Clinical trials: Whipple Procedure
Reflux Esophagitis
Incidence of Reflux Esophagitis After Pancreaticoduodenectomy
Reflux esophagitis is a common complication following distal gastrectomy. According to the investigators preliminary data, an Roux-en--Y gastrointestinal reconstruction in pancreaticoduodenectomy is associated with higher rates…
- Trial name
- NCT01311908
- Testing
- Methods of gastrojejunostomy reconstruction
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Cancer, Common Bile Duct Diseases
A Prospective Clinical Study Using an Artery-first Intermediate Approach in Robot-assisted Pancreaticoduodenectomy
Pancreaticoduodenectomy, as a standard surgical procedure for malignant tumors of the head of the pancreas, ampulla and distal common bile duct, has brought the hope of clinical cure for these diseases.In the whole surgical…
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05660915
- Testing
- Intermediate approach, Standard approach
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of University of South China
Pancreatic Cancer
Standardization of Surgery on the Pancreatic Cancer
This study was designed to test the hypothesis that more extensive nodal and soft-tissue clearance in patients with adenocarcinoma of the head of the pancreas would improve survival without an increase in morbidity and mortality.
- Trial name
- NCT00679913
- Testing
- Standard pancreatoduodenectomy, Extended pancreatoduodenectomy
- Where
- South Korea
- Volunteers
- 244 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer
Post-operative Drainage After Pancreaticoduodenectomy
The study compares regular use of surgical drains and no use of surgical drains in patients subjected to pancreaticoduodenectomy with expected low to intermediate risk for post operative pancreatic fistula.
- Trial name
- Drain 1 (NCT05270564)
- Testing
- Drain, No drain
- Where
- 2 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Linkoeping University
Laparoscopic Pancreaticoduodenectomy
Establishment and Application of an Artificial Intelligence Algorithm for Automatic Identification of Intraoperative Bleeding During Laparoscopic Pancreaticoduodenectomy
Surgeons will label surgical videos of laparoscopic pancreaticoduodenectomy with bleeding information from multicenter. The labeled surgical video will be used as training material to train the algorithmic model so as to build an…
- Trial name
- NCT06172062
- Testing
- laparoscopic pancreaticoduodenectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xinrui Zhu，MD
Postoperative Acute Pancreatitis, Pancreaticoduodenectomy
Clinical and Economic Validation of the ISGPS Definition of PPAP
This prospective validation study aims to investigate the incidence of PPAP after pancreaticoduodenectomy (PD) by applying the ISGPS definition and grading system, to demonstrate its clinical impact by examining associated…
- Conditions
- Postoperative Acute Pancreatitis, Pancreaticoduodenectomy, Postoperative Pancreatic Fistula, Postoperative Complications
- Trial name
- ISGPS-PPAP (NCT05680623)
- Testing
- PPAP diagnosis
- Where
- Italy
- Volunteers
- 2,900 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreatic Adenocarcinoma, Pancreatic Head Cancer
Superior Mesenteric Artery First Versus Standard Approach in Pancreaticoduodenectomy
"Pancreatic cancer, especially pancreatic ductal adenocarcinoma, is one of the most serious and deadly cancers. Its outlook is very poor, with fewer than 10% of patients surviving five years after diagnosis.
- Trial name
- EQUINOXE (NCT07547033)
- Testing
- SMA-first pancreaticoduodenectomy using either right posterior or anterior approach. SMA identified and isolated with peri-adventitial dissection before any irreversible section., Conventional pancreaticoduodenectomy without prior isolation of the SMA; antero-posterior approach of the uncinate process after pancreatic section.
- Where
- 23 sites in France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatectomy, Pancreatoduodenectomy
Twenty Years of Pancreatic Surgery in Iceland
A retrospective analysis of patients undergoing pancreatic operations in Landspitali University Hospital, Reykjavik, Iceland, between 2003 and 2022.
- Conditions
- Pancreatectomy, Pancreatoduodenectomy, Distal Pancreatectomy (DP)
- Trial name
- NCT06738914
- Volunteers
- 244 people
- Sponsor
- Linkoeping University
Resectable Pancreatic Head Neoplasm, Resectable Periampullary Neoplasm
Economisation of Whipple Resection Using an Ultrasonic Dissection Device
Including 150 randomised patient, the studies aim is to determine whether an economisation and/or improvement in terms of operating time, drainage fluid, blood loss, time of hospitalisation can be found using an ultrasonic…
- Conditions
- Resectable Pancreatic Head Neoplasm, Resectable Periampullary Neoplasm, Chronic Pancreatitis
- Trial name
- NCT01321450
- Where
- 3 sites in Germany, Greece and 1 more
- Volunteers
- 82 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pancreaticoduodenectomy, Nasogastric Tube Decompression
Omitting Nasogastric Tube Decompression in Minimally Invasive Pancreaticoduodenectomy
This study will evaluate two perioperative nasogastric tube strategies in patients undergoing laparoscopic pancreatoduodenectomy.
- Conditions
- Pancreaticoduodenectomy, Nasogastric Tube Decompression, Minimally Invasive Surgical Procedures
- Trial name
- NCT07370116
- Testing
- nasogastric tube decompression, Omission of nasogastric tube decompression
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pancreatic Fistula
Effects of Intraarterial Octreotide on Pancreatic Texture
The aim of the study is to test the hypothesis that intraarterial bolus application of 500 µg Octreotide in the gastroduodenal artery during the resectional phase of pancreatoduodenectomy in patients with soft pancreatic tissue…
- Trial name
- NCT01400100
- Testing
- Intraarterial application of Octreotide, sterile NaCl (sodium chloride) 0,9% solution
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- St. Josef Hospital Bochum
Pancreatic Neoplasms, Bile Duct Neoplasms
Evaluation of Isolated Roux-en-Y Reconstruction After Pancreaticoduodenectomy
The purpose of this study is to evaluate the incidence of complications with the isolated Roux-en-Y reconstruction after pancreaticoduodenectomy in pancreatic tumor and periampullary tumor patients.
- Conditions
- Pancreatic Neoplasms, Bile Duct Neoplasms, Ampullary Neoplasms, Duodenal Neoplasms
- Trial name
- NCT00915863
- Testing
- Billroth-II-type reconstruction, Isolated Roux-en-Y type reconstruction
- Where
- Japan
- Volunteers
- 150 people
- Sponsor
- Wakayama Medical University
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
Resectable Lesions Located in the Pancreatic Head or Periampullary Region
Laparoscopic Pancreatoduodenectomy Versus Open Pancreatoduodenectomy
This is a single, retrospective, real-world study to investigate the surgical outcomes of minimally invasive pancreatoduodenectomy and open pancreatoduodenectomy, with the perioperative characteristics and long-term overall…
- Trial name
- NCT05520606
- Testing
- pancreatoduodenectomy
- Volunteers
- 800 people
- Sponsor
- Tongji Hospital
Locally Advanced Malignant Neoplasm
Chemoimmunotherapy and Radiation in Pancreatic Cancer
The goal of this study is to evaluate the safety of combination treatment that includes chemotherapy, radiation therapy, and immunotherapy in patients with pancreatic cancer.
- Trial name
- CRIT (NCT01903083)
- Testing
- Tadalafil, Gemcitabine, Radiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Providence Health & Services
Pancreatic Carcinoma, Surgery
The Comparision of Minimally-invasive and Open Pancreaticoduodenectomy for Pancreatic Cancer
Minimally invasive pancreaticoduodenectomy remains one of the most challenging abdominal procedures. Safety and feasibility remain controversial when comparing minimally-invasive with open pancreaticoduodenectomy, especially for…
- Trial name
- MIOPP (NCT03747588)
- Testing
- Minimally-invasive pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Cancer, Cancer of the Duodenum
Early Oral Versus Enteral Nutrition After Pancreatoduodenectomy
Pancreatoduodenectomy carries high morbidity rates even in high-volume centers. Postoperative complications often preclude or delay adequate oral nutrition and nutritional support may be required.
- Conditions
- Pancreatic Cancer, Cancer of the Duodenum, Cholangiocarcinoma, Chronic Pancreatitis
- Trial name
- NCT01642875
- Testing
- Enteral nutrition, Oral nutrition
- Where
- Poland
- Volunteers
- 96 people
- Sponsor
- Medical University of Warsaw
Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein
Postoperative Pancreatic Fistula in Patients Undergoing Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality.
- Conditions
- Pancreatic Fistula After Pancreaticoduodenectomy, C-Reactive Protein, Albumin
- Trial name
- popf (NCT06300801)
- Testing
- Is the preoperative c-reactive protein/albumin ratio successful in predicting postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy?
- Where
- 2 sites in Turkey (Türkiye)
- Sponsor
- Erol Olcok Corum Training and Research Hospital
Hospital Stay
Effect of Incentive Spirometer and Pursed Lip Breathing After Whipple Procedure.
Whipple procedure is one of the most complex surgeries among hepatobiliary surgeries. It has named as Pancreaticoduodenectomy. It can cause many PPCs. Lung volumes are reduced due to atelectasis and pneumonia.
- Trial name
- NCT06460584
- Testing
- Pursed Lip Breathing, Incentive Spirometer
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Pancreatic Cancer, Adult, Margin, Tumor-Free
Usefulness of the Artery First Approach in Pancreatic Cancer Surgery
This study is aimed to evaluate difference of the 2 year recurrence free survival after pancreaticoduodenectomy for pancreatic cancer between artery-first approach and conventional procedure groups.
- Conditions
- Pancreatic Cancer, Adult, Margin, Tumor-Free, Surgery Site Fistula, Recurrence Tumor
- Trial name
- NCT04136522
- Testing
- conventional pancreaticoduodenectomy, total mesopancreas excision including superior mesenteric artery first approach
- Where
- South Korea
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center