Clinical trials: Volume Expansion
Hemodynamic, Fluid Responsiveness
Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion
Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes.
- Conditions
- Hemodynamic, Fluid Responsiveness, Venous Congestion, Fluid Challenge
- Trial name
- FREVO (NCT06772038)
- Where
- 3 sites in China, France
- Volunteers
- 64 people
- Sponsor
- Bicetre Hospital
Diabetes Mellitus, Type 2, Diastolic Dysfunction
PDD in Type 2 Diabetes w/wo Diastolic Dysfunction
This study will advance the investigator's knowledge of the integrated cardiorenal and humoral physiology in type 2 diabetic patients with and without pre-clinical diastolic dysfunction, and test a novel therapeutic strategy…
- Trial name
- NCT03744975
- Testing
- LCZ 696
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HEALTHY
Bioimpedance Spectroscopy in Humans During Acute Fluid Volume Expansion With Different Crystalloid Solutions
The objective of the study is to identify a pattern of bioimpedance in humans during acute food changes. As a part of this study the investigators will be administering sodium bromide in oder to measure extracellular water via…
- Trial name
- NCT01930578
- Testing
- Treatment with 0.9% normal saline, Treatment with D5+ 0.45 saline, Treatment with D5
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Blood Volume Expansion
Evaluation of the Venous Excess Ultrasound Score (VExUS) After Circulating Volume Modification in Children.
Venous overload has an impact on peripheral organ perfusion and on the short- and long-term prognosis of intensive care patients. The VExUS ultrasound score is a new tool whose parameters can be used to estimate this impact.
- Trial name
- VExUS-Mod (NCT06695546)
- Testing
- VExUS evaluation ultrasound
- Where
- France
- Volunteers
- 67 people
- Sponsor
- University Hospital, Toulouse
Root Resorption, Orthodontic Appliance
Three-dimensional CBCT Analysis of Root Volume Changes Following Tooth-bone and Bone-borne Maxillary Expansion: A Pilot Study.
External root resorption (ERR) is an undesired side effect observed after rapid maxillary expansion (RME). This study aimed to investigate changes in the root volume of maxillary permanent first molars after RME using tooth-borne…
- Conditions
- Root Resorption, Orthodontic Appliance, CBCT Segmentation
- Trial name
- NCT06912568
- Testing
- Miniscrew insertion, Expander, CBCT
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- University of Roma La Sapienza
Dehydration, Hydration
Oral Fluid Volume Expansion
When subjected to fluid loss or fluid deficiency irrespective of disease or environmental factors it is discussed how to rehydrate or how to hydrate prophylactic. In medical care it is common to give infusions.
- Trial name
- OFVEX (NCT01360333)
- Testing
- tap water, sodium chloride, carbohydrate rich fluid
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Contrast Media Induced Nephropathy (CIN)
Neutrophil Gelatinase-associated Lipocalin (NGAL) and Contrast Media Induced Nephropathy
Introduction: Patients with pre-existing impaired renal function are prone to develop acute contrast media induced nephropathy (CIN).
- Trial name
- NCT01292317
- Testing
- application of intravenous volume, oral fluid application
- Where
- Austria
- Volunteers
- 819 people
- Sponsor
- Medical University of Graz
Syncope
Exercise and Prevention of Syncope: EXPOSE
The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).
- Trial name
- NCT00203593
- Testing
- Exercise, Blood volume, VO2max test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Orthodontic Appliance Complication, Dental Malocclusion
Changes in the Upper Airway Volume After Rapid Maxillary Expansion in Adults Using Pure Skeletal Anchorage
The objective of this study is to evaluate the effect of bone-anchored rapid maxillary expansion (RME) in the volume of the right maxillary sinus, left maxillary sinus and nasal and maxillary sinus airway complex, through bone…
- Conditions
- Orthodontic Appliance Complication, Dental Malocclusion, Bone Anchored Rapid Maxillary Expansion, Maxillary Hypoplasia
- Trial name
- NCT05831722
- Testing
- Rapid Maxillary Expansion
- Where
- 3 sites in Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Blood Volume Expansion
Ability of Changes in End Tidal Carbon Dioxide to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Volume expansion is the cornerstone of perioperative hemodynamic optimization. The main objective of volume expansion is to increase and to maximize stroke volume.
- Trial name
- REVCO2 (NCT03635307)
- Testing
- End Tidal Carbon Dioxide measure
- Where
- France
- Volunteers
- 115 people
- Sponsor
- University Hospital, Bordeaux
Subarachnoid Hemorrhage
Intensive Management of Pressure and Volume Expansion in Patients With Subarachnoid Hemorrhage
The purpose of our study is to determine how well Triple-H works and how safe it is. The investigators are hoping to determine the effects of starting the therapy early and to explore if hypervolemia and/or hypertension are…
- Trial name
- IMPROVES (NCT01414894)
- Testing
- Fluid manipulation, Blood Pressure Manipulation
- Volunteers
- 20 people
- Sponsor
- University of Washington
Surgical Procedure, Unspecified
Lung Expansion Technics on Chest Wall Mechanics and Preventing Pulmonary Complication After Abdominal Surgery
The lung expansion techniques are widely used to prevent postoperative pulmonary complications. However, the effect of each technique on thoracoabdominal mechanics after abdominal surgery and if it influences the rate of…
- Trial name
- NCT01993602
- Testing
- Breathing exercises
- Where
- Brazil
- Volunteers
- 171 people
- Sponsor
- University of Sao Paulo General Hospital
Venous Congestion, Microcirculation
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
- Conditions
- Venous Congestion, Microcirculation, Volume Expansion
- Trial name
- MICRO-CONGEST (NCT07499401)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Sepsis, Severe
Early Administration of Norepinephrine in Sepsis
The management of septic states includes, in addition to the specific treatment (antimicrobials and eradication of the source), a restoration of the hemodynamic disorders and assistance of the failing organs.
- Trial name
- EA-NE-TUN (NCT05836272)
- Testing
- Norepinephrine Bitartrate
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Tunis University
Hemolytic-Uremic Syndrome
Shiga Toxin Producing Escherichia Coli (STEC) Volume Expansion
This study will provide feasibility data regarding the conduct of a clinical trail evaluating the use of early aggressive inpatient intravenous rehydration in children with Shiga Toxin producing E. coli infection.
- Trial name
- NCT03275792
- Testing
- D5-0.9%NS, Routine home oral rehydration
- Where
- Canada
- Sponsor
- University of Calgary
Systemic Inflammatory Response Syndrome, Circulatory Failure
Accuracy of Pulse Pressure Variations Measured by a Non Invasive Digital Device to Predict Fluid Responsiveness
It has been well established that only 40 to 60% of the patients hospitalized for inflammatory response syndrome (SIRS) positively respond to volume expansion (VE).
- Conditions
- Systemic Inflammatory Response Syndrome, Circulatory Failure, Mechanical Ventilation
- Trial name
- NCT03066388
- Testing
- Pulse pressure variations
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Non-metastatic Nasopharyngeal Carcinoma
Individualized Primary Clinical Target Volume Based on Margin Expansion for Nasopharyngeal Carcinoma
This is a non-inferiority, multicenter, randomized phase 3 trial aimed to evaluate whether primary clinical target volume (CTVp) delineation based on margin expansion provides comparable outcomes compared with the consensus CTVp…
- Trial name
- CTV-MARGIN-NPC (NCT07661771)
- Testing
- Comprehensive Therapy Based on Tumor Stage, IMRT with Primary Clinical Target Volume Based on Margin Expansion, IMRT with Consensus Primary Clinical Target Volume
- Where
- 7 sites in China
- Volunteers
- 568 people
- Sponsor
- Sun Yat-sen University
Congestive Heart Failure
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure
This study is being done to determine the effects of subcutaneous (under the skin) injection of human B-type natriuretic factor (BNP), Natrecor (nesiritide), a hormone produced by the heart, in combination with Tadalafil on: The…
- Trial name
- NCT01544998
- Testing
- Nesiritide, Tadalafil, Saline load
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Hypertension, Portal, Ascites
Comparing Ascites Relief In Two Standard Treatments: Large Volume Paracentesis Vs. Early Tips Using Viatorr Controlled Expansion Stents
For this study, the investigators will be collecting data based on patients' random selection to two different approved standard of care treatments for ascites: Subjects will get randomized into either Group A: Large Volume…
- Trial name
- NCT04315571
- Testing
- Gore® Viatorr® Endoprosthesis with controlled expansion, Large Volume Paracentesis with albumin infusion
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of California, Los Angeles
Continuous Hemoglobin Measurement
The Accuracy of Noninvasive and Continuous Hemoglobin Measurement by Pulse CO-Oximetry™ in Children Undergoing Volume Expansion
Measuring total hemoglobin(tHb) is a precious step to decide to start or to stop transfusion during operation. The newly developed instrument pulse CO-Cooximetry (Masimo) makes noninvasive monitoring of venous hemoglobin level…
- Trial name
- NCT01364116
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital