Clinical trials: Vitamin B 12 Deficiency
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Nutritional Status, Nutrient Deficiency
Adults Nutrition as a Protective or Health-risk Factor
To obtain up-to-date data on nutrient intakes in adults, a national dietary survey - the EU Menu study will be conducted during 12 consecutive months in 2017/2018, providing data on the consumption of foods and enabling the…
- Conditions
- Nutritional Status, Nutrient Deficiency, Micronutrient Deficiency, Vitamin D Deficiency
- Trial name
- NUTRIHEALTH (NCT03284840)
- Testing
- Assessement of nutritional status, Thyroid size
- Where
- 3 sites in Slovenia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
IVF, Body Weight
Nutritional Status of Women Undergoing in Vitro Fertilization
Infertility affects around 15 % of couples in their reproductive years. Even though the use of assisted reproductive technologies (ART) in aforementioned couples is increasing, their success rate is still relatively low.
- Conditions
- IVF, Body Weight, Nutrient Deficiency, Dietary Vitamin B12 Deficiency Anemia
- Trial name
- NCT05865015
- Where
- 2 sites in Slovenia
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Vitamin B12 Deficiency
Vitamin B12 Supplementation Study
We hope to learn the clinical and functional signs of sub-clinical vitamin B12 deficiency and its response to supplementation in non-anemic, non-pregnant, and non-lactating women in Rural Mexico.
- Trial name
- NCT00826657
- Testing
- Vitamin B12
- Where
- Mexico
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Vitamin B12 Deficiency, Folic Acid Deficiency
The Association Between Religious Origin and Age, and Vitamin B12 and Folic Acid Plasma Levels in Non Jewish Population in Western Galilee
Vitamin B12 deficiency is more widespread in the population than has been assumed so far. Since a deficiency in this vitamin can lead to irreversible neurological damage, early diagnosis is essential.
- Trial name
- NCT01297361
- Testing
- Blood Sample
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Vitamin B 12 Deficiency
A Comparison of Two Different Doses of Maternal B12 Supplementation in Improving Infant B12 Deficiency and Neurodevelopment
Supplementation with Iron and folate have been part of a worldwide strategy targeting anaemia and neural tube defects for many years. However, vitamin B12 deficiency has received much less attention.
- Trial name
- MATCOBIND (NCT04083560)
- Testing
- Vit B12
- Where
- 2 sites in India, Nepal
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Sitaram Bhartia Institute of Science and Research
Choline Deficiency, Vitamin B-12 Deficiency
Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador
The proposed study will fill an important gap in the literature by examining, through a randomized controlled trial, the effect of egg consumption on biochemical markers of choline, vitamin B-12, lipids, and amino acids in young…
- Conditions
- Choline Deficiency, Vitamin B-12 Deficiency, Lipids Deficiency, Amino Acids Deficiency
- Trial name
- NCT02446873
- Testing
- Egg supplementation
- Where
- Ecuador
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Macrocytic Anemia With Vitamin B12 Deficiency
Transdermal Iontophoresis of Vitamin B12 Under Three Different Skin Preparations
STUDY DESIGN: Phase I Clinical Trial The researchers set out to assess the effectiveness of transdermal iontophoretic administration of Vitamin B12 (V.B12) under three different skin preparatory conditions. SETTING: James J.
- Trial name
- NCT04027959
- Testing
- Vitamin B12
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Neural Tube Defects, Folic Acid Deficiency
Using Iodized Salt to Improve Serum Folate, B12 and Iron Levels
Question: How effective is fortified iodized salt in increasing serum concentrations of folate, B12 and iron among non-pregnant and non-lactating women of reproductive age? Hypothesis: Micronutrient fortified iodized salt can…
- Conditions
- Neural Tube Defects, Folic Acid Deficiency, Spina Bifida, Anencephaly-Spina Bifida
- Trial name
- NCT06904612
- Testing
- Micronutrient fortified iodized salt
- Where
- 2 sites in United States, India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hydrocephalus and Neuroscience Institute
Child Developmental Delay, Child Malnutrition
Maternal B12 Supplementation to Improve Infant B12 Deficiency and Neurodevelopment
Vitamin B12 plays a key role in the development and normal functioning of the brain and nervous system. Unborn and new-born infants derive their vitamin B12 stores almost entirely from maternal B12 stores.
- Conditions
- Child Developmental Delay, Child Malnutrition, Maternal Exposure, Vitamin B 12 Deficiency
- Trial name
- MATCOBIND (NCT03783104)
- Testing
- B12 Supplement
- Where
- 2 sites in India, Nepal
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- University College, London
Vitamin B 12 Deficiency
Vitamin B12 Dose Escalation Trial in Pregnancy
Vitamin B12 is a cofactor for 2 enzymes that have essential functions in pregnancy, both for maternal health and for fetal development.
- Trial name
- MM4MN-B12 (NCT05426395)
- Testing
- Vitamin B12 2.6 µg, Vitamin B12 10 µg, Vitamin B12 50 µg
- Where
- Tanzania
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- George Washington University
Vitamin B12 Deficiency
Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the Institutionalized Elderly
This study was designed to determine whether elderly residents of long term care facilitated who had been taking proton pump inhibitors (PPI) for more than 12 months were more likely to have vitamin B12 deficiency than residents…
- Trial name
- NCT00843453
- Testing
- blood collection, treatment (cyanocobalamin nasal spray)
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Anemia in Pregnancy, Pre-eclampsia
A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy
This study is a multi-site, retrospective chart review to determine the effect of Neevo® or NeevoDHA® (with higher folate and B12) versus standard prenatal vitamins on hemoglobin (Hgb) levels in pregnant women throughout the…
- Trial name
- NCT01193192
- Testing
- Neevo®, Prenatal vitamins
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pamlab, L.L.C.
Iron Deficiency, Vitamin A Deficiency
Nutritional Status and Bouillon Use in Northern Ghana
This pilot aims to generate data that are critical for informing the design of a planned, more detailed study to evaluate the effect of multiple micronutrient (MN)-fortified bouillon cube on biomarkers of nutrient status of women…
- Conditions
- Iron Deficiency, Vitamin A Deficiency, Vitamin B 12 Deficiency, Folate Deficiency
- Trial name
- NCT04632771
- Testing
- N/A (observational study)
- Where
- Ghana
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitamin B-12 Deficiency, Achlorhydria
Cobalamin Absorption From Fortified Food
To determine B12 bioavailability from 14C-B12 fortified bread in healthy subjects and in subjects with proton pump inhibitor induced achlorhydria.
- Trial name
- FL-72 (NCT01399164)
- Testing
- 14C-B12 fortified bread
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Vitamin B 12 Deficiency
Cobalamin Deficiency - Diagnosis and Therapy
In a retrospective study with existing values of vitamin B12 and holotranscobalamin 4 strategies are simulated and the results and costs are compared. Generally, cobalamin ist substituted by intramuscular administration.
- Trial name
- NCT04243707
- Where
- Switzerland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Vitamin d Deficiency, Vitamin B 12 Deficiency
ETOL-Elderly Study of the Efficiency of the Innovative Food Supplement in Elderly Adults
The aim of this pilot study is to conduct a study on geriatric population in Slovenia (non-users of dietary supplements/medicines with vitamine D, vitamin B12 and protein) and assess deficiency of selected nutrients, and to…
- Conditions
- Vitamin d Deficiency, Vitamin B 12 Deficiency, Protein Deficiency
- Trial name
- ETOL-Elderly (NCT05661006)
- Testing
- Use of food supplement
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Hypovitaminosis b 12
This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week
This randomized, clinical trial evaluates the efficacy of oral versus sublingual vitamin B12 supplementation in correcting early-onset vitamin B12 deficiency in adult patients using proton pump inhibitors (PPIs).
- Trial name
- NCT06966856
- Testing
- Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Tanta University
Organic Acidemia, Methylmalonic Acidemia
Clinical and Laboratory Study of Methylmalonic Acidemia
Methylmalonic acidemia (MMA), one of the most common inborn errors of organic acid metabolism, is heterogeneous in etiology and clinical manifestations.
- Conditions
- Organic Acidemia, Methylmalonic Acidemia, Inborn Errors of Metabolism
- Trial name
- NCT00078078
- Where
- 3 sites in United States
- Volunteers
- 2,275 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)