Clinical trials: White Blood Cells
Cystic Fibrosis, Pulmonary Exacerbation
Cystic Fibrosis (CF) Leukocyte Genes as Biomarkers for Novel Therapies
Presently, effectiveness of treatments for CF lung disease is judged by improvement in lung function (FEV1). However, in CF patients, FEV1 can range from severely decreased to normal, and improvements may occur slowly.
- Trial name
- NCT00727285
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Jewish Health
Fever, Sweats, and Hot Flashes, Infection
Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia
RATIONALE: Levofloxacin may be effective in reducing fever and controlling other symptoms of neutropenia in patients who are being treated for cancer.
- Conditions
- Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma
- Trial name
- NCT00020865
- Testing
- cefepime hydrochloride, levofloxacin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Aging, Skin Laxity
Association of Leucocyte Telomere Length With DPAS Score in Skin Aging
The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length The main questions of Research are: what is the profile of photoaging based on clinical…
- Trial name
- NCT06501547
- Testing
- Leucocyte Telomere Length from blood draw
- Where
- 3 sites in Indonesia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Dr.dr.Irma Bernadette, SpKK (K)
HIV Infections
The Effects of Zidovudine on the Blood of HIV-Infected Patients
To define the pharmacokinetic parameters (blood levels) of total phosphorylated zidovudine (AZT) in peripheral blood mononuclear cells (PBMC) from HIV-infected patients.
- Trial name
- NCT00000965
- Testing
- Zidovudine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cancer Childhood, Febrile Neutropenia
Clusterin, Ptx3 and Pediatric Febrile Neutropenia (CluPPFeN)
Febrile aplasia is a common occurrence in children/adults treated with chemotherapy for malignant blood diseases or solid cancers.
- Trial name
- CluPPFeN (NCT05584930)
- Testing
- Collection of blood sample
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Angers
Eosinophilic Disorder, Food Allergy
Gastrointestinal STRING Test With Oral Immunotherapy
This STRING study will examine markers of esophageal inflammation using a minimally-invasive testing device, the esophageal string test (EST).
- Trial name
- STRING (NCT04943744)
- Testing
- Entero-tracker, omalizumab, dupliumab
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Eosinophilic Esophagitis
Exhaled Nitric Oxide as a Biomarker of Disease Activity in Eosinophilic Esophagitis
There is currently no reliable, noninvasive biomarker for eosinophilic esophagitis (EoE), a chronic allergic diseases characterized by significant infiltration of eosinophils in the esophagus.
- Trial name
- NCT01170234
- Testing
- NIOX MINO® Airway Inflammation Monitor
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Tufts Medical Center
Human Leukocyte Antigens (HLA)
Clinical Protocol SeCore, uTYPE and 3500 Dx System
The purpose of this study is to compare the Invitrogen SeCore(R) sequencing system and uTYPE(R) interpretation software to the predicate device Invitrogen SSP UniTray(R) with UniMatch(R) interpretation software and show 95%…
- Trial name
- NCT01285427
- Volunteers
- 300 people
- Sponsor
- Life Technologies Corporation
Bone Marrow Failure Syndromes, Erythrocyte Disorder
Investigation of the Genetics of Hematologic Diseases
The purpose of this study is to collect and store samples and health information for current and future research to learn more about the causes and treatment of blood diseases.
- Conditions
- Bone Marrow Failure Syndromes, Erythrocyte Disorder, Leukocyte Disorder, Hemostasis
- Trial name
- NCT02720679
- Where
- United States
- Volunteers
- 1,716 people
- Sponsor
- St. Jude Children's Research Hospital
Kidney Transplant Rejection
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
This is a randomized, open-label, controlled clinical trial designed to compare clinical outcomes after kidney transplantation using extended-release tacrolimus (Envarsus XR) versus immediate tacrolimus among highly-sensitized…
- Trial name
- NCT04225988
- Testing
- Extended-release tacrolimus, Immediate-release tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Leukemia
Total-Body Irradiation Plus Stem Cell Transplantation And White Blood Cell Infusion in Treating Older Patients With Acute Myeloid Leukemia
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by radiation therapy used to kill tumor cells.
- Trial name
- NCT00005801
- Testing
- therapeutic allogeneic lymphocytes, peripheral blood stem cell transplantation, radiation therapy
- Where
- 2 sites in United States
- Sponsor
- University of Colorado, Denver
Asthma; Eosinophilic, Severe Asthma
Efficacy of Mepolizumab in Severe Asthmatics on a Long Term (MESILICO)
Interleukin (IL)-5 is the main cytokine responsible for the activation of eosinophils, hence therapeutic strategies have been investigated and developed for clinical use.
- Conditions
- Asthma; Eosinophilic, Severe Asthma, Late-Onset Asthma
- Trial name
- MESILICO (NCT04612556)
- Testing
- Mepolizumab 100 MG [Nucala]
- Where
- Greece
- Volunteers
- 45 people
- Sponsor
- Aristotle University Of Thessaloniki
Renalase(rs10887800) Genotyping & Leucocytes Telomere Length in Patients With Postpartum Hypertension
Renalase(rs10887800) Genotyping & Leucocytes Telomere Length in Postpartum. Hypertension
This is an observertional study aimed at Study the association between Renalase(rs10887800) Genotyping \& Leucocytes telomere length in patients with postpartum hypertension whether new onset( denovo) or persistent following…
- Trial name
- NCT06500351
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Sohag University
Eosinophilic Asthma, EGPA - Eosinophilic Granulomatosis With Polyangiitis
Prospective Registry of Eosinophilia With Respiratory Manifestations With Translational Research Identifying and Characterizing Eosinophils
Introduction: The etiology and therapy of eosinophilic lung diseases are still poorly understood. For individual forms of disease, such as eosinophilic asthma or eosinophilic granulomatosis with polyangiitis (EGPA), new…
- Conditions
- Eosinophilic Asthma, EGPA - Eosinophilic Granulomatosis With Polyangiitis, Samter Triad, HES - Hypereosinophilic Syndrome
- Trial name
- PROMETHEos (NCT04538937)
- Testing
- no intervention
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Chemotherapy, Neutropenia
Garlic in Patients With Febrile Neutropenia
To determine the clinical effects of garlic in preventing and treatment of patients with chemotherapy related febrile neutropenia.These patients have a very high incidence of infections which are not routinely covered by the…
- Trial name
- NCT00247039
- Testing
- Solgar Israel
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Hadassah Medical Organization
Eosinophilic Esophagitis
New Serological Markers for Eosinophilic Esophagitis
The purpose of the study is to investigate if serological parameters such as "extracellular Serum-Tryptase (ST)" and "eosinophilic cationic protein (ECP)" are useful for the diagnosis and surveillance of the eosinophilic…
- Trial name
- NCT01624129
- Testing
- Fluticasone
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Technical University of Munich
Eosinophilic Asthma
AD17002 Treating Poorly Controlled, Moderate to Severe Eosinophilic Asthma
This clinical trial aims to investigate patients with poorly controlled, moderate to severe eosinophilic asthma. The main questions it seeks to answer are 1.
- Trial name
- NCT05985694
- Testing
- AD17002
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Advagene Biopharma Co. Ltd.
Osteo Arthritis Knee
Intraarticular Leukocyte-rich and Leukocyte-poor PRP for Osteoarthritis of the Knee
To compare the efficacy of intraarticular knee injection between leukocyte-rich and leukocyte-poor platelet-rich plasma in knee osteoarthritis treatment
- Trial name
- PRP (NCT05737173)
- Testing
- Leukocyte-rich platelet-rich plasma, Leukocyte-poor platelet-rich plasma, Corticosteroid
- Where
- Thailand
- Volunteers
- 93 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Breast Cancer, Neutropenia
Placebo-controlled Trial of F-627 in Women With Breast Cancer Receiving Myelotoxic Chemotherapy
This is a randomized, double-blind and placebo controlled phase 3 study to evaluate the efficacy and safety of F-627 in women with stage II-IV breast cancer receiving chemotherapy treatment.
- Trial name
- NCT02872103
- Testing
- F-627
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- EVIVE Biotechnology
Severe Eosinophilic Asthma
Patient Reported Outcomes in Adults With Severe Eosinophilic Asthma on Benralizumab.
This study will generate patient reported outcomes (PROs) associated with the use of benralizumab as treatment for severe eosinophilic asthma.
- Trial name
- POWER (NCT03833141)
- Testing
- Survey Administration
- Where
- 20 sites in Canada
- Volunteers
- 170 people
- Sponsor
- AstraZeneca