Clinical trials: Ventilated Patient in Intensive Care
Enteral Feeding, Nutrition Disorders
Intermittent Versus Continuous Enteral Nutrition in Mechanically Ventilated Patients in the Medical Intensive Care Unit
Evaluate effective delivery of goal nutrition with intermittent as compared with continuous enteral nutrition schedules, as defined by percentage of recommended calories that patient receives per day of interest.
- Trial name
- NCT04437264
- Testing
- Intermittent feed participant, Continuous feeds participant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Poor Quality Sleep, Sleep Deprivation
The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit
The investigators are going to compare the sleep quality and quantity between dexmedetomidine group and midazolam group using 24 hour polysomnography in critically ill patients.
- Conditions
- Poor Quality Sleep, Sleep Deprivation, Sleep Arousal Disorders, Delirium
- Trial name
- NCT01966315
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- Seoul National University Hospital
Prevalence of Airway Closure, in Adults in Intensive Care
Abbreviated Title: Airway Opening Pressure in Mechanically VENTilated Patients
Context: Mechanical ventilation is an essential treatment for patients admitted to intensive care. It is estimated that approximately 50% of adult patients admitted to intensive care require invasive mechanical ventilation.
- Conditions
- Prevalence of Airway Closure, in Adults in Intensive Care, Mechanical Ventilation in Controlled Mode
- Trial name
- AOP-VENT (NCT07512713)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine Combined With Dexmedetomidine for Sedation of Mechanically Ventilated Patients
A prospective, randomized controlled study was conducted to compare the effects of esketamine combined with dexmedetomidine in the sedation and analgesia treatment of mechanically ventilated patients in the ICU on the time to…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Intensive Care Units
- Trial name
- SEEDS (NCT05466708)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Non Ventilated ICU Patients
Relevance and Nuisances of Respiratory Rate Alarm Generated by Multi-parametric Monitors in Non Ventilated ICU Patients
In ICU setting, a large number of medical devices are attached to patients, generating numerous alarm signals. Several studies have demonstrated that most of these alarms are not clinically relevant and tend to lower the…
- Trial name
- FR-REA (NCT02908659)
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Pharmacokinetics, Sedation
Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU
The study will examine dexmedetomidine levels in the blood of critically ill intensive care patients to understand how it is broken down by the body.
- Trial name
- DEX PK (NCT00747721)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Orion Corporation, Orion Pharma
Critically Ill, Mechanical Ventilation
The TEAM Long-Term Cohort Study (A Sub-study of TEAM(III))
This study is a prospective cohort study to evaluate the long-term effects of early activity and mobilisation compared to standard care on disability, function and health status for patients at 1, 2 and 5 years after recruitment…
- Conditions
- Critically Ill, Mechanical Ventilation, Long Term Outcome
- Trial name
- NCT05298982
- Testing
- Early activity and Mobilisation Intervention
- Where
- 16 sites in Australia
- Volunteers
- 250 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Intensive Care, Invasive Mechanical Ventilation
Lung Recruitment During Chest Physiotherapy in Mechanically Ventilated Patients
In intensive care, respiratory physiotherapy is an integral part of the daily care of patients under invasive mechanical ventilation.
- Conditions
- Intensive Care, Invasive Mechanical Ventilation, Chest Physiotherapy, Airway Clearance
- Trial name
- RECRUTKI (NCT06805357)
- Testing
- Chest Physiotherapy by Rib Cage Compressions (RCC)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Midazolam for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- MIDEX (NCT00481312)
- Testing
- Dexmedetomidine, Midazolam
- Where
- 43 sites in Belgium, Estonia and 7 more
- Volunteers
- 501 people
- Sponsor
- Orion Corporation, Orion Pharma
Critical Illness, Intensive Care Unit Acquired Weakness
PRotEin Provision in Critical IllneSs
Rapid skeletal muscle wasting during critical illness had a detrimental impact on both short and long term outcomes following ICU admission.
- Trial name
- PRECISe (NCT04633421)
- Testing
- PRECISe protocol EN 8g protein/100kcal, PRECISe protocol EN 5g protein/100kcal
- Where
- 10 sites in Belgium, Netherlands
- Volunteers
- 935 people
- Sponsor
- Maastricht University Medical Center
Critical Illness
The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.
The aim of the study was to describe the feasibility of the nociception flexion reflex and the pupillary dilatation reflex as objective pain assessment tools in the Intensive Care Unit (ICU).
- Trial name
- NCT02916004
- Testing
- Measurement of NFR and PDR
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Antwerp
Sleep Deprivation, Sleep
Sleep Headphones and HDU: a Novel Intervention and Sound Evaluation
It is well established that patients sleep poorly in the Intensive Care Unit (ICU), and excessive noise is considered to be a modifiable cause of this.
- Trial name
- SHH: Noise! (NCT03774212)
- Testing
- Active noise cancelling headphones
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Edinburgh
Sepsis
Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis
Despite of a remarkable decrease in overall mortality has been achieved following the International Guidelines for Management of Sepsis and Septic Shock since 2004,the short-and long-term outcomes remain poor in critically ill…
- Trial name
- PTMVP (NCT03406494)
- Testing
- Early multicomponent physical therapy program
- Volunteers
- 800 people
- Sponsor
- Zhujiang Hospital
Sedation and Analgesia, Pain Intensity Assessment
Prevalence of Pain in Mechanically Ventilated Patients in Intensive Care Units
Introduction: Pain is a subjective symptom, a physiological response that is difficult to assess, which affects the body physically and/or emotionally.
- Conditions
- Sedation and Analgesia, Pain Intensity Assessment, Mechanical Ventilation Complication
- Trial name
- PainICU (NCT07182851)
- Where
- 4 sites in Brazil
- Volunteers
- 370 people
- Sponsor
- Centro Universitário Augusto Motta
Weaning From Mechanical Ventilation
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit
Ventilator-induced diaphragmatic dysfunction appears to contribute to slow weaning from mechanical ventilation. Several trials of inspiratory muscle training to facilitate weaning in intensive care have been performed, with…
- Trial name
- EFES (NCT03140267)
- Testing
- Difficult to wean patients
- Where
- 2 sites in France
- Volunteers
- 22 people
- Sponsor
- University Hospital, Bordeaux
Mechanically Ventilated Patients
Mechanical Ventilation Practices in Uganda's Intensive Care Units
A prospective cohort study carried out in four ICUs in Uganda. All patients, 18 years and above initiated on mechanical ventilation will be recruited.
- Trial name
- NCT03800849
- Where
- Uganda
- Volunteers
- 214 people
- Sponsor
- Makerere University
Mechanically Ventilated Patients
Early Directed Physical Therapy in the Management of Mechanically Ventilated Patients in a Medical Intensive Care Unit
To study all ICU patients with an independent baseline functional status, who experience a critical illness requiring intubation and mechanical ventilation, evaluating the role of protocol-directed, early physical and…
- Trial name
- NCT00322010
- Testing
- early PT OT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of Chicago
Critical Illness, Intensive Care Unit
Oxygen Consumption (VO2), Effort, and Weaning in the Mechanically Ventilated Patient in the Intensive Care Unit (ICU)
In patients who are mechanically ventilated for more than 72 hours weaning failure is a common issue. The Spontaneous breathing trial (SBT) is often done to assess if the patient can be extubated with a high chance of success.
- Conditions
- Critical Illness, Intensive Care Unit, Oxygen Consumption, Weaning Failure
- Trial name
- EXTUBATE (NCT06391424)
- Testing
- Spontaneous Breathing Trial
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Intensive Care Unit Syndrome
High Protein Intake in Critically Ill Ventilated Patients
This prospective interventional randomized control study was conducted on forty patients with respiratory failure; all patients were intubated and mechanically ventilated for at least three days.
- Trial name
- NCT04977440
- Testing
- Whey protein
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University