Clinical trials: Veterans, open to volunteers
Tobacco Use Disorder
Neuroimaging Correlates and Feasibility of Transcranial Magnetic Stimulation (TMS) to Improve Smoking Cessation Outcomes in Veterans With Comorbid PTSD
Tobacco use is the number one preventable cause of the death in the United States, and is high among US Veterans, and those who have experienced trauma are more likely to smoke.
- Trial name
- TMS-STOP (NCT05723588)
- Testing
- active repetitive transcranial magnetic stimulation, cognitive behavioral therapy for smoking cessation, nicotine replacement therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Functional Impairment, Frailty
A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings
Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent.
- Trial name
- NCT06404970
- Testing
- Screening intervention, Standard bundle of implementation strategies, Enhanced bundle of implementation strategies
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- VA Office of Research and Development
PTSD, Post Traumatic Stress Disorder
Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery
The overall strategy is to recruit veterans with PTSD who report minimal current cannabis use but are interested in or considering therapeutic cannabis to manage mental health symptoms (anxiety, depression, PTSD and/or…
- Conditions
- PTSD, Post Traumatic Stress Disorder, Suicide, Cannabis Use
- Trial name
- CAPER (NCT06222268)
- Testing
- Cannabidiol (CBD) only, Delta-9-tetrahydrocannabinol (THC) only, THC:CBD 1:1
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Leslie Lundahl
PTSD, Posttraumatic Stress Disorder
Repurposing Low-Dose Clonidine for PTSD in Veterans
Hypothesis: Veterans with PTSD prescribed clonidine will demonstrate improvements in PTSD symptoms, including daytime, nighttime, and sleep-related behaviors.
- Conditions
- PTSD, Posttraumatic Stress Disorder, Sleep
- Trial name
- NCT04877093
- Testing
- Clonidine Pill
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Psychosis
Enhancing Rehabilitation for Veterans With Serious Mental Illness
This study addresses the critical need for innovative therapeutic interventions in Veterans with serious mental illnesses (SMI) receiving care in VA Psychosocial Rehabilitation and Recovery Centers (PRRCs).
- Conditions
- Schizophrenia, Psychosis, Serious Mental Illness, PTSD
- Trial name
- NCT06586164
- Testing
- Targeted Cognitive Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Football, Injury
The Relationship Between Training Dynamics and General Health Status in Veteran Football Players
The goal of this observational study is to learn how training habits and general health status are related to injury risk in veteran football players (men over 35 years old who play recreational football).
- Conditions
- Football, Injury, Veteran
- Trial name
- NCT07027592
- Testing
- Survey Study
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Izmir Bakircay University
Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA)
A Clinical Trial of Resistant Potato Starch for Gut MDRO Decolonization
Multidrug-resistant organisms (MDROs) cause serious infections that are difficult to treat, leading to increased morbidity and mortality, longer hospital stays, and increased healthcare costs.
- Conditions
- Clostridium Infections, Methicillin-resistant Staphylococcus Aureus (MRSA), Vancomycin-Resistant Enterococci, Carbapenem-Resistant Enterobacteriaceae
- Trial name
- MDRO-Fiber (NCT07792915)
- Testing
- Resistant Potato Starch, Maltodextrin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Fibromyalgia
Auricular Neuromodulation in Veterans With Fibromyalgia
PENFS (percutaneous electrical nerve field stimulation) is an FDA-cleared acupuncture-like therapy applied to the external ear targeting several cranial nerve branches including the auricular branch of the vagus nerve to improve…
- Trial name
- PENFS (NCT06415591)
- Testing
- Percutaneous electrical nerve field stimulation
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD)
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)
This study is testing a personalized form of brain stimulation called PrTMS as a treatment for post-traumatic stress disorder (PTSD) in military service members and veterans.
- Trial name
- NCT07526285
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Opioid Use Disorder
A Study Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous formulation of buprenorphine at a target dose of 300 milligrams (mg) is superior in retaining Veterans in opioid treatment and in sustaining opioid…
- Trial name
- VA-BRAVE (NCT04375033)
- Testing
- Sublingual buprenorphine with naloxone, Injectable subcutaneous buprenorphine
- Where
- 25 sites in United States
- Volunteers
- 952 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Alcohol Abuse
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
Alcohol Use Disorders are currently positioned as the third leading cause of preventable death in the United States, constituting a humanitarian crisis with substantial financial burden on society and medical facilities.
- Conditions
- Alcohol Use Disorder, Alcohol Abuse, Alcoholism, Drinking Behavior
- Trial name
- NCT06415721
- Testing
- Active Transcranial Magnetic Simulation
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Palo Alto Health Care System
Spinal Cord Injury, Chronic Pain
VR Mindfulness Training for Veterans With SCI
This study involves delivering a mindfulness program that was developed for Veterans called VA Compassionate Awareness Learning Module (VA CALM) to Veterans with spinal cord injuries (SCI) to develop accommodations to make the VA…
- Trial name
- NCT06587607
- Testing
- VA Compassionate Awareness Learning Module (VA CALM) a mindfulness curriculum.
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Pulmonary Disease, Chronic Obstructive
Virtual Nurse and Social Worker Palliative Care Team to Improve Quality of Life in Veterans With Heart Failure or COPD
Many Veterans living with heart failure or chronic obstructive pulmonary disease (COPD) experience significant symptoms - such as breathlessness, fatigue, depression, and anxiety -that reduce their quality of life.
- Conditions
- Heart Failure, Pulmonary Disease, Chronic Obstructive, Interstitial Lung Disease
- Trial name
- VITALVET:ADAPT (NCT07714252)
- Testing
- Virtual Nurse and Social Worker Palliative Care Team, Enhanced Implementation Support, Standard Implementation Support
- Where
- 7 sites in United States
- Volunteers
- 420 people
- Sponsor
- VA Office of Research and Development
E Cigarette Use
Adapting an Intervention for Vaping in Young Veterans
The objective of this proposal is to adapt an evidence-based combustible tobacco counseling intervention following an evidence-based process to include e-cigarette use and update its components for emerging adults (EA). 1.
- Trial name
- NCT06196489
- Testing
- adapted vaping cessation intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Veterans Medical Research Foundation
Stress Disorders, Post-Traumatic, Pain, Chronic
Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain
Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions…
- Trial name
- NCT07725588
- Testing
- Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- VA Office of Research and Development
Suicide
Testing the Efficacy of ACT for Life
Psychiatric hospitalization is a critical opportunity to provide treatment to reduce the risk of suicide and lay the groundwork for functional recovery.
- Trial name
- NCT04829682
- Testing
- ACT for Life, Present Centered Therapy
- Where
- 2 sites in United States
- Volunteers
- 278 people
- Sponsor
- VA Office of Research and Development
PTSD
Rapid Acceleration Process for Intensive Treatment of PTSD in 5 Days
Veterans with posttraumatic stress disorder (PTSD) need more effective treatments. Existing options can have limited adherence and can be very time-consuming. As such, alternative interventions are needed.
- Trial name
- RAPID5 (NCT07167940)
- Testing
- Transcranial magnetic stimulation
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- VA Office of Research and Development
Chronic Low Back Pain
Durability of Yoga for Veterans With Low Back Pain
Chronic low back pain is a prevalent condition among VA patients, but many current treatment options have side effects or limited effectiveness.
- Trial name
- NCT07053787
- Testing
- Standard Yoga, Enhanced Yoga
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- VA Office of Research and Development
Frailty
High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans
Frailty is defined as a greater susceptibility to stressors resulting from age-related impairments in adaptive biological systems.
- Trial name
- HIIT@Home (NCT05625204)
- Testing
- Center based attention (stretching only) control, Center based HIIT, Home based HIIT
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Spinal Cord Disease
Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury
Antimicrobial resistance is a major public health concern that worsens healthcare outcomes. Antibiotic resistant organisms occur more often in Veterans with spinal cord injury or disease (SCI/D) given their frequent exposure to…
- Trial name
- NCT07430904
- Testing
- Empowerment Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development