Clinical trials: Weight Management
Obesity & Overweight, Weight Loss Maintenance
Can Two Dietary Interventions Maintain Weight Loss for 12 Months After GLP-1 Therapy in Adults With Overweight/Obesity?
So far, treatment with semaglutide (Wegovy) for therapy of obesity demonstrates substantial effects. However, most patients do not desire life-long pharmaceutical therapy or discontinue this treatment regime.
- Trial name
- DIET-SLIM (NCT07711548)
- Testing
- NutriAct plus, Rescue VLCD
- Volunteers
- 292 people
- Sponsor
- Knut Mai
Infant, Very Low Birth Weight
Oropharyngeal Administration of Colostrum to Very Low Birth Weight Infants
The purpose of this study is to explore the effects of Oropharyngeal administration of colostrum to very low birth weight infants on sIgA and lactoferrin, in order to explore the protect immune function of colostrum to very low…
- Trial name
- NCT02389478
- Testing
- Oropharyngeal administration of colostrums, Oropharyngeal administration of Normal saline
- Volunteers
- 64 people
- Sponsor
- Children's Hospital of Fudan University
Obesity
Intensive Weight Loss Intervention Versus Bariatric Surgery for Adults With Severe and Complex Obesity: the LightBAR Randomised Trial
With this trial, the aim is to assess the benefits and harms of a non-surgical intensive weight loss intervention that includes total dietary replacements, behavioural support and weight-loss medication compared with bariatric…
- Trial name
- LightBAR (NCT06309238)
- Testing
- Intensive weight loss intervention, Bariatric surgery
- Where
- 14 sites in Denmark, United Kingdom
- Volunteers
- 500 people
- Sponsor
- Carsten Dirksen
Obesity
Awareness, Care & Treatment In Obesity Management - An International Observation
The purpose of this survey is to collect the data on perceptions, behaviours and awareness related to obesity and obesity management for People with Obesity (PwO) and Health Care Professionals (HCP) treating obesity.
- Trial name
- ACTION-IO (NCT03584191)
- Testing
- No treatment given
- Where
- 9 sites in Australia, Israel and 7 more
- Volunteers
- 17,287 people
- Sponsor
- Novo Nordisk A/S
Body Weight
Effect of Coffee and Tea Consumption on Adolescent Weight Control
Introduction: The influence of tea or coffee supplementation on body weight in adolescents has never been tested. The aim of the present study was to investigate the effect of tea and coffee consumption on body weight and body…
- Trial name
- NCT05181176
- Testing
- Coffee, Green tea
- Where
- Israel
- Volunteers
- 63 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Obesity
Integrating Small Changes and Positive Psychology to Improve Treatment Readiness: A Weight Loss Trial
The study is designed to compare short- and long-term changes in body weight (kg) and subjective well-being in adult females with obesity who have been randomized to receive one of two 6-month treatment conditions: INSPIRE or…
- Trial name
- INSPIRE (NCT04487158)
- Testing
- Small Changes, INSPIRE
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Body Weight Changes, Overweight
Lifestyle Education for Activity and Nutrition for a Leaner You
Although weight loss programs are effective in the short-term, maintaining weight loss is more challenging. Regularly tracking and logging physical activity (PA) and diet is related to greater improvements in PA and diet and to…
- Trial name
- LEAN (NCT00957008)
- Testing
- Group weight loss program, Group weight loss program plus use of the Senseware Armband, Use of the senseware armband alone program
- Where
- United States
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Obesity
A Study to Learn How Different Amounts of the Study Medicine Danuglipron Are Taken up Into the Blood in Otherwise Healthy Adults With Overweight or Obesity
The purpose of this study is to learn the following about the study medicine, danuglipron, after multiple days of dosing in healthy adults who are overweight or obese: how the study medicine, danuglipron, is taken up into the…
- Trial name
- NCT06568731
- Testing
- Danuglipron
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls
Teenagers and adults who are overweight or obese have an increase in fat in the abdomen, which increases their risk for diabetes and heart disease.
- Trial name
- NCT01169103
- Testing
- recombinant human growth hormone (rhGH)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Child Nutrition Disorders, Malnutrition
Community Based Management of Severe Malnutrition in Tribal Area of Melghat- Cluster Randomized Control Field Trial
Provision of community based health care to severely malnourished children (Age group: 6 months through 5 years) in 16 tribal villages by trained semi-literate village health workers. 1.
- Trial name
- SAMMAN (NCT02671786)
- Testing
- MAHAN RUTF & MAHAN Vit-Min mix
- Where
- India
- Volunteers
- 824 people
- Sponsor
- MAHAN Trust
Obesity and Obesity-related Medical Conditions
Precision Nutrition Technologies for Obesity Management
The implementation of this project will develop and apply precision health dietary solutions tailored for weight management in China's obese population, establishing a precision nutrition intervention model.
- Trial name
- NCT07101133
- Testing
- Control group: Energy-limited balanced diet group
- Volunteers
- 600 people
- Sponsor
- Yuan He
Obesity
PATHWEIGH: Pragmatic Weight Management in Primary Care
The study examines patient weight loss and maintenance, associated predictors (patient health characteristics and demographics), and contextual factors in the practice environment that influence the intervention's adoption…
- Trial name
- NCT04678752
- Testing
- Weight management care path, Control
- Where
- 64 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- University of Colorado, Denver
Physical Disability, Obesity
Healthy Weight and Stress Management Study
Approximately 1 in 10 mid-life (age 35-64) Americans have mobility impairing disabilities. People with mobility impairing disabilities are defined using the World Health Organization criteria: community living adults with…
- Conditions
- Physical Disability, Obesity, Muscle Weakness, Anxiety
- Trial name
- NCT05279989
- Testing
- Seated Tai Chi Qigong, Health Information Videos
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Arizona State University
Obesity
Extension of the 5As Team Study for Improved Provider Obesity Management to Physicians and Medical Trainees (Part 2)
Results from the 5As Team (5AsT) Study have identified critical gaps in medical school curricula on obesity, leading to a wave of new family physicians who lack confidence and are poorly equipped to manage obesity with their…
- Trial name
- 5AsT-MD2 (NCT02648308)
- Testing
- Obesity Management Workshop
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Obesity
Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over
This study aims to find out how well a combination of oral azelaprag taken once a day (QD) or twice a day (BID), along with a weekly injection of tirzepatide, works for weight management in adults 55 years and older.
- Trial name
- STRIDES (NCT06515418)
- Testing
- Oral Azelaprag (BGE-105), Tirzepatide
- Where
- 14 sites in United States
- Volunteers
- 204 people
- Sponsor
- BioAge Labs, Inc.
Overweight , Obesity, Weight Loss
Retrospective Continuous Glucose Monitor (CGM) Study on Glycemic Response and Body Composition in College Students
This retrospective study evaluates the real-world effect of individualized glycemic response-guided dietary management, based on continuous glucose monitoring (CGM), on weight and body composition in overweight and obese…
- Trial name
- RCSOGRABCICS (NCT07818005)
- Where
- China
- Volunteers
- 59 people
- Sponsor
- He Eye Hospital
Longevity, Quality of Life
Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures
The goal of this clinical study has two objectives. The Primary Objective is to evaluate the effectiveness of microdosed GLP-1 receptor agonists in improving measures of health, quality of life, and longevity.
- Conditions
- Longevity, Quality of Life, Mood, Inflammation
- Trial name
- NCT07092605
- Testing
- GLP-1
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Healthy
Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BI 653048 BS H3PO4 Capsule Assessing Endotoxin-induced Inflammatory Response in Healthy Male Subjects
The general aim of the current study was to investigate the safety and tolerability, and pharmacodynamics (endotoxin-induced inflammatory response of a single intravenous bolus administration of 2 ng/kg body weight Escherichia…
- Trial name
- NCT02224105
- Testing
- BI 653048 BS, Prednisolone low, Prednisolone high
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Obesity
Sleep Deprivation and Energy Balance
Observational and epidemiological studies have found a link between obesity and short sleep duration with the prevalence of both increasing in the past decades.
- Trial name
- Sleep (NCT00935402)
- Testing
- Sleep
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Diabetes Mellitus, Type 2, Obesity
Sleeve Gastrectomy Versus Medical Management for Remission of Diabetes in Mild to Moderately Obese Patients
The investigators plan to randomize mild to moderately obese (BMI 30-34.9) subjects to medical management (diet, exercise, and best medical therapy) versus sleeve gastrectomy with medical management, with a primary endpoint of…
- Trial name
- NCT00965302
- Testing
- Laparoscopic sleeve gastrectomy, Intensive medical management
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- 59th Medical Wing