Clinical trials: Ventilator Acquired Pneumonia
Ventilator Associated Pneumonia ( VAP), Intensive Care (ICU)
Integrated vs Manual Endotracheal Tube Cuff Pressure Monitoring and Ventilator-Associated Pneumonia
Ventilator-associated pneumonia (VAP) is a frequent complication in mechanically ventilated patients in intensive care unit (ICU).
- Trial name
- ICPM-VAP (NCT07423208)
- Testing
- Continous measurement of cuff pressure in endotracheal tube, Intermittent manual cuff pressure monitoring with manometer.
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Ventilator Associated Pneumonia
Effect of Eliminating Gastric Residual Volume Monitoring on Ventilator Associated Events
The aims of this study are to investigate the effect of eliminating routine GRV monitoring on VAEs in patients receiving MV and early EF, Determine the effect of eliminating routine GRV monitoring on nutritional adequacy in…
- Trial name
- NCT06059040
- Testing
- eliminating gastric residual volume monitoring
- Volunteers
- 160 people
- Sponsor
- Damanhour University
Ventilator Associated Pneumonia
The Gravity-VAP (Ventilator-Associated Pneumonia) Trial
This study is planned to compare, in patients sedated, intubated and mechanically ventilated, the efficacy and safety of the Lateral Trendelenburg position in comparison to the Semirecumbent Position to prevent incidence of…
- Trial name
- Gravity-VAP (NCT01138540)
- Testing
- lateral-Trendelenburg position
- Where
- 2 sites in Italy, Spain
- Volunteers
- 800 people
- Sponsor
- Policlinico Hospital
Covid19, Ventilator Associated Pneumonia
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:
A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation.
- Conditions
- Covid19, Ventilator Associated Pneumonia, Nosocomial Pneumonia
- Trial name
- COVAP (NCT04488510)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Ventilator Associated Pneumonia
Efficacy Study of Colistimethate Sodium Inhalation in Patients With Ventilator-associated Pneumonia
There might be additional benefit on clinical outcomes from adjunctive colistimethate sodium inhalation as therapy for multidrug resistant Gram-negative ventilator-associated pneumonia.
- Trial name
- NCT01975350
- Where
- Taiwan
- Volunteers
- 49 people
- Sponsor
- National Taiwan University Hospital
Mechanical Ventilation, Infection Prevention
Oral Care Layered Enhancement for Improved Oral Hygiene in Intensive Care Units
The goal of the ORACLE study is to evaluate the impact of implementing a standardized oral hygiene bundle on outcomes in critically ill, mechanically ventilated patients.
- Conditions
- Mechanical Ventilation, Infection Prevention, Oral Care, Oral Hygiene, Oral Health
- Trial name
- ORACLE (NCT07129733)
- Testing
- Oral hygiene bundle
- Where
- 6 sites in Brazil
- Volunteers
- 4,800 people
- Sponsor
- Hospital do Coracao
Neonatal SEPSIS, Nosocomially Acquired Neonatal Sepsis
A Study on Ventilator-associated Pneumonia as a Risk for Nosocomial Infection in Mechanically Ventilated Neonates In NICU of Assiut University Children Hospital (Nicu Eta)
Abstract Background: Neonatal ventilator associated pneumonia (VAP) is a major hospital-acquired infection in acute care settings, associated with high mortality and poor outcome.
- Trial name
- nicu eta (NCT03310840)
- Testing
- others
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assiut University
Mechanical Ventilation
Hyperoxemia and Ventilator-associated Pneumonia
The aim of this prospective cohort single-center observational study is to determine the impact of hyperoxemia on ventilator-associated pneumonia (VAP) occurrence.
- Trial name
- SOH-VAP (NCT03434821)
- Where
- France
- Volunteers
- 534 people
- Sponsor
- University Hospital, Lille
Ventilator Associated Pneumonia
Pharmacokinetics of Nebulized Amikacin in Patients With Pneumonia Undergoing Mechanical Ventilation
Inclusion of patients undergoing mechanical ventilation and presenting a pneumonia in order to determine serum pharmacokinetics of nebulized amikacin.
- Trial name
- DARTAGNAN (NCT00861315)
- Testing
- Nebulized amikacin, Intravenous amikacin
- Where
- 2 sites in France
- Volunteers
- 24 people
- Sponsor
- Association Pour La Promotion A Tours De La Reanimation Medicale
Acinetobacter Baumannii-calcoaceticus Complex Infection (ABC)
A Study to Assess Sulbactam-durlobactam in Pediatric Patients With Acinetobacter Baumannii-calcoaceticus Complex Infection
The goal of this clinical trial is to investigate the use of Sulbactam-Durlobactam (SUL-DUR) in pediatric patients and is being conducted to collect pharmacokinetic (PK) and safety data to enable the identification of appropriate…
- Trial name
- NCT06801223
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Sulbactam 20mg/kg-Durlobactam 20mg/kg (Every 8 hours), Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 8 hours)
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Innoviva Specialty Therapeutics
Ventilator-Associated Pneumonia
Diagnostic and Prognostic Value of Reticulated Platelet Fraction in Ventilator-Associated Pneumonia (REPLAY-VAP)
Ventilator-associated pneumonia (VAP) is a serious infection that occurs in patients who have been on mechanical ventilation for more than 48 hours in the intensive care unit (ICU).
- Trial name
- REPLAY-VAP (NCT07013032)
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Konya City Hospital
Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP)
Innate Immune Immunoparalysis and Ventilator-Associated Pneumonia in Critically Ill Elderly Patients
This prospective observational cohort study aims to evaluate the role of innate immune immunoparalysis in the development of ventilator-associated pneumonia (VAP) in critically ill mechanically ventilated patients.
- Conditions
- Intubated ICU Patients, Ventilator Associated Pneumonia ( VAP), Immunoparalysis
- Trial name
- IMP-VM (NCT07551258)
- Where
- Spain
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari de Bellvitge
Ventilator Associated Pneumonia
SUBSUS (SUBglottic Secretion at Ultrasound Score)
To compare the performance of ultrasound in detecting subglottic secretion above the ETT tube cuff in comparison to computed tomography (CT) scan.
- Trial name
- SUBSUS (NCT04739878)
- Testing
- Airway Ultrasound
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- Hospital Raja Permaisuri Bainun
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
Healthcare-associated Pneumonia (HCAP), Hospital Acquired Pneumonia (HAP)
Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens
The primary objective of this study is to compare all-cause mortality at Day 14 in participants receiving cefiderocol with participants receiving the comparator, meropenem, in adults with hospital-acquired bacterial pneumonia…
- Conditions
- Healthcare-associated Pneumonia (HCAP), Hospital Acquired Pneumonia (HAP), Ventilator Associated Pneumonia (VAP)
- Trial name
- APEKS-NP (NCT03032380)
- Testing
- Cefiderocol, Meropenem, Linezolid
- Where
- 119 sites in United States, Belgium and 17 more
- Volunteers
- 300 people
- Sponsor
- Shionogi
Pneumonia, Bacterial, Ventilator Associated Pneumonia
MASTERMIND-Pneumonia Study (Also Known as Pneumonia Direct Pilot)
The MASTERMIND-Pneumonia Study (also known as Pneumonia Direct Pilot Study) is designed to assess whether combining molecular diagnostics for bacteria and AMR markers with host-response profiling improves agreement and predictive…
- Trial name
- PDP (NCT06181669)
- Testing
- Pathogen and Host Directed testing
- Where
- 4 sites in United States
- Volunteers
- 173 people
- Sponsor
- Duke University
Pneumonia, Ventilators, Mechanical
Doripenem in the Treatment of Ventilator-Associated Pneumonia
The purpose of this study is to compare the clinical response rate of doripenem versus comparator in patients with ventilator-associated pneumonia (VAP).
- Trial name
- NCT00211016
- Testing
- doripenem
- Volunteers
- 318 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Ventilation-associated Pneumonia, Severe Trauma Patient
Impact of the Addition of a Device Providing Continuous Pneumatic Regulation of Tube Cuff Pressure to an Overall Strategy Aimed at Preventing Ventilator-associated Pneumonia in the Severe Trauma Patient. A Multicentre, Randomised, Controlled Study.
Ventilation-associated pneumonia is the main site of healthcare-associated infections in the severe trauma patient, with a mean incidence rate of 35%.
- Trial name
- AGATE (NCT02534974)
- Testing
- NOSTEN
- Where
- 13 sites in France
- Volunteers
- 440 people
- Sponsor
- Poitiers University Hospital
Hepatic Encephalopathy, Cirrhosis
A Study to Evaluate Role of Inhaled Amikacin to Prevent Ventilator Associated Pneumonia in Patients With Cirrhosis
The recent AMIKINHAL trial found that prophylactic inhaled amikacin was effective in lowering the incidence of ventilator-associated pneumonia in ICU patients.
- Conditions
- Hepatic Encephalopathy, Cirrhosis, Ventilator Associated Pneumonia (VAP)
- Trial name
- NCT06808074
- Testing
- Inhaled amikacin
- Where
- 2 sites in India
- Volunteers
- 162 people
- Sponsor
- Asian Institute of Gastroenterology, India
COVID-19 Pneumonia, Bromelains Adverse Reaction
Nebulised BromAc in Healthy Volunteers
COVID-19 is a disease that has multiple facets including an inflammatory storm, it promotes blood clotting and causes kidney damage, mucinous secretions in the lung are of great importance to outcome.
- Conditions
- COVID-19 Pneumonia, Bromelains Adverse Reaction, Acetylcysteine Adverse Reaction, Mucus; Plug
- Trial name
- NCT05220605
- Testing
- BromAc
- Where
- Australia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Mucpharm Pty Ltd