Clinical trials: Weight Changes, Body
Pompe Disease, Muscle Loss
Nutritional Therapy in Late-onset Pompe Disease
RATIONALE: Pompe disease (PD) is a recessive genetic disorder wherein the body cannot break down glycogen due to a mutation in the acid alpha glucosidase (GAA) gene, which encodes for acid alpha-glucosidase.
- Conditions
- Pompe Disease, Muscle Loss, Obesity, Nutrition Poor
- Trial name
- PDT-MIS (NCT06130228)
- Testing
- Multi-ingredient supplement (PDT-MIS)
- Volunteers
- 28 people
- Sponsor
- McMaster University
Overweight and Obesity, Inhibition, Psychological
Inhibitory Control Training for Excess Weight: Behavioural, Cognitive and Anthropometric Changes
People with excess weight (EW) are characterized by high impulsivity, high levels of craving for high-calorie foods, deficits in inhibitory control, and maladaptive decision-making.
- Trial name
- InhibeT (NCT06600100)
- Testing
- Inhibitory control training
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Raquel Vilar López
Psychotic Disorders
Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics
This study will test the effectiveness of two different treatments for children and adolescents who have gained weight on their antipsychotic medications.
- Trial name
- IMPACT (NCT00806234)
- Testing
- Aripiprazole or Perphenazine, Metformin, Olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone, paliperidone, or olanzapine/fluoxetine
- Where
- 4 sites in United States
- Volunteers
- 127 people
- Sponsor
- Johns Hopkins University
Genetics, Taste, Altered
Genetics of Bitter and Fat Taste
Obesity is an increasing problem for adults in the UK. Diets high in fat and sugar are the major contributors to weight gain. Individual differences in taste perception are a crucial factor in determining the investigator's…
- Conditions
- Genetics, Taste, Altered, Diet Habit, Obesity
- Trial name
- NCT04038281
- Testing
- Sensory tests
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St Mary's University College
Obesity
The Effect of a Structured Weight-loss Programme on the Metabolic Profiles of Obese and Overweight Children
Aim: The overall aims of this study to look at what changes are seen overweight and obese (very overweight) children, as they get thinner.
- Trial name
- NCT02608398
- Testing
- no intervention
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Imperial College London
Body Weight Changes
Effect of the Administration of L-Carnitine on Body Weight in Women in Crossfit Training
The L-carnitine has demonstrated effects in the treatment of obesity mainly promoting the fat degradation during exercise.
- Trial name
- NCT03436277
- Testing
- L-Carnitine, Sucralose
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Morbid Obesity
Glucose Homeostasis Pre and Post Bariatric Surgery
The investigators wish to study the effects of three forms of bariatric surgery: Roux-en-Y gastric bypass, Sleeve Gastrectomy, and Gastric Banding. The surgery is not part of the clinical trial.
- Trial name
- RB (NCT00981500)
- Testing
- gastric bypass, gastric banding, sleeve gastrectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Cachexia, NSCLC
Pilot Study of Safety and Tolerability of Nutrifriend Cachexia in NSCLC Cachexia
SF-C002 is a pilot study in patients with newly diagnosed NSCLC suffering from involuntary weight loss. The study is 12 weeks, double-blinded, placebo controlled and the main objective is to study the safety and tolerability of…
- Trial name
- NCT02515032
- Testing
- Nutrifriend Cachexia
- Where
- 14 sites in Croatia, Italy and 2 more
- Volunteers
- 56 people
- Sponsor
- Smartfish AS
Depression, Major Depressive Disorder
Diet and Depression
This study is a pilot open label crossover trial to assess the feasibility and acceptability of reducing ultra- processed foods (UPF) in a personalized manner from the diets of patients with major depressive disorder who eat a…
- Conditions
- Depression, Major Depressive Disorder, Weight Gain, Obesity
- Trial name
- NCT06252701
- Testing
- Reduction of Ultra-processed foods
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Cachexia; Cancer
A Phase I Clinical Study to Evaluate the Efficacy and Safety of GB18 Injection in Patients With Tumor Cachexia
KXZY-GB18-101(1B) is an extension of KXZY-GB18-101, a first-in-human, dose-escalation trial in healthy adult participants to evaluate the safety, tolerability, PK, PD, and immunogenicity of GB18.
- Trial name
- NCT07519564
- Testing
- GB18
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- Kexing Biopharm Co., Ltd.
Pre Diabetes, Polycystic Ovary Syndrome
Liraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
There is a growing need to develop pharmacologic interventions to improve metabolic function in women with polycystic ovary syndrome (PCOS).
- Conditions
- Pre Diabetes, Polycystic Ovary Syndrome, Obesity Android
- Trial name
- SAXAPCOS (NCT03480022)
- Testing
- Liraglutide Pen Injector [Saxenda]
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Woman's
Nutrition, Healthy, Body Weight Changes
Evaluation of the Impact of the Consumption of Plant-derived Protein Supplements Compared to Animal-derived Proteins
The goal of the study is to evaluate how the consumption of plant-based protein supplements compares to animal-based protein supplements in terms of their effects on metabolic state and body composition in individuals who engage…
- Trial name
- NCT06610253
- Testing
- Protein
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Warmia and Mazury in Olsztyn
Weight Loss
Risk Management Plan (RMP) Survey for Purchasers of Alli® (60 mg Orlistat) in the European Union.
Following results from the first survey that forms part of the EU RMP for Alli® (RMP survey 1; WEUSRTP3350), several amendments to the information included on the pack carton for Alli® (orlistat 60 mg) were recommended.
- Trial name
- NCT02141230
- Testing
- Alli® 60 mg
- Sponsor
- GlaxoSmithKline
Knee Pain, Knee Osteoarthritis
The Effects of Bariatric Surgery Weight Loss on Knee Pain in Patients With Osteoarthritis of the Knee
This project is a prospective observational study that will involve the participation of 25 volunteers that qualify for having knee osteoarthritis, are going to be having gastric bypass surgery and are willing to participate in…
- Trial name
- NCT00752765
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Penn State University
Obesity, Weight Gain
Preventing Obesity in Military Communities, Adolescents
This research study is aimed at the prevention of excessive weight gain in female military dependents at high risk for adult obesity.
- Conditions
- Obesity, Weight Gain, Disordered Eating, Eating Disorder
- Trial name
- POMC-A (NCT02334202)
- Testing
- Interpersonal Psychotherapy-Weight Gain, Health Education
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cachexia, HIV Infections
A Phase I/II Study to Evaluate Single Agent and Combination Therapy With Megestrol Acetate and Dronabinol for the Treatment of HIV-Wasting Syndrome
To obtain data on the safety of administering megestrol acetate and dronabinol as single agents or in combination to patients with human immunodeficiency virus (HIV)-wasting syndrome.
- Conditions
- Cachexia, HIV Infections, HIV Wasting Syndrome
- Trial name
- NCT00000737
- Testing
- Dronabinol, Megestrol acetate
- Where
- 9 sites in United States
- Volunteers
- 56 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis, Overweight
Ultrasound Assessment of Rheumatoid Arthritis Patients Who Changed Diet
The purpose of this research study is to evaluate if a weight loss intervention will improve your rheumatoid arthritis disease activity.
- Trial name
- NCT02881307
- Testing
- Whey Protein&Prebiotic Supplement, Dietary Counseling, Dietary recommendations
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Veena Ranganath, MD, MS
Pancreatic Cancer, Neuroendocrine Tumors
Open Label Study to Analyze the Effect of Telotristat Ethyl on Weight Regulation/Gain
This single arm study will evaluate whether Xermelo (telotristat ethyl) associated weight gain is affects lean body mass, dietary intake, and physical and cognitive functioning among neuroendocrine tumor (NET) patients with a…
- Conditions
- Pancreatic Cancer, Neuroendocrine Tumors, Cachexia; Cancer
- Trial name
- NCT04034745
- Testing
- telotristat ethyl
- Sponsor
- Andrew Hendifar, MD
Weight Loss, Bariatric Surgery Candidate
Liraglutide Effectiveness in Preoperative Weight-loss for Bariatric-metabolic Surgery
Severe obesity is associated with considerable reduction of wellbeing and life expectancy. People living with severe obesity tend to die 8 to 10 years earlier.
- Conditions
- Weight Loss, Bariatric Surgery Candidate, Obesity, Morbid
- Trial name
- NCT06201819
- Testing
- Liraglutide injection
- Where
- Mexico
- Volunteers
- 37 people
- Sponsor
- Hospital Civil Juan I. Menchaca
Obesity
Testing Strategies for Weight Loss, II
In the pilot study, Testing Strategies for Weight Loss, we tested two different approaches using financial incentives to encourage weight loss.
- Trial name
- NCT00739492
- Testing
- financial incentives
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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