even permanent neurological deficits and poor outcome of the patients.
- Trial name
- IMCVS (NCT01400360)
- Testing
- Combination of TBA and intraarterial application of vasodilators
- Where
- 5 sites in Germany
- Volunteers
- 92 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Post-Traumatic Subarachnoid Hemorrhage
Superior Cervical Sympathetic Block Versus Stellate Ganglion Block in Post-traumatic Subarachnoid Hemorrhage
Posttraumatic Subarachnoid hemorrhage (SAH) is a life-threatening neurological problem with a high mortality rate. Delayed cerebral ischemia (DCI) is the second-leading cause of death and disability in patients suffering from…
- Trial name
- NCT06134583
- Testing
- Superior cervical sympathetic block group, Stellate ganglion block group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Stroke, Brain Ischemia
Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Dexmedetomidine is a unique sedative medication able to provide sedation without causing respiratory depression and maintaining neurological functions.
- Conditions
- Stroke, Brain Ischemia, Vasospasm, Intracranial, Hemorrhage, Intracranial
- Trial name
- NCT01845441
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University Hospitals Cleveland Medical Center
Aneurysmal Subarachnoid Hemorrhage
Clazosentan in Aneurysmal Subarachnoid Hemorrhage
The aim of this study is to demonstrate that clazosentan, administered as a continuous intravenous infusion at either 5 mg/h or 15 mg/h until Day 14 post aneurysmal subarachnoid hemorrhage (aSAH), reduces the incidence of…
- Trial name
- CONSCIOUS-3 (NCT00940095)
- Testing
- Clazosentan 5 m/h, Clazosentan 15 mg/h
- Where
- 145 sites in United States, Argentina and 26 more
- Volunteers
- 577 people
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Tbi, Vasospasm
Cerebral Autoregulation and Vasospasm in Patients With TBI
Traumatic brain injury (TBI) affects 1.5 million patients per year in the United States, resulting in more than 50,000 deaths and more than 230,000 hospitalizations annually.
- Conditions
- Tbi, Vasospasm, Cerebral Ischemia, Cerebral Infarct
- Trial name
- NCT02351518
- Testing
- No intervention
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore