Clinical trials: Ventilation and Oxygenation
ARDS
Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS
The study was designed to comparison the effectiveness of recruitment maneuvers(RM) and lung protective ventilation strategy(LPVS) for patients with moderate to severe ARDS.
- Trial name
- ARDS (NCT05023226)
- Testing
- RM, LPVS
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Asia University
Colonoscopy, Oxygenation
Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Nasal continuous positive airway pressure (nCPAP) has been shown to effectively relieve upper airway obstruction in patients with OSA as it creates a pneumatic stent in the hypopharynx that reduces obstruction and allows for…
- Conditions
- Colonoscopy, Oxygenation, Ventilation
- Trial name
- NCT03139448
- Testing
- Oxygen via nasal cannula, Oxygen via SuperNO2VA nasal mask
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Vanderbilt University Medical Center
Coronavirus, COVID-19
Cytokine Adsorption in Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation
In December 2019 in the city of Wuhan in China, a series of patients with unclear pneumonia was noticed, some of whom have died of it.
- Conditions
- Coronavirus, COVID-19, SARS-CoV Infection, Respiratory Failure
- Trial name
- CYCOV (NCT04324528)
- Testing
- vv-ECMO + cytokine adsorption (Cytosorb adsorber), vv-ECMO only (no cytokine adsorption)
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Dr. Alexander Supady
Heart Failure, Respiratory Failure
Reduced Anticoagulation Targets in ECLS (RATE)
The objective of the RATE-trial is to study if reduced anticoagulation targets during ECLS diminish bleeding complications without an increase in thromboembolic complications or a negative impact on outcome.
- Conditions
- Heart Failure, Respiratory Failure, Extracorporeal Membrane Oxygenation, Bleeding
- Trial name
- RATE (NCT04536272)
- Testing
- Heparin, LMWH
- Where
- 8 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- University Medical Center Groningen
Acute Respiratory Failure
Variable Ventilation During Acute Respiratory Failure
Acute respiratory failure requiring support with mechanical ventilation occurs with an incidence of 77-100 per 100,000 person-years and accounts for half of all patients admitted to the intensive care unit.
- Trial name
- NCT01083277
- Testing
- variable ventilation, Conventional ventilation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Boston Medical Center
Pulmonary Hypertension
Acute Exposure to High Altitude on Blood and Tissue Oxygenation (ABGA, NIRS)
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) on blood and tissue oxygenation (ABGA, NIRS).
- Trial name
- NCT03600415
- Testing
- Low altitude: 470m above sea level, Säntis; 2500m above sea level
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Apnea of Prematurity, Preterm Birth
Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants
Intermittent episodes of hypoxemia and/or bradycardia, also defined as cardio-respiratory events (CRE) are very frequent in preterm infants and may result in transient hypoxia and hypoperfusion of target organs, with possible…
- Conditions
- Apnea of Prematurity, Preterm Birth, Patent Ductus Arteriosus, Hypoxia, Brain
- Trial name
- NCT04184245
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Adult Patients, Requiring Intubation
PREoxygenation for the Intubation of Hypoxemic Patients: Comparison of Standard Oxygenation, High Flow Nasal Oxygen Therapy, and NonInvasive Ventilation
Prospective, randomized clinical multicentric study, in ICU, during preoxygenation for the intubation of hypoxemic patients.
- Conditions
- Adult Patients, Requiring Intubation, Hypoxemia (Defined by PaO2/FiO2( Fraction of Inspired Oxygen) Below 200), Patient Covered by French Health Care System
- Trial name
- PREONIV (NCT01782430)
- Testing
- - standard oxygenation
- Where
- France
- Volunteers
- 132 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critical Illness, Sepsis
Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness
Purpose of the Study Critical illness requiring life support affects over 150 000 people in Ontario every year. With aggressive support, the number of people who die from critical illness is decreasing.
- Conditions
- Critical Illness, Sepsis, Delirium, Respiratory Failure
- Trial name
- CONFOCAL (NCT02344043)
- Testing
- Near infrared spectroscopy
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- Queen's University
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Acute respiratory distress syndrome (ARDS) is a lesional pulmonary edema that occurs as a result of direct or indirect lung injury.
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation Complication, Hypothermia
- Trial name
- HypoLungECMO (NCT05306392)
- Testing
- Moderate Hypothermia, Normothermia
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Acute Respiratory Failure
Pragmatic Trial Examining Oxygenation Prior to Intubation
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States.
- Trial name
- PREOXI (NCT05267652)
- Testing
- Preoxygenation with Non-Invasive Positive Pressure Ventilation, Facemask Oxygen
- Where
- 16 sites in United States
- Volunteers
- 1,301 people
- Sponsor
- Vanderbilt University Medical Center
Critical Illness, Respiratory Failure
Cerebral Oxygenation and Neurological Outcomes FOllowing CriticAL Illness-2
This study is designed to test the hypothesis that poor cerebral perfusion during critical illness is a risk factor for acute and long-term neurological dysfunction among survivors.
- Conditions
- Critical Illness, Respiratory Failure, Shock, Delirium
- Trial name
- CONFOCAL-2 (NCT03141619)
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Dr. Gordon Boyd
Lung Cancer
Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation
A continuous loss of moisture and heat occurs during mechanical ventilation and prediposes patients to airway damage. Vaporizing humidifier has known to be advantages of improvement of oxygenation and protection of airway damage.
- Trial name
- NCT01636973
- Testing
- Vaporizing humidifier
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Cerebral Ischemia
Total Shoulder Arthroplasty Near-infrared Spectroscopy
The purpose of this study is to measure cerebral oxygenation and cardiac output of total shoulder replacement patients undergoing general anesthesia (GA) and positive-pressure ventilation (PPV).
- Trial name
- TSA NIRS (NCT02198183)
- Testing
- Casmed Fore-Sight Elite, Non-invasive Cardiac Output Monitor (NICOM)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Hospital for Special Surgery, New York
Hypoxemic Respiratory Failure, Oxygen Toxicity
Handling Oxygenation Targets in the Intensive Care Unit
Handling oxygenation targets (HOT) is standard of care in the intensive care unit (ICU), however the quality and quantity of evidence is low and potential harm has been reported.
- Trial name
- HOT-ICU (NCT03174002)
- Testing
- Oxygen
- Where
- 37 sites in Denmark, Finland and 5 more
- Volunteers
- 2,928 people
- Sponsor
- Aalborg University Hospital
Chest Trauma
High Flow Nasal Oxygenation Versus Non-invasive Ventilation for Patients With Blunt Chest Trauma
Chest trauma remains an issue for health services for both severe and apparently mild trauma management. Severe chest trauma is associated with high mortality and is liable for 25% of mortality in multiple traumas.
- Trial name
- NCT05342103
- Testing
- high flow oxygenation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Huda Fahmy Mahmoud, PhD
Hip-fracture, General Anaesthesia
Regional Versus General Anesthesia for Hip Fracture and Postoperative Oxygenation
With this study, the investigators intend to measure oxygen saturation before and after hip surgery in the context of proximal femur fracture, comparing two types of anesthesia (general or spinal).
- Conditions
- Hip-fracture, General Anaesthesia, Regional Anaesthesia
- Trial name
- REGENERATION (NCT07309575)
- Where
- Portugal
- Volunteers
- 102 people
- Sponsor
- University of Lisbon
Sleep, Cerebral Oxygenation
Respiratory Support and Brain Health in Preterm Infants
Premature babies often require breathing support during their neonatal intensive care unit stay. This is because their lungs are not fully developed to perform the work of breathing on their own.
- Trial name
- NCT05589831
- Testing
- Non-invasive Neurally Adjusted Ventilatory Assist
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Mount Sinai Hospital, Canada
Oxygen Toxicity, Respiratory Failure
Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and Oxygenation
The investigators recently evaluated 4 different oximeters among the most commonly used with arterial catheter in place and compared SpO2 with SaO2 obtained on arterial gas.
- Trial name
- Oxygap pong (NCT05590130)
- Testing
- Manual Oxygen titration with Philips oximeter (SpO2 target 90%), Manual oxygen titration with Nonin oximeter (SpO2 target 90%), Manual Oxygen titration with Philips oximeter (SpO2 target 94%)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University