Clinical trials: Weight Changes, Body
Overweight (BMI > 25), Obese Patients
Intervention Effects on Health Promoting Behaviors and Factors Influencing Long-Term Behavior Change
This study aims to compare the 8-week virtual Healthy YOU Program with a standard care intervention that sends weekly nutrition and healthy living tips via email.
- Trial name
- HYP (NCT06892587)
- Testing
- An 8-week virtual group intervention designed to promote sustainable health behavior changes in participants, Standard of care Nutritional Information
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Colorado State University
Obesity, Weight Loss
An Open-Label Pilot Trial of Alpha Lipoic Acid (ALA) for Weight Loss in Schizophrenia
The aim of this study is to collect pilot data to compare the effectiveness of treatment with Alpha Lipoic Acid (ALA) for reduction in body weight in 40 obese outpatients with schizophrenia or schizoaffective disorder in an…
- Conditions
- Obesity, Weight Loss, Schizophrenia
- Trial name
- ALA (NCT01355952)
- Testing
- Alpha Lipoic Acid
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Overweight/Obesity, Puberty
Improving Health Among Disadvantaged Girls to Slow Pubertal Onset and Reduce Long-term Health Risks
This study is testing whether improving health in girls during the prepubertal period may slow the onset of puberty. This study will focus on prepubertal girls who have a high weight status (at or above the 85th percentile for…
- Conditions
- Overweight/Obesity, Puberty, Health Behavior, Cardiometabolic Health
- Trial name
- NCT07460544
- Testing
- Family-Based Treatment (FBT)
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Washington
Weight Loss, Weight Change, Body
Study of an International Commercial Program on Weight Loss and Health Outcomes
This study is a randomized controlled trial (RCT) of the Weight Watchers (WW) Freestyle ® (Flex® in UK) weight loss program compared to a control group following a do-it-yourself (DIY) approach for 12 months.
- Conditions
- Weight Loss, Weight Change, Body, Obesity, Diet Modification
- Trial name
- NCT03571893
- Testing
- Weight Watchers Freestyle (Flex), DIY Personal Plan
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 373 people
- Sponsor
- University of North Carolina, Chapel Hill
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604421
- Testing
- Thermoregulation-standard care, Thermoregulation with plastic bag
- Where
- Zambia
- Sponsor
- University of Alabama at Birmingham
Acute Malnutrition in Infancy, Acute Malnutrition in Childhood
ComPAS Low-WAZ RCT Mali
Admissions criteria which treat children with only low mid-upper arm circumference (MUAC) or children with low weight-for-height z-score (WHZ) are not aligned with the evidence on which children are at risk of mortality.
- Conditions
- Acute Malnutrition in Infancy, Acute Malnutrition in Childhood, Underweight
- Trial name
- NCT05248516
- Testing
- Simplified dose of ready-to-use therapeutic food (RUTF), Standard dose of ready-to-use therapeutic food (RUTF), No nutritional treatment
- Where
- 11 sites in Mali
- Volunteers
- 1,500 people
- Sponsor
- International Rescue Committee
Obesity, Weight Loss
An Adipocyte-Driven Mechanism For Weight Regain After Weight Loss: The Yo-Yo Effect
Almost half of the Dutch population is currently characterized by overweight and obesity. Losing weight is not the problem in obesity treatment, it is the seemingly obligatory weight regain after weight loss: the yoyo-effect.
- Conditions
- Obesity, Weight Loss, Diet
- Trial name
- ADIPOSTRESS (NCT01559415)
- Testing
- Meal replacement diet using Modifast, Normal diet combined with Modifast diet
- Where
- Netherlands
- Volunteers
- 58 people
- Sponsor
- Maastricht University Medical Center
Asthma, Obesity
Weight Loss for Uncontrolled Asthma Associated With Elevated BMI
Weight loss for uncontrolled asthma associated with elevated BMI. Asthma is a common condition with different types recognised that have variable responses to current treatments.
- Trial name
- NCT03858608
- Testing
- Counterweight Plus, Usual asthma care
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- NHS Greater Glasgow and Clyde
Body Weight Changes
Efficacy Of Trimrox On Body Recomposition And Weight Management (TRCAP21)
Protocol Number: VNI/121/TrimRox: A unique stimulant- and sugar-free TRCAP21 Prodosomed® nutraceutical formulation, TrimROXTM, has been developed in a cGMP and NSF-certified manufacturing facility that is CFR-111 A compliant as…
- Trial name
- VNI (NCT05283525)
- Testing
- Anthropometric Measurement of the Chest, Upper Arm/Bicep, Hips, Thighs and Waist/ Belly in Inches, Oxygen Saturation, Total Blood Chemistry
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Victory Nutrition International, Inc.
Obstructive Sleep Apnea
Weight Gain After CPAP Treatment in Patients With Obstructive Sleep Apnea
The purpose of this trial is to investigate the mechanisms leading to weight gain during CPAP treatment for obstructive sleep apnea (OSA).
- Trial name
- OSA (NCT03567317)
- Testing
- CPAP withdrawal
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Weight Loss, Obesity
Thermic Effect of Three Different Meals in Healthy Women
This study will investigate the acute effect of three isocaloric meals varying in level of food processing, including a whole foods, gluten-free, and highly processed meal on energy metabolism and blood glucose in 8-12 young…
- Trial name
- NCT04440826
- Testing
- Whole Food Meal, Processed Food Meal, Gluten-free and lactose-free
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Breast Cancer, Body Weight Changes
A Nutritional Intervention and Physical Activity Program Reduce Body Weight in Women Newly Diagnosed With Breast Cancer.
To evaluate a nutritional intervention for women newly diagnosed with breast cancer on a weight control and physical activity program.
- Conditions
- Breast Cancer, Body Weight Changes, Weight Loss, Nutrition Related Cancer
- Trial name
- NCT04980118
- Testing
- Control group, Nutrition and physical activity group
- Where
- Spain
- Volunteers
- 56 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Diarrhea, Malnutrition
Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development
Malnutrition is considered one of the most prevalent risk factors for morbidity and mortality in children under five. An estimated 20% of children in the developing world are malnourished [1] and poor nutrition is linked to more…
- Conditions
- Diarrhea, Malnutrition, Stunting, Wasting
- Trial name
- MAL-ED (NCT02441426)
- Where
- 8 sites in Bangladesh, Brazil and 6 more
- Volunteers
- 1,796 people, healthy volunteers welcome
- Sponsor
- Foundation for the National Institutes of Health
Obesity, Obesity; Drug
Long-term Effectiveness of the Antiobesity Medication Phentermine
The purpose of this research study is to understand the long-term effects of the drug phentermine on weight, blood pressure, other health outcomes, and safety.
- Conditions
- Obesity, Obesity; Drug, Lifestyle, Healthy
- Trial name
- LEAP (NCT05176626)
- Testing
- Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG
- Where
- 4 sites in United States
- Volunteers
- 870 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Weight Change Trajectory
Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide
Fractyl is evaluating Revita Duodenal Mucosal Resurfacing (DMR) in the REMAIN-1 pivotal study, which is designed to include two cohorts - an open label cohort referred to as REVEAL-1, and a randomized cohort, which includes both…
- Conditions
- Obesity, Weight Change Trajectory, Weight Change, Body
- Trial name
- REMAIN-1 (NCT06484114)
- Testing
- Revita Duodenal Mucosal Resurfacing (DMR)
- Where
- 32 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fractyl Health Inc.
Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia
Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer
The goal of this clinical trial is to learn if a combination treatment of a hormonal intrauterine device (LNG-IUD), semaglutide, and a structured weight loss program can treat endometrial atypical hyperplasia or grade 1…
- Conditions
- Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Cancer Stage I, Endometrial Cancer
- Trial name
- SWIFT (NCT07820358)
- Testing
- Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- The Methodist Hospital Research Institute
Prediabetes, Obesity / Overweight
Very-Low-Carbohydrate Diet for Prediabetes and Obesity
Prediabetes is a condition where blood sugar is higher than normal but not yet high enough to be called type 2 diabetes. It is common in adults who are overweight or obese, and without treatment it often progresses to diabetes…
- Conditions
- Prediabetes, Obesity / Overweight, VERY LOW CARBOHYDRATE DIET
- Trial name
- VLCBD (NCT07830121)
- Testing
- Standard Dietary Advice, Very-Low-Carbohydrate Diet (VLCBD)
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- Universiti Teknologi Mara
Type1diabetes, Obesity
Tirzepatide Use in People With Obesity and Type 1 Diabetes
Tirzepatide, a gut hormone-based medication, has shown promising results in treating obesity, with ~22% weight loss and mild side effects.
- Trial name
- NCT07096908
- Testing
- Tirzepatide
- Where
- Kuwait
- Volunteers
- 60 people
- Sponsor
- Dasman Diabetes Institute
Type I Diabetes
Obesity and Metabolic Surgery in Patients With Type I Diabetes
Obesity is the indication for bariatric surgery in type I diabetes. Interestingly postsurgery the patients improve remarkable in their need for insulin, not only in the daily total insulin dosage but also in the dosage of IU per…
- Trial name
- NCT02612493
- Testing
- Obese patients with type I diabetes
- Volunteers
- 16 people
- Sponsor
- Sana Klinikum Offenbach
Obesity
Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight
Phase 2, multicenter, randomized, double-blind, placebo-controlled study evaluating once-weekly subcutaneous retatrutide (LY3437943) at multiple maintenance dose levels versus placebo in adults with obesity or overweight with…
- Trial name
- GZBF (NCT07467447)
- Testing
- Retatrutide (LY3437943), Standardized diet and physical activity counseling throughout the study.
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Hudson Biotech