Clinical trials: Weakness
Respiratory Muscle Weakness, Mechanical Ventilation Weaning
Progressive Pressure Support Reduction as Inspiratory Muscle Endurance Training in Mechanically Ventilated Patients
Mechanical ventilation causes rapid diaphragm muscle atrophy, detectable within 18 hours of ventilator support, which is a major contributor to weaning failure and prolonged ICU stay.
- Conditions
- Respiratory Muscle Weakness, Mechanical Ventilation Weaning, Physiotherapy, Endurance Training
- Trial name
- inspira-rct (NCT07689110)
- Testing
- Progressive Pressure Support Reduction (IRT-PS), Standard ICU Care
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Santiago de Compostela
Asthenia, COVID-19
Safety and Efficacy of the Therapy With BRAINMAX® for the Treatment of Patients With Asthenia After COVID-19
This is prospective multicentre comparative randomized double blind placebo controlled study conducted in 6 medical facilities.The objective of the study is to assess the safety and efficacy of the sequential therapy with…
- Trial name
- NCT05689827
- Testing
- Ethyl methyl hydroxypyridine succinate + Meldonium
- Where
- 6 sites in Russia
- Volunteers
- 160 people
- Sponsor
- Promomed, LLC
Strain of Fascia of Intrinsic Muscle of Foot (Disorder), Elastography
Integrated Exercise Therapy Interventions on the Performance and Injury Prevention in Competitive Sports
Football is an increasingly popular exercise and common practice among adolescent and elite athletes. However, these athletes tend to have injuries involving the lower extremity and foot.
- Conditions
- Strain of Fascia of Intrinsic Muscle of Foot (Disorder), Elastography, Muscle Weakness
- Trial name
- NCT04384003
- Testing
- Shear Wave Ultrasound Elastography, The 3-D Motion Analysis, Electromyographic
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Post Intensive Care Syndrome
Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS).
- Trial name
- FICUF (NCT05984069)
- Testing
- observational prospective data collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cancer, Geriatric
The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older
This study will look at the impact of a self-directed walking program on post-chemotherapy survivors experiencing fatigue. It is hypothesized that the walking program will help lessen fatigue.
- Conditions
- Cancer, Geriatric, Fatigue
- Trial name
- S-PACT (NCT02191982)
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Stroke Rehabilitation
Muscle Strength Loss In Stroke Individuals - Control Study
ABSTRACT The muscle strength (MS) is necessary to overcome the resistance encountered during the activity. The present study aims to determine MS loss in stroke individuals (SI).
- Trial name
- NCT04395209
- Testing
- assesment
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Vocal Cord Paralysis Unilateral
Laryngeal Reinnervation Versus Thyroplasty in Patients With Vocal Fold Weakness.
The purpose of this study is to help determine the most effective treatment for participants with Unilateral Vocal Fold Paralysis. There are currently two types of operations used to treat this condition.
- Trial name
- VOCALIST (NCT02973152)
- Testing
- Thyroplasty, Reinnervation
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Royal National Throat, Nose and Ear Hospital
MuSK Myasthenia Gravis
Open-label Study to Evaluate the Safety of Various Dosing Regimens of MuSK-CAART for MuSK Myasthenia Gravis
Muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG) is a rare but potentially severe disease, in which patients develop pathogenic autoantibodies that specifically target the MuSK protein in the neuromuscular junction.
- Trial name
- NCT05451212
- Testing
- MuSK-CAART
- Where
- 5 sites in United States
- Volunteers
- 7 people
- Sponsor
- Cabaletta Bio
Hypermobility, Joint, Muscle Weakness
"Core" Muscle Endurance, Upper Extremity Muscle Strength, Grip Strength, and Hand-eye Coordination in Generalized Joint Hypermobility
Every individual with joint hypermobility may not apply to a health institution because they do not have a complaint that will affect their daily life.
- Conditions
- Hypermobility, Joint, Muscle Weakness, Coordination Lack
- Trial name
- NCT05896722
- Testing
- Core muscle endurance, Upper extremity muscle strength, Grip strength
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Coronavirus Infection, Sars-CoV2
Outcomes in Hospitalized Older Patients With COVID-19
In December 2019, the first patients infected with the 2019 novel coronavirus (2019-nCoV) were diagnosed in Wuhan. The clinical presentation and course of Severe Acute Respiratory Syndrome-CoV-2 (SARS-CoV-2) infection is poorly…
- Conditions
- Coronavirus Infection, Sars-CoV2, Elderly Infection, Old Age; Debility
- Trial name
- NCT04385212
- Where
- Switzerland
- Volunteers
- 230 people
- Sponsor
- University Hospital, Geneva
Metastatic Cancer, Cachexia; Cancer
Cancer-Associated Muscle Atrophy and Weakness: An Investigation of Etiology
This study is designed to gain a better understanding of the mechanisms leading to muscle wasting and metabolic abnormalities in skeletal muscle of cancer patients.
- Trial name
- NCT03012139
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Intensive Care Unit-acquired Weakness, Artifical Intelligence
AI Based Muscular Ultrasound to Assess Intensive Care Unit-acquired Weakness
The aim of this observational case-control study is to investigate, whether artificial intelligence can detect ultrasound-derived imaging characteristics typical for intensive care unit-acquired weakness.
- Conditions
- Intensive Care Unit-acquired Weakness, Artifical Intelligence, Ultrasound
- Trial name
- ACTIVATE (NCT06765551)
- Testing
- Neuromuscular Ultrasound
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Jena University Hospital
Sarcopenia, Stroke, Acute
Effects of Mobility Dose on Discharge Disposition in Critically Ill Stroke Patients
The primary aim of the study is to assess the mobility dose in neurocritical care patients with ischemic stroke or intracranial hemorrhage and its effects on discharge disposition and patient outcomes.
- Conditions
- Sarcopenia, Stroke, Acute, Muscle Weakness, Critical Illness
- Trial name
- NCT03347656
- Where
- 3 sites in United States, Germany
- Volunteers
- 164 people
- Sponsor
- Beth Israel Deaconess Medical Center
Osteoarthritis
Osteoarthritis: Weakness From Inflammation
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
- Trial name
- NCT00104312
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke
Peer Group Regulated mCIMT Program for Adult Stroke Patients: Effects on Functional Activities
Each year more than 17 million people in the world are experiencing a stroke. Stroke is a major cause of mortality and one of the prevalent causes of serious disablement.
- Conditions
- Weakness of Extremities as Sequela of Stroke, Modified Constraint Induced Movement Therapy After Stroke, Upper Extremity Functional Performance After Stroke
- Trial name
- PEPS-MIT (NCT04264195)
- Testing
- Constraint-induced movement therapy: PEPS-MIT, Bimanual manipulation exercises (PEPS-Bimanual)
- Where
- Bangladesh
- Volunteers
- 140 people
- Sponsor
- Centre for the Rehabilitation of the Paralysed, Bangladesh
Muscle Weakness, Balance Disorders
Different Proprioceptive Neuromuscular Facilitation (PNF) Technique in Patients With Knee Osteoarthritis
The aim of this study is to investigate the effects of 6-week physiotherapy and rehabilitation programs involving different 'Proprioceptive Neuromuscular Facilitation' (PNF) techniques in patients with knee osteoarthritis on…
- Conditions
- Muscle Weakness, Balance Disorders, Knee Pain, Knee Osteoarthritis
- Trial name
- NCT03615521
- Testing
- Hotpack, Ultrasound, Combine Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Karamanoğlu Mehmetbey University
Exercise, Detraining
Effects of COVID-19 Lockdown in Exercising Early Postmenopausal Women
While "conditioning" by exercise training has been widely evaluated, the available literature on "passive deconditioning" (i.e. forced deconditioning) is predominately limited to studies with or with almost complete mechanical…
- Conditions
- Exercise, Detraining, Muscle Weakness, Muscle Atrophy
- Trial name
- NCT04420806
- Testing
- HIT-exercise
- Where
- Germany
- Volunteers
- 21 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Thoracic Surgery, Postoperative Period
Efficacy of Triburter on Respiratory Muscle Function in Patients After CABG in Cardiac Rehabilitation Phase II
Post-surgery patients have muscle impairments, especially in the respiratory muscles, because the anesthesia, surgical incision, mechanical ventilation, pain, and prolonged postures, affect the mechanical condition of respiratory…
- Conditions
- Thoracic Surgery, Postoperative Period, Weakness, Muscle
- Trial name
- NCT05496049
- Testing
- Triburter, Incentive spirometry
- Where
- Colombia
- Volunteers
- 30 people
- Sponsor
- Fundación Cardiovascular de Colombia
Anterior Cruciate Ligament Injury, Muscle Weakness
WEakness and Atrophy: isoKinetic With Surface Electromyography Assessment in ACL Surgery
An assessment of the effect of surgical anterior cruciate ligament (ACL) on thigh muscles is critical to the improvement of knee rehabilitation and preservation.
- Trial name
- WEAKNESS (NCT03200678)
- Testing
- isokinetic assessment
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Aging, Foot Muscle Dysfunction
Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults
This study is designed as a randomized controlled trial. A total of 40 healthy older adults residing in private and public nursing homes and rehabilitation centers in Mersin will be enrolled.
- Conditions
- Aging, Foot Muscle Dysfunction, Sarcopenia, Age-Related Muscle Weakness
- Trial name
- EXG-FOOT (NCT07357662)
- Testing
- Exergame-based Balance and Foot Muscle Training, Conventional Functional Balance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tarsus University
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