Clinical trials: Ventilator-Associated Pneumonia (VAP)
Ventilator Associated Pneumonia
Diagnostic Modalities for VAP Detection
asses diagnostic performance of different methods for detection of ventilator associated pneumonia.
- Trial name
- NCT04911244
- Testing
- bronchoalveolar lavage
- Volunteers
- 100 people
- Sponsor
- Assiut University
Ventilator Associated Pneumonia ( VAP)
Impact of Antibio Prophylaxis on Occurence of Ventilator Associated Pneumonia in Trauma Patients
The relevance of a short course of antibiotic prophylaxis for the prevention of ventilator assocaited pneumonia (VAP) in trauma patients, and its impact on bacterial ecology, remains to be clarified.
- Trial name
- antiVAP (NCT07059039)
- Where
- France
- Volunteers
- 2,143 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventilator Associated Pneumonia, Lower Respiratory Infection
Pharmacokinetics, Safety and Efficacy of POL7080 in Patients With Ventilator Associated Pseudomonas Aeruginosa Pneumonia
To investigate the pharmacokinetic characteristics of POL7080 co-administered with SoC during 10 to 14 days of treatment in VAP patients due to suspected or documented Pseudomonas aeruginosa infection
- Trial name
- NCT02096328
- Testing
- POL7080
- Where
- 10 sites in Greece, Spain
- Volunteers
- 25 people
- Sponsor
- Polyphor Ltd.
Atelectasis, Acute Respiratory Distress Syndrome
Physiological Effects and Safety of Continuous High-frequency Oscillatory Ventilation in Mechanical Ventilation Patients
Mechanical ventilation is an important treatment modality for intensive care unit (ICU) patients, but it also brings a series of problems such as ventilator-associated pneumonia, ventilator-induced lung injury, and atelectasis.
- Conditions
- Atelectasis, Acute Respiratory Distress Syndrome, VAP - Ventilator Associated Pneumonia
- Trial name
- NCT06662630
- Testing
- High-Frequency Oscillatory Ventilation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Ventilation Acquired Pneumonia, Mechanical Ventilation
Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia
This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP)…
- Conditions
- Ventilation Acquired Pneumonia, Mechanical Ventilation, Oral Care
- Trial name
- TEA-VAP (NCT07688057)
- Testing
- Clorhexidine group, Green Tea group, white tea group
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Ventilator Associated Pneumonia
Application of VAP Bundle Among ICU Nurses
Background: Ventilator associated pneumonia (VAP) is a recognized healthcare-associated infection in lungs parenchyma that occurs in patients in which they are connected to mechanical ventilator.
- Trial name
- NCT05517759
- Testing
- Educational program
- Where
- Bahrain
- Volunteers
- 58 people
- Sponsor
- University of Bahrain
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Ventilator-associated Pneumonia
B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)
Diagnosis of VAP relies on a set of non-specific clinical, biological, and imaging criteria. Understanding host-pathogen interactions and the mechanisms of deregulations leading to infection of pulmonary tissue appears essential.
- Trial name
- OLYMPE (NCT07436780)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Ventilator Acquired Pneumonia
Study to Determine Quicker Methods of Diagnosing Pneumonia Caused by a Breathing Machine in Critically Ill Patients
Critically ill patients on a breathing machine are at risk of developing a type of pneumonia called Ventilator Acquired Pneumonia (VAP).
- Trial name
- NCT00938002
- Testing
- Acceler8 Pheno
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Denver Health and Hospital Authority
VAP - Ventilator Associated Pneumonia, Care
Effect of the Aspiration Care Bundle on Preventing VAP
Many pharmacological and non-pharmacological interventions are used to prevent ventilator-associated pneumonia (VAP). Nurses are directly responsible for implementing non-pharmacological interventions and therefore have an…
- Conditions
- VAP - Ventilator Associated Pneumonia, Care, Bundle Care, Aspiration
- Trial name
- NCT07138651
- Testing
- Aspiration care bundle
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Pneumonia
Serial Changes in sTREM-1 During Ventilator-associated Pneumonia (VAP)
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses.
- Trial name
- NCT00976157
- Testing
- Bronchoscopy BAL
- Where
- Taiwan
- Volunteers
- 35 people
- Sponsor
- Mackay Memorial Hospital
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Ventilator-associated Pneumonia
Biomarker-based Exclusion of VAP for Improved Antibiotic Stewardship
Critically ill patients whose lungs are supported by breathing machines (ventilators) commonly develop a new lung infection, called ventilator-associated pneumonia (VAP).
- Trial name
- VAPRapid-2 (NCT01972425)
- Testing
- Biomarker-based diagnostic
- Where
- 19 sites in United Kingdom
- Volunteers
- 211 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Mechanical Ventilation
Lung Microbiota and VAP Development (PULMIVAP)
Ventilator-associated pneumonia (VAP) refers to a lower respiratory tract nosocomial infection acquired >48h after being intubated in Intensive Care Units.
- Trial name
- PULMIVAP (NCT04849039)
- Where
- Italy
- Volunteers
- 700 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion to Prevent VAP in Prolonged Intubated Patients
Ventilator-associated pneumonia (VAP) is the most frequent infection occurring in patients who are admitted to the ICU. The accumulation of respiratory secretions in the subglottic space is a well-proven cause of VAP.
- Trial name
- NCT02632539
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Volunteers
- 220 people
- Sponsor
- Beijing Chao Yang Hospital
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
Respiratory Failure
Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)
The purpose of this study is to determine if the use of a silver-coated endotracheal tube (ETT) can reduce the incidence and/or delay the time of onset of VAP when compared to a non silver-coated ETT in patients who have been…
- Trial name
- NASCENT (NCT00148642)
- Testing
- silver salts coated endotracheal tube, uncoated endotracheal tube
- Where
- 5 sites in United States
- Volunteers
- 2,003 people
- Sponsor
- C. R. Bard
Ventilator Associated Pneumonia ( VAP)
Effect of Two Oral Care Methods on Oral Flora and VAP in Mechanically Ventilated Patients
This randomized controlled trial aims to evaluate the effect of two oral care methods on oral bacterial colonization and ventilator-associated pneumonia (VAP) in mechanically ventilated intensive care unit (ICU) patients.
- Trial name
- ORAVAP-RCT (NCT07283380)
- Testing
- Pediatric toothbrush, Sponge stick
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Marmara University
Ventilator Associated Pneumonia (VAP)
Addition of Tobramycin Inhalation in the Treatment of Ventilator Associated Pneumonia
This study evaluates the addition of tobramycin inhalation treatment to standard intravenous therapy in the treatment of ventilator associated pneumonia.
- Trial name
- VAPORISE (NCT02440828)
- Testing
- tobramycin inhalation
- Where
- 2 sites in Netherlands, Spain
- Volunteers
- 80 people
- Sponsor
- Erasmus Medical Center
VAP - Ventilator Associated Pneumonia
Efficiency and Safety of the Prolonged Use of Heat and Moisture Exchangers in ICU
FILTRex is a single-centre, controlled, randomised, prospective, non-inferiority clinical trial to compare the efficiency and safety of prolonged (72-hours) versus standard (24-hours) duration of use for Heat and Moisture…
- Trial name
- FILTRex (NCT06410664)
- Testing
- 72-hour HME exchange interval group, 24-hour HME exchange interval group
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Charles University, Czech Republic