Clinical trials: Weight Loss Maintenance, open to volunteers
Obesity and Obesity-related Medical Conditions, Obesity and Overweight
MAINTAIN (Mucosal AblatIoN Therapy After INcretins)
The purpose of this study is to assess the effect of gastric fundal mucosal ablation (GFMA) on weight trajectory following discontinuation of once-weekly semaglutide or tirzepatide in adults with obesity.
- Conditions
- Obesity and Obesity-related Medical Conditions, Obesity and Overweight, Obesity Prevention, Obesity Recidivism
- Trial name
- MAINTAIN (NCT06734312)
- Testing
- Gastric Fundal Mucosal Ablation (GFMA)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dr. Christopher McGowan
Obesity
Effect of GLP-1 Receptor Agonists on Body Composition in Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance
This study investigates how weight-loss medications, specifically GLP-1 receptor agonists, affect body composition, with a special focus on preserving muscle mass in adults with obesity.
- Trial name
- LEAN-PRO GLP-1 (NCT07495904)
- Testing
- High Protein Dietary Intervention, Control (Standard Mediterranean Diet Counseling)
- Where
- 2 sites in Greece
- Volunteers
- 130 people
- Sponsor
- Hellenic Mediterranean University
Obesity & Overweight
A Randomized Controlled Study of Dose-tapering Regimen of Semaglutide for Weight-Loss Maintenance in Adults With Overweight or Obesity
The goal of this clinical trial is to determine whether a semaglutide dose-tapering regimen is non-inferior to a treatment-dose maintenance regimen for weight-loss maintenance in adults with overweight or obesity who have…
- Trial name
- NCT07783854
- Testing
- Semaglutide Dose-Tapering Regimen, Semaglutide Maintenance-Dose Regimen
- Volunteers
- 72 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Weight Loss, Weight Regain
Testing a Tailored Approach to Long-Term Weight Loss Success
The purpose of this study is to develop and test an adaptive, individually tailored intervention to prevent weight regain in people who have intentionally lost weight.
- Conditions
- Weight Loss, Weight Regain, Obesity & Overweight
- Trial name
- NCT07577765
- Testing
- Adaptive weight regain prevention
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Cardiovascular Diseases, Cardiac Rehabilitation
SMART to Optimize an Intervention to Maintain Health Improvements After Cardiac Rehabilitation
The study is sponsored by the National Heart, Lung, and Blood Institute, which is part of the National Institutes of Health. The study expects to enroll 400 subjects.
- Trial name
- EMPOWER ME (NCT06886789)
- Testing
- Text Messaging, Fully Automated Online Program, Low-Intensity Cardiac Rehabilitation Maintenance Program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The Miriam Hospital
Overweight and Obesity
Control Systems Engineering for Weight Loss Maintenance
This project capitalizes on principles of control systems engineering to build a dynamical model that predicts weight change during weight loss maintenance using behavioral, psychosocial, and environmental indicators evaluated in…
- Trial name
- NCT06244888
- Testing
- Intervention Targeting Stress and Emotion Regulation, Intervention Targeting Motivation and Self-efficacy for Weight Management, Intervention for Normalization of Eating
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- The Miriam Hospital
Chronic Insomnia, Overweight/Obesity
Cognitive Behavioral Therapy for Insomnia as an Adjunct to Time-restricted Eating on Weight Loss in Adults With Overweight or Obesity and Chronic Insomnia
Obesity (being overweight due to excess body fat) is a common health condition that increases the risk of developing problems such as diabetes, high blood pressure, and heart disease.
- Trial name
- NCT07770516
- Testing
- Flexible Time-restricted eating group (FTRE), Flexible Time-restricted eating plus cognitive behavioural therapy for insomnia group (CBTI+FTRE)
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Overweight , Obesity, Adults
Study to Assess the Effect and Safety of ALV-100 on Maintenance of Weight Loss
A study of ALV-100 to assess efficacy, safety and tolerability among participants with overweight or obesity who have previously achieved a body weight reduction of ≥10% while treated with incretin-based therapies.
- Trial name
- PRESERVE (NCT07837973)
- Testing
- ALV-100
- Where
- 20 sites in United States
- Volunteers
- 220 people
- Sponsor
- Alveus Therapeutics, Inc.
Obesity Prevention, Weight Change
Optimizing an Extended Care Intervention to Promote Weight Loss Maintenance
The purpose of this study is to find out what combination of components, if any, offers the best support for keeping weight off after someone loses weight.
- Conditions
- Obesity Prevention, Weight Change, Weight Loss, Weight Loss Maintenance
- Trial name
- OPT-X (NCT06785064)
- Testing
- Reduced Food Variety (RFV), Home-based Resistance Training (HBRT), Buddy Training and Support (BTS)
- Where
- United States
- Volunteers
- 544 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity & Overweight, Weight Loss Maintenance
Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?
So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime.
- Trial name
- DIET-SLIM (NCT07711548)
- Testing
- NutriAct plus, Rescue VLCD
- Volunteers
- 292 people
- Sponsor
- Knut Mai
Breast Cancer, Insomnia
The Effects of Treating Insomnia on Behavioral Weight Loss Outcomes in Survivors of Breast Cancer
The investigators propose a randomized controlled clinical trial in 250 women with a history of early stage breast cancer who are overweight or obese with insomnia to test whether a brief, cognitive-behavioral intervention for…
- Conditions
- Breast Cancer, Insomnia, Weight Gain
- Trial name
- COIN (NCT05780814)
- Testing
- Cognitive-Behavioral Therapy for Insomnia (CBT-I), Sleep Education Control (EDU)
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Weight Loss, Weight Gain
Time Restricted Eating for WeIght LoSs MainTenance-2
The TWIST 2.0 Study is a 12-month, 2-arm RCT in adults with recent weight loss. We will examine the efficacy of TRE on weight (Aim 1a) and fat mass (Aim 1b) regain, and describe changes in subjective appetite following a…
- Conditions
- Weight Loss, Weight Gain, Weight Loss Maintenance
- Trial name
- TWIST-2 (NCT07190170)
- Testing
- TRE, Weight-Loss Maintenance Advice
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Obesity
Identification of Phenotypic Factors That Predict Success for Weight Loss and Long-term Weight Maintenance
The Investigational Weight Management Clinic now entitled the Weight Management Program at the University of Michigan was created to identify strategies that will result in cost-effective, long term weight management for…
- Trial name
- NCT02043457
- Testing
- phenotyping
- Where
- United States
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity & Overweight, Obesity & Overweight Sleep
Sleep Evaluation Before and After Metabolic Surgery
Obesity is frequently associated with sleep disturbances, including poor sleep quality, insomnia symptoms, daytime sleepiness, and obstructive sleep apnea.
- Conditions
- Obesity & Overweight, Obesity & Overweight Sleep, Sleep, Metabolic Surgery
- Trial name
- SLEEP-BAM (NCT07693491)
- Testing
- Primary Metabolic Surgery
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Obesity, Women (Between 30 to 60 Years Old)
Increased Dietary Protein Intake During GLP-1 Medication Use (in Middle-aged Women With Overweight/Obesity)
Middle-aged women with (overweight/)obesity who will begin or have begun GLP-1 medication use will be recruited to complete a 12-week diet intervention study.
- Trial name
- NCT07480109
- Testing
- Protein Rich Foods
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Overweight or Obesity; Type 2 Diabetes, Weight Loss Maintenance
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
This is a randomized controlled trial to compare the effect of AI-assisted multi-domain lifestyle and continued tirzepatide on body weight loss maintenance.
- Trial name
- NCT07555730
- Testing
- AI assisted multi-domain lifestyle intervention, Tirzepatide
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Huazhong University of Science and Technology
Obesity (Disorder), Bariatric Surgery
Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function
Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating…
- Trial name
- BariaGut Taste (NCT07268508)
- Testing
- Nutritional counseling
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Overweight, Obesity
Weight and Metabolic Management Study
The goal of this clinical trial is to learn whether elénzia CONTROL®, a nutritional supplement, can support weight management in adults who have either never used GLP-1 weight-loss medications or have recently stopped using them.
- Conditions
- Overweight, Obesity, Weight Maintenance
- Trial name
- WMMS (NCT07789223)
- Testing
- elénzia CONTROL®
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Elenzia
Weight Loss, GLP - 1
Scalable Behavioral Program for Weight Loss Maintenance After GLP-1 and Anti-Obesity Medication Discontinuation
This study is a single-site, pilot randomized factorial trial designed to evaluate the feasibility, acceptability, participant perceptions and preliminary effects of a multi-component behavioral intervention to support weight…
- Conditions
- Weight Loss, GLP - 1, Weight Loss Maintenance, Obesity & Overweight
- Trial name
- NCT07535892
- Testing
- Weight Loss Maintenance Program (Foundational), Mom's Meals, YMCA Membership
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Alabama at Birmingham
Obesity
Motivating Increases in Physical Activity for Prevention of Weight Regain After Metabolic Bariatric Surgery
The goal of this clinical trial is to learn if a psychological intervention can increase regular physical activity to help prevent weight regain after metabolic bariatric surgery in adults.
- Trial name
- NCT06484621
- Testing
- Acceptance and Commitment Therapy-Based Physical Activity Intervention, Physical Activity Education Control
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Hartford Hospital