Clinical trials: Weight Changes
Healthy Lifestyle, Overweight
Deaf Weight Wise: Community-engaged Implementation Research to Promote Healthy Lifestyle Change With Deaf ASL Users
The purpose of the Deaf Weight Wise Implementation Study is to study with diverse partners the approaches and strategies that lead to successful implementation of Deaf Weight Wise (DWW), an evidence-based healthy lifestyle…
- Conditions
- Healthy Lifestyle, Overweight, Obesity, Cardiovascular Risks
- Trial name
- NCT05211596
- Testing
- Deaf Weight Wise intervention
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Obesity
BLOSSOM: Behavioral Modification and Lorcaserin Second Study for Obesity Management
The purpose of this study is to assess the weight loss effect of lorcaserin during and at the end of 1 year of treatment in overweight and obese patients.
- Trial name
- NCT00603902
- Testing
- Lorcaserin 10 mg once daily (QD), Lorcaserin 10 mg twice a day (BID)
- Where
- United States
- Volunteers
- 4,008 people
- Sponsor
- Eisai Inc.
Maternal Obesity, Gestational Weight Gain
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
Obesity is a serious and increasing health problem in the Western World with about one third of all pregnant women in Denmark being overweight. Among these are more than 11% severe obese.
- Conditions
- Maternal Obesity, Gestational Weight Gain, Obstetric Complications
- Trial name
- LiP (NCT00530439)
- Testing
- Lifestyle intervention, Control, Physical activity, dietetic counselling
- Where
- Denmark
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Obesity
Rural Engagement in Primary Care for Optimizing Weight Reduction
The purpose of this study is to compare three methods for managing obesity in rural patients, to see which method will result in patients being able to attain their weight loss goal and maintain that weight loss.
- Trial name
- RE-POWER (NCT02456636)
- Testing
- Fee-for-Service Model (FFS, In clinic individual visits), Patient Centered Medical Home (PCMH, In clinic group visits), Disease Management (DM, Phone group visits)
- Where
- United States
- Volunteers
- 1,432 people
- Sponsor
- University of Kansas Medical Center
Type 2 Diabetes Mellitus
Effect on Weight Loss of Exenatide Versus Placebo
This trial is designed to compare the effects of twice-daily exenatide and twice-daily placebo on weight loss. This trial will evaluate overweight and obese subjects with type 2 diabetes who have inadequate glycemic control with…
- Trial name
- NCT00375492
- Testing
- exenatide
- Where
- 10 sites in United States
- Volunteers
- 196 people
- Sponsor
- AstraZeneca
Obesity, Overweight
A Study of LY3437943 in Participants Who Have Obesity or Are Overweight
This is a study of LY3437943 in participants who have obesity or are overweight. The main purpose is to learn more about how LY3437943 affects body weight loss. The study will last about 18 months and may include up to 18 visits.
- Trial name
- NCT04881760
- Testing
- LY3437943
- Where
- 28 sites in United States, Puerto Rico
- Volunteers
- 338 people
- Sponsor
- Eli Lilly and Company
Diabetes, Gestational, Gestational Weight Gain
Meals for Moms: Medically-Tailored Meals for Women Who Had Gestational Diabetes
The purpose of this research study is to test whether delivery of medically tailored meals (meals designed specifically to be healthy) can be used to help reduce high blood sugar after delivery of a baby.
- Conditions
- Diabetes, Gestational, Gestational Weight Gain, Postpartum Weight Retention
- Trial name
- NCT04866823
- Testing
- Medically Tailored Meals
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Schizophrenia, Schizoaffective Disorder
Lifestyle Intervention for Young Adults With Serious Mental Illness
This is a four year project evaluating the effectiveness of a group-based lifestyle intervention (PeerFIT) supported by mobile health (mHealth) technology and social media compared to Basic Education in fitness and nutrition…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depressive Disorder
- Trial name
- NCT02815813
- Testing
- PeerFIT, BEAT
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Obesity, Cardiovascular Disease
Effectiveness of Four Popular Diet Strategies for Weight Loss and Cardiac Risk Reduction
A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia.
- Conditions
- Obesity, Cardiovascular Disease, Metabolic Syndrome
- Trial name
- NCT02454127
- Testing
- Atkins Diet, Zone Diet, Weight Watchers Diet
- Volunteers
- 160 people
- Sponsor
- Tufts Medical Center
Severe Obesity
Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity
Long-term weight loss maintenance is seldom achieved by individuals with obesity owing to numerous biological adaptations involving appetite, satiety, and energy expenditure in the post- weight loss setting.
- Trial name
- NCT02496611
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Schizophrenia
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
The study investigates the use of Atomoxetine in combination with exercise and a diet support group (Weight Watchers)to treat weight gain associated with Olanzapine or clozapine.
- Trial name
- NCT00176436
- Testing
- Diet support group, Group counseling and exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Binge Eating Disorder, Overweight and Obesity
Neural Response to Food Stimuli: fMRI Changes Following Cognitive Behavioral Therapy for Binge Eating Disorder
The purpose of this research is to conduct a randomized controlled trial (RCT) assessing the impact of CBT on neural responses to binge eating stimuli.
- Trial name
- NCT03604172
- Testing
- Cognitive behavioral therapy, Waitlist
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity, Metabolic Surgery
Qsymia as an Adjunct to Surgical Therapy in the Superobese
This study tests the efficacy of the medication, Qsymia, as an adjunct therapy in superobese individuals planning to undergo weight loss surgery.
- Conditions
- Obesity, Metabolic Surgery, Weight Loss, Bariatric Surgery Procedures
- Trial name
- NCT02301416
- Testing
- Phentermine/topiramate, low calorie diet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Weight Loss
Weight Loss Study-Mechanism Underlying the Improvement of Insulin Resistance in Response to Weight Loss
The main purpose of this study is to assess factors mediating the changes in insulin sensitivity and glucose tolerance before and after 10 lbs ± or 2% weight loss reduction as well as 2, 3, 6, 12, and 24 months after initiation…
- Trial name
- NCT01780870
- Testing
- Weight loss group (Full meal replacement products)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Morbid Obesity
Bariatric Embolization of Arteries for the Treatment of Obesity
The purpose of this study is evaluate the safety and effectiveness of bariatric embolization as a minimally-invasive image-guided procedure for morbid obesity.
- Trial name
- BEAT Obesity (NCT02165124)
- Testing
- Artificial Embolization Device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Weight Gain, Obesity
The GEM (Goals for Eating and Moving) Study
The GEM intervention leverages the patient-centered medical home model by using the GEM tool to provide individually tailored, patient-centered care, promote standardized weight management counseling by health coaches and primary…
- Trial name
- GEM (NCT03006328)
- Testing
- GEM, Enhanced Usual Care
- Where
- United States
- Volunteers
- 489 people
- Sponsor
- NYU Langone Health
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Gestational Weight Gain, Diet, Healthy
Implementation of a Mediterranean Diet Program for Overweight or Obese Pregnant Women in a Low-resource Clinical Setting
The purpose of this Pilot randomized clinical Trial is to compare two healthy diet styles during pregnancy. Patients between 8 and 16 weeks of gestation who agree to participate will be randomly assigned (like flipping a coin) to…
- Trial name
- MedDiet (NCT05868954)
- Testing
- MedDiet Program, ACOG-based Dietary Program
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Obesity, Pain
PDA+: A Personal Digital Assistant for Obesity Treatment
The purpose of this study is to determine whether including a PDA decision support tool plus distance support enhances the outcomes attainable by the MOVE2! (Managing Obesity for Veterans Everywhere) standard care alone.
- Trial name
- PDA+ (NCT00371462)
- Testing
- Use of PDA + support to reduce weight and pain, MOVE! level 2 group weight loss counseling
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- VA Office of Research and Development
Obesity
Spatz Adjustable Balloon for Obesity (SABO)
The purpose of this study is to determine whether the Spatz3 Adjustable balloon, a non-surgical device, is effective in the treatment of obesity.
- Trial name
- SABO (NCT02812160)
- Testing
- Spatz3 Adjustable Balloon
- Where
- 7 sites in United States
- Volunteers
- 288 people
- Sponsor
- Spatz FGIA, Inc