Clinical trials: Volume Overload, active
Heart Failure, Heart Failure (for Example, Fluid Overload)
Molecular Underpinnings of Heart Failure, Integrative Multi-Omics, and Non-Coding RNA Profiling
The main objective of the study is to achieve a comprehensive phenotyping of patients with heart failure, combining detailed clinical characterization with in-depth molecular profiling.
- Trial name
- BIOCARDIUM-HF (NCT07158086)
- Where
- Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Zurich
Critical Illness, Fluid Over-load
Effect of Dynamic Arterial Elastance and Assisted Fluid Management Software Guided Resuscitation in Septic Shock: Pilot Study
To investigate the benefit of using the AFM and Eadyn-guided fluid and vasopressor therapy in septic shock resuscitation for mechanically ventilated patients compared with the standard of care.
- Conditions
- Critical Illness, Fluid Over-load, Dynamic Arterial Elastance, Septic Shock
- Trial name
- DAFM shock (NCT06937918)
- Testing
- The AFM and Eadyn - guided resuscitation group, The standard care for septic shock
- Where
- 3 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD)
Euvolemia-Based Assessment of Pulmonary Hypertension in Stable Hemodialysis Patients
Pulmonary hypertension (PH) is a frequent and clinically significant complication in patients with end-stage kidney disease (ESKD) undergoing maintenance hemodialysis (HD).
- Conditions
- Pulmonary Hypertension (PH), End Stage Kidney Disease (ESRD), Hemodialysis Patients, Volume Overload
- Trial name
- EU-PHASE-HD (NCT07676786)
- Testing
- Observational Assessment
- Where
- 2 sites in Romania
- Volunteers
- 30 people
- Sponsor
- Stefan Lujinschi
Weakness Acquired in the ICU, Muscle Wasting
Muscle and Subcutaneous Tissue Variation by Ultrasound and Impedance Linked to Fluid Balance in ICU Patients
This cross-sectional study aims to investigate the relationship between variations in muscle thickness and subcutaneous tissue, measured by ultrasound, and fluid compartments, evaluated using bioelectrical impedance analysis…
- Conditions
- Weakness Acquired in the ICU, Muscle Wasting, Edema, Fluid Overload
- Trial name
- NCT06697470
- Testing
- Ultrasound and Bioelectrical Impedance Analysis for Muscle Thickness and Fluid Balance Assessment Translation
- Where
- 2 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Dr F Duprez
Trauma (Including Fractures), Trauma Patients
Renal and Hepatic Abnormal Doppler Patterns in Trauma
The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.
- Conditions
- Trauma (Including Fractures), Trauma Patients, Kidney Disease, Hypovolemia
- Trial name
- RECREANT (NCT07492511)
- Testing
- Point of care ultrasound
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- Azienda Usl di Bologna
Lung Ultrasound Score, Transurethral Resection (TUR) Syndrome
Lung Ultrasound Versus Inferior Vena Cava Collapsibility Index for Early Prediction of Volume Overload During Transurethral Resection of Prostate
The aim of this study is to compare between accuracy of lung US and IVC CI for early prediction of volume overload during TURP. Primary outcome: The incidence of volume overload during transurethral resection of prostate.
- Conditions
- Lung Ultrasound Score, Transurethral Resection (TUR) Syndrome, Prostate
- Trial name
- NCT07164638
- Testing
- lung ultrasound (LUS), IVC collapsibility index
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Kidney Disease, Peritoneal Dialysis (PD)
Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)
To explore the use of the Bodyport Cardiac Scale in predicting worsening of events due to fluid overload in patients with kidney disease on peritoneal dialysis.
- Conditions
- Kidney Disease, Peritoneal Dialysis (PD), End Stage Kidney Disease (ESRD)
- Trial name
- SCALE-PD (NCT07059962)
- Testing
- Bodyport Cardiac Scale
- Where
- 7 sites in United States, Canada
- Volunteers
- 125 people
- Sponsor
- Bodyport Inc.
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
End Stage Chronic Renal Failure, Congestive Heart Failure (CHF)
The FILTRATE Trial: High-Rate Ultrafiltration for Intravascular Congestion
The purpose of this study is to evaluate whether a personalized, high-rate fluid removal strategy guided by ultrasound is as safe and effective as the standard fluid removal rate for patients with advanced kidney disease who are…
- Conditions
- End Stage Chronic Renal Failure, Congestive Heart Failure (CHF), Intravascular Congestion, Fluid Overload
- Trial name
- FILTRATE (NCT07705269)
- Testing
- High-rate ultrafiltration, Standard fluid removal
- Where
- Mexico
- Volunteers
- 70 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Kidney Transplantation, Delayed Graft Function
Bioimpedance and Multiparametric Ultrasound-Guided Fluid Management After Kidney Transplantation
After a kidney transplant, the amount of fluid in the body must be carefully balanced. Too much fluid can accumulate in the lungs, the tissues and the new kidney itself and may delay its recovery; too little fluid can also damage…
- Conditions
- Kidney Transplantation, Delayed Graft Function, Fluid Overload
- Trial name
- VLMM-MC (NCT07905963)
- Testing
- Multiparametric assessment, Structured usual care
- Volunteers
- 650 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Urine Output Decreased
"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"
This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload.
- Trial name
- FANTASTIC (NCT07417969)
- Testing
- Furosemide plus albumin, Furosemide (Diuretic)
- Where
- Mexico
- Volunteers
- 56 people
- Sponsor
- Jose J Zaragoza, MD MSc
Cirrhosis, Liver
Transitional Care Program for Fluid Overload in Cirrhosis
The goal of this clinical trial is to learn about an intensive monitoring plan (transitional care program) in patients with cirrhosis and excessive swelling that are going to be discharged from the hospital.
- Trial name
- NCT06174272
- Testing
- Transitional Care Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Milton S. Hershey Medical Center
Shiga Toxin-Producing Escherichia Coli (E. Coli) Infection, Hemolytic-Uremic Syndrome
Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection
The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E.
- Trial name
- HIKO-STEC (NCT05219110)
- Testing
- Infusion of 200% maintenance fluids as balanced crystalloid IV solution, Oral fluids; infusion of up to 110% maintenance fluids as balanced crystalloid IV solution
- Where
- 26 sites in United States, Canada
- Volunteers
- 1,040 people
- Sponsor
- University of Calgary
Hydration Status, Macular Thickness
Hydration Status and Ocular Parameters Study
This study will examine how hydration status (drinking a large amount of water or avoiding water for a short period of time) affects the eye.
- Conditions
- Hydration Status, Macular Thickness, Ocular Biometry
- Trial name
- HYDRI-EYE (NCT07177131)
- Testing
- Relative Dehydration Protocol, Hyperhydration Protocol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ante Kreso
Fluid Overload
Controlled Fluid Removal in Critical Ill Patients With Fluid Overload in the Intensive Care Unit.
This study evaluates the benefits and harms of goal directed fluid removal with furosemide versus placebo in critical ill adult patients with fluid overload in the intensive care unit.
- Trial name
- GODIF (NCT04180397)
- Testing
- Furosemide, Isotonic saline
- Where
- 29 sites in Australia, Czechia and 7 more
- Volunteers
- 1,000 people
- Sponsor
- Morten H. Bestle
Chronic Heart Failure, CKD Stage 3
Reducing Fluid Overload in Heart Failure Patients Using a Non-invasive, Renal Independent System
The REFORM-HF study aims to test a new technology, AQUAPASS, designed to assist patients experiencing symptoms of fluid overload due to Heart Failure.
- Trial name
- REFORM-HF (NCT06360380)
- Testing
- AquaPass System
- Where
- 10 sites in United States, Israel
- Volunteers
- 40 people
- Sponsor
- AquaPass Medical Ltd.
Heart Failure, Obstructive Sleep Apnea (OSA)
The Impact of Volume Overload on Obstructive Sleep Apnea in Patients With Congestive Heart Failure
The goal of this observational study is to learn how removing extra fluid from the body (diuresis) affects sleep apnea in adults hospitalized with heart failure.
- Trial name
- NCT07601724
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Itshak Amsalem
Acute Kidney Injury, Uremia
Timing of Renal Replacement Therapy in the Critically Ill Patients
Background: Severe acute kidney injury (AKI) among critically ill patients is sometimes treated with renal replacement therapy (RRT), and in Sweden continuous RRT (CRRT) is the dominant modality used in this population.
- Conditions
- Acute Kidney Injury, Uremia, Fluid Overload, Dialysis; Complications
- Trial name
- TORRT (NCT03629977)
- Testing
- CRRT
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska University Hospital
Ovarian Cancer, Hemodynamic Instability
Proactive Hemodynamic Management During Cytoreductive Surgery and HIPEC
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a complex surgical procedure carried out through laparotomic approach.
- Conditions
- Ovarian Cancer, Hemodynamic Instability, Fluid Overload
- Trial name
- HEMOPEC (NCT07070973)
- Testing
- Assisted Fluid Management, Goal Directed Fluid Therapy (GDT)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Fluid Accumulation, Blood Pressure Management
Dry Weight Reduction Intervention Via Extra Ultrafiltration
Most patients who receive hemodialysis treatments have excess fluid in their body that has slowly built up over the course of kidney disease.
- Conditions
- Fluid Accumulation, Blood Pressure Management, End Stage Renal Disease (ESRD)
- Trial name
- DRIVE-UF (NCT07637110)
- Testing
- Ultrafiltration
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington