Clinical trials: Ventral Hernia Midline
Open Midline Laparotomy
Prophylactic Reinforcement of Ventral Abdominal Incisions Trial
This trial is being conducted to evaluate the efficacy of Phasix™ Mesh implantation at the time of midline fascial closure compared to primary suture closure in preventing a subsequent incisional hernia in subjects at risk for…
- Trial name
- PREVENT (NCT03911700)
- Testing
- Phasix™ Mesh
- Where
- 32 sites in United States, Austria and 3 more
- Volunteers
- 477 people
- Sponsor
- C. R. Bard
Large Midline Ventral Hernia
Anterior Component Separation Versus Posterior Component Separation for Repair of Large Ventral Hernias
This study evaluates effect of anterior component separation and posterior component separation and transversus abdominis muscle release methods for treatment of midline ventral hernias.
- Trial name
- NCT03793738
- Testing
- Anterior component separation, Posterior component separation
- Where
- Georgia
- Volunteers
- 40 people
- Sponsor
- Zaza Demetrashvili
Ventral Hernia
Absorbable Versus Permanent Mesh Fixation Trial in Laparoscopic Midline Ventral Hernia Repair
To compare the use of absorbable tackers versus permanent tack fixation using a polyester large pore mesh in laparoscopic midline ventral hernia repair in a multicenter (Belgian) prospective randomized single-blinded trial.
- Trial name
- SORBET (NCT01109771)
- Testing
- permanent mesh fixation, absorbable mesh fixation
- Where
- 11 sites in Belgium
- Volunteers
- 105 people
- Sponsor
- University Hospital, Ghent
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Gangrenous Postoperative Ventral Hernia (Diagnosis), Dehiscence of Laparotomy Wound
Prevention of Postoperative Ventral Hernias
The research is aimed at identifying factors of herniation after median laparotomy and developing surgical methods for preventing postoperative ventral hernias and eventrations.
- Trial name
- NCT04562363
- Testing
- Suturing of a laparotomic wound with modified methods
- Where
- 2 sites in Russia
- Volunteers
- 700 people
- Sponsor
- Ryazan State Medical University
Incisional Hernia
Xen Matrix™ AB Surgical Graft in Ventral or Incisional Midline Hernias
This study aims to prospectively explore the use of XenMatrix™ AB Surgical Graft for ventral or incisional midline hernia repair in patients across all wound classes ("All Comers") through 24 months post repair.
- Trial name
- NCT02691962
- Testing
- Xen Matrix AB
- Where
- 11 sites in United States
- Volunteers
- 75 people
- Sponsor
- C. R. Bard
Ventral Incisional Hernia
Observational Study to Evaluate Ventral Incisional Hernia Repair Using a Biologic Mesh (Cook Biodesign)
The purpose of this study is to evaluate the efficacy of the Cook Biodesign mesh for the repair of complex ventral incisional hernias.
- Trial name
- NCT02129140
- Testing
- Hernia graft/mesh
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hernia, Ventral
Small Versus Large Bite Closure of Emergency Midline Laparotomy
In daily practice, midline laparotomy is an incision frequently performed by surgeons to achieve a rapid and wide access to the abdomen.
- Trial name
- E-STITCH (NCT04098380)
- Testing
- Small Bite, Larger bite
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Mansoura University
Hernia, Ventral, Hernias Intestinal
Optimization of Surgical Treatment of Patients With Incisional Ventral Hernias
The goal of our work of optimization of the treatment of postoperative hernias is to improve the results of treatment of patients with median and median-lateral postoperative hernias of medium (W2) and large (W3) sizes by…
- Conditions
- Hernia, Ventral, Hernias Intestinal, Hernia Abdominal Wall
- Trial name
- NCT05734222
- Testing
- A new method of repair of the abdominal wall of mid-lateral postoperative ventral hernias
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Samara State Medical University
Incisional Hernia of Midline of Abdomen
Open Vs. Endoscopic Transversus Abdominis Release Trial
This study aims to comparatively evaluate the early and long-term results of open and endoscopic TAR procedure for large midline incisional ventral hernias.
- Trial name
- NCT06195332
- Testing
- open TAR, endoscopic TAR
- Where
- Russia
- Volunteers
- 36 people
- Sponsor
- City Clinical Hospital No.1 named after N.I. Pirogov
Ventral Hernia Midline, Hernia Lumbar
Prospective Study of Minimally Invasive (Laparoscopic and Robotic) Hernia Repair (Incisional and Primary, Midline and Lateral, Not Inguinal)
The participating researchers register all adult patients (who have given informed written consent) scheduled for elective repair of an abdominal wall hernia (NOT inguinal hernias) via minimally invasive operation technique…
- Conditions
- Ventral Hernia Midline, Hernia Lumbar, Incisional Hernia Repair
- Trial name
- PROMISER (NCT07544238)
- Testing
- Minimally invasive hernioplastia
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Hernia, Ventral
Endoscopic Mini/Less Open Sublay(EMILOS) Repair
Ventral hernias in the midline of the abdominal wall are one of the most frequent diseases in general and visceral surgery worldwide. The optimal operative technique is still in discussion.
- Trial name
- EMILOS (NCT05912868)
- Testing
- Endoscopic Mini/Less Open Sublay Repair
- Where
- 3 sites in Germany
- Volunteers
- 174 people
- Sponsor
- Diakonie-Klinikum Stuttgart
Ventral Incisional Hernia
Shear-Wave Elastography
Prospective cohort study of patients with midline ventral incisional hernia with a range of hernia morphology who plan to undergo open retromuscular VHR.
- Trial name
- ELASTOGRAPHY (NCT06306976)
- Testing
- Elective Midline Laparotomy, Imaging: Ultrasound, Tensiometry
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Prisma Health-Upstate
Hernia, Ventral, Rectus Diastasis
Endoscopic eTEP Versus Open Rives-Stoppa
Observational cohort study (partially retrospective, partially prospective) comparing the endoscopic extended totally extraperitoneal prosthesis (eTEP) repair for midline abdominal hernias to open Rives-Stoppa repair (control).
- Trial name
- NCT05446675
- Testing
- Endoscopic eTEP, Open Rives-Stoppa
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- AZ Alma
Incisional Hernia of Midline of Abdomen
Laparoscopic IPOM Plus vs. eTEP Trial
The survey will compare primary and secondary outcomes of laparoscopic intraperitoneal onlay mesh (IPOM plus) and extended totally extraperitoneal (eTEP) repair for incisional hernia.
- Trial name
- NCT05528107
- Testing
- Lap IPOM plus, eTEP
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- City Clinical Hospital No.1 named after N.I. Pirogov
Hernia Incisional Ventral
Management Of Large Incisional Hernia, Double Mesh Modification Of Chevrel's Technique Versus On Lay Mesh Hernioplasty
comparison between two groups of large midline incisional hernia, the first group managed by double mesh modification of chevrel's technique the second one managed by conventional onlay mesh repair
- Trial name
- NCT04430816
- Testing
- double mesh modification of chevrel's technique, on lay mesh hernioplasty
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Zagazig University
Hernia, Ventral, Body Image
Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair
Background: Midline incisional hernia is reported from 0,5 to 11% after abdominal operations. Primary repair without mesh reinforcement is almost abandoned because of high recurrence rates (24 to 46%).
- Conditions
- Hernia, Ventral, Body Image, Respiratory Function Tests, Quality of Life
- Trial name
- GINCISHERNIA (NCT00625053)
- Testing
- Laparoscopic repair, Open midline incisional hernia repair
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University Hospital, Geneva
Ventral Hernia
Ventralex Vs Stratafix for Primary Ventral Hernias
Randomised controlled trial comparing Ventralex Hernia Patch with Stratafix suture for repair of primary ventral hernias in the midline.
- Trial name
- VPatchPriRCT (NCT04356976)
- Testing
- Ventralex, Stratafix
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Ventral Incisional Hernia
Open Complex Ventral Incisional Hernia Repair Using Biosynthetic Material for Midline Fascial Closure Reinforcement
Prospective, multicenter, observational study to evaluate performance of GORE® BIO-A® Tissue Reinforcement when used to reinforce midline fascial closure in single-staged open complex ventral incisional hernia repair.
- Trial name
- COBRA (NCT01325792)
- Testing
- GORE® BIO-A® Tissue Reinforcement
- Where
- 9 sites in United States, Netherlands
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Ventral Hernia Midline
The Effect of Sutures Versus Mesh in Umbilical Hernia Repair
Background Mesh repair reduces the risk of reoperation for recurrence in patients with small umbilical and epigastric hernias compared with sutured repair.
- Trial name
- ABSNOME (NCT01635868)
- Where
- Denmark
- Volunteers
- 1,313 people
- Sponsor
- Hvidovre University Hospital