Clinical trials: Vitreous Disorder
Retinoblastoma, Retinoblastoma, Recurrent
High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed
Retinoblastoma is the most common intraocular malignancy in infancy and childhood,with an estimated 8000 new cases globally each year.The major cause of failure in the management of retinoblastoma remains the persistence or…
- Trial name
- NCT06972602
- Testing
- Topotecan, Collection of aqueous humor, Electroretinogram
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Posterior Vitreous Detachment, Vitreomacular Traction
Vitreopapillary Interface and Optic Disc Morphology
The vitreous fills the posterior chamber of the eye and is firmly attached, at the posterior pole, to the macula and the optic nerve head (ONH).
- Conditions
- Posterior Vitreous Detachment, Vitreomacular Traction, Glaucoma, Vitreopapillary Traction
- Trial name
- NCT02290795
- Testing
- OCT imaging/HRT imaging
- Where
- Belgium
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Vitreous Hemorrhage Secondary to PDR
Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Vitreous Hemorrhage
The purpose of this study is to determine the effect of pre and intra-operative bevacizumab injection on postoperative vitreous hemorrhage after diabetic vitrectomy in comparison to vitrectomy without bevacizumab injection.
- Trial name
- NCT01091896
- Testing
- Bevacizumab
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- University of Sao Paulo
Retinopathy of Prematurity
Vascular Endothelial Growth Factor in Stage V ROP
Vascular Endothelial Growth Factor (VEGF) is a dimeric glycoprotein, naturally expressed in epithelial and tumor cells (1). Normal Retinal vascularization has two phases: In the first fase, cells of mesenquimatous origin form the…
- Trial name
- NCT00500396
- Testing
- Open-Sky Vitrectomy
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Retinopathy, Vitreous Hemorrhage
Preoperative Bevacizumab for Vitreous Hemorrhage
The purpose of this study is to determine whether preoperative intravitreal bevacizumab is effective in reducing intra-operative and postoperative bleeding in diabetic patients submitted to pars plana vitrectomy for vitreous…
- Trial name
- IBEVI (NCT00596297)
- Testing
- bevacizumab, pars plana vitrectomy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Proliferative Diabetic Retinopathy
Changes in Vitreous Temperature During Phacoemulsification
Temperature in the vitreous cavity decreases during vitrectomy, and the same effect is seen during an uneventful phaco surgery. Significant changes occur between the baseline temperature and after every step of the surgery.
- Trial name
- NCT01568242
- Testing
- Phacoemlsification
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Myopia, Cataract
Influence of Posterior Vitreous Detachment on Retinal Detachment After Lens Surgery in Myopic Eyes
Phacoemulsification with implantation of posterior chamber lenses represents the gold standard of care for patients needing lens surgery, but there is an increased risk of developing pseudophakic retinal detachment after surgery.
- Conditions
- Myopia, Cataract, Pseudophakic Retinal Detachment, Refractive Lens Exchange
- Trial name
- MYOPRED (NCT03152747)
- Where
- Austria
- Volunteers
- 609 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Primary Angle-Closure Glaucoma
Vitreous Zonule in Primary Angle-Closure Glaucoma
This study aims to investigate the role of the vitreous zonule (VZ) in the pathogenesis of primary angle-closure glaucoma (PACG) and to explore the feasibility of three-dimensional ultrasound biomicroscopy (3D-UBM) for imaging…
- Trial name
- NCT07523139
- Where
- China
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Macular Disease, Rhegmatogenous Retinal Detachment
Combined Vitrectomy and Femtosecond Laser-assisted Cataract Surgery
Based on the progress of cataract surgery, intraocular lens development, vitreoretinal surgery and anesthesia technology in recent years, the purpose of this study is to develop a new type of more accurate and minimally invasive…
- Conditions
- Macular Disease, Rhegmatogenous Retinal Detachment, Epiretinal Membrane, Cataract
- Trial name
- NCT05588037
- Testing
- FLACS +PPV+IOL + air, FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex, FLACS + PPV+IOL + internal limiting membrane peeling + air
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Posterior Vitreous Detachment
Incidence of Complete Posterior Vitreous Detachment After Trabeculectomy.
Intraocular surgery could induce vitreous degeneration and posterior vitreous detachment (PVD). Vitreomacular interface (VMI) abnormalities usually are caused by abnormal PVD, vitreoschisis and partial-thickness PVD.
- Trial name
- NCT04726267
- Testing
- Wide-field optical coherence tomography
- Where
- Thailand
- Volunteers
- 46 people
- Sponsor
- Khon Kaen University
Posterior Vitreous Detachment, Myopic Vitreopathy
YAG Laser Vitreolysis for Vitreous Floaters
The purpose of this study is to measure how the quality of life, the structure of eye, and vision change after treatment for the opacities in the gel (vitreous) that fills the center of eye which cause vision disturbances…
- Conditions
- Posterior Vitreous Detachment, Myopic Vitreopathy, VISION DEGRADING MYODESOPSIA
- Trial name
- YLV Protocol (NCT06915922)
- Testing
- Neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser therapy
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VMR Consulting, Inc.
Diabetic Retinopathy, Glaucoma, Neovascular
Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma
To determine the efficacy of intravitreal ranibizumab injection as adjuvant therapy in the treatment of postvitrectomy diabetic vitreous hemorrhage (PDVH) accompanied by neovascular glaucoma (NVG) as a means of preventing…
- Trial name
- NCT02647515
- Testing
- ranibizumab
- Volunteers
- 18 people
- Sponsor
- Ruijin Hospital
Eye Disease, Inflammation
Cyclosporin Implant to Treat Uveitis
This study will evaluate the safety and effectiveness of a sustained-release cyclosporin implant to treat uveitis, a sight-threatening eye inflammation caused by an immune system abnormality.
- Conditions
- Eye Disease, Inflammation, Uveitis
- Trial name
- NCT00001737
- Testing
- Cyclosporin A Implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Eye Institute (NEI)
Cataract, Retina Detachment
Different Hemostasis According to the Anesthetic Agents
We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability…
- Conditions
- Cataract, Retina Detachment, Pterygium, Keratitis
- Trial name
- NCT02151305
- Testing
- Propofol, remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Bundang Hospital
Age Related Macular Degeneration
Identification of Molecular Signals in Vitreous Humor Associated With Suboptimal Response to Vascular Endothelial Growth Factor (VEGF) Inhibition in Neovascular Age-related Macular Degeneration (nAMD) Within a Clinical Trial Setting
Neovascular age-related macular degeneration (nAMD), also called wet AMD, can cause serious vision loss. While anti-VEGF (anti Vascular Endothelial Growth Factor) treatments such as ranibizumab help many patients, about 20 40%…
- Trial name
- M-VIVA (NCT07249216)
- Testing
- Faricimab, Ranibizumab
- Where
- Singapore
- Volunteers
- 117 people
- Sponsor
- Singapore National Eye Centre
Proliferative Diabetic Retinopathy
A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathy
The purpose of this study is to assess whether preoperative pegaptanib sodium safely improves vitreous hemorrhage prior to surgical intervention and to evaluate the stability of pre-existing tractional retinal detachment.
- Trial name
- No-Crunch01 (NCT01589718)
- Testing
- Macugen
- Where
- United States
- Sponsor
- Greater Houston Retina Research
Uveitis
Grading Scale of Vitreous Haze in Patients With Uveitis Using Ultrasonography
This study is aimed at creation and validation of a vitreous haze scoring system using ultrasonography B-scan of the eye. Images will be obtained from patients with uveitis and quantification of inflammation will be done to…
- Trial name
- NCT02311192
- Testing
- Ultrasonography B-scan
- Sponsor
- University of Nebraska
Vitreous Detachment, Cataract (Post-operative Cataract Surgery Follow-up)
Evaluation of Vitreous Modifications After Cataract Surgery
This study aims to evaluate changes in vitreous structure and the vitreoretinal interface following cataract surgery using spectral-domain optical coherence tomography (OCT).
- Trial name
- VitCat (NCT07816887)
- Testing
- cataract surgery
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University of Trieste
Persistent Fetal Vasculature, Congenital Cataract
Congenital Cataract With Persistent Fetal Vasculature
To observe the clinical characteristics and surgical treatment of 24 cases of congenital cataract complicated with Persistent Fetal Vasculature (PFV) in 28 cases of congenital cataract in our hospital.
- Trial name
- NCT03341624
- Testing
- cataract surgery cataract extraction and intraocular implantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Yune Zhao
Vitreous Disorder, Vitreous Anomalies
Vitreous Fragments Length After Pars Plana Vitrectomy
To measure vitreous collagen fragments length after pars plana vitrectomy performed at different cut rates
- Trial name
- NCT04570007
- Testing
- Pars Plana Vitrectomy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Ospedale Policlinico San Martino