Clinical trials: Vision Disorders
Autism, Ocular Surface Disease
Ocular Function in Autism Spectrum Disorder
This study will investigate the visual function in individuals with ASD, with a particular focus on the ocular surface condition and visual function assessment.
- Trial name
- NCT04010422
- Testing
- no intervention
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Glaucoma, Glaucoma, Primary Open Angle
UCP (Ultrasound Cyclo Plasty) in the Treatment of Chinese Patients With Primary Open-angle Glaucoma
Traditional ciliary body photocoagulation treatment uses the photocoagulation of long-wavelength laser to destroy the ciliary body tissue that can produce aqueous humor.
- Trial name
- NCT04321122
- Testing
- ultrasound cyclo plasty
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Ocular Hypertension
Effect of Alternate Therapies on Intraocular Pressure in Ocular Hypertension
The purpose of this study is to evaluate the effect of complementary and alternative therapies, specifically alternate nostril breathing and foot reflexology, on intraocular pressure in patients with ocular hypertension.
- Trial name
- NCT02993445
- Testing
- Alternate Nostril Breathing, Foot Reflexology
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Temple University
Ocular Surface Disease, Irregular Astigmatism
Evaluation of the Safety and Efficacy of Rigid Breathable Scleral Contact Lenses for the Correction of Ametropia
To evaluate the short-term efficacy and safety of scleral contact lens in the clinical treatment of patients with irregular astigmatism after corneal transplantation by analyzing ocular parameters and ocular surface conditions of…
- Conditions
- Ocular Surface Disease, Irregular Astigmatism, Contact Lens Complication, Corneal Astigmatism
- Trial name
- NCT06256770
- Where
- China
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Primary Open-angle Glaucoma
Effects of Primary Open-angle Glaucoma on Visual-motor Coordination
Commonly used visual function assessments in glaucoma diagnosis and treatment-such as visual acuity, visual field, and contrast sensitivity-do not directly capture the impact of the disease on patients' daily abilities.
- Trial name
- NCT06692205
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Presbyopia, Refractive Error
Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia
Phase 3 study to evaluate the safety and effectiveness of LNZ100 \& LNZ101 for the treatment of Presbyopia.
- Conditions
- Presbyopia, Refractive Error, Eye Diseases, Near Vision
- Trial name
- CLARITY 1 (NCT05656027)
- Testing
- Aceclidine+Brimonidine combination ophthalmic solution, Aceclidine ophthalmic solution, Brimonidine
- Where
- 25 sites in United States
- Volunteers
- 469 people, healthy volunteers welcome
- Sponsor
- LENZ Therapeutics, Inc
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Glaucoma
Retinal Nerve Fiber Layer Thickness Measurement on Parapapillary Atrophy With the Cirrus High-Definition (HD) Optical Coherence Tomography (OCT)
Retinal nerve fiber layer (RNFL) thickness measurement on the parapapillary atrophy is incorrect. Because a new spectral domain OCT, the Cirrus HD OCT, uses a movable circle to analyze the RNFL thickness, we may suggest a new…
- Trial name
- NCT00742196
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Open Angle Glaucoma, Ocular Hypertension
A Study to Investigate the Effect of IOP-lowering With TO-O-1001 Eye Drops in Healthy Subjects and in Patients With Open-Angle Glaucoma or Ocular Hypertension
This is a Phase I/II stage to investigate the safety, tolerability, and ocular hypotensive efficacy of TO-O-1001 in healthy volunteers and patients with Open-Angle Glaucoma or Ocular Hypertension.
- Trial name
- NCT05456724
- Testing
- TO-O-1001
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Theratocular Biotek Co.
Glaucoma, Glaucoma; Drugs
Efficacy and Necessity of Time Interval Between Instillation of Two Glaucoma Eye Drops
According to the American Academy of Ophthalmology's Preferred Practice Pattern on Primary Open Angle Glaucoma, patients should wait five minutes between administering topical drops for intra-ocular pressure reduction.
- Trial name
- NCT03220490
- Testing
- 5 minute interval between regular glaucoma drops - Long term, no interval between regular glaucoma drops - Long term, IOP reduction of Brimonidine and Timolol with time interval
- Where
- Israel
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Diabetic Macular Edema, Branch Retinal Vein Occlusion
EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN)
This is a randomized, double-masked, multicenter, study to evaluate the efficacy, safety, and tolerability of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Conditions
- Diabetic Macular Edema, Branch Retinal Vein Occlusion, Glaucoma/Closed Angle Glaucoma
- Trial name
- CLEAN (NCT05127525)
- Testing
- IRX-101, Control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Age-Related (Dry) Macular Degeneration
Ocular Proteomics Testing In Chronic Atrophy
Study to evaluate the safety of routine diagnostic anterior chamber paracentesis (ACP) for proteomic profiling in patients with geographic atrophy (GA)
- Trial name
- OPTICA (NCT07298291)
- Testing
- AC Tap (anterior chamber paracenthesis)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ClinOmicsAI
Glaucoma,Primary Open-Angle ,Primary Angle Closure
Comparison of Optical Coherence Tomography Angiography Microvascular Changes in Primary Open Angle and Primary Angle Closure Glaucoma
This work aims to study the peripapillary and macular microvascular changes in primary open angle and primary angle closure glaucoma using Optical Coherence Tomography Angiography (OCTA).
- Trial name
- NCT06000176
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Omar Said
Bradycardia, Strabismus
The Alaska Oculocardiac Reflex Study
Observation study monitoring vital signs and anesthetic variables particularly heart rate during prospective, ocular manipulation and specifically uniform tension on extra ocular muscles during strabismus surgery.
- Trial name
- AK-OCR (NCT04353960)
- Testing
- electrocardiograph
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Alaska Blind Child Discovery
Stroke, Ischemic, Hemianopia, Homonymous
Statistical Learning as a Novel Intervention for Cortical Blindness
This project aims to develop a novel visual training paradigm for use in visually-intact participants and those sufferings from stroke-induced visual impairments.
- Conditions
- Stroke, Ischemic, Hemianopia, Homonymous, Hemianopsia, Occipital Lobe Infarct
- Trial name
- NCT06578117
- Testing
- Vision Training and Learning Task
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Primary Open-angle Glaucoma (POAG)
Role of Peripheral Vision in Scene Perception (PERISCE)
Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the…
- Trial name
- PERISCE (NCT05539508)
- Testing
- Psychophysical evaluation
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Child Development Disorder
Postural Control Among Children with and Without Dyslexia
As Chinese-speaking children with dyslexia typically have different cerebellar sign behavior from non-Chinese-speaking counterparts, this study compared the effect of visual occlusion on the static balance between dyslexic and…
- Trial name
- NCT05072418
- Testing
- Eye-opened and Eye-closed
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Myopia
Safety and Tolerability Evaluation of PRO-230 Ophthalmic Solution
Phase I Study to evaluate safety and tolerability of PRO-230 (atropine sulphate 0.05%) ophthalmic solution through evaluation of incidence of non-expected adverse events (AE), photophobia, pupillary diameter, incidence of…
- Trial name
- PRO-230 (NCT05481489)
- Testing
- Atropine Sulfate
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Glaucoma
Evaluation of Corneal Temperature by Infrared Thermography in Glaucoma Patients
Measurement of corneal temperature gives indirect information about the ocular blood flow. For this reason corneal temperature can be used as a surrogate to quantify ocular blood flow.
- Trial name
- NCT02674074
- Testing
- infrared thermography
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Dry Eye Disease
Ocular Microbiome and Immune System in Dry Eyes
The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease.
- Trial name
- NCT04658238
- Testing
- Ocular microbiome, Ocular immune system
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern