Clinical trials: Ventilation and Oxygenation
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
COVID-19 Pneumonia
Leronlimab in Patients With Coronavirus Disease 2019 (COVID-19) With Need for Mechanical Ventilation or Extracorporeal Membrane Oxygenation
Leronlimab (PRO 140) is a humanized IgG4,k monoclonal antibody (mAb) that recognizes the C-C chemokine receptor type 5 (CCR5). Disruption of the C-C chemokine ligand 5 (CCL5)-CCR5 axis via leronlimab-mediated CCR5 blockade might…
- Trial name
- NCT04901689
- Testing
- Leronlimab
- Where
- 23 sites in Brazil
- Volunteers
- 316 people
- Sponsor
- Hospital Israelita Albert Einstein
Ventilation Therapy; Complications
Physiological Dead Space Measured by Volumetric Capnography in BiPAP and APRV .
Background and Rationale : Mechanical ventilation is an essential component of the care of patients with respiratory failure.Biphasic positive Airway Pressure (BiPAP) and Airway Pressure release ventilation (APRV) are relatively…
- Trial name
- NCT03218943
- Testing
- APRV ventilation mode, BIPAP ventilation moood
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Respiratory Failure
Flow veRsus OxygeNaTion In acutE ReSpiratory Failure
High flow nasal oxygen therapy has been widely used but guidelines as to the optimal starting flow rate and oxygen percentage are not available.
- Trial name
- Frontiers (NCT03223948)
- Testing
- 'Optiflow'
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- NHS Greater Glasgow and Clyde
VA-ECMO
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by…
- Trial name
- ECMO-VP (NCT07141524)
- Testing
- Physiology measurements
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
COVID-19, Hypoxia
Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation
Previous research has shown that high dose intravenous vitamin C (HDIVC) may benefit patients with sepsis, acute lung injury (ALI), and the acute respiratory distress syndrome (ARDS).
- Trial name
- AVoCaDO (NCT04357782)
- Testing
- L-ascorbic acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Lung Neoplasms, Pulmonary Disease
Does PEP Compensate the Reduction of Tidal Volume During One Lung Ventilation?
During general anesthesia, airway closure and the formation of atelectasis impair oxygenation. During one-lung ventilation, large tidal volumes are used to resume atelectasis with a risk of regional over distension and…
- Trial name
- REVOLU (NCT00534690)
- Testing
- One-Lung ventilation, One-Llung ventilation
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Bordeaux
Fascial Plane Block, ICU Length of Stay
Postoperative Analgesia and Ventilation After Cardiac Surgery
Cardiac surgery performed via median sternotomy is associated with significant postoperative pain due to extensive tissue trauma, sternal bone healing, and mediastinal retraction.
- Conditions
- Fascial Plane Block, ICU Length of Stay, Mechanical Ventilation Duration, Oxygenation
- Trial name
- NCT07475884
- Testing
- conventional analgesic regimen, Fascial Plane Blocks
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people
- Sponsor
- Bursa City Hospital
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Obesity, Morbid
EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
The risk of complication associated with airway in obese patient is important. The result of pre-oxygenation gives the clinician a prolonged non-hypoxic apnea time.
- Trial name
- EPO2-A (NCT02590406)
- Testing
- Beach chair (BC) and ZEEP, Reverse Trendelenburg and NIPPV
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Laval University
Neonatal Respiratory Distress
Tolerance of nHFPV Versus nCPAP in Neonatal Respiratory Distress
Respiratory distress is the main cause of morbimortality in preterm and term neonates. In most of the case, these babies required the use of positive end expiratory pressure (PEEP) delivered by a non invasive device.
- Trial name
- TONIPEP (NCT02030691)
- Testing
- Nasal continuous airway positive pressure (nCPAP), Nasal high frequency percussive ventilation (nHFPV)
- Where
- France
- Volunteers
- 49 people
- Sponsor
- University Hospital, Bordeaux
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Respiratory Distress Syndrome, Prematurity
The Effect of Surfactant Administration on Cerebral Oxygenation
The purpose of this study is to assess changes in cerebral oxygenation during two different types (beractant and poractant) and two different routes (double lumen or single lumen endotracheal tube) of surfactant administration…
- Trial name
- NCT01258517
- Testing
- near infrared spectroscopy (INVOS 5100)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Upper Abdominal Surgery
Compare the Effect of Incentive Spirometry Versus Chest Mobilization on Oxygenation and Chest Expansion for Patient Undergoing Upper Abdominal Surgery: A Randomized Clinical Trial
This study compares the effects of incentive spirometry and chest mobilization on oxygenation and chest expansion in patients after upper abdominal surgery.
- Trial name
- NCT07109934
- Testing
- deep breathing exercises, chest mobilization:
- Where
- Iraq
- Volunteers
- 112 people
- Sponsor
- Marwa karim jabr
Breast Cancer
Hyperventilation and Oxygenation to Prolong Breath Hold in Breast Cancer Irradiation Treatment
With the HOBBIT trial, the investigators want to develop a technology that allows volunteers to hold their breath for a long time.
- Trial name
- HOBBIT (NCT04091542)
- Testing
- Optiflow/Ventilator
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
High Altitude Pulmonary Hypertension, Sleep
Nocturnal Oxygenation and Sleep-related Breathing Disorders During the First Night of a Stay at 2500m of High Altitude in Patients With Precapillary Pulmonary Hypertension
The impact of hypoxia at 2500m of high altitude on sleep in patients with precapillary pulmonary hypertension
- Trial name
- NCT05089487
- Testing
- Nocturnal rest (sleep study)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Bronchopulmonary Dysplasia
Fluid Filled Lung Oxygenation Assistance Trial
The primary study objective is to assess the safety and feasibility of perfluorooctylbromide (PFOB) partial liquid ventilation (PLV) in infants with severe Bronchopulmonary Dysplasia (BPD).
- Trial name
- FFLOAT (NCT03041740)
- Testing
- Perfluorooctyl Bromide
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital of Philadelphia
Oxygen, pH
Comparison of the Effects of High-flow Nasal Cannula Oxygen and Jet Ventilation Techniques
Endoscopic microsurgical procedures of the larynx (direct examination-bx, microlaryngeal resection) require the anesthesiologist and surgeon to work in the same area throughout the procedure, and while ventilation is provided…
- Conditions
- Oxygen, pH, End-tidal Carbon Dioxide
- Trial name
- NCT05746949
- Testing
- oxygenization techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Generalized Anxiety Disorder, Oxygenation Sensitive CMR
BreathinG-induced Myocardial and Cerebral Perfusion in Anxiety Disorders
This study aims to view variations in MRI measurements of the heart and the brain in people with anxiety versus healthy volunteers.
- Trial name
- B-GLAD (NCT05574140)
- Testing
- Cardiac MRI
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Apnea
Acute and Chronic Effects of Dynamic Apnea in Healthy Untrained Subjects
The inclusion of short periods of apnea (several seconds) during exercise (i.e. dynamic apnea) induces a significant decrease in blood oxygenation and muscle tissue.
- Trial name
- APNEX (NCT03095677)
- Testing
- Program of training with exercises including apnea, Program of training with exercises without apnea
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans