Clinical trials: Whipple Procedure
Hepatopancreaticobiliary (HPB) Malignancy, Gall Bladder Cancer
Outcomes and Prognostic Factors in Hepatopancreatoduodenectomy
1. In biliary tract malignancies, achieving a microscopically clear resection margin (R0) is considered the only treatment for a cure. 2.
- Conditions
- Hepatopancreaticobiliary (HPB) Malignancy, Gall Bladder Cancer, Bile Duct Cancer, Pancreatoduodenectomy
- Trial name
- HPD_single (NCT06631352)
- Testing
- Hepatopancreatoduodenectomy
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer, Bile Duct Cancer
Trial on the Evaluation of Pylorus-ring in Pancreaticoduodenectomy
The purpose of this study is to clarify whether resecting pylorus-ring decreases delayed gastric emptying after pancreaticoduodenectomy and improves postoperative quality of life (QOL).
- Conditions
- Pancreatic Cancer, Bile Duct Cancer, Ampullary Cancer, Duodenal Cancer
- Trial name
- NCT00639314
- Testing
- pylorus-preserving pancreaticoduodenectomy, pylorus-resecting pancreaticoduodenectomy
- Where
- Japan
- Volunteers
- 130 people
- Sponsor
- Wakayama Medical University
Pancreatic Cancer, Anemia
Efficacy of Ferric Carboxymaltose (Ferinject®) in Anemic Patients Anticipating Pancreatoduodenectomy
This phase II study is to evaluate the safety and efficacy of Ferinject® in reducing perioperative transfusion in iron deficiency anemia patients anticipating pancreatoduodenectomy.
- Trial name
- FCM (NCT02628860)
- Testing
- Ferinject (Ferric Carboxymaltose)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- National Cancer Center, Korea
Pancreatic Cancer, Malnutrition
Whipple Protein Study
Study investigators aim to assess the effect of providing high-protein nutritional supplementation before and after surgery
- Trial name
- WPS (NCT04306874)
- Testing
- Ensure Max Protein
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Thomas Jefferson University
Pancreatic Neoplasms
Single-centre Propensity Score-matched Comparison of Laparoscopic Versus Open Pancreatoduodenectomy
Minimally invasive pancreatoduodenectomy is increasingly performed. However, technical challenges and a perceived higher risk of complications has hindered wide adoption of a minimally invasive approach.
- Trial name
- PSMLOPD (NCT05110573)
- Testing
- pancreatoduodenectomy
- Where
- Belgium
- Volunteers
- 172 people
- Sponsor
- General Hospital Groeninge
Pancreatic Fistula
Total pancrEaTectomy vs High-Risk Pancreatic anastomosiS
Postoperative pancreatic fistula (POPF) is the main driver of surgical morbidity after pancreatoduodenectomy (PD). The aim of the present study is to compare total pancretectomy (TP) and primary pancreatic anastomosis (PA) in a…
- Trial name
- TETRIS (NCT05212350)
- Testing
- Total pancreatectomy, Pancreatic anastomosis
- Where
- 5 sites in Germany, Italy
- Volunteers
- 98 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Borderline Resectable Pancreatic Cancer
Laparoscopic Versus Open Pancreatoduodenectomy Following Neoadjuvant Chemotherapy for BRPC
The aim of this study is to evaluate the safety and efficacy of laparoscopic versus open pancreatoduodenectomy following neoadjuvant chemotherapy for borderline resectable pancreatic cancer
- Trial name
- NCT04855331
- Testing
- Laparoscopic pancreatoduodenectomy, Open pancreatoduodenectomy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Pancreatic Fistula
Risk Factors for Post Whipple Pancreatic Fistula
Postoperative pancreatic fistula (POPF) following pancreaticoduodenectomy is considered a life-threatening complication. This study was designed to analyze the risk factors for development of such fistula in a tertiary care…
- Trial name
- NCT05014425
- Testing
- pancreaticoduodenectomy
- Volunteers
- 96 people
- Sponsor
- Assiut University
Periampullary Carcinoma Resectable
New Technique of End-to-Side Two-Layered Duct-to-Mucosa Pancreaticojejunostomy With Omental Wrapping and Glue (Glubran 2) During Laparoscopic Whipple Operation
Following pancreaticoduodenectomy, omental flaps around the pancreatic anastomosis and adhesive glue can lower the risk of pancreatic fistula, post-pancreatectomy bleeding, and delayed gastric emptying.
- Trial name
- NCT07333755
- Testing
- Pancreaticojejunostomy without omental patch, Pancreaticojejunostomy with omental patch and glue
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Theodor Bilharz Research Institute
Pancreatic Fistula
Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula
For periampullary and pancreatic head disorders, pancreaticoduodenectomy (PD) is the standard treatment. However, PD is technically demanding and has high morbidity and mortality rates.
- Trial name
- NCT05687825
- Testing
- pancreaticoduodenectomy procedure
- Where
- Egypt
- Volunteers
- 107 people
- Sponsor
- South Valley University
Infection, Bacterial
Colonization of Bile Ducts and Infectious Complications in Cephalic Duodenopancreatectomy
Cephalic duodenopancreatectomy is part of the curative treatment for pancreatic cancer of the head and peri-ampullary area. The mortality of the procedure is around 5%, with a morbidity ranging from 30 to 50%.
- Trial name
- NCT04555252
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Pancreatic Head Neoplasm, Delayed Gastric Emptying
Nasogastric Decompression Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) remains the gold-standard operation for peri-ampullary neoplasms. Traditionally, gastric decompression via nasogastric intubation has been employed postoperatively to prevent nausea, vomiting…
- Conditions
- Pancreatic Head Neoplasm, Delayed Gastric Emptying, Post Operative Ileus, Whipple Procedure
- Trial name
- whipple (NCT06413888)
- Testing
- pancreaticoduodenectomy
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Baylor College of Medicine
Pancreaticoduodenectomy
The Effect of Perioperative DEXamethasone on Postoperative Complications After PANcreaticoduodenectomy
The primary objective of this clinical trial is evaluate the effect of dexamethasone on postoperative complications after pancreaticoduodenectomy.
- Trial name
- PANDEX (NCT05567094)
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
Pancreas; Fistula
Impact of Highest Drain Fluid Amylase Levels on Surgical Outcomes and Postoperative Interventions in Patients Undergoing Pancreaticoduodenectomy
This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF.
- Trial name
- NCT04448795
- Volunteers
- 600 people
- Sponsor
- Chang Gung Memorial Hospital
Pancreatic Cancer
Randomized Trial of Restrictive Versus Liberal Perioperative Fluid Management for Patients Undergoing Pancreatic Resection
The purpose of this study is to help us learn what the best amount of fluid is that patients should receive during pancreas surgery.
- Trial name
- NCT01058746
- Testing
- restrictive perioperative fluid management, Liberal perioperative fluid management
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pancreas Cancer, DVT
Pharmacokinetics of Apixaban in Patients Undergoing Pancreaticoduodenectomy
Study investigators will examine the absorption characteristics of apixaban, a direct-acting oral anticoagulation, in patients who have underwent a particular kind of surgery (pancreaticoduodenectomy) which involves resection of…
- Conditions
- Pancreas Cancer, DVT, Pulmonary Embolism
- Trial name
- PAP-UP (NCT04191928)
- Testing
- Apixaban
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Thomas Jefferson University
Delayed Gastric Emptying
Quality of Life and Nutritional Status After Two Surgical Techniques in Pancreatoduodenectomy
This was a randomized unblinded single-centre trial. The main hypothesis of the study was that pylorus-preserving pancreatoduodenectomy reduces the incidence of delayed gastric emptying .
- Trial name
- QUANUPAD (NCT03984734)
- Testing
- Pancreatoduodenectomy with antrectomy, Pylorus-preserving pancreatoduodenectomy
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari de Bellvitge
Terlipressin, Blood Loss
Terlipressin Infusion During Whipple Procedure: Effect on Blood Loss and Transfusion Needs
The present study aims to look at the effect of terlipressin infusion on blood loss and blood transfusion needs during Whipple procedure
- Trial name
- NCT03572088
- Testing
- Terlipressin, normal saline
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pain Management, Pain, Postoperative
Intrathecal Morphine Injection Versus Continuous Wound Infiltration After Pancreaticoduodenectomy
This is a prospective randomized open-label noninferiority trial that compares intrathecal morphine injection and continuous wound infiltration after open pancreaticoduodenectomy.
- Trial name
- ITM_PPPD (NCT06761989)
- Testing
- Intrathecal morphine injection, Continuous wound infiltration
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Seoul National University Hospital
Delirium in Old Age
Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Robot-assisted Pancreaticoduodenectomy: a Randomized Controlled Study
To observe the effect of intraoperative dexmedetomidine on the incidence of postoperative delirium, postoperative analgesic drug requirements and pain scores in elderly patients undergoing robot-assisted pancreaticoduodenectomy.
- Trial name
- NCT05274789
- Testing
- Dexmedetomidine, Saline
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chinese PLA General Hospital