Clinical trials: Weakness
Aging, Rehabilitation
Physical Function of Older Citizens During Municipality-based Rehabilitation
When choosing outcomes to assess rehabilitation's effect or progress, it is essential to consider the constructs being measured and their value to the patient and the psychometric properties.
- Conditions
- Aging, Rehabilitation, Frailty, Sarcopenia
- Trial name
- NCT04862481
- Where
- Denmark
- Volunteers
- 115 people
- Sponsor
- University College Absalon
Primary Mitochondrial Disease
Efficacy of KL1333 in Adult Patients With Primary Mitochondrial Disease
The primary objective of the FALCON study is to evaluate the efficacy of KL1333 on selected disease manifestations of primary mitochondrial disease (PMD) following 48 weeks of treatment.
- Trial name
- FALCON (NCT05650229)
- Testing
- KL1333
- Where
- 55 sites in United States, Australia and 9 more
- Volunteers
- 180 people
- Sponsor
- Pharming Technologies B.V.
Diastasis Recti and Weakness of the Linea Alba
Anatomo-radiological Study on Semilunar Line as Risk Factor fo Diastasis Recti Abdominis
Multicenter cross-sectional observational study with the aim of investigating the prevalence of diastasis recti abdominis in adults and identifying its risk factors.
- Trial name
- Semilunare (NCT05162612)
- Testing
- abtominal CT
- Where
- 2 sites in Italy
- Volunteers
- 987 people
- Sponsor
- Marta Cavalli
ICU Acquired Weakness
ICU-Recover Box 2.0, Smart Technology for Home Monitoring of ICU Patients
Smart technology could improve quality of care in patients who have been admitted to the ICU and have been discharged from ICU and hospital, by early diagnosis of complications and early (ambulatory) treatment.
- Trial name
- NCT07162948
- Testing
- The ICU-Recover Box: using smart technology for monitoring health status after ICU admission Pilot 2.0
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Diastasis Recti and Weakness of the Linea Alba, Abdominal Wall Defect
Patient-Reported Outcomes in Women With Postpartum Abdominal Wall Insufficiency (PPAWIS)
Postpartum abdominal wall insufficiency syndrome (PPAWIS) is a multidimensional condition that may affect physical function, quality of life, body image, and sexual health in women after childbirth.
- Conditions
- Diastasis Recti and Weakness of the Linea Alba, Abdominal Wall Defect, Postpartum Complication, Abdominal Wall Anomaly
- Trial name
- EMPOWER (NCT07407374)
- Testing
- Routine Clinical Care
- Volunteers
- 30 people
- Sponsor
- Swissmed Hospital
Muscle Weakness, Gait, Unsteady
High Intensity Interval Training in Geriatrics
This is a pilot study for evaluating the feasibility of using High Intensity Interval Training in geriatric hospitalized patients compared to the standard current rehabilitation practice.
- Trial name
- HIITERGY (NCT02318459)
- Testing
- high intensity interval training-HIIT, Traditionnal group rehabilitation
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Metabolomics, Critical Care
Metabolomics Study on Intensive Care Acquired Muscle Weakness in Polytrauma
In this mono-center pilot trial, polytrauma patients admitted to intensive care will be included. Investigators are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular…
- Conditions
- Metabolomics, Critical Care, Critical Illness, Critical Illness Myopathy
- Trial name
- MIRACLE II (NCT03819959)
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Technical University of Munich
Post Intensive Care Syndrome
Impact of Frailty and ICU-AW on Post-ICU Fatigue Self-reported
After a prolonged stay in Intensive Care Unit (ICU), fatigue is the most common symptom reported by patients in the Post Intensive Care Syndrome (PICS).
- Trial name
- FICUF (NCT05984069)
- Testing
- observational prospective data collection
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Intensive Care Unit Acquired Weakness, Critical Illness
The CONFUCIUS Oral Protein Supplementation Trial
Study the effect of 6-weeks porcine protein supplementation vs isocaloric comparator (carbohydrate) on functional outcomes in post ICU-patients. Patients will be included at ICU discharge.
- Trial name
- CONFUCIUS (NCT05405764)
- Testing
- Porcine protein supplement, Control product maltodextrin supplement
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- ARH van Zanten
Liver Transplantation, Postoperative Recovery
Effects of The Telerehabilitation-Based Exercise Program in Liver Transplant Patients
This randomized controlled study aims to evaluate the effects of a telerehabilitation-based exercise program on muscle strength, exercise capacity, fatigue level, and cognitive status in adult liver transplant recipients.
- Conditions
- Liver Transplantation, Postoperative Recovery, Muscle Weakness, Functional Capacity
- Trial name
- NCT07425314
- Testing
- Telerehabilitation Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Hasan Kalyoncu University
Sarcopenia, Old Age; Debility
Study the Impact of Hirsutella Sinensis Nutrient Supplements Has on Improving Muscle Health and Metabolism in Elderly
Sarcopenia has now been officially recognized as a muscle disease related to aging, which may increase the risk of falls and fractures and both heart and respiratory diseases in the elderly.
- Conditions
- Sarcopenia, Old Age; Debility, Muscle Loss
- Trial name
- HSN (NCT05284149)
- Testing
- Hirsutella Sinensis Nutrient Supplements
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Thymidine Kinase 2 Deficiency
An Open-Label Study of Continuation Treatment With Combination Pyrimidine Nucleosides in Patients With TK2 Deficiency
This is a Phase 2 prospective open-label treatment study of the safety and efficacy of doxecitine and doxribtimine in study participants with thymidine kinase 2 (TK2) deficiency who participated in the retrospective study…
- Trial name
- Continuation (NCT03845712)
- Testing
- doxecitine and doxribtimine
- Where
- 8 sites in United States, Israel and 1 more
- Volunteers
- 47 people
- Sponsor
- UCB BIOSCIENCES, Inc.
Obesity, Overweight
Abdominal and Core Exercises on Respiratory Functions in Obese and Overweight Women (COREBREATH)
This study aims to examine the effects of an 8-week Pilates-based exercise program on breathing functions in overweight and obese women (BMI ≥ 25).
- Conditions
- Obesity, Overweight, Pulmonary Disease, Muscle Weakness
- Trial name
- COREBREATH (NCT07103499)
- Testing
- Pilates-Based Core and Breathing Exercise Program
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Aortic Diseases, Intensive Care Unit Syndrome
Muscle Recovery Following Aortic Surgery Induced ICUAW.
To identify determinants of 'good and bad recovery' from ICUAW and build knowledge around the timing of these processes. Also, the investigators want to discover the effects of ICUAW on physical function and HRQoL following…
- Conditions
- Aortic Diseases, Intensive Care Unit Syndrome, Intensive Care Neuropathy, Intensive Care (ICU) Myopathy
- Trial name
- VARIANCE (NCT03714399)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- Barts & The London NHS Trust
Pelvic Floor Muscle Weakness, Urinary Incontinence in Old Age
Investigation of The Effect of Pelvic Floor Exercise Programme in Elderly.
Alteration of hormonal structure and decreasing of muscle tissue with aging causes pelvic floor dysfunction. Over age of 65 so many factors such as decrease in volume of muscle tissue, decrease in the amount of estrogen /…
- Conditions
- Pelvic Floor Muscle Weakness, Urinary Incontinence in Old Age, Sexual Dysfunction, Quality of Life
- Trial name
- NCT04036604
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Polyneuropathy
Neuromuscular Electrical Stimulation in the Critically Ill
Neuromuscular stimulation (NMES) has been used for several years in the rehabilitation of COPD (chronic obstructive pulmonary disease) patients (among others) to improve their resistance to efforts in everyday life.
- Trial name
- NCT02566941
- Testing
- Gymna Belgium, DUO 400 (Neuromuscular electrical stimulation)
- Where
- Belgium
- Sponsor
- Brugmann University Hospital
Immobility and Weakness Associated With Long Intensive Care Unit Stays
Early Progressive Mobility in the CVICU: Assessing Current Status
The current study is proposed to assess the frequency and type of progressive mobility procedures currently performed in the CVICU The study will evaluate the type and frequency of progressive mobility orders, whether or not…
- Trial name
- NCT01295541
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hill-Rom
ACL Injury, Muscle Weakness
Nordic Hamstring Exercise After ACL Reconstruction Reconstruction
Anterior cruciate ligament (ACL) injuries constitute a significant portion of major knee joint injuries sustained by young, active individuals, and significantly increase risk for long-term disability.
- Conditions
- ACL Injury, Muscle Weakness, Neuromuscular Manifestations
- Trial name
- NCT05738200
- Testing
- Nordic Hamstring Exercise
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Toledo
COPD
Inspiratory Muscle Training on Respiratory Muscle Function，Quality of Life and Exercise Capacity in Stable COPD
Comparable RCTs of clinical therapeutic effects using respiratory physiology-oriented IMT device in different operation principle in COPD are so far lacking.
- Trial name
- NCT03101774
- Testing
- Threshold inspiratory muscle training, Resistive inspiratory muscle training, Control group
- Volunteers
- 60 people
- Sponsor
- Guangzhou Institute of Respiratory Disease
Urinary Incontinence
Translating Unique Learning for Incontinence Prevention
More than one in three US women suffers from the distressing, embarrassing, and often unreported problem of urinary incontinence (UI). UI severity increases with age and the financial cost exceeds $19 billion per year .
- Trial name
- TULIP (NCT01599715)
- Testing
- Instructional DVD, Bladder Health Class
- Where
- 2 sites in United States
- Volunteers
- 647 people, healthy volunteers welcome
- Sponsor
- University of Michigan
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