Clinical trials: Ventilator Lung
Bronchopulmonary Dysplasia, BPD
Follow-up Study of Safety and Efficacy in Subjects Who Completed PNEUMOSTEM® Phase II (MP-CR-012) Clinical Trial
This is a follow-up study to investigate the long-term safety and efficacy of PNEUMOSTEM® versus placebo, for the treatment of BPD in premature infants.
- Trial name
- NCT04003857
- Testing
- PNEUMOSTEM®, normal saline
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Medipost Co Ltd.
Ventilator Acquired Pneumonia
Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates
Evaluate the preventive value of probiotics on VAP among ventilated neonates.
- Trial name
- NCT07001163
- Testing
- Probiotic
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Lamiaa Khaled Zidan
Bronchopulmonary Dysplasia
Inhaled Extra-fine Hydrofluoalkane-beclomethasone (QVAR) in Premature Infants With Bronchopulmonary Dysplasia (BPD)
Premature infants with chronic lung disease (bronchopulmonary dysplasia [BPD]) are commonly treated with inhaled steroids, an optional treatment according to textbooks and guidelines .
- Trial name
- NCT01373008
- Testing
- Inhaled extra-fine hydrofluoalkane-beclomethasone (QVAR)
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Bnai Zion Medical Center
Acute Respiratory Distress Syndrome
Flow-flow ECCO2-R and 4 ml/kg Tidal Volume vs. 6 ml/kg Tidal Volume to Enhance Protection From VILI in Acute Lung Injury
The main objective of this randomized multicenter clinical trial is to test the hypothesis that further reduction of VT to 4mL/kg may enhance lung protection in patients with ARDS as compared to the conventional "ARDS-Net"…
- Trial name
- ELP (NCT01522599)
- Testing
- ARDS-Net Strategy, ECCO2-R
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- University of Turin, Italy
Inflammation
Study of the Influence of Various Tidal Volumes on Exhaled Breath Condensate (EBC) in Mechanically Ventilated Patients
The aim of the present study is to evaluate the effect of low (6 ml/kg) and high (12 ml/kg) tidal volume ventilation on inflammatory and oxidative stress biomarkers in the exhaled breath condensate (EBC) of ICU patients without…
- Trial name
- TDEBC (NCT00910026)
- Testing
- low tidal volume ventilation, high tidal volume ventilation
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Larissa University Hospital
Chronic Hypercapnic Respiratory Failure
Patients-ventilator Interaction During Sleep: Effect of Humidification System
At present, little data is available in the medical literature regarding the affects of humidification on NIMV efficacy, sleep quality and upper airway symptoms in patients undergoing nocturnal NIMV.
- Trial name
- NCT01038791
- Testing
- heated humidification, heat and moisture exchanger, usual mechanical ventilation without humidification
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Pleural Line Sliding
Ultrasound Measurement of Pleural Line Sliding as a Surrogate Indicator of Lung Volume Change: A Comparative Study With Ventilator Volume Data
The pleural line is a commonly observed structure in clinical ultrasound, used to evaluate pulmonary pathophysiology such as pulmonary edema, pneumothorax, or pneumonia.
- Trial name
- NCT06833151
- Testing
- Ultrasound Respiratory Assessment
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
Ascorbic Acid, Neurosurgical Procedures
Effect of Vitamin C on Postoperative Pulmonary Complications After Intracranial Tumor Surgery
The goal of this clinical trial is to investigate the effect of perioperative administration of vitamin C on postoperative pulmonary complications, with the aim of providing a safe and effective medication regimen for the…
- Conditions
- Ascorbic Acid, Neurosurgical Procedures, Humans, Ventilator-Induced Lung Injury
- Trial name
- NCT06421688
- Testing
- Ascorbic acid, Saline
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qianfoshan Hospital
Lung Infection, Pneumonia, Ventilator-Associated
Adjunctive Therapy to Antibiotics in the Treatment of S. Aureus Ventilator-Associated Pneumonia With AR-301
AR-301 is being evaluated as an adjunctive treatment of ventilator-associated pneumonia (VAP) due to Staphylococcus aureus (S. aureus) in combination with standard of care (SOC) antibiotic therapy in patients with confirmed S.
- Conditions
- Lung Infection, Pneumonia, Ventilator-Associated, Infection, Bacterial, Staphylococcus Aureus
- Trial name
- AR-301-002 (NCT03816956)
- Testing
- AR-301
- Where
- 45 sites in Belarus, Belgium and 13 more
- Volunteers
- 174 people
- Sponsor
- Aridis Pharmaceuticals, Inc.
Mechanical Ventilation, Ventilator-associated Conditions
ED Lung Protective Ventilation to Reduce Complications
Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS).
- Conditions
- Mechanical Ventilation, Ventilator-associated Conditions, ARDS
- Trial name
- NCT02543554
- Testing
- lung protective ventilation
- Where
- United States
- Volunteers
- 1,705 people
- Sponsor
- Washington University School of Medicine
Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia
Hospital-acquired Pneumonia in Intensive Care Unit
hospital-acquired pneumonia are a common disease in intensive care unit. The prevention, the diagnosis and the treatment of hospital acquired pneumonia are a frequent challenge.
- Conditions
- Hospital Acquired Pneumonia, Ventilator-Associated Pneumonia, Sepsis, Pneumonia
- Trial name
- PNEUMOCARE (NCT03348579)
- Testing
- Guidelines publication and application, Targeted experience feedback
- Where
- France
- Volunteers
- 1,850 people
- Sponsor
- Nantes University Hospital
Ventilator Associated Pneumonia
The Effectiveness of Oral Care With Chlorhexidine in Medical Intensive Care Unit
Oral care with chlorhexidine was used to be considered an effective way to prevent ventilator-associated pneumonia (VAP). However, recent evidence revealed that oral care with chlorhexidine may associate with higher mortality and…
- Trial name
- NCT05913856
- Testing
- Normal saline, Chlorhexidine
- Where
- Taiwan
- Volunteers
- 141 people
- Sponsor
- National Taiwan University Hospital
Bronchopulmonary Dysplasia, Chronic Lung Disease
Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes
Important developmental processes continue until the completion of 40 weeks gestation. Even during fetal life, intrinsic and environmental factors determine the balance between health and the onset and development of diseases.
- Trial name
- NCT03373539
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Ventilator Lung
Airway Pressure Changes Using Esophageal Balloon Catheter (OBC) in Laparoscopic Surgery
This is a single centre study. The investigators intend to recruit 20 subjects over 4 months. Patients undergoing laparoscopic abdominal surgery for cholecystectomy, laparoscopic gynaecological surgery and laparoscopic urologic…
- Trial name
- NCT03411239
- Testing
- Adult esophageal balloon catheter (obc)
- Where
- Singapore
- Volunteers
- 35 people
- Sponsor
- National University Hospital, Singapore
Chronic Respiratory Failure, COPD
Microbiologic Contamination of Home Non Invasive Ventilators
Home non-invasive ventilators are daily used by patients with chronic respiratory failure. There are frequently used with warming and humidifying systems. These systems need to be cared for and frequently washed by the patient.
- Conditions
- Chronic Respiratory Failure, COPD, Obesity Hypoventilation Syndrome
- Trial name
- MiCONIV (NCT03809832)
- Testing
- Microbiological sampling
- Where
- France
- Volunteers
- 54 people
- Sponsor
- University Hospital, Rouen
Ventilator Associated Pneumonia
The Gravity-VAP (Ventilator-Associated Pneumonia) Trial
This study is planned to compare, in patients sedated, intubated and mechanically ventilated, the efficacy and safety of the Lateral Trendelenburg position in comparison to the Semirecumbent Position to prevent incidence of…
- Trial name
- Gravity-VAP (NCT01138540)
- Testing
- lateral-Trendelenburg position
- Where
- 2 sites in Italy, Spain
- Volunteers
- 800 people
- Sponsor
- Policlinico Hospital
Premature Birth, Obstructive Lung Disease
Pulmonary Outcomes of Bronchopulmonary Dysplasia in Young Adulthood
Preterm birth alters the normal sequence of lung development with lasting respiratory consequences. It is still unclear whether observed respiratory morbidities in preterm born individuals reflect sequelae from a non-progressive…
- Conditions
- Premature Birth, Obstructive Lung Disease, Bronchopulmonary Dysplasia
- Trial name
- NCT02820818
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
Ventilator-associated Pneumonia
Ventilator-associated Pneumonia (VAP) and Humidification System
The purpose of this study is to determine which humidification system is more effective in preventing pneumonia in mechanically ventilated patients.
- Trial name
- NCT01546974
- Testing
- HME filter Twin Star 55, Drager Medical, Germany, Heated humidification
- Where
- Brazil
- Volunteers
- 306 people
- Sponsor
- Hospital Sao Domingos
Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm
Structural and Microbiological Characterization of Endotracheal Tube Biofilm in Patients at Increased Risk for the Development of Ventilator-associated Pneumonia in the Intensive Care Unit
Ventilator-associated pneumonia (VAP) remains the most frequent healthcare-associated infection (HAI) in the intensive care unit (ICU) and one of the most critical risk factors associated with both significant morbidity as well…
- Conditions
- Biofilm Formation, Structural and Microbiological Characterization of Endotracheal Tube Biofilm, Ventilator-associated Pneumonia (VAP)
- Trial name
- BIOPAVIR (NCT04926493)
- Testing
- microbiological characterization
- Where
- France
- Volunteers
- 61 people
- Sponsor
- Centre Hospitalier Universitaire Dijon