Clinical trials: Ventricular Repolarization
Ventricular Arrythmia
China Inherited Ventricular Arrhythmias Registry
This is an observational, prospective, multi-center registry, aiming at building a risk stratification for malignant inherited ventricular arrhythmias, including Brugada syndrome(Brs)、Long QT syndrome(LQTS)、Short QT…
- Trial name
- NCT03880708
- Where
- China
- Volunteers
- 500 people
- Sponsor
- China National Center for Cardiovascular Diseases
Premature Ovarian Insufficiency
Ventricular Repolarization in Patients With Premature Ovarian Insufficiency (QTIOP)
Ventricular repolarization, measured by corrected QT interval (QTc), is influenced by sex hormones. A QTc above 460msec predisposes to the risk of "torsades-de-pointes"(TdP).
- Trial name
- QTIOP (NCT04167033)
- Testing
- Hormone replacement therapy:effect on ventricular repolarization, ECG
- Where
- 3 sites in France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ventricular Repolarization
A Randomized, Single-Dose, Comparative, Positive and Placebo Controlled, Four-Way, Four Period, Cross-Over Study to Evaluate the Effect of DIC075V on QTc Intervals in Healthy Subjects
This study is conducted to evaluate the effectiveness of DIC075V on ventricular repolarization in healthy subjects compared to placebo after a single dose of DIC075V administered intravenously (IV) and to evaluate ECG assay…
- Trial name
- NCT01812538
- Testing
- DIC075V
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Pregnancy, Long QT Syndrome
Ventricular Repolarization During the Pregnancy-to-Postpartum Transition (QuTe)
Pregnancy and the postpartum period are accompanied by marked changes in heart rate, circulating hormones, and electrolyte balance that may influence ventricular repolarization.
- Trial name
- QuTe (NCT02931695)
- Testing
- Evaluation of QT interval duration, Circulating sex hormones levels sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- French Cardiology Society
Arrhythmias, Cardiac, Diabetes Mellitus
Effect of Dapagliflozin on Electrocardiographic Parameters in Type 2 Diabetes Patients: DAPA - ECG Study
The goal of this clinical trial is to evaluate whether dapagliflozin can reduce ventricular electrical remodeling, as measured by electrocardiographic parameters, in patients with type 2 diabetes (T2D).
- Trial name
- DAPA-ECG (NCT06721442)
- Testing
- Dapagliflozin (DAPA)
- Where
- 2 sites in Brazil
- Volunteers
- 174 people
- Sponsor
- Beneficência Portuguesa de São Paulo
Aortic Aneurysm, Abdominal, Ventricular Arrythmia
Cardiac Complication After Vascular Surgery
The vascular surgery is a highest risk procedure when considering postoperative complications associated with the cardiovascular system. The leading clinical presentation is acute hemodynamic decompensation.
- Conditions
- Aortic Aneurysm, Abdominal, Ventricular Arrythmia, Peripheral Arterial Disease, Cardiac Complication
- Trial name
- CCVS (NCT03188341)
- Testing
- vascular surgery procedure
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Cardiac Disease, Ventricular Arrythmia
Development of an Artificial Intelligence Algorithm to Detect Pathological Repolarization Disorders on the ECG and the Risk of Ventricular Arrhythmias
Torsades de Pointes (TdP) are potentially fatal ventricular arrhythmias that are promoted by prolonged ventricular repolarization (Long QT, LQT).
- Trial name
- DEEPECG4U (NCT05829993)
- Where
- France
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases, Electrocardiogram: Electrical Alternans
Gated SPECT Abnormality With J Point Elevation
The investigators present an interesting co-incidence of Gated wall abnormality in the inferolateral wall in normal sestamibi myocardial perfusion images with J wave in the inferior derivations of the ECG in a patient.
- Conditions
- Cardiovascular Diseases, Electrocardiogram: Electrical Alternans, Myocardial Ischemia, Early Repolarization Syndrome
- Trial name
- NCT03472898
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Ankara Education and Research Hospital
Cardiac Arrest, Long QT Syndrome
Registry of Unexplained Cardiac Arrest
The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network.
- Conditions
- Cardiac Arrest, Long QT Syndrome, Brugada Syndrome, Catecholaminergi Polymorphic Ventricular Tachycardia
- Trial name
- NCT00292032
- Where
- Canada
- Volunteers
- 1,529 people
- Sponsor
- University of British Columbia
Diabetes Mellitus, Type 2, Coronary Heart Disease
Effect of Empagliflozin on Ventricular Repolarization.
The present project aims to investigate if the empagliflozin has an antiarrhythmic action. Analyzing the T-wave heterogeneity index, a new electrocardiographic risk marker associated with the prediction of cardiovascular risk, in…
- Conditions
- Diabetes Mellitus, Type 2, Coronary Heart Disease, Arrythmia, Cardiac
- Trial name
- EMPATHYHEART (NCT04117763)
- Testing
- Empagliflozin 25 MG
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Atrial Fibrillation, Ventricular Fibrillation
Evaluation of Depolarization and Repolarisation Activity During Cardiac Arrhythmia Using a Novel Monophasic Action Potential Catheter
Monophasic action potential (MAP) recording plays an important role in a more direct view of human myocardial electrophysiology under both physiological and pathological conditions.
- Conditions
- Atrial Fibrillation, Ventricular Fibrillation, Junctional Tachycardia
- Trial name
- EvaMAP (NCT01254474)
- Testing
- Cardiac chambers mapping with MAP 4
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic
Cardiac Safety Study of Brentuximab Vedotin (SGN-35)
The purpose of this study is to evaluate cardiac safety of brentuximab vedotin (SGN-35) in patients with CD30-positive cancers. The study will assess electrical activity of the heart before and after brentuximab vedotin…
- Conditions
- Disease, Hodgkin, Lymphoma, Large-Cell, Anaplastic, Lymphoma, Non-Hodgkin
- Trial name
- NCT01026233
- Testing
- brentuximab vedotin
- Where
- 9 sites in United States, Germany
- Volunteers
- 52 people
- Sponsor
- Seagen Inc.
Brugada Syndrome, Early Repolarization Syndrome
VF Mapping in Brugada and Early Repolarization Syndromes
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
- Trial name
- NCT03764592
- Testing
- radiofrequency ablation
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Coronavirus Infection, Intensive Care Patients
Effects on the Qt Interval of COVID-19 Coronavirus Infection
The present study aims to evaluate the impact of COVID-19 disease and its treatment on ventricular repolarization, assessed by measuring the QTc interval, in patients admitted to the critical care unit.
- Trial name
- QT-COVID-19 (NCT04422535)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Matilde Zaballos
Sudden Cardiac Death, Prolonged QTc Interval
Smoking and Ventricular Repolarization
Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization.
- Trial name
- NCT03916341
- Testing
- EC with nicotine, EC without nicotine, control
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Hypertension, Blood Pressure Monitoring, Ambulatory
Nocturnal Blood Pressure Dipping and Ventricular Repolarization in Hypertension
The primary aim is to determine whether non-dipping status is associated with adverse repolarization markers and impaired myocardial mechanics compared to dipper hypertensive patients.
- Conditions
- Hypertension, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Electrocardiography
- Trial name
- NBP-DIP (NCT07200856)
- Testing
- Nocturnal Blood Pressure Dipping
- Volunteers
- 140 people
- Sponsor
- Assiut University
Congestive Heart Failure, Chronic Heart Failure
Significance of Impedance Cardiography and Early Repolarization Pattern in ECG in Congestive Heart Failure
Congestive heart failure (CHF) is a disorder of the heart when structural or functional heart disease impairs the heart's ability to work properly.
- Conditions
- Congestive Heart Failure, Chronic Heart Failure, Right Ventricular Failure, Heart Failure
- Trial name
- SICERE-CHF (NCT05480345)
- Testing
- Impedance cardiography
- Where
- Lithuania
- Volunteers
- 301 people
- Sponsor
- Lithuanian University of Health Sciences
Sudden Cardiac Death, End Stage Renal Disease
T-Wave Alternans in Dialysis Patients
Sudden cardiac death due to arrhythmia is the leading cause of death in end-stage renal disease (ESRD) patients treated with hemodialysis (HD).
- Trial name
- NCT00621426
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Northwestern University
Cardiomyopathies, Primary, Arrhythmia
An Arrhythmia Risk Stratification and Genetic Trial
The prospective EUTrigTreat multi-center study is an observational, advanced diagnostics and genetic risk stratification trial in patients with standard indications for ICD treatment, with and without myocardial infarction in…
- Conditions
- Cardiomyopathies, Primary, Arrhythmia, Sudden Cardiac Death, Calcium Metabolism Disorders
- Trial name
- EUTrigTreat (NCT01209494)
- Where
- 4 sites in Belgium, Germany and 2 more
- Volunteers
- 672 people
- Sponsor
- University Medical Center Goettingen
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital