Clinical trials: Whipple Procedure
Pancreatic Fistula
One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy
The aim of this study is to investigate a new pancreaticojejunal (PJ) anastomosis procedure named "One-layer duct-to-mucosa pancreaticojejunostomy" in pancreatoduodenectomy, which could provide a feasible option to pancreatic…
- Trial name
- NCT02511951
- Testing
- pancreaticojejunostomy
- Where
- China
- Volunteers
- 114 people
- Sponsor
- The Second Hospital of Anhui Medical University
Periampullary Tumors
Impact of Prophylactic Octreotide to Pancreatic Exocrine Secretion
This study aims to examine whether octreotide has an effect on inhibition of the exocrine secretion fo the pancreas, which might lower the rate of postoperative pancreatic fistula after pancreatoduodenectomy.
- Trial name
- NCT02920567
- Testing
- Octreotide
- Where
- South Korea
- Volunteers
- 282 people
- Sponsor
- Saint Vincent's Hospital, Korea
Surgical Site Infection
Efficacy of NPWT in Reducing the Incidence of Wound Infection After Pancreatic Surgery
A disposable negative wound pressure device will be compared to standard sterile wound dressing in reducing the rate of wound infection after clean-contaminated surgical procedures on biliary tract and pancreas in patients at…
- Trial name
- NCT03700086
- Testing
- Disposable negative wound pressure device (PICO), OPsite post-op visible standard sterile dressing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Pancreaticoduodenectomy, Diabetes
Effect of More Distal Enteral Bypass After Pancreaticoduodenectomy: A Prospective Multicenter Randomized Clinical Trial
Pancreaticoduodenectomy (PD) includes en bloc resection of duodenum, head of pancreas, proximal jejunum, distal common bile duct (CBD), gallbladder, and distal stomach, which was followed by complicated reconstructions.
- Trial name
- NCT01755273
- Testing
- Pancreaticoduodenectomy with more distal enteral bypass
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Pancreatic Cancer
Gemcitabine and Radiation Therapy Compared With Gemcitabine Alone in Treating Patients Who Have Undergone Surgery for Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00064207
- Testing
- gemcitabine hydrochloride, adjuvant therapy, radiation therapy
- Where
- 59 sites in Belgium, France and 4 more
- Volunteers
- 97 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Pancreatoduodenectomy
Neck Division Level and Postoperative Pancreatic Fistula After Pancreaticoduodenectomy
Brief Summary:* Aim of the study : To evaluate if the neck division level significantly influences the postoperative pancreatic fistula rate of pancreatico-jejunal anastomosis after pancreatoduodenectomy.
- Trial name
- PaNECK (NCT03850236)
- Where
- France
- Volunteers
- 196 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Tumor, Bile Duct Tumor
Additional Effects of Perioperative Immunonutrition in Patients Undergoing Pancreaticoduodenectomy
The purpose of this study is to investigate whether perioperative immunonutrition has additional effects on cell-mediated immunity in patients undergoing pancreaticoduodenectomy.
- Trial name
- NCT01969110
- Testing
- Oral IMPACT
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Chiba University
Laparoscopic Pancreaticoduodenectomy
Extended Pancreatic Neck Transection Versus Conventional Pancreatic Neck Transection During Laparoscopic Pancreaticoduodenectomy( LPDEXCEPT)
The investigators conduct the clinical randomized controlled trial to evaluate the superiority of extended pancreatic neck transection during laparoscopic pancreaticoduodenectomy (LPD).
- Trial name
- LPDEXCEPT (NCT05808894)
- Testing
- extended pancreatic neck transection during laparoscopic pancreaticoduodenectomy
- Where
- China
- Volunteers
- 154 people
- Sponsor
- Xinrui Zhu，MD
Duodenal Diverticulization, Pyloric Exclusion
National Retrospective Study of Duodenal Trauma
Duodenal injuries remain rare among abdominal trauma, concerning less than 5 % of cases. However, due to its central location, it is most commonly associated with multiple organs lesions, with the main three organs being the…
- Conditions
- Duodenal Diverticulization, Pyloric Exclusion, Gastrojejunostomy, Retrograde Duodenostomy
- Trial name
- TRAUMADUOD (NCT06058975)
- Testing
- Observational
- Where
- France
- Volunteers
- 135 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Pancreatic Ductal Adenocarcinoma
Survival Among Patients With Pancreatic Cancer Depending on Surgical Resection Rate
The primary aim of this population-based study is to investigate how a high resection rate of pancreaticoduodenectomy affects overall survival among patients aged ≥70 years with pancreatic ductal adenocarcinoma.
- Trial name
- NCT04802993
- Testing
- Resection rates
- Volunteers
- 5,123 people
- Sponsor
- Linkoeping University
Pancreatoduodenectomy
Early Oral Feeding for Patients After Pancreaticoduodenectomy
This study intends to retrospectively analyze the patients who underwent pancreatoduodenectomy and compare the safety and feasibility between early enteral nutrition through nasojejunal tube and early oral feeding after…
- Trial name
- NCT05573399
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Changhai Hospital
Pancreaticoduodenectomy
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the standard treatment for tumors of the pancreatic head, distal bile duct, duodenum, and ampulla of Vater.
- Trial name
- NCT06322680
- Testing
- Main pancreatic duct and biliary duct external drainage, Main pancreatic duct and biliary duct internal drainage
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Zhongshan Hospital
Pancreatic Disease, Pancreatic Neoplasms
Early (4 Days) Versus Standard Drainage of the Abdominal Cavity After Pancreaticoduodenectomy
Around two thousand pancreaticoduodenectomy (PD) are performed each year in France. This intervention is associated with a high rate of postoperative complications including: pancreatic fistulas (PF); surgical site infections…
- Trial name
- DRAINAGE DPC (NCT01368094)
- Testing
- Drain removal at D4, Standard drain removal
- Where
- 5 sites in France
- Volunteers
- 141 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pancreaticoduodenectomy
Comparison of Chen's U-suture Technique with Duct-to-Mucosa Anastomosis and Invagination Pancreaticojejunostomy After Pancreaticoduodenectomy
Data of patients treated with pancreaticoduodenectomy in 21 hospitals from January 2014 to December 2019 were retrospectively collected and classified to Chen's group, duct-to-mucosa group and invagination group according to…
- Trial name
- NCT06863389
- Testing
- Chen's U-suture technique, invagination, Duct-to-Mucosa
- Volunteers
- 5,788 people
- Sponsor
- Chen Xiaoping
Pancreas Disease, Fistula Pancreatic
Prevention of CR-POPF in PD With the Technique of Connexion the Pancreatic Duct to Jejunum Stented (CONDUCTJE-ST).
Objective: To assess the efficacy of the "connexion pancreatic duct to jejunum stented (CONDUCTJE-ST)" technique to prevent clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreaticoduodenectomy (PD).
- Trial name
- CONDUCTJE-ST (NCT04898517)
- Testing
- Pancreaticoduodenectomy with the CONDUCTJE-ST technique
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Pancreatic Exocrine Insufficiency, Pancreatic Enzyme Replacement Therapy
The Effect of PERT on Patients Undergoing Pancreaticoduodenectomy
A comprehensive perioperative nutrition management plan for pancreaticoduodenectomy, primarily based on pancreatic enzyme replacement therapy (PERT).
- Conditions
- Pancreatic Exocrine Insufficiency, Pancreatic Enzyme Replacement Therapy, Pancreaticoduodenectomy
- Trial name
- NCT06119880
- Testing
- Pancreatin Enteric-coated Capsules, Routine treatment plan
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ruijin Hospital
Distal Cholangiocarcinoma
Minimally Invasive Pancreatoduodenectomy for Distal Cholangiocarcinoma
Outcomes for minimally invasive and open pancreatoduodenectomy for distal cholangiocarcinoma have not been compared. This is an international multicenter propensity score matched cohort study including patients after MIPD or OPD…
- Trial name
- NCT05478889
- Testing
- Minimally invasive pancreatoduodenectomy
- Where
- Italy
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Periampullary Carcinoma, Pancreatic Fistula
Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complication in Patients Undergoing Pancreatoduodenectomy
Despite the fact that pancreatoduodenectomy is the standard treatment of malignant tumor at periampullary area, the morbidity and mortality rate with intra-abdominal collection, post pancreatectomy hemorrhage, and delayed gastric…
- Trial name
- NCT03083938
- Testing
- Omental Roll-up
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Pancreatic Cancer, Common Bile Duct Diseases
A Multicenter Prospective Randomized Controlled Study of RPD Versus LPD
laparoscopic pancreaticoduodenectomy(LPD) and Robot Pancreaticoduodenectomy (RPD), as two minimally invasive methods of pancreaticoduodenectomy(PD), have obvious advantages over traditional open pancreaticoduodenectomy(OPD) in…
- Conditions
- Pancreatic Cancer, Common Bile Duct Diseases, Periampullary Carcinoma
- Trial name
- NCT05755607
- Testing
- laparoscopic pancreaticoduodenectomy, Robot Pancreaticoduodenectomy
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of University of South China
Pancreas Neoplasm, Neuroendocrine Tumors
Portal Vein Resection in Pancreatic Neuroendocrine Tumours
The limited evidence on the value of portal vein resection in patients with borderline resectable and/or locally advanced PanNENs is an incentive to carry out a retrospective multicentre study amongst centres with specific…
- Trial name
- PVNET (NCT04336839)
- Testing
- Portal vein resection / reconstruction
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Royal Free Hospital NHS Foundation Trust