Clinical trials: Very Low Calorie Diet
Type2diabetes, Obesity
Depletion of Liver Fat in Type 2 Diabetes
The aim of this randomized trial is to determine whether liver fat depletion via a short-term (i.e., two weeks) very-low calorie diet will restore the normal exercise-induced secretion of a signaling protein (fibroblast growth…
- Trial name
- DepLiv (NCT06211556)
- Testing
- Very-low calorie diet
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Healthy
Effects of Dihydrocapsiate on Adaptive and Diet-Induced Thermogenesis With a High Protein Very Low Calorie Diet
The study is designed to determine the effects of a non-pungent supplement from sweet chilli pepper on resting metabolic rate and diet-induced thermogenesis (DIT) after a period of very low calorie intake over 4 weeks.
- Trial name
- NCT01142687
- Testing
- dihydrocapsiate capsule
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes Mellitus, Overweight and Obesity
Type 2 Diabetes Treatment and Remission With a Very Low-Calorie Ketogenic Diet (VLCKD) and Lifestyle Changes
There is a strong correlation between being overweight, specifically with abdominal fat, and type 2 diabetes mellitus (T2DM). Recent scientific literature has highlighted the connection between significant weight loss…
- Trial name
- NCT05984459
- Testing
- VLCKD
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- Cabinet Medical
Obesity
The Effect of a Short-term Very Low Calorie Diet on Heart Rate Variability in Obese Individuals
The purpose of this study is to determine whether short-term adherence to a very low calorie diet is effective in improving heart rate variability in obese individuals.
- Trial name
- NCT02070770
- Testing
- Very low calorie diet, Standard weight loss diet
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- King's College London
Obesity & Overweight, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis)
Adherence and Tolerability of Four Very Low-Calorie Ketogenic Diet Approaches in Adults With Obesity or Complicated Overweight
This study, called KOBE Study, looks at how well different very low-calorie ketogenic diets (VLCKD) are followed and tolerated by adults with obesity or complicated overweight in routine clinical practice.
- Conditions
- Obesity & Overweight, MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis), Type 2 Diabetes, Insulin Resistance
- Trial name
- KOBE (NCT07389122)
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Bologna
Type 1 Diabetes (T1D), Obesity (Disorder)
Vey Low-Energy Ketogenic Therapy in Adults With Type 1 Diabetes and Obesity on Intensive Insulin Therapy Using Advanded Hybrid Closed Loop System
Overweight and obesity are frequent in adults with type 1 diabetes (T1D), with prevalence exceeding 50% in recent studies. Excess weight in T1D is associated with higher cardiometabolic risk and therapeutic challenges, while…
- Trial name
- KET1D (NCT07185555)
- Testing
- VLEKT
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Diabetic Kidney Disease
Very Low Calorie Diet for Diabetic Kidney Disease
The purpose of this study is to determine whether a very low calorie diet will stabilize or improve diabetic kidney disease.
- Trial name
- NCT01671969
- Testing
- very low calorie diet
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease
Effects of VLCKD in Metabolic Syndrome
VLCKD has showed to be an impactful diet on several metabolism aspects and has proven to be useful for preventing and treating diabetes mellitus type 2, overweight, chronic inflammation and fatty liver.
- Conditions
- Diabetes Mellitus, Type 2, Non-alcoholic Fatty Liver Disease, Obesity, Metabolic Syndrome
- Trial name
- KETO-MI (NCT05275608)
- Testing
- VLCKD diet with replacing meals, Hypocaloric mediterranean Diet
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Obesity, Morbid
Weight Loss Maintenance and Compensatory Mechanisms Activated With a Very-low Calorie Diet
Very-low calorie diets are relatively safe and effective in inducing significant weight loss, when used in selective individuals and under clinical supervision.
- Trial name
- NCT01834859
- Testing
- Multidisciplinary outpatient program, Inpatient lifestyle program
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian University of Science and Technology
Healthy
Very Low-calorie Diet & Cardiometabolic Health
To investigate the effects of a short-term (1-week) nutritional intervention in healthy individuals using very low-calorie (fasting-mimicking) diets with different protein content on markers of cardiometabolic health and…
- Trial name
- NCT06560996
- Testing
- Very low calorie diet with low protein content (VLCD-LP group), Very low calorie diet with high protein content (VLCD-HP group)
- Where
- Switzerland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
HCG
Muscle-Sparing Effect Of Human Chorionic Gonadotropin (hCG) During a Very Low Calorie Diet (VLCD)
Subjects are female patients, randomized to HCG group or placebo group, during a prospective trial, in order to determine the significance, if any, of HCG on maintaining muscle mass during a very low calorie diet in order to…
- Trial name
- NCT02427529
- Testing
- Human Chorionic Gonadotropin, Low calorie diet
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Dr. Emma's Corporation
Liver Fat
MR Fat Quantification and Elastography During a Very Low-calorie-ketogenic Diet (Pronokal Method®) vs a Low Calorie Diet
Prospective, multicenter, open-label, randomized and controlled study of the effects of weight loss and reduced visceral fat on non-alcoholic fat infiltration into liver after a very low calorie ketogenic diet (VLCK diet)…
- Trial name
- NCT04322110
- Testing
- PronoKal Method, Low calorie diet
- Volunteers
- 40 people
- Sponsor
- Protein Supplies SL
Obesity
Acceptability and Feasibility of a Preoperative Very Low Calorie Diet Intervention on Surgical Weight Loss Outcomes (SAFETY)
Class 4 obesity is defined as a BMI ≥50Kg/m2, representing approximately ≥150 pounds of excess weight. For patients with Class 4 obesity, metabolic and bariatric surgery (MBS) is the only effective treatment.
- Trial name
- SAFETY (NCT06183034)
- Testing
- Very Low Calorie Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hartford Hospital
Migraine, Overweight and Obesity
Very Low Calories Ketogenic Diet in Migraine.
Ketogenesis is a physiologic phenomenon due to starvation or ketogenic diet (KD), a drastic restricted carbohydrate dietary regimen that induces lipid metabolism and ketone body (KB) synthesis.
- Trial name
- Ketomig (NCT03076060)
- Testing
- Ketogenic diet
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University of Roma La Sapienza
Morbid Obesity, Steatosis
Very Low Calorie Liquid Diet for Pre op Patients
Despite the relative consensus on the benefits of pre-surgical weight loss, i.e., the reduction of comorbidities associated with surgical act, such as decreased visceral fat, liver volume, hemorrhage perioperative and surgical…
- Trial name
- NCT01748682
- Testing
- A very low calorie diet of two different consistencies
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Weight Regain Post Bariatric Surgery, Obesity (Disorder)
Naltrexone/Bupropion With or Without Very Low Calorie Ketogenic Diet for Weight Regain After Bariatric Surgery
The goal of this clinical trial is to evaluate the superiority of combined VLCKD, intensive lifestyle intervention and naltrexone/bupropion (N/B) versus standard of care with naltrexone/bupropion on weight loss for people with…
- Trial name
- Relay (NCT06881485)
- Testing
- Very Low Calorie Diet
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bariatric Surgery Candidate, Very Low Calorie Diet
Use of Very Low Calorie Diet Preoperatively to Bariatric Surgery
To investigate use of Very Low Calorie Diet preoperatively to bariatric surgery can optimize weight loss prior to surgery and increase the patients' satisfaction.
- Conditions
- Bariatric Surgery Candidate, Very Low Calorie Diet, Weight Loss
- Trial name
- NCT05291741
- Testing
- VLCD, Standard care
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Aarhus University Hospital
Obesity
Enteroprotein Modified Fast ( EMF )
The purposes of the esperience is: 1. to verify the safety of protein sparing modified fast(PSMF) by enteral route ( EMF )performed in cycles of ten days/months for six months 2.
- Trial name
- EMF (NCT01538654)
- Testing
- enteral protein tube feeding in obese
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- M.D. Samir G. Sukkar
Obesity, Weight Loss
Changes in Anthropometric, Biochemical and DNA Damage Parameters After 3-weeks VLCD in Severely Obese Patients
Obesity manifest with inflammation, hyperglycaemia and dyslipidaemia. These conditions disturb redox system by generating excessive reactive oxygen species (ROS) and causing oxidative stress (OS) leading to DNA damage.
- Conditions
- Obesity, Weight Loss, DNA Damage
- Trial name
- NCT05007171
- Testing
- Very low calorie diet
- Where
- Croatia
- Volunteers
- 22 people
- Sponsor
- Special Hospital for Extended Treatment of Duga Resa