Clinical trials: Volume Overload
Respiratory Insufficiency
Preventive Versus Curative Treatment of Fluid Overload
Fluid overload is associated with a poor prognosis in critically ill patients, especially during weaning from mechanical ventilation as it may promote weaning induced pulmonary edema.
- Trial name
- PCT-Fluid (NCT04050007)
- Testing
- Preventive initiation of fluid removal, Curative initiation of fluid removal
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury, Fluid Overload
Neutral Versus Liberal fLuId In Traumatic Brain Injury: a Randomised Controlled Trial
Feasibility and safety of targeting neutral vs liberal fluid balance in traumatic brain injured patients: a phase II randomized controlled trial
- Conditions
- Traumatic Brain Injury, Fluid Overload, Outcome, Fatal
- Trial name
- LIMIT (NCT05983549)
- Testing
- fluid balance
- Volunteers
- 80 people
- Sponsor
- Universita degli Studi di Genova
Respiratory Insufficiency
Description of Fluid Balance in Patients With Acute Respiratory Failure
The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a…
- Trial name
- NCT02523872
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Smiths Medical, ASD, Inc.
Water-Electrolyte Imbalance, Intensive Care Units
Fluid Overload and Pulmonary Function
Esophageal atresia is a rare but severe malformation, and it requires early surgery. Coloesophagoplasty is surgical repair of the esophageal with an isoperistaltic transverse colon graft.
- Conditions
- Water-Electrolyte Imbalance, Intensive Care Units, Pediatric, Critical Illness
- Trial name
- NCT05129930
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Pirogov Russian National Research Medical University
Fluid Overload Without Edema
Fluid Administered According to PVI Versus Fluid Management in Laparoscopic Trendelenburg Surgeries
Investigating the ideal fluid management in Trendelenburg positions during lower abdominal laparoscopic surgeries in gynecological oncology and surgical oncology patients
- Trial name
- NCT06633510
- Testing
- massimo group, standart group
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Hemolytic Anemia, Thalassemia
Native T1 Mapping and ECV in Chronic Hemolytic Anemia
This cross-sectional study aims to evaluate the diagnostic performance of native T1 mapping and extracellular volume fraction for the detection of myocardial iron overload and fibrosis in patients with chronic hemolytic anemia…
- Conditions
- Hemolytic Anemia, Thalassemia, Iron Overload
- Trial name
- NCT07882303
- Volunteers
- 54 people
- Sponsor
- Assiut University
Septic Shock
Septic Shock Management Guided by Ultrasound: SEPTICUS Trial
This clinical study aims to compare the recent septic shock management protocol from American College of Critical Care Medicine (ACCM) to Ultrasound-guided Septic Shock Management (USSM) protocol.
- Trial name
- NCT04728529
- Testing
- USSM protocol, ACCM protocol
- Where
- Indonesia
- Volunteers
- 340 people
- Sponsor
- Saptadi Yuliarto
Weaning Failure, Fluid Overload
Fluid unLoading On Weaning (FLOW)
The purpose of this study is to determine if testing preload responsiveness, the normal physiologic state that means that changes in preload determine changes in cardiac output, allows an earlier and physiologically safer weaning…
- Conditions
- Weaning Failure, Fluid Overload, Cardiac Failure Acute
- Trial name
- FLOW (NCT04496583)
- Testing
- Fluid depletion strategy
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Fluid Overload, Mechanical Ventilation
Tidal Volume Challenge to Assess Volume Responsiveness
The purpose of this study is to investigate the ability of changes in PPV and SVV after Tidal Volume Challenge to predict fluid responsiveness in patients undergoing general anesthesia with protective mechanical ventilation.
- Trial name
- NCT05254951
- Testing
- Tidal Volume Challenge
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Attikon Hospital
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
End-Stage Renal Disease, Hemodialysis
Hemocontrol and Blood Pressure Control in Dialysis Patients
Volume overload contributes significantly to the pathogenesis of hypertension in hemodialysis patients. The Hemocontrol(HC)system (Gambro), which automatically adjusts ultrafiltration rate and dialysate conductivity according to…
- Trial name
- NCT00319774
- Testing
- Hemocontrol Biofeedback System
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Water Balance Disorders, Dehydration
The Jugular Vein Ultrasonography for Hydration Assessment in Healthy Participants
The aim of this cross-sectional, descriptive analysis is to compare 3 different ultrasound-based protocols to measure the internal jugular vein pressure (uJVP) in healthy individuals.
- Conditions
- Water Balance Disorders, Dehydration, Hypervolemia
- Trial name
- NCT06706960
- Testing
- measurement of IJV-height
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Shock
Consistency of Fluid Tolerance Evaluation Methods and Their Correlation With Clinical Outcomes in Patients With Shock
This study aims to explore the feasibility and scientific validity of carotid-jugular Doppler in evaluating volume tolerance in shock patients (with the VExUS score as an important reference standard), and to conduct an in-depth…
- Trial name
- NCT07373717
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Southeast University, China
Fluid Overload, Congestion
Determinants of Portal Vein Pulsatility Index
The pulsatile pattern of the portal vein is considered a marker of right ventricular dysfunction, but volemia may also contribute to this phenomenon.
- Trial name
- NCT06582368
- Where
- Romania
- Volunteers
- 60 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Hemodialysis Complication, Fluid Overload
Dialysate Sodium Lowering Trial
This is a pilot randomized clinical trial in which patients treated with 3X per weekly conventional hemodialysis will be treated to a dialysate sodium 135 mEq/L vs.
- Conditions
- Hemodialysis Complication, Fluid Overload, Dialysis Disequilibrium, Intra-dialytic Hypotension
- Trial name
- DeSaLT (NCT03144817)
- Testing
- Dialysate Sodium Lowering
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Tufts Medical Center
Heart Failure
Cardiovascular and Neurohormonal Effects of Faster Atrial Pacing Rate
Many patients with heart failure are unable to increase their heart rate appropriately when their body needs increased blood flow. As a result, they may be unable to mobilize excess fluid that their body retains.
- Trial name
- NCT00698139
- Testing
- Medtronic Pacemaker
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Columbia University
Heart Failure, Congestive Heart Failure
PROSPECT: Predictors of Response to Cardiac Re-Synchronization Therapy
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Conditions
- Heart Failure, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00253357
- Where
- 28 sites in United States, Austria and 11 more
- Volunteers
- 450 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Respiratory Infection, Fluid Overload
Fluid Restriction Keeps Children Dry
Rationale: Fluid overload is a common complication in children who are admitted to the pediatric intensive care for mechanical ventilation.
- Conditions
- Respiratory Infection, Fluid Overload, Critical Illness, Respiratory Insufficiency
- Trial name
- LESSER (NCT02989051)
- Testing
- Restrictive fluid regimen, Liberal fluid regimen
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
End Stage Renal Disease (ESRD), Volume Overload
Blood Volume Monitoring Via Critline in Volume Overload: Hospitalization and Readmission
The investigators are examining how adding relative blood volume monitoring (RBVM) to the best clinical practice affects outcomes (length of stay and rehospitalization) among dialysis patients hospitalized for or with volume…
- Trial name
- NCT07866872
- Testing
- Relative Blood Volume Monitoring (RBVM)
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Hypervolemia, Cardiogenic Shock
Capital Offload-Shock
CAPITAL OFFLOAD-SHOCK will aim to answer if early use of renal replacement therapy, like dialysis, in patients with reduced body fluids causing the heart to be unable to pump enough blood through the body reduces in-hospital…
- Conditions
- Hypervolemia, Cardiogenic Shock, Renal Replacement Therapies
- Trial name
- OFFLOAD-SHOCK (NCT07756801)
- Testing
- Immediate renal replacement therapy
- Where
- Canada
- Volunteers
- 456 people
- Sponsor
- Ottawa Heart Institute Research Corporation