Clinical trials: Vision Disorder
Vision Loss
Perception of Objects and Natural Scenes in People With Vision Loss (ACTIVIS)
The loss of central vision causes difficulty not only in reading but also in faces recognition, and in particular in the identification of facial expression, objects or spaces.
- Trial name
- ACTIVIS (NCT02862405)
- Testing
- vision tests
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Glaucoma, Intraocular Pressure
Effect of Topical Dexmedetomidine on Intraocular Pressure
Evaluate the short-term safety and efficacy of dexmedetomidine (0.0055%) drops on intraocular pressure (IOP) in healthy eyes.
- Trial name
- NCT03690622
- Testing
- Dexmedetomidine, Balanced salt solution
- Where
- Lebanon
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Beirut Eye Specialist Hospital
Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular
Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.
It has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy.
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular, Choroidal Effusion
- Trial name
- NCT04773561
- Testing
- Corneal tomography, optical coherence tomography and optical coherence tomography angiography
- Where
- Thailand
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Glaucoma
Posterior Cornea in Primary Open Angle Glaucoma
Characterization of posterior corneal changes in primary open angle glaucoma patients, using Scheimpflug examination.
- Trial name
- NCT02356094
- Testing
- Pentacam
- Where
- Portugal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar do Baixo Vouga
Dry Eye Disease
Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye
Observational and prospective cohort study that seek to evaluate the epidemiological characteristics and changes in the ocular surface of patients diagnosed with dry eye disease who are treated with preservative-free lubricating…
- Trial name
- NCT06162442
- Testing
- Preservative-free sterile ophthalmic solution, with 0.3% propylene glycol and 0.4% polyethylene glycol (400)
- Where
- Colombia
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Tecnoquimicas
Glaucoma
Baerveldt Versus Paul Study
The Baerveldt Versus Paul (BvP) Study is a Registry-based Randomised Controlled Trial, Comparing the Baerveldt Glaucoma Implant (BGI) and the Paul Glaucoma Implant (PGI).
- Trial name
- BvP (NCT07733453)
- Testing
- Baerveldt Glaucoma Implant, Paul Glaucoma Implant
- Where
- 4 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Ocular Infection and Inflammation
Non-Inferiority of Gatifloxacin/Prednisolone Association vs Isolated Administration in Prevention of Ocular Infection/Inflammation
The purpose of the study is to evaluate the safety and tolerance of the 0.3% gatifloxacin and 1.0% prednisolone acetate association in eye drops in the prevention of infection and inflammation after refractive surgery (Lasik) and…
- Trial name
- NCT01218737
- Testing
- 0.3% gatifloxacin and 1.0% prednisolone acetate association, isolated 0.3% gatifloxacin and 1.0% prednisolone acetate
- Where
- Brazil
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Glaucoma
Comparison of Intraocular Pressure Measurement With the Novel TonoVera Device With Other Commonly Used Devices
We are testing the accuracy of Reichert's Tono-Vera tonometer by comparing measurements of IOP with this device and measurements with other commonly-used tonometers, including Goldmann Applanation and iCare.
- Trial name
- NCT05523622
- Testing
- Tono-Vera tonometer, Goldman Applanation Tonometry
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Glaucoma
Comparing SD-tVEP and PERG Tests Between Patients With Glaucoma, Patients With High Eye Pressure and "Normal" Patients
Wills Eye Hospital Glaucoma Research Center will conduct a 1-year prospective study to assess the ability of a Short Duration Transient Visual Evoked Potential (SD- tVEP) and a Steady-State Pattern electro-retinogram (PERG)…
- Trial name
- NCT02604953
- Testing
- Short Duration Transient Visual Evoked Potential (SDtVEP), Pattern electroretinogram (PERG)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Erectile Dysfunction
A Study of Visual Effects of Erectile Dysfunction Medications Dosed Daily for Six Months
This is a multicenter, randomized, double-blind, placebo-controlled study to evaluate the effects on vision of six months of daily dosing of 5 mg tadalafil or 50 mg sildenafil compared with placebo.
- Trial name
- NCT00333281
- Testing
- tadalafil
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Eye Manifestations, Lupus Erythematosus, Systemic
Microvascular Ocular Changes of Systemic Lupus Erythematous
The goal of this observational study is to to assess the ocular microvascular status of SLE patients with inactive disease and without ocular involvement.
- Trial name
- VascLup (NCT05863689)
- Testing
- Spectralis SD-OCT
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Ocular Hypertension, Glaucoma
Tolerance and Effect on Intraocular Pressure After Administration of SYL040012
The purpose of this study is to determine whether SYL040012 is safe for the treatment of ocular hypertension and glaucoma.
- Trial name
- NCT00990743
- Testing
- SYL040012
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Melanoma, Ocular Melanoma
Study of Adjuvant Ipilimumab and Nivolumab in Subjects With High-risk Ocular Melanoma
This is an open-label, multi-site, single-arm Phase 2 study of adjuvant nivolumab combined with ipilimumab for the treatment of adult subjects with completely treated high-risk ocular melanoma, as defined in eligibility criteria…
- Trial name
- NCT03528408
- Testing
- Nivolumab, Ipilimumab
- Where
- 6 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Suthee Rapisuwon
Allergic Rhinoconjunctivitis
Investigating Nasal and Ocular Immune Response to Conjunctival Allergen Exposure
The goal of this pilot study is to develop an eye allergen challenge model, called a conjunctival allergen challenge (CAC), using timothy grass as the allergen.
- Trial name
- INQUIRE (NCT07801625)
- Testing
- Standardized Allergen Extract, Timothy Grass (Phleum pratense)
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Dr. Anne Ellis
Glaucoma, Open-Angle
The Effect of Pseudoexfoliation on Choroidal Thickness in Open Angle Glaucoma
Purpose: To investigate the effect of pseudoexfoliation (PEX) on choroidal thickness in primary open-angle glaucoma (POAG). Methods: This prospective, randomized study included 30 POAG patients and 30 PEX glaucoma patients with…
- Trial name
- NCT03373942
- Testing
- Choroidal thickness measurements with SD-OCT device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Emine Deniz Egrilmez
Glaucoma
Analysis of Clinical Profiles of Chinese Patients With Normal Tension Glaucoma
To obtain demographic and baseline ophthalmic parameters (such as Intraocular Pressure profiles, disc morphological characteristics, central corneal thickness, peripapillary retinal nerve fibre layer thickness and its serial…
- Trial name
- NCT00321386
- Where
- 2 sites in Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Dry Eye
Safety and Efficacy of Dexamethasone Ophthalmic Insert (Dextenza®) in the Management of Clinically Significant Dry Eye
To determine efficacy and safety profile of dexamethasone 0.4mg lacrimal insert in dry eye related ocular surface inflammation.
- Trial name
- NCT04498468
- Testing
- Sustained Release Dexamethasone, 0.4 mg, E-Caprolactone-L-Lactide copolymer (PCL) punctal plug
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Skin Laxity, Meibomian Gland Dysfunction
Evaluation of Ocular Surface Changes Following RF Electrocoagulation Treatment of the Periorbital Region
This protocol will evaluate THERMIeyes® for its ability to treat periorbital skin laxity and wrinkles and monitor ocular surface changes and their effect on evaporative dry eye associated with MGD.
- Trial name
- NCT03280069
- Testing
- THERMIeyes® 20 RF System
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ophthalmic Consultants of Long Island
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Ophthalmic Solutions, Glaucoma
Evaluation of a New Method for Instilling Eye Drops
The purpose of this project is to demonstrate that there is a new easier method to instill eye drops in ones own eye that is as effective as applying a drop directly to their open eye.
- Trial name
- NCT02697318
- Testing
- Timolol maleate 0.5% ophthalmic solution
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Waterloo