Clinical trials: Ventilated Patient in Intensive Care
Hyperoxia, Complication
The Effectiveness of the Use of Oxygen Reserve Index in Preventing Hyperoxia in the Intensive Care Unit.
Oxygen therapy is the most common treatment modality for patients with hypoxemia in intensive care units, but target values for normoxemia are not clearly defined. Therefore, iatrogenic hyperoxemia is a very common situation.
- Conditions
- Hyperoxia, Complication, Mechanical Ventilation Complication
- Trial name
- NCT05807815
- Testing
- Titration of fraction of inspired oxygen (FiO2) guided by ORI and oxygen saturation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Tepecik Training and Research Hospital
Mechanical Ventilation, Critical Illness
Acupressure for Agitation, Pain, and Sleep in Mechanically Ventilated ICU Patients
Mechanically ventilated intensive care unit (ICU) patients commonly experience agitation, pain, and sleep disturbances, which may negatively affect recovery and increase the need for sedative medications.
- Conditions
- Mechanical Ventilation, Critical Illness, Agitation, Pain
- Trial name
- CALM-ICU (NCT07619326)
- Testing
- Acupressure, Light Touch
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Yang Yun Shiuan
Mechanical Ventilation Complication, Communication, Nonverbal
Communication Strategies for Mechanically Ventilated Patients in Intensive Care Units
This prospective study consisted of (1) a descriptive cross-sectional part describing communication difficulties related to mechanical ventilation as experienced by intensive care professionals and patients, and (2) an…
- Trial name
- NCT05651984
- Testing
- Comparison between communication board and eye tracking
- Where
- Belgium
- Volunteers
- 44 people
- Sponsor
- University of Liege
Pulmonary Disease, Chronic Obstructive
Timing of Dilation Tracheostomy in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is: to evaluate the optimal time-point for percutaneous dilation tracheostomy in COPD patients in terms of duration on mechanical ventilation, length of stay on ICU and mortality; to evaluate the rate of…
- Trial name
- NCT01021202
- Testing
- Percutaneous dilation tracheostomy
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Mechanical Ventilation, Pain Perception
Turkish Validity and Reliability of the Behavioral Indicators of Pain Scale(ESCID)
A significant proportion of patients hospitalized in intensive care units (ICUs) require mechanical ventilation, and the treatments applied during this process may cause pain.
- Conditions
- Mechanical Ventilation, Pain Perception, Intensive Care (ICU)
- Trial name
- NCT07467551
- Testing
- The ESCID scale
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Saglik Bilimleri Universitesi
Lung, Diaphragm
Lung and Diaphragm Ultrasound in Predicting Extubation and Weaning of Mechanically Ventilated Patients in Intensive Care Unit
This study aims to evaluate the role of lung ultrasound score (LUS), diaphragmatic excursion (DE), and diaphragmatic thickening fraction (DTF) as predictors of successful extubation in mechanically ventilated patients in the…
- Conditions
- Lung, Diaphragm, Ultrasound, Extubation
- Trial name
- NCT07057804
- Testing
- Lung Ultrasound, Diaphragm Ultrasound
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Kafrelsheikh University
Intensive Care Unit Acquired Weakness, Critical Care
TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very vulnerable to weakness and disability.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- TryCYCLE (NCT01885442)
- Testing
- In-bed leg cycle ergometry
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- McMaster University
Critical Illness
Ultrasound Guided Axillary Versus Jugular Central Venous Catheterization
The main intention of this study is to compare two ultrasound-guided central venous catheterization procedures namely: real-time, ultrasound-guided, in plane axillary vein catheterization and real-time, ultrasound-guided, out of…
- Trial name
- NCT02624323
- Testing
- Real-time ultrasound-guided central vein catheterization.
- Where
- 2 sites in Poland
- Volunteers
- 614 people
- Sponsor
- Uniwersytecki Szpital Kliniczny w Opolu
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Adult Disease, Intensive Care Unit Syndrome
Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients
For patients undergoing mechanical ventilation, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased…
- Conditions
- Adult Disease, Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Delirium
- Trial name
- NCT03172897
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Peking University First Hospital
Respiratory Failure, Pulmonary Disease
Respiratory Mechanics Assessment at Different Head of the Bed Elevations in Mechanically Ventilated Patients
The effects of different degrees of head-of-bed elevation on respiratory mechanics are poorly explored in the literature, and no study has investigated such effects using electrical impedance tomography, esophageal and gastric…
- Trial name
- NCT06409897
- Testing
- Sequencial increasing of head of the bed elevation and alveolar recruitment maneuver followed by a PEEP titration with 10° of head of the elevation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Ventilation-Associated Pneumonia
Study of Impact of Not Measuring Residual Gastric Volume on Nosocomial Pneumonia Rates
Early enteral feeding is a key component of the management of critically ill patients receiving mechanical ventilation. However, enteral feeding has been associated with serious complications such as aspiration followed by…
- Trial name
- NUTRIREA1 (NCT01137487)
- Testing
- monitoring of residual gastric volume, not monitoring of residual gastric volume
- Where
- 6 sites in France
- Volunteers
- 452 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Emergency Medical Services, Response
Response Times in Danish Emergency Medical Services
The overall aim of this retrospective observational study is to investigate the association of emergency medical services response time with patient survival and treatment outcomes.
- Conditions
- Emergency Medical Services, Response, Triage, Survival Outcomes
- Trial name
- AHRTEMIS (NCT06666647)
- Testing
- Treatment by ambulance or helicopter services with response times
- Where
- Denmark
- Volunteers
- 2,500,000 people
- Sponsor
- Peter Martin Hansen
Intensive Care, Ventilator Lung
Respiratory Mechanics in Intensive Care Patients
This study aims at assessing the respiratory mechanics of intubated patients in intensive care unit.
- Trial name
- PREMIER (NCT03420417)
- Testing
- Esophageal pressure measurement
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Nosocomial Pneumonia, Ventilator Associated Pneumonia
Characteristics of Lower Respiratory Tract Escherichia Coli Isolates in Mechanically Ventilated Intensive Care Patients
Prospective, multicenter observational study to collect Escherichia coli (E. coli) isolates originating from mechanically ventilated intensive care unit (ICU) patients; in order to characterize phenotype and genotype of E.
- Conditions
- Nosocomial Pneumonia, Ventilator Associated Pneumonia, Escherichia Coli Infections, Escherichia Coli Pneumonia
- Trial name
- COLOCOLI (NCT03303937)
- Volunteers
- 289 people
- Sponsor
- Hôpital Louis Mourier
Acute Respiratory Failure, Critical Illness
Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.
- Trial name
- NCT06189924
- Testing
- Proteomic analysis of exhaled breath condensate
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Mechanical Ventilation Complication
Automated Secretion Removal in ICU Patients
SUMMARY Rationale In intubated and mechanically ventilated critically ill patients, removal of airway secretions is typically performed by tracheal suctioning, an intervention that is labor-intensive and very unpleasant for the…
- Trial name
- TrachFlush (NCT05056103)
- Testing
- TrachFlush
- Where
- Netherlands
- Volunteers
- 28 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Failure
Effects of PBMT-sMF in Mechanically Ventilated Patients
The goal of this clinical trial is to evaluate the effectiveness of photobiomodulation therapy combined with static magnetic field (PBMT-sMF) in adult patients who require mechanical ventilation.
- Trial name
- NCT06454006
- Testing
- Active PBMT-sMF
- Where
- Brazil
- Volunteers
- 112 people
- Sponsor
- University of Nove de Julho
Intensive Care Unit Acquired Weakness, Critical Care
CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients
Patients who survive critical illness usually experience long-lasting physical and psychological impairments, which are often debilitating. Rehabilitation interventions started in the ICU may reduce this morbidity.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- CYCLE (NCT03471247)
- Testing
- In-Bed Cycle Ergometer, Routine PT
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 363 people
- Sponsor
- McMaster University
Adult ICU Patients
Metabolic Trajectories and Protein Intake in Long-Stay Ventilated Intensive Care Unit (ICU) Patients
Survival of critically ill patients has improved, resulting in a growing population of chronically critically ill (CCI) individuals with prolonged organ dysfunction, mechanical ventilation, and high morbidity.
- Trial name
- MetaChronic (NCT07268274)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Universidade do Algarve