Clinical trials: Volume Expansion
Atrophy of Breast
Efficacy and Safety Study of EVERA to Augment Small Breast
Expected Total Number of Subjects Level of significance, alfa 0.05 Power 0.80 Mean difference between two treatments is assumed 35 Standard Deviation is assumed 35. Follow-up loss is assumed 20% N=34(each group:17)
- Trial name
- NCT02009137
- Testing
- EVERA, ESTES
- Where
- South Korea
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Septic Shock
CO2 Gap Changes in Septic Shock in Relation to Cardiac Output
Background The arteriovenous difference of partial pressure of carbon dioxide (PCO2) between mixed or central venous blood and arterial blood is the ∆PCO2 or CO2 gap.
- Trial name
- NCT05578534
- Where
- Egypt
- Volunteers
- 76 people
- Sponsor
- Cairo University
Hemolytic-Uremic Syndrome
Shiga Toxin Producing Escherichia Coli (STEC) Volume Expansion
This study will provide feasibility data regarding the conduct of a clinical trail evaluating the use of early aggressive inpatient intravenous rehydration in children with Shiga Toxin producing E. coli infection.
- Trial name
- NCT03275792
- Testing
- D5-0.9%NS, Routine home oral rehydration
- Where
- Canada
- Sponsor
- University of Calgary
Venous Congestion, Microcirculation
Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study
The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion
- Conditions
- Venous Congestion, Microcirculation, Volume Expansion
- Trial name
- MICRO-CONGEST (NCT07499401)
- Testing
- fluid challenge
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università Politecnica delle Marche
Congestive Heart Failure
Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure
This study is being done to determine the effects of subcutaneous (under the skin) injection of human B-type natriuretic factor (BNP), Natrecor (nesiritide), a hormone produced by the heart, in combination with Tadalafil on: The…
- Trial name
- NCT01544998
- Testing
- Nesiritide, Tadalafil, Saline load
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Mayo Clinic
Premature Baby 26 to 32 Weeks, Premature Baby 33 to 36 Weeks
Fluid Responsiveness Evaluation by a Non-invasive Method in Children, Extended to PREterm Infants - FRENCH-PREMA
In this study, the investigators aim to validate a non-invasive marker of fluid-responsiveness in preterm infants (term below 37 gestational week) with acute circulatory failure based on standardized abdominal compression.
- Trial name
- FRENCH-PREMA (NCT06287710)
- Testing
- Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Hypovolemia, Hypotension
Dynamic Parameters in Evaluation of Fluid Responsiveness
Intravenous infusion of fluids in patients after surgery is a very important part of treatment. However, administering too much or too little fluid can lengthen the stay in the intensive care unit or even harm the patient.
- Conditions
- Hypovolemia, Hypotension, Surgery
- Trial name
- NCT04283851
- Testing
- testing functional haemodynamic parameters for preload assessment
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Anesthesia Morbidity
Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients
In this study we try to review the possible effects when using modern hydroxyethylstarch solutions 6 % versus albumin 5% during living donor renal transplantation.
- Trial name
- NCT03306914
- Testing
- Albumin resuscitation, Hydroxyethylstarch resuscitation, Albumin 5%
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
Non-metastatic Nasopharyngeal Carcinoma
Individualized Primary Clinical Target Volume Based on Margin Expansion for Nasopharyngeal Carcinoma
This is a non-inferiority, multicenter, randomized phase 3 trial aimed to evaluate whether primary clinical target volume (CTVp) delineation based on margin expansion provides comparable outcomes compared with the consensus CTVp…
- Trial name
- CTV-MARGIN-NPC (NCT07661771)
- Testing
- Comprehensive Therapy Based on Tumor Stage, IMRT with Primary Clinical Target Volume Based on Margin Expansion, IMRT with Consensus Primary Clinical Target Volume
- Where
- 7 sites in China
- Volunteers
- 568 people
- Sponsor
- Sun Yat-sen University
Airway Obstruction
Maxillary Expansion Effects in Children With Upper Airway Obstruction
The most frequent causes of mouth breathers are the adenotonsillar hypertrophy. Adenotonsillectomy is the main choice for the elimination of the obstruction.
- Trial name
- NCT03004300
- Testing
- Rapid maxillary expansion, Adenotonsillectomy
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Syncope
Exercise and Prevention of Syncope: EXPOSE
The purpose of this study is to determine whether eight weeks of exercise performed at an intensity of approximately 65% VO2max will improve symptoms associated with fainting (vasovagal syncope).
- Trial name
- NCT00203593
- Testing
- Exercise, Blood volume, VO2max test
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Aortic Stenosis
Regression of Myocardial Fibrosis After Aortic Valve Replacement
Aortic stenosis (AS) is the most common valvular heart condition in the United Kingdom and the Western world. Surgery for severe AS prior to symptom onset is controversial.
- Trial name
- RELIEF-AS (NCT02174471)
- Where
- United Kingdom
- Volunteers
- 181 people
- Sponsor
- University College, London
Blood Loss, Surgical, Fluid Retention
Comparison Between Hyperoncotic and Isooncotic Albumin to Support Blood Loss Replacement
Fluid intravascular replacement is usually performed with either balanced crystalloids or iso-oncotic colloids, (synthetic colloids, plasma and 5% albumin).
- Trial name
- VASCALB (NCT05391607)
- Testing
- Hyperoncotic Albumin 20%, Isooncotic Albumin 5%, Ringer's Lactate Crystalloid Solutions (control group)
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
X-ray Contrast Media Adverse Reaction
Bioimpedance Analysis Guided Volume Expansion for the Prevention of Contrast Induced-acute Kidney Injury
Bioelectrical impedance analysis guided volume expansion for the prevention of contrast induced-acute kidney injury
- Trial name
- BELIEVE (NCT02449317)
- Testing
- Bioimpedance guided, standard hydration
- Volunteers
- 56 people
- Sponsor
- Mahidol University
Hypotension, Shock
Fluid Responsiveness Prediction at the Bedside
The purpose of this study is to verify the accuracy and applicability of predictors of fluid administration efficacy in hypotensive critically ill patients.
- Trial name
- NCT00721604
- Testing
- fluid administration
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Circulatory Failure (Shock)
Fluid Responsiveness Evaluation by a Non-invasive Method in CHildren
In this study, the investigators aim to validate a non-invasive marker of fluid-responsiveness in children with acute circulatory failure based on standardized abdominal compression.
- Trial name
- FRENCH (NCT05919719)
- Testing
- Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
Systemic Inflammatory Response Syndrome, Circulatory Failure
Accuracy of Pulse Pressure Variations Measured by a Non Invasive Digital Device to Predict Fluid Responsiveness
It has been well established that only 40 to 60% of the patients hospitalized for inflammatory response syndrome (SIRS) positively respond to volume expansion (VE).
- Conditions
- Systemic Inflammatory Response Syndrome, Circulatory Failure, Mechanical Ventilation
- Trial name
- NCT03066388
- Testing
- Pulse pressure variations
- Where
- France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Lille
Septic Shock
Effects of Norepinephrine and Volume Expansion in Capillary Refill Time in Septic Shock in Angers University Hospital
the purpose of this study is to assess the effect of norepinephrine and fluid expansion on capillary refill time during septic shock.
- Trial name
- NOVECAR-A (NCT05325957)
- Where
- France
- Sponsor
- University Hospital, Angers
Cardiomyopathy, Renal Impairment
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)
To determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects…
- Trial name
- Aim2 (NCT01970176)
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
HEALTHY
Bioimpedance Spectroscopy in Humans During Acute Fluid Volume Expansion With Different Crystalloid Solutions
The objective of the study is to identify a pattern of bioimpedance in humans during acute food changes. As a part of this study the investigators will be administering sodium bromide in oder to measure extracellular water via…
- Trial name
- NCT01930578
- Testing
- Treatment with 0.9% normal saline, Treatment with D5+ 0.45 saline, Treatment with D5
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children