Clinical trials: Ventilation and Oxygenation
Pediatric Acute Respiratory Distress Syndrome, Extracorporeal Membrane Oxygenation
Prone Position During ECMO in Pediatric Patients With Severe ARDS
In 2023, the second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) updated the diagnostic and management guidelines for Pediatric Acute Respiratory Distress Syndrome (PARDS).
- Trial name
- PEPAD (NCT06369584)
- Testing
- prone position
- Where
- 8 sites in China
- Volunteers
- 7 people
- Sponsor
- Seventh Medical Center of PLA General Hospital
Apnea, Respiration; Arrest
The Effect of High-flow Nasal Oxygen Flow Rate on Gas Exchange During Apnoea
Apnoeic oxygenation refers to oxygenation that occurs through the insufflation of oxygen into the lungs in the absence spontaneous respiration or positive pressure ventilation.
- Conditions
- Apnea, Respiration; Arrest, Anesthesia
- Trial name
- Apox-HFNO (NCT05124093)
- Testing
- Apnoeic oxygenation
- Where
- Ireland
- Volunteers
- 114 people
- Sponsor
- University College Hospital Galway
Type 1 Diabetes
Muscle Oxygenation, Type 1 Diabetes, and Glycated Hemoglobin
Most of the studies concerning aerobic fitness in Type 1 diabetic patients noted a relationship between impaired aerobic fitness and high glycated haemoglobin (HbA1c) levels, reflecting poor long term glycaemic control.
- Trial name
- OXYDIAB (NCT02051504)
- Testing
- Incremental maximal exercise, Oral Glucose Tolerance Test, Muscle biopsy
- Where
- France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Respiratory Failure
The Physiologic Effect of the Flow Generated by High Flow Nasal Cannula in Mild Respiratory Failure
High flow nasal cannula (HFNC) oxygen therapy is increasingly used for hypoxemic respiratory failure and is proving useful in avoiding or delaying intubation and mechanical ventilation.
- Trial name
- NCT05708287
- Testing
- HFNC
- Where
- Israel
- Volunteers
- 28 people
- Sponsor
- Hadassah Medical Organization
Other Complications of Surgical and Medical Procedures
SJOV With WNJ in Microlaryngeal Surgery
The key to a successful microlaryngoscopy is adequate operative field exposure and illumination. A variety of airway control procedures has been developed to improve operative exposure.
- Trial name
- WNJ (NCT03840876)
- Testing
- WEI NASAL JET (WNJ)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in patients with…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, High Altitude, Echocardiography
- Trial name
- NCT07804693
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
ARDS, Acute Lung Injury
Low Frequency, Ultra-low Tidal Volume Ventilation in Patients With ARDS and ECMO
The acute respiratory distress syndrome (ARDS) is the most severe form of respiratory failure, presented in 10% of all intensive care patients and carrying a high mortality rate.
- Conditions
- ARDS, Acute Lung Injury, Extracorporeal Membrane Oxygenation, Respiratory Distress Syndrome
- Trial name
- NCT03764319
- Testing
- Ultra-protective ventilator settings, Standard ventilator settings
- Where
- Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Vienna
Morbid Obesity
Oxygenation Test During General Anesthesia
The study investigates if applying a special ventilatory strategy during anesthesia for laparoscopic gastric by pass, produces less atelectasis and better oxygenation in spite of using 100 % oxygen during pre oxygenation and…
- Trial name
- NCT01559402
- Testing
- CPAP and 100% oxygen, CPAP and 31% oxygen, No CPAP and 100% oxygen
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Västmanland
Heart Rate Monitoring
Vital Signs Monitoring of Emergency Responders in Different States
The goal of this observational study is to learn about emergency responder in different states. The main questions it aims to answer are: Ten vital signs and behavioral parameters in different states (quiet, after post, after…
- Trial name
- NCT06076057
- Testing
- vital signs monitoring
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Lung Cancer
Effect of Optimal Positive End-Expiratory Pressure on Oxygenation and Intrapulmonary Shunt During One-lung Ventilation
To observe the effect of compliance guided an optimal Positive End-Expiratory Pressure（PEEP）on arterial oxygenation and intrapulmonary shunt during one-lung ventilation(OLV)，and discuss the lung protective effect of optimal PEEP…
- Trial name
- NCT03804398
- Testing
- compliance guided an optimal Positive End-Expiratory Pressure, PEEP level of 5 cmH2O
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fujian Medical University Union Hospital
Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients
This prospective, blinded observational clinical study was aimed to determine the effect of hyperhydration and muscle loss measured by Bioelectrical impedance vector analysis (BIVA) on mortality.
- Conditions
- Respiratory Distress Syndrome, Acute, Respiratory Insufficiency, Lung Ventilator, Hyperhydration
- Trial name
- NCT05991778
- Testing
- Bioelectrical impedance vector analysis (BIVA), Blood and urine analysis, cumulative water balance
- Where
- Czechia
- Volunteers
- 61 people
- Sponsor
- University Hospital Ostrava
Obesity, Laparoscopic Gastric Bypass Surgery
CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
The purpose of this study is to investigate if a deep neuromuscular block with a continuous infusion of rocuronium titrated to a post-tetanic count (PTC) of 1-2 responses combined with reversal of neuromuscular blockade with…
- Conditions
- Obesity, Laparoscopic Gastric Bypass Surgery, Surgical Conditions, Respiratory Function
- Trial name
- CURES (NCT01748643)
- Testing
- deep neuromuscular blockade with rocuronium, reversal with sugammadex, normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Ziekenhuis Oost-Limburg
Respiratory Distress Syndrome
Diaphragm Dysfunction in ARDS Patients With V-V ECMO
Use of veno-venous extracorporeal oxygenation membrane is a therapeutic option for the management of the most severe patients with acute respiratory distress syndrome (ARDS).
- Trial name
- DD-ECMO (NCT04613752)
- Testing
- diaphragmatic function measurements and diaphragmatic ultrasound
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Nebulized Verapamil in COPD Exacerbations
This clinical trial evaluated whether adding nebulized verapamil to conventional treatment could improve oxygenation and clinical status in patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease…
- Trial name
- NCT07866989
- Testing
- Verapamil hydrochloride, Conventional treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
COVID-19
Treatment of COVID-19 Patients With Anti-interleukin Drugs
The purpose of this study is to test the safety and effectiveness of individually or simultaneously blocking IL-6 and IL-1 versus standard of care on blood oxygenation and systemic cytokine release syndrome in patients with…
- Trial name
- COV-AID (NCT04330638)
- Testing
- Usual Care, Anakinra, Siltuximab
- Where
- 15 sites in Belgium
- Volunteers
- 342 people
- Sponsor
- University Hospital, Ghent
Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of…
- Conditions
- Acute Respiratory Syndrome Distress, Positive End-Expiratory Pressure, Mechanical Ventilation, Electrical Impedance Tomography (EIT)
- Trial name
- PEEP (NCT06733168)
- Testing
- electrical impedance tomography, Non-EIT
- Where
- Vietnam
- Volunteers
- 76 people
- Sponsor
- Vietnam Military Medical University
ARDS (Acute Respiratory Distress Syndrome)
Pressure Release Ventilation Compared to Lung Protective Ventilation in Moderate and Severe ARDS
This study compares two different ways of providing mechanical ventilation to patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition in which the lungs become inflamed and make it…
- Trial name
- NCT07803614
- Testing
- Arm 1 Intervention Name: Low-Tidal-Volume Ventilation (LTV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Koot Ahmad
Sedation Complication, Obesity
Effect of HFNO on Spontaneous Ventilation in Obese Patients During Analgo-sedation for Vitrectomy
Patients suffering from pathology of posterior eye chamber such as diabetic retinopathy, retinal detachment, traumatic eye injury, retained lens fragments, macular hole, pucker, dislocated intraocular lens after cataract surgery…
- Conditions
- Sedation Complication, Obesity, Hypoxic Respiratory Failure, Airway Obstruction, Nasal
- Trial name
- NCT04049240
- Testing
- Device: low-flow nasal oxygenation (LFNO) 18<BMI<30 kg/m2, Device: low-flow nasal oxygenation (LFNO) 30≤BMI<35 kg/m2, Device: low-flow nasal oxygenation (LFNO) BMI≥35 kg/m2
- Where
- Croatia
- Volunteers
- 126 people
- Sponsor
- University of Split, School of Medicine
Oxygenation During One Lung Ventilation
Nebulized Epoprostenol (FLOLAN) and Phenylephrine on One Lung Ventilation (OLV)
This is a pilot study of a new use of Epoprostenol via inhalation (Epoprostenol is approved for intravenous use). The purpose of this study is to administered inhaled Epoprostenol and intravenous Phenylephrine to improve arterial…
- Trial name
- FLOLAN (NCT02748265)
- Testing
- Inhaled Epoprostenol and phenylephrine, Sevoflurane, Propofol
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University Health Network, Toronto
Obesity (BMI > 35), Sleeve Gastrectomy
Perioperative Respiratory Function in Sleeve Gastrectomy
This retrospective single-center cohort study aims to evaluate the effects of two intraoperative ventilation strategies on perioperative oxygenation and respiratory outcomes in obese patients undergoing laparoscopic sleeve…
- Conditions
- Obesity (BMI > 35), Sleeve Gastrectomy, Oxygenation, Peep Titration in Lung Protective Ventilation
- Trial name
- NCT07629102
- Testing
- PEEP 8 cmH2O + Recruitment Maneuvers, PEEP 5 cmH2O
- Where
- Turkey (Türkiye)
- Volunteers
- 53 people
- Sponsor
- Istanbul Saglik Bilimleri University