Clinical trials: WOUNDS INJURIES
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Traumatic Brain Injury
To Evaluate the Effect of Glibenclamide in Reducing Brain Edema of TBI
Brain edema is one of the main mechanisms of secondary brain injury and one factor in the prognosis of traumatic brain injury . The clinical study of glibenclamide in the treatment of brain edema after traumatic brain injury is…
- Trial name
- NCT05148403
- Testing
- glibenclamide
- Where
- 2 sites in China
- Volunteers
- 76 people
- Sponsor
- Beijing Tiantan Hospital
Bile Duct Obstruction
Flushing of Internalized Percutaneous Transhepatic Biliary Drainage Catheters
Percutaneous transhepatic biliary drainage (PTBD) is a drainage method for biliary obstruction. Patients with a PTBD catheter often need multiple re-interventions because of symptoms of catheter obstruction such as pain…
- Trial name
- FLUSH (NCT04915703)
- Testing
- Flushing of PTBD catheter
- Where
- Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Hip Fractures
Functional Later Rehabilitation in Older Adults: Effectiveness of Physical Exercises
Hip fractures resulting from falls increase substantially with advancing age and less than a half of the elderly that have sustained and survived after the surgery regain their former levels of mobility.
- Trial name
- REATIVE (NCT02295527)
- Testing
- Home-based physical exercise intervention, Control Group Usual Care
- Where
- Brazil
- Volunteers
- 82 people
- Sponsor
- Universidade Cidade de Sao Paulo
Open Fracture
Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures
To evaluate the feasibility, safety, and potential efficacy of applying vancomycin powder locally to open fractures in the emergency department prior to definitive surgical intervention.
- Trial name
- NCT07659886
- Testing
- Vancomycin (VAN) treatment, Standard Open Fracture Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Atlantic Health System
Injury;Sports
The Effect of Different Instruction Trainings in Semi-Professional Female Athletes
Feedback is implanted into workouts to prevent lower extremity injuries. There are different studies where external focus and internal focus feedback were found to be superior.
- Trial name
- NCT06424886
- Testing
- Landing error scoring system (LESS)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Osteoporosis, Cognitive Decline
Vitamin B12 and Folic Acid Supplementation for Preventing Fractures in Elderly People
It is hypothesized that vitamin B12 and folic acid supplementation reduces the number of incident fractures. The proposed study, a randomized placebo-controlled intervention trial, compares daily supplementation with folic acid…
- Trial name
- B-PROOF (NCT00696514)
- Testing
- Vitamin B12, folic acid, Vitamin D3
- Where
- 3 sites in Netherlands
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Open Wound, Wound Heal
Micro/Nanobubbles (MNBs) for Treatment of Acute and Chronic Wounds
The purpose of this study is to assess the safety and efficacy of Micro/nanobubbles (MNB's) for the healing of acute and chronic wounds.
- Trial name
- MNB (NCT05169814)
- Testing
- Micro/nanobubble (MNB) - Irrigation, 0.9% Normal Saline - Irrigation, Micro/nanobubble (MNB) - Negative Pressure Wound Therapy with Instillation (NPWTi)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Pain
Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain
The purpose of the study is to evaluate the efficacy and safety of OraVescent fentanyl treatment compared to placebo treatment monthly over a 12-week treatment period in alleviating breakthrough pain (BTP) in opioid-tolerant…
- Trial name
- NCT00343733
- Testing
- OraVescent Fentanyl
- Where
- 21 sites in United States
- Volunteers
- 120 people
- Sponsor
- Cephalon
Acquired Brain Injury, Disorders of Consciousness
tDCS in Pediatric Acquired Brain Injury
In this preliminary study, we will examine the safety, tolerability, and feasibility of transcranial direct current stimulation (tDCS), in the setting of dosage escalation, as a candidate intervention for children with Acquired…
- Trial name
- NCT03618849
- Testing
- tDCS
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Gene Abnormality, Meniscus Injury
Study on Susceptibility Genes of Anterior Cruciate Ligament, Patella Dislocation and Discoid Meniscus
Genomes of all sports medicine-related genes will be exome sequenced to find relevant gene mutations. To further study the molecular mechanisms and signaling pathways related to sports injury.
- Conditions
- Gene Abnormality, Meniscus Injury, Cruciate Ligament Rupture
- Trial name
- NCT04997538
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Spinal Cord Injury, Neurogenic Bladder
Multifaceted Treatment of Catheter-related Urinary Tract Infection
The specific objective of this clinical trial is to demonstrate that a multifaceted approach for treatment for catheter-related urinary tract infection (UTI) in patients with spinal cord injury is effective and feasible.
- Conditions
- Spinal Cord Injury, Neurogenic Bladder, Urinary Tract Infection
- Trial name
- NCT00732238
- Testing
- Shortened course of antibiotic therapy, Standard Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Department of Veterans Affairs
Bone Fractures, Splints
A Randomized Trial Comparing Conventional Plaster and Thermoplastic Splints to Treat Pediatric Boxer's Fractures
The investigators are conducting a randomized clinical trial comparing two types of splints for treatment of Boxer's fractures in children up to age 17 inclusive.
- Conditions
- Bone Fractures, Splints, Metacarpal Fracture, Boxer's Fracture
- Trial name
- NCT01759758
- Testing
- Plaster Ulnar Gutter Splint, Thermoplastic Splint
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre
Tibial Meniscus Injuries, Knee Injuries
Ultrasound-Guided Injections for Meniscal Injuries in Active-Duty Military
Knee injuries are common among active-duty military personnel. One of the most common knee injuries is a meniscus tear, which can have several consequences.
- Conditions
- Tibial Meniscus Injuries, Knee Injuries, Knee Injuries and Disorders
- Trial name
- NCT04274543
- Testing
- Lipogems, Normal Saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury, Pressure Injury
Telemedicine Makes the Patient Stay in Hospital at Home
The goal of the project is to study whether multidisciplinary follow- up performed via telemedicine to the patient in his or her own home, will improve the healthcare services offered to a particular group of patients.
- Trial name
- TeleSCIpi (NCT02800915)
- Testing
- Service innovation with focus on multidisciplinary collaboration
- Where
- Norway
- Volunteers
- 56 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Hand Injury
Retroclavicular Approach vs Infraclavicular Approach for Plexic Bloc Anesthesia of the Upper Limb
Locoregional anesthesia provides several advantages over general anesthesia in terms of postoperative pain, decreased postoperative opioid needs and reduced recovery time for patients undergoing orthopaedic surgery.
- Trial name
- NCT02913625
- Testing
- Ultrasound guided retroclavicular block, Ultrasound guided infraclavicular block
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- Université de Sherbrooke
Post-traumatic Stress Disorder (PTSD), Trauma
Functional Brain Imaging in PTSD
Patients with post-traumatic stress disorder (PTSD) have abnormalities in the function of the amygdala and medial prefrontal cortex (particularly anterior cingulate), in addition to abnormalities of hippocampal volume.
- Trial name
- NCT02053532
- Testing
- Positron emission tomography/magnetic resonance imaging
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
ACL Injuries
Exercise Program for Knee Recovery in Football Players with ACL Injuries
This study aims to evaluate the effectiveness of a structured exercise program in improving knee function, muscle strength, and range of motion in football players recovering from anterior cruciate ligament (ACL) injuries.
- Trial name
- NCT06808763
- Testing
- Knee Rehabilitation Exercise Program
- Where
- Saudi Arabia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- King Saud University
Foreign-Body Reaction, Soft Tissue Filler Complication
Prospective Paired Evaluation of Conventional Versus Structured Magnetic Resonance Imaging Interpretation for Preoperative Assessment of Gluteal Permanent Synthetic Filler Disease
This prospective paired diagnostic-impact study will compare conventional qualitative MRI reporting with a new structured anatomic classification in adults undergoing surgery for gluteal permanent synthetic filler disease.
- Conditions
- Foreign-Body Reaction, Soft Tissue Filler Complication, Gluteal Permanent Synthetic Filler Disease
- Trial name
- NCT07808463
- Testing
- Conventional Qualitative MRI Interpretation, Structured Gluteal Filler MRI Classification, Standardized Intraoperative Anatomic Mapping
- Volunteers
- 200 people
- Sponsor
- Research Inc
Tissue Repair, Soft Tissue Reconstruction
Urinary Bladder Matrix (UBM) Registry
The purpose of this registry is to collect real-world information on patients treated with Urinary Bladder Matrix (UBM) products.
- Conditions
- Tissue Repair, Soft Tissue Reconstruction, Wound Management, Pressure Ulcer (PU)
- Trial name
- NCT07805798
- Testing
- Urinary Bladder Matrix (UBM) Products
- Volunteers
- 300 people
- Sponsor
- Integra LifeSciences Corporation
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