Clinical trials: Ventilation
Mechanical Ventilation
DIAPHRAGM STRENGTH AND LUNG VOLUMES
Diaphragm dysfunction (loss of diaphragm strength) is common in the intensive care unit (ICU) patients using ventilators. The diaphragm is the main muscle of respiration and its dysfunction can prolong mechanical ventilation and…
- Trial name
- DIAVOLA (NCT07206459)
- Testing
- Healthy Patients, Critically Care Patients
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Manual Ventilation
Prolonged Manual Ventilation Simulation
A pilot study on simulated lung scenarios using the standard manual resuscitator bag, flow limiting resuscitator bag, and an FDA approved flow rate limiting device paired with a standard manual resuscitator.
- Trial name
- NCT06805838
- Testing
- Sotair
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- SafeBVM
Mechanical Ventilation Complication, Vascular Injury
Vascular Injury in Mechanical Ventilation: a Proof-of-Concept Study
Investigation of the effect of mechanical ventilation on biomarkers of microvascular damage
- Conditions
- Mechanical Ventilation Complication, Vascular Injury, Endothelial Dysfunction
- Trial name
- NCT05538858
- Testing
- Mechanical Ventilation
- Where
- Canada
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Mechanical Ventilation, Lung Protective Ventilation
Driving Pressure Guided Mechanical Ventilation Versus Lung Protective Ventilation Among Patients Undergoing Elective Surgeries
Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient.
- Conditions
- Mechanical Ventilation, Lung Protective Ventilation, Driving Pressure
- Trial name
- NCT07092943
- Testing
- Lung protective ventilation, Driving pressure guided ventilation
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Ventilation Therapy; Complications, Technical Skills
Educational Strategies for Maintaining Technical Skills in Neonatal Resuscitation for the Nursing Team
Despite efforts for initial training in neonatal resuscitation, health professionals show a decline in post-training skills, requiring continuing training.
- Conditions
- Ventilation Therapy; Complications, Technical Skills, Nurse's Role
- Trial name
- Neo-VPP (NCT06882018)
- Testing
- Repeated practice guided by peers, Instructor-guided deliberate practice
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ahmed Moussa
Neonates, Respiratory Distress
Non-invasive Secondary Respiratory Support in Late Preterm and Term Infants
The aim of the present work is to compare between various modes of non-invasive respiratory support (including NCPAP, NIPPV, and NHFOV) as secondary respiratory support modes in late preterm and term neonates as regards the need…
- Conditions
- Neonates, Respiratory Distress, Non- Invasive Ventilation
- Trial name
- NCT07000071
- Testing
- NCPAP, NIPPV, NHFOV
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Ventilation Modes, Mechanical Ventilation
Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchronized Intermittant Mandatory Ventilation Using Bioelectrical Impedance Tomography
Synchronized Intermittent Mandatory Ventilation (SIMV) is a commonly used ventilatory mode available in many modern ventilators, frequently applied in intensive care units for patients requiring invasive mechanical ventilation.
- Conditions
- Ventilation Modes, Mechanical Ventilation, Critical Illness, Respiratory Support
- Trial name
- NCT06961227
- Testing
- No investigational intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Harran University
Mechanical Ventilation Complication, Postoperative Pulmonary Atelectasis
Flow Controlled Ventilation in Robot-assisted Laparoscopic Surgery
The optimization of ventilation is especially important during general anaesthesia, when active, physiologic respiration suspends and is replaced by non-physiologic mechanical positive pressure ventilation.
- Trial name
- FCV-IMPALA (NCT06256900)
- Testing
- Flow-controlled ventilation, Pressure-controlled ventilation
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Healthy Volunteers, Noninvasive Ventilation
The Effect of Mask Design on Transcutaneous Carbon Dioxide in Healthy Volunteers: A Pilot Clinical Investigation
The goal of this randomized cross-over study is to investigate whether the design of non-invasive ventilation (NIV) mask impacts transcutaneous CO2 in healthy volunteers on NIV therapy.
- Trial name
- NCT06670482
- Testing
- Non-invasive ventilation (NIV)
- Where
- New Zealand
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Adjustable Headrests, Ventilation Function
A Study on Application of Adjustable Headrest in Painless Curettage Surgery for Overweight and Obese Patients
The aim of this study is to observe the effect of adjustable headrests on ventilation function in overweight and obese patients through clinical experiments, and to explore the impact on the incidence of hypoxemia during painless…
- Conditions
- Adjustable Headrests, Ventilation Function, Obese Patients
- Trial name
- NCT06929000
- Testing
- the supine head-lateral position group, the adjustable headrest group, the supine head-straight position group
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Ventilation During Resuscitation
Intra Arrest Ventilation in Human Cadavers II
The study investigates the influence of three types of ventilation mode by using Bi-Level positive airway pressure (pinsp 20 mbar, PEEP 5, AF 10/min) with two different types of ventilators ( Medumat vs.
- Trial name
- NCT06885398
- Testing
- treatment
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Muehlenkreiskliniken, MKK
Ventilation, Bariatric Surgery
Effects of Different Anesthesia Machine Modalities on Bariatric Surgery Patients: a Prospective Randomized Controlled Study
The goal of this clinical trial is to explore the clinical significance and value of the PRVC ventilation mode in Bariatric Surgery Patients.
- Conditions
- Ventilation, Bariatric Surgery, Intracranial Pressure, Carbon Dioxide
- Trial name
- NCT06547411
- Testing
- PC Ventilation mode, VC Ventilation mode, PRVC Ventilation mode
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Yu-Long Jia
Focus of the Study is the Anatomy of the Soft Palate, Non-invasive Ventilation
The Inflate Study; Defining the Soft Palate in the Upper Airway Flow Pathway
The goal of this clinical trial is to understand the impact of the size and shape of the soft palate on gas airflow in the upper airway in healthy volunteers.
- Trial name
- NCT06738589
- Testing
- non-invasive ventilation
- Where
- New Zealand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fisher and Paykel Healthcare
Mechanical Ventilation Pressure High, Bariatric Surgery Candidate
Effect of Individualized PEEP on Postoperative Pulmonary Complication in Bariatrics
Ventilation with low tidal volume and high PEEP (positive end expiratory pressure) has been shown to improve oxygenation in patients with ARDS (acute respiratory distress syndrome).
- Trial name
- NCT06168162
- Testing
- titated PEEP to best static compliance
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Esketamine, One-lung Ventilation
Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery
A total of 126 patients undergoing elective thoracoscopic surgery under general anesthesia were randomly divided into three groups: normal saline group (Group C), dexmedetomidine group (Group D), and esketamine group (Group…
- Conditions
- Esketamine, One-lung Ventilation, Oxygenation Indices
- Trial name
- OLV;Esk (NCT06822088)
- Testing
- Esketamine, Dexmedetomidine, Normal Saline
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Jinqiao Qian
Radiofrequency Ablation, Atrial Fibrillation
Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation
Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium.
- Conditions
- Radiofrequency Ablation, Atrial Fibrillation, Mechanical Ventilation
- Trial name
- NCT06791915
- Testing
- Radiofrequency Ablation with FCV., Radiofrequency Ablation with VCV.
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kocaeli City Hospital
Ventilation Therapy; Complications
Comparing Different Startegies of Positive Pressure Ventilation in Children
The most basic modes of mechanical ventilation are volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV).
- Trial name
- NCT06612125
- Testing
- volume controlled ventilation, pressure controlled ventilation, pressure controlled volume grantanteed ventilation
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Mechanical Ventilation Complication, Respiratory Distress Syndrome in Premature Infant
Effect of Implementing Evidence Based Practices on Prevention of Associated Nasal Pressure Injuries Among Preterm Neonates With Non-Invasive Respiratory Support
This study aims to evaluate the effect of implementing evidence based practices on prevention of associated nasal pressure injuries among preterm neonates with non invasive respiratory support
- Trial name
- NCT06642285
- Testing
- Non Invasive Respiratory Support bundle
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Pre-hospital Ventilation
Ability of Caregivers to Provide Ventilation With the SAVe Resuscitator in a Model
This study will compare three methods of delivering mechanical ventilation using a test lung. Ventilation will be delivered using (1) a mask held in place by a caregiver, (2) a mask strapped to the model using a securing device…
- Trial name
- NCT01477710
- Testing
- Hold mask, Strap Mask, Airway
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati