Clinical trials: Viral Respiratory Tract Infections
Covid19
Rapid Diagnosis of COVID-19 by Chemical Analysis of Exhaled Air
Since the start of 2020, the new SARS-CoV-2 coronavirus is causing a real global health crisis. In France, nasopharyngeal swabs are used to obtain the sample needed for respiratory infection screening.
- Trial name
- COVIDAIR (NCT04706039)
- Testing
- Performance evaluation (sensitivity and specificity) for COVID-19 diagnosis of the Vocus PTR-TOF process
- Where
- France
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Vaccine Refusal
Exploring Changes in COVID-19 Vaccination Intentions by Prompting Altruistic Motives Using a Video Intervention
As Canada records over 1,400,000 COVID-19 infections and 26,000 deaths, the need to stop the spread of the virus has become increasingly critical.
- Trial name
- NCT04960228
- Testing
- Altruism Video, COVID-19 Informational Text
- Where
- Canada
- Volunteers
- 2,097 people, healthy volunteers welcome
- Sponsor
- Zeev Rosberger
COVID, Sars-CoV2
Using GM-CSF as a Host Directed Therapeutic Against COVID-19
The coronavirus disease 2019 (COVID-19) has rapidly become a pandemic. COVID-19 poses a mortality risk of 3-7%, rising to 20% in older patients with co-morbidities.
- Conditions
- COVID, Sars-CoV2, ARDS, Human
- Trial name
- NCT04400929
- Testing
- Sargramostim, Normal Saline 0.9%
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Singapore General Hospital
COVID-19, Coronavirus Infections
Safety, Tolerability, and Immunogenicity of Trivalent Coronavirus Vaccine Candidate VBI-2901e With E6020 Adjuvant
VBI-2901e is an investigational vaccine candidate that uses enveloped virus-like particles (eVLPs) to express the spike proteins of three coronaviruses: SARS-CoV-2 (the virus that causes COVID-19 disease), SARS-CoV-1 and…
- Trial name
- NCT05614245
- Testing
- VBI-2901e
- Where
- 4 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- VBI Vaccines Inc.
Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Antigen Rapid Diagnostic Tests for Community Identification of Severe Acute Respiratory Syndrome Coronavirus 2
Background: Background: Testing with antigen-detecting rapid diagnostic tests (Ag-RDTs), including in asymptomatic individuals, has the potential to promptly identify more Severe Acute Respiratory Syndrome Coronavirus 2…
- Trial name
- NCT05458557
- Testing
- Rapid Antigen Testing
- Where
- Kenya
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Elizabeth Glaser Pediatric AIDS Foundation
COVID-19
A Study to Evaluate the Safety and Immunogenicity of COVID-19 Vaccine and Influenza Combination Vaccine
This is a medical study where participants will be randomly assigned to receive either a new combination vaccine that protects against both COVID-19 and the flu, or a standard flu vaccine.
- Trial name
- NCT06291857
- Testing
- CIC Vaccine Co-formulated tNIV2 , SARSCoV-2 rS and Matrix-M Adjuvant, Novavax COVID-19 Vaccine, tNIV Vaccine
- Where
- 58 sites in Australia, New Zealand
- Volunteers
- 9,320 people, healthy volunteers welcome
- Sponsor
- Novavax
AIDS Pneumonia, Septic Shock
Clinical Application of Cytokine Adsorption Technique in AIDS Patients With Severe Pneumonia and/or Septic Shock
Observing the Real-World Application Effectiveness of Cytokine Immune Adsorption Technology in AIDS Patients with Severe Pneumonia or septic shock.
- Trial name
- NCT06145828
- Testing
- Cytokine Adsorption
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Guangzhou 8th People's Hospital
COVID19, Cardiovascular Diseases
Multi-modality Imaging & Immunophenotyping of COVID-19 Related Myocardial Injury
Cardiovascular involvement in coronavirus disease-2019 (COVID-19) encompasses a wide range of vascular and myocardial pathologies, including both acute and long-term sequelae.
- Trial name
- MIIC-MI (NCT04412369)
- Testing
- Non-invasive cardiac imaging
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- University of Cambridge
COVID-19
A First in Human Study to Evaluate the Safety and Immunogenicity of RBM-001 in Healthy Adult Volunteers
A First in Human Study to Evaluate the Safety and Immunogenicity of RBM-001 in Healthy Adult Volunteers
- Trial name
- NCT06878170
- Testing
- RBM-001
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rock BioMedical, Inc.
Invasive Group A Beta-Haemolytic Streptococcal Disease
Severe Group A Streptococcus Infections in Paris, France, 2018-2023
Streptococcus pyogenes, commonly referred to as Group A Streptococcus (GAS), has the ability to induce a diverse range of illnesses.
- Trial name
- IGASI (NCT06297122)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 269 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
SARS-CoV2 Infection
Use of Saliva for COVID-19 Diagnosis
Aim of the study is to evaluate the presence of SARS-CoV2 RNA in the saliva of patients with suspected or confirmed COVID-19 in order to validate the analysis of this type of sample for the diagnosis of SARS-CoV2 infections.
- Trial name
- SALIVA-01 (NCT04953039)
- Where
- Italy
- Volunteers
- 109 people
- Sponsor
- University of Milano Bicocca
Viral Vaccines
Flu Vaccine Responses in the Setting of Melanoma Treatment
Influenza vaccination is indicated for all adults, but the immunogenicity of vaccination has not been assessed in all situations. We are conducting a prospective unblinded study of influenza vaccine recipients.
- Trial name
- NCT03315975
- Testing
- Inactivated influenza vaccine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Covid19
Patients Reactions Towards Their Diagnosis as Having COVID-19
Patients reactions towards their diagnosis as having COVID-19. The effect of patients' reaction toward their prospect management. How this can make many hazards. Also, obstacle and barrier to better management.
- Trial name
- NCT04581928
- Where
- Egypt
- Volunteers
- 3,812 people
- Sponsor
- ClinAmygate
Cancer, Covid19
CCP Cancer UK Companion Study
Currently, there is extremely limited information regarding the risks posed by SARS-CoV-2 to patients with cancer. This study aims to understand the presentation, management and outcomes of patients with cancer.
- Trial name
- NCT04603105
- Where
- United Kingdom
- Volunteers
- 9,000 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
COVID-19
Evaluating Public Health Interventions to Improve COVID-19 Testing Among Underserved Populations
The COVID-19 pandemic has disproportionately affected people from underserved and vulnerable populations such as low-income/uninsured, unhoused, and immigrant communities.
- Trial name
- NCT05270694
- Testing
- Public Health Intervention Package
- Where
- 3 sites in United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Kathleen Fairfield
Obesity, Covid19
Effect of Obesity Among COVID-19 Patients in Critical Care Settings
A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic.
- Trial name
- NCT04674553
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Coronavirus, Inflammation
Treatment of Patients With Mild Coronavirus-19 (COVID-19) Disease With Methotrexate Associated to LDL Like Nanoparticles (Nano-COVID19)
The investigators propose a prospective, randomized, double-blind, placebo-controlled study, conducted in two phases. The purpose of the study is to evaluate the safety and efficacy of methotrexate in a cholesterol-rich…
- Conditions
- Coronavirus, Inflammation, Covid19
- Trial name
- Nano-COVID19 (NCT04610567)
- Testing
- Methotrexate-LDE phase 1, Methotrexate-LDE phase 2
- Where
- 3 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- University of Sao Paulo General Hospital
Covid19, Pregnancy Related
Evaluation of COVID-19 IgG Antibodies in Maternal and Cord Blood Samples
Protocol Summary Study design: Prospective cohort study of pregnant COVID-19 positive patients at delivery. Study Objective: To collect umbilical cord blood and placenta samples at the time of delivery in COVID-19 positive women…
- Conditions
- Covid19, Pregnancy Related, Antibody Response
- Trial name
- NCT04732767
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
COVID-19 Infection
Assessment of the Psychosocial Impact of the COVID-19 Pandemic on the MD Anderson Cancer Center Workforce
This study investigates the impact of the COVID-19 pandemic on the psychosocial health of employees of MD Anderson Cancer Center.
- Trial name
- NCT04491292
- Testing
- Questionnaire Administration
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- M.D. Anderson Cancer Center
Pain, Chronic
PR-VR At-home Program During and After COVID-19
Poorly controlled chronic pain in teens can impact quality of life, increase opioid use and is a risk factor for developing chronic pain in adulthood.
- Trial name
- NCT04912817
- Testing
- Off the Shelf VR, Custom VR
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- The Hospital for Sick Children
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