Clinical trials: Weakness
Muscle Weakness Conditions, Weaning Failure
Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated Patients
Levosimendan is a relatively new drug that improves cardiac contractility in patients with heart failure. Its main mechanism of action is enhanced binding of calcium to the myocardial contractile proteins.
- Trial name
- NCT01721434
- Testing
- Levosimendan
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- University Medical Center Nijmegen
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Prone Positioning and Thoracoabdominal Binding on Lung and Muscle Protection in ARDS Patients During Spontaneous Breathing
Ventilator-induced diaphragmatic dysfunction and intensive care unit (ICU)-acquired weakness are two consequences of prolonged mechanical ventilation and critical illness in patients with acute respiratory distress syndrome…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- NCT05826847
- Testing
- Prone Positioning, Thoracoabdominal Binding, Control
- Where
- Chile
- Volunteers
- 14 people
- Sponsor
- University of Chile
Muscle Loss, Muscle Weakness
Impact of Increased Protein Density Diet to Muscle Mass and Strength Among Mid-aged and Older Adults
The subjects of this intervention program are mainly based on community-dwelling mid-aged and older adults. The investigator's program will provide meals containing different proportionated protein.As this project is a double…
- Conditions
- Muscle Loss, Muscle Weakness, Fragility
- Trial name
- NCT03784456
- Testing
- 25% protein, 15% protein
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Yang Ming Chiao Tung University
Postural Imbalance, Muscle Weakness
Effects of Corrective Exercises in Adolescent Fencers
The goal is to learn if a Functional Corrective Training (FCT) exercise program improves posture, core muscle endurance, jumping ability, and reaction time in adolescent fencers.
- Conditions
- Postural Imbalance, Muscle Weakness, Athletic Performance
- Trial name
- FMS exercise (NCT06927778)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Pelvic Floor Muscle Weakness
Verbal Instruction for Contraction Pelvic Floor Muscles Among Males
The aim of this study is to compare the effectiveness of different verbal instruction on pelvic floor muscle contraction among males. Pelvic floor contraction will be measured via ultrasound.
- Trial name
- NCT03507660
- Testing
- verbal instruction
- Where
- Israel
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Frailty, Weakness, Muscle
Precision Medicine and Physical Function
The investigators aim to conduct a 12-week, single-arm, pre/post-intervention of b-hydroxy-methylbutyrate in persons aged 65 to 85 years to assess feasibility and acceptability of the intervention and study procedures, secondary…
- Conditions
- Frailty, Weakness, Muscle, Multiple Chronic Conditions
- Trial name
- HMB (NCT05877846)
- Testing
- Beta-hydroxymethyl butyrate supplement, Vitamin D supplement, Matching Beta-hydroxymethyl butyrate supplement without Vitamin D
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Breast Cancer, Chemotherapy Effect
Effects of Creatine Supplementation in Breast Cancer Survivors
The purpose of this study is to test the hypothesis that creatine will accelerate adaptations associated with exercise in breast cancer survivors recently completing chemotherapy.
- Conditions
- Breast Cancer, Chemotherapy Effect, Muscle Weakness, Muscle Loss
- Trial name
- NCT04207359
- Testing
- Creatine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Muscle Weakness, Mechanical Ventilation Complication
Cycling Exercise in Mechanical Ventilation
Prolonged critical illness renders survivors with increased long-term morbidity associated with high healthcare costs. Muscle weakness and fatigue are reported as the main contributors to long-term poor functional outcomes.
- Trial name
- NCT03581760
- Testing
- Cycling Exercise, Conventional Physiotherapy
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Pain; Cancer
An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Cancer Participants With Inadequately Controlled Pain by Non-Narcotic Analgesics
The purpose of this study is to evaluate the efficacy and safety of Transdermal Therapeutic System (TTS)-fentanyl D-Trans (transdermal patch containing a drug that is put on the skin so the drug will enter the body through the…
- Trial name
- NCT01060124
- Testing
- Fentanyl D-trans
- Volunteers
- 103 people
- Sponsor
- Janssen Korea, Ltd., Korea
Spinal Induced Hypotension, Old Age; Debility
Efficacy of Subclavian Vein/Artery Diameter Index in Predicting the Incidence of the Spinal-Induced Hypotension in Geriatric Patients
The hypothesis of the study will be that the subclavian vein/subclavian artery diameter (SCVD/SCAD) index will be a good predictor of spinal-induced hypotension in geriatric patients.
- Trial name
- NCT07286422
- Testing
- Assessment of the SCV & SCA, Assessment of the IVC and aorta
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- Tanta University
Cancer, Hospital Acquired Condition
Prevention of Functional and Cognitive Impairment in Hospitalized Oncogeriatric Patients
Hospitalized older patients usually remain bedridden for many hours and this may lead to the appearance of unwanted negative consequences, such as cognitive or physical decline upon discharge.
- Conditions
- Cancer, Hospital Acquired Condition, Debility, Aging
- Trial name
- NCT05424055
- Testing
- Multicomponent exercise
- Where
- Spain
- Volunteers
- 58 people
- Sponsor
- Fundacion Miguel Servet
Aging, Muscle Weakness
Leg Heat Therapy in Elderly Individuals
This pilot randomized, sham-controlled trial aimed to establish the feasibility and safety of home-based leg HT in community-dwelling older adults and inform the design of a future, larger study.
- Trial name
- NCT05543980
- Testing
- Leg heat therapy device
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Purdue University
Covid19, Sarcopenia
Muscular Rehabilitation by Eccentric Exercise After Severe COVID-19 Infection
With the COVID-19 pandemic, the number of patients to be treated in rehabilitation increased . Hospitalization for severe infection can induce muscular atrophy and muscular dysfunction that persists for several months and…
- Conditions
- Covid19, Sarcopenia, Muscle Weakness
- Trial name
- CovExc (NCT04649086)
- Testing
- Rehabilitation by Eccentric exercises, Rehabilitation by Concentric exercises
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
SARS-CoV Infection, Covid19
Muscle Weakness in COVID-19 Patients
Although the Covid-19 infection mainly manifests itself with respiratory symptoms, as early as two months after the onset of the pandemic, the presence of other symptoms, including muscle ones, became clear.
- Conditions
- SARS-CoV Infection, Covid19, Muscle Weakness, Exercise Intolerance
- Trial name
- MIOCOVID (NCT04959773)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Pavia
Covid19, Diaphragm Injury
Respiratory Muscle Assesment in COVID-patients Without Hospitalization
Fatigue and exercise intolerance after survived COVID-19-infection might be related to weakness of the respiratory muscles. The aim of the project is to measure respiratory muscle function and strength in our respiratory…
- Trial name
- RMA-COVID-19 (NCT06105450)
- Testing
- Comprehensive assessment of respiratory muscle function.
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- RWTH Aachen University
Spinal Cord Injuries or Similar Neurological Weakness
EKSO Trial: Powered Exoskeleton for Ambulation in Subjects With Spinal Cord Injury (SCI)
This study seeks to test the safety and efficacy of the Esko device in SCI population and in populations with similar neurological weakness to the SCI population.
- Trial name
- EKSO (NCT01701388)
- Testing
- Ekso exoskeleton
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Cerebral Palsy (CP), Dysarthria
Speech and Arm Combined Exergame
The purpose of this study is to develop innovative home therapy games to train the weak arm and improve speech intelligibility (clarity) of children with hemiplegia from cerebral palsy.
- Trial name
- SPACE (NCT06817941)
- Testing
- Speech only, Hand/Arm only, Speech and arm combined
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Rutgers, The State University of New Jersey
Muscle Cramp, Ache
7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle Events
Over 40 million Americans take statins to reduce their risk of atherosclerotic cardiovascular disease (ASCVD). Unfortunately, 10 to 20% stop taking them due to statin-associated muscle symptoms (e.g.
- Conditions
- Muscle Cramp, Ache, Weakness, Muscle, Statin Adverse Reaction
- Trial name
- NCT04507373
- Testing
- Simvastatin 40mg
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Rheumatoid Arthritis, Myositis
Comparison of Training Load With/Out Blood Flow Restriction Training in Rheumatoid Populations
The study will investigate the effects of a traditional, high-intensity strengthening program compared to an investigational low-intensity strengthening program that also uses blood flow restriction as part of the training…
- Conditions
- Rheumatoid Arthritis, Myositis, Osteoarthritis, Weakness, Muscle
- Trial name
- NCT04309227
- Testing
- Strength Training
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Functional Neurological Disorder, Conversion Disorder
Restoring Independence With Stimulation-Enhanced Treatment for People With Functional Neurological Disorder
The goal of this clinical trial is to test a new treatment for adults with walking problems due to Functional Neurological Disorder (FND).
- Trial name
- RISE-FND (NCT07769970)
- Testing
- Stimulation-Enhanced Physical Therapy, Active Comparator
- Where
- New Zealand
- Volunteers
- 60 people
- Sponsor
- University of Auckland, New Zealand
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