Clinical trials: Ventilated Patient in Intensive Care
Critical Illness, Respiratory Failure
Sedation in the Intensive Care Unit
High-risk critically ill patients often require mechanical ventilation either to primarily support the respiratory function or when the ventilation is insufficient to maintain adequate gas exchanges as a result of other organ…
- Trial name
- NCT00221520
- Testing
- midazolam with 2 different levels of sedation scores
- Where
- Switzerland
- Volunteers
- 126 people
- Sponsor
- University Hospital, Geneva
Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD)
The Effect of Neuromuscular Electrical Stimulation
The effect of neuromuscular electrical stimulation on muscle atrophy in sedated patients on intensive care was studied. The aim of this study was to explore if electrical stimulation could prevent muscle atrophy.
- Conditions
- Postoperative Coronary Artery Bypass Grafting (CABG), Chronic Obstructive Pulmonary Disease (COPD), Ventilatory Failure
- Trial name
- NCT00442728
- Testing
- ELECTRICAL STIMULATION
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Provinciale Hogeschool Limburg
Mechanically Ventilated Patients
Cough Assist Device in Mechanically Ventilated Patients
Aspiration of respiratory secretions is a frequently needed procedure in intubated patients . Cough is an important defence mechanism to clear mucus from the upper and lower airways .
- Trial name
- NCT05480371
- Testing
- Conventional tracheal suctioning, Mechanical insufflation/exsufflation
- Volunteers
- 200 people
- Sponsor
- Assiut University
Critical Illness
Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
The purpose of this study is to evaluate the efficacy and safety of fospropofol disodium for injection compared to propofol for sedation in mechanically ventilated ICU patients.
- Trial name
- NCT05491278
- Testing
- Fospropofol disodium for injection, Propofol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaobo Yang, MD
Pain, Pediatric ALL
Validation of the ANI in Perpubescent Patients in Pediatric Intensive Care Unit.
The ANI monitor is a medical device allowing to measure the response of the autonomic nervous system to a painful stimulus. In the pediatric population under general anesthesia, the ANI score can detect failure of locoregional…
- Trial name
- ANI-EP (NCT04913038)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Lille
Intensive Care Units, Pediatric, Anesthetics, Inhalation
Advancing Brain Outcomes in Pediatric Critically Ill Patients Sedated With Volatile AnEsthestic Agents
The goal of a pilot study is to test a study plan to see if it is appropriate for a larger study. This study plan is looking at whether the use of inhaled sedatives (medications that help people be calm and sleep) can reduce…
- Conditions
- Intensive Care Units, Pediatric, Anesthetics, Inhalation, Mechanically Ventilated, Critically Ill Children
- Trial name
- ABOVE (NCT05867472)
- Testing
- Isoflurane Inhalant Product
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Sunnybrook Health Sciences Centre
Adult, Intensive Care Unit
Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients
Delirium is common in septic patients, especially those receiving mechanical ventilation in the intensive care unit (ICU). Dexmedetomidine is a highly selective α2 adrenoreceptor agonist with anxiolytic, sedative, analgesic, and…
- Conditions
- Adult, Intensive Care Unit, Sepsis, Mechanical Ventilation
- Trial name
- NCT04876937
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Peking University First Hospital
Intensive Care Unit
Study to Evaluate Hemodynamic Effect of Different Loading Doses of Precedex in Post-surgical Intensive Care Unit (ICU) Patients
The objective of this study is to characterize the hemodynamic effects of Precedex (dexmedetomidine (DEX)) during 3 loading-dose paradigms in mechanically ventilated post-surgical subjects in an intensive care setting.
- Trial name
- NCT01169571
- Testing
- Dexmedetomidine
- Where
- 17 sites in Canada
- Volunteers
- 373 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Acute Respiratory Failure Requiring Mechanical Ventilation
Eye-Control Trial: Wearable Eye-Tracking Device as Means of Communication
The purpose of this study is to evaluate the feasibility of use of a wearable communication device for critically ill patients who are admitted to the intensive care unit (ICU) and mechanically ventilated.
- Trial name
- NCT04582149
- Testing
- EyeControl Eye-tracking Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Intensive Care Unit Acquired Weakness
Blood Flow Restriction Training for Mechanically Ventilated Patients With ICU-Acquired Weakness
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop ICU-acquired weakness - a condition marked by widespread muscle loss and weakness caused by prolonged bed rest, severe illness, and…
- Trial name
- BFRT-ICU (NCT07802743)
- Testing
- Blood flow restriction training, Standard ICU Care and Routine Rehabilitation
- Volunteers
- 120 people
- Sponsor
- Affiliated Hospital of Jining Medical University
Ventilator Weaning, Mechanical Ventilation
Comparison of Diaphragm Ultrasound and RSBI for Predicting Weaning Success in Mechanically Ventilated ICU Patients
The goal of this observational study is to evaluate the predictive value of diaphragmatic ultrasound compared to the Rapid Shallow Breathing Index (RSBI) in determining weaning success among mechanically ventilated patients in…
- Conditions
- Ventilator Weaning, Mechanical Ventilation, Respiratory Insufficiency Requiring Mechanical Ventilation, Weaning From Mechanical Ventilation
- Trial name
- NCT07120438
- Volunteers
- 55 people
- Sponsor
- Gadjah Mada University
Critical Illness
Does the Sara Combilizer®, an Early Mobilization Aid, Reduce the Time Taken to First Mobilise Ventilated Patients in Intensive Care?
This study investigates the impact of introducing an early mobilisation device called the Sara Combilizer on time taken to mobilise in critical care.
- Trial name
- NCT03143777
- Testing
- Sara Combilizer
- Volunteers
- 80 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Patient Care, Quality of Health Care
Comparison of Two Chest Radiograph Prescription Strategies in Intensive Care Unit
Current guidelines recommend Routine daily chest radiographs (CXRs) for mechanically ventilated patients in intensive care units (ICUs).
- Conditions
- Patient Care, Quality of Health Care, Intensive Care Units, Ventilation, Mechanical
- Trial name
- RARE (NCT00893672)
- Where
- France
- Volunteers
- 849 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Associated Pneumonia ( VAP), Sepsis
High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit
Prospective, Randomized clinical trial study will be carried out in intensive care unit in Ain Shams University Hospitals on 40 forty septic patients admitted to ICU and mechanically ventilated.
- Trial name
- NCT04029675
- Testing
- Vitamin C
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Respiratory Insufficiency
Ventil Device Usefulness in Mechanically Ventilated ICU Patients
During Covid-19 pandemic many patients require mechanical ventilation due to disastrous impact of SARS-CoV-2 on lungs. In several countries there is a shortage of ICU beds and ventilators.
- Trial name
- NCT04355754
- Testing
- Ventil - a gas flow divider
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Gdansk
Mechanical Ventilation
Effect of Post-suction Recruitment on Lung Volume in Mechanically Ventilated ICU Patients
Patients who are intubated and mechanically ventilated in the intensive care unit (ICU) require repeated endotracheal suctioning to remove airway secretions.
- Trial name
- RESPIRE (NCT07358039)
- Testing
- Suction + Recruitment maneuver, Closed-circuit endotracheal suctioning
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Infection Prophylaxis
Pharmacokinetics, Pharmacodynamics and Safety Evaluation of SAR279356 in Intensive Care Unit Mechanically Ventilated Patients
Primary Objective: To determine the pharmacokinetics (PK) of a single intravenous (IV) dose of SAR279356 administered to intensive care unit (ICU) patients on mechanical ventilation Secondary Objectives: To determine the safety…
- Trial name
- NCT01389700
- Testing
- SAR279356
- Where
- 6 sites in United States
- Volunteers
- 7 people
- Sponsor
- Sanofi
COVID-19, Bacterial Infections
Incidence of Colonization by Multidrug-resistant Organisms in Mechanically Ventilated Patients With Severe COVID-19
Retrospective single-center cohort study to evaluate the incidence of colonization by multidrug-resistant organisms (MDRO) in mechanically ventilated patients admitted to a large intensive care unit (ICU) for severe acute…
- Conditions
- COVID-19, Bacterial Infections, Colonization, Asymptomatic
- Trial name
- MDR_in_Fiera (NCT05293418)
- Testing
- data collection
- Where
- Italy
- Volunteers
- 435 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator-associated Pneumonia and Oral Health
The Effect of Two Different Oral Care Solutions on Ventilator-Associated Pneumonia and Oral Health of Mechanically Ventilated Patients in the Intensive Care Unit
The aim of this observational study is to evaluate the effects of two different oral care solutions on ventilator-associated pneumonia and oral health in mechanically ventilated participants in the intensive care unit.
- Trial name
- NCT06966817
- Testing
- control group(chlorhexidine), Experimental Group(cetylpyridinium chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Deep Sedation, Ventilators, Mechanical
Pain, Agitation and Delirium (PAD) Protocol in the Duke CICU
This study aims to examine the use of protocol directed sedation using the Duke PAD protocol with the current sedation medications of propofol or dexmedetomidine compared to the PAD protocol with midazolam, per cardiac intensive…
- Conditions
- Deep Sedation, Ventilators, Mechanical, Critical Illness
- Trial name
- NCT02903407
- Testing
- Midazolam, Propofol, Dexmedetomidine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University