Clinical trials: Vulnerability to Disease
Mild Cognitive Impairment, Alzheimer Disease
Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease
The goal of this clinical trial is to learn about how genetics and the response to stress predicts cognitive decline in individuals with mild cognitive impairment.
- Trial name
- Stress-AD (NCT05795634)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Johns Hopkins University
Incurable Disease
Impact of an Early Palliative Approach
In 2003, MAHO study (Ferrand E, Jabre P, Vincent-Genod C, et al. Circumstances of death in hospitalized patients and nurses' perceptions: French multicenter Mort-a-l'Hôpital survey. Arch Intern Med.
- Trial name
- MAHO2 (NCT02906462)
- Testing
- Early consideration of vulnerability, Usual practices
- Where
- 23 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Hopital Foch
Metastatic Breast Cancer, Positive Hormonal Receptors
Quality of Life and Psychological Vulnerability in Patients With RH+ Metastatic Breast Cancer
Metastatic breast cancer (MBC) is a dark prognostic disease with survival at 5 years of less than 20% and a median survival of 24 to 30 months after diagnosis of metastasis.
- Trial name
- EPOCA (NCT03636776)
- Testing
- Quality of life in metastatic BC
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut Cancerologie de l'Ouest
Aging, Heat Stress
Establishing Evidence-based Indoor Temperature Thresholds to Protect Health
An individual's ability to adequately cope with short- or long-term increases in ambient temperature is critical for maintaining health and wellbeing.
- Conditions
- Aging, Heat Stress, Physiological Stress
- Trial name
- HW2 (NCT04348630)
- Testing
- Simulated heatwave exposure
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Acute Myocardial Infarction (AMI)
Very Early PCSK9 Inhibition for Acute Myocardial Infarction
Acute myocardial infarction (AMI) remains a major cause of morbidity and mortality, particularly in patients with multivessel coronary artery disease.
- Trial name
- NCT07208006
- Testing
- Standard Lipid-Lowering Therapy, Early Intensive Lipid-Lowering Therapy (PCSK9 Inhibitor)
- Where
- China
- Volunteers
- 1,518 people
- Sponsor
- Shanghai Zhongshan Hospital
Postoperative Delirium
EEG Spectrogram, Brain Vulnerability and POD
An assessment of difference in prespecified processed electroencephalography variables between cognitively intact older surgical patients who develop postoperative delirium compared to those who do not develop postoperative…
- Trial name
- NCT05368272
- Testing
- Processed electroencephalography, Postoperative delirium assessment
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Chronic Disease
Impact of a Therapeutic Education Program on the Acceptance of Disease and Management of Care
Through its patient-centered approach and focus on developing coping skills and coping strategies, Health Education could be an effective approach in therapeutic coordination apartments to reduce the perceived treatment burden…
- Trial name
- EDUPACT (NCT03361761)
- Testing
- Health education program
- Where
- 6 sites in France
- Volunteers
- 66 people
- Sponsor
- Nantes University Hospital
Type2 Diabetes, Atherosclerosis
Coronary Artery Plaque Burden and Morphology in Type 2 Diabetes Mellitus.
Unstable plaque, the primary cause of myocardial infarction, is characterized by distinct a morphology including positive remodeling (PR), low attenuated plaque (LAP), napkin ring sign (NRS), and spotty calcifications (SC) The…
- Conditions
- Type2 Diabetes, Atherosclerosis, Plaque, Atherosclerotic, Plaque Vulnerability
- Trial name
- CARPEDIEM (NCT03016910)
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Svendborg Hospital
Pelvic Fracture, Prostate Cancer
A COhort Study on Factors Leading to Vulnerability in Adult Patients With Serious Medical cOnditionS: the COSMOS-I Trial
The objective of this prospective multicentre study that recruits altogether 1500 older patients from the university hospitals of Tampere, Kuopio, and Oulu is to explore the clinical significance and detection of causes of…
- Conditions
- Pelvic Fracture, Prostate Cancer, Lung Cancer, Brain Metastasis
- Trial name
- COSMOS-I (NCT07740239)
- Testing
- Test set to determine vulnerability
- Where
- Finland
- Volunteers
- 2,050 people
- Sponsor
- Tampere University Hospital
Atherosclerosis, Carotid Artery Plaque
New Technologies to Determine Carotid Plaque Vulnerability
Hypothesis: Identification of vulnerable atherosclerotic plaques (with or without neovascularization) using carotid CEUS is an independent predictor of MACE (over clinical risk factors, stress echo wall motion results, and…
- Trial name
- CEUS (NCT02224339)
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- Mayo Clinic
Alcoholism
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence"…
- Trial name
- NCT00611767
- Testing
- Thiopental
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Yale University
Neuropathic Pain, Cancer
Vulnerability and Risk of Neuropathic Pain in Cancer
Successive and repeated therapeutic interventions during cancer management - surgery, chemotherapy, radiotherapy - can all, to varying degrees, generate acute pain, central pain sensitization and chronic pain.
- Conditions
- Neuropathic Pain, Cancer, Predictive
- Trial name
- CANOPY (NCT06511674)
- Testing
- Cognitive-emotional and pain assessments
- Where
- 19 sites in France
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Substance Abuse
The Genetic Basis for Vulnerability to Substance Abuse
This investigation seeks to better define the genetic basis for vulnerability to substance abuse.
- Trial name
- NCT00247819
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Borderline Personality Disorder
Transcutaneous Vagus Nerve Stimulation (tVNS) for Borderline Personality Disorder (tVNS-BPD)
The goal of this clinical trial is to test the efficacy of transcutaneous vagus nerve stimulation (tVNS) in borderline personality disorder.
- Trial name
- tVNS-BPD (NCT05892900)
- Testing
- Transcutaneous vagus nerve stimulation (tVNS)
- Where
- Sweden
- Volunteers
- 42 people
- Sponsor
- Sahlgrenska University Hospital
Alzheimer Disease
Illiteracy and Vulnerability to Alzheimer's Disease: Evaluation of Amyloid Pathology by PET Imaging
The goal of this study is to improve the diagnosis of Alzheimer's disease (AD) at two different stages (MCI and dementia) in illiterate subjects, using FDG- fluorodeoxyglucose - and florbetapir F 18 -PET imaging.
- Trial name
- AVILL (NCT02494531)
- Testing
- Fluorodeoxyglucose-PET, florbetapir F 18-PET
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Panic Disorder
Evaluating the Effects of Stress in Pregnancy
This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy.
- Conditions
- Depression, Panic Disorder, Generalized Anxiety Disorder, Post-Traumatic Stress Disorder
- Trial name
- NCT00525226
- Where
- United States
- Volunteers
- 1,431 people, healthy volunteers welcome
- Sponsor
- Emory University
Depression, Economic Vulnerability
ASHA Bangladesh--An Integrated Intervention to Address Poverty and Depression
The goal of this randomized controlled trial is to compare the impact of an integrated intervention combining poverty alleviation and depression treatment to depression treatment alone, in low income rural Bangladeshi women with…
- Conditions
- Depression, Economic Vulnerability, Anxiety, Culture Specific Symptoms
- Trial name
- NCT06295250
- Testing
- Manualized Group Based Psychotherapy, Poverty Alleviation
- Where
- Bangladesh
- Volunteers
- 600 people
- Sponsor
- University of Massachusetts, Worcester
Alcoholism
Ketamine/Placebo Family History Positive Study
The proposed study is the first to explore the contribution of brain glutamate systems, a major target of ethanol in the brain, to the vulnerability to develop alcoholism.
- Trial name
- NCT00588952
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Yale University
Aging, Cognitive Change
Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging
Much of human interaction is based on trust. Aging has been associated with deficits in trust-related decision making, likely further exacerbated in age-associated neurodegenerative disease (Alzheimer's disease/AD), possibly…
- Conditions
- Aging, Cognitive Change, Neurocognitive Disorders, Mild
- Trial name
- DecidingBrain (NCT05457725)
- Testing
- Contingent rtfMRI neurofeedback training
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Florida