Clinical trials: White Spot Lesion
Tooth Demineralization, White Spot Lesion
Comparison of a 3-step Bonding System (Transbond™ XT) and a 2-step System (GC Ortho Connect™) on Demineralization Around Maxillary Orthodontic Brackets
White spot lesions (WSLs) are one of the most common adverse effects of fixed orthodontic treatments, affecting up to 97% of patients treated with labial appliances.
- Conditions
- Tooth Demineralization, White Spot Lesion, Demineralization, Orthodontic Appliance Complication
- Trial name
- ORTHOCOLLAGE (NCT07355322)
- Testing
- Transbond™ XT bonding procedure, GC Ortho Connect™ bonding procedure
- Where
- France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Montpellier
White Spot Lesion of Tooth
Effect of Different Pastes on Remineralization of Early Caries Lesions in Primary Teeth
This study is a randomized controlled trial involving 118 children ages between 4 and 5 years to assess the remineralization effect of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in primary…
- Trial name
- NCT03526276
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
White Spot Lesion
Remineralization Potential of Pearl Powder Compared to CPP-ACP on Enamel White Spot Lesions
The aim of this study is to evaluate the remineralization potential of pearl powder on early ('white spot') lesions in enamel in orthodontic patients compared to casein phosphopeptide-amorphous calcium phosphate.
- Trial name
- NCT03976583
- Testing
- Cpp-Acp, Pearl powder
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Crowding, Tooth; Lesion, White Spot Lesions
Comparison Of Different Orthodontic Aligner Systems Applied On Single Stage And Three Stage
Applying to the Orthodontics Department of the Faculty of Dentistry of Erciyes University for orthodontic treatment, a periodontally healthy 16-26 year-old periodontally healthy, non-congenital or congenital anomaly in the…
- Trial name
- NCT04678596
- Testing
- EonAligner, Clearfix
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
White Spot Lesion of Tooth
Clinical Outcomes, Cost-Effectiveness and Patient Satisfaction of Two Resin Infiltration Systems for The Management of White Spot Lesions
The aim of this study is to clinically evaluate and compare the color matching of white spot lesions (WSLs) following treatment with two resin infiltration systems: ICON resin infiltration and I-Mate resin infiltration.
- Trial name
- NCT07799350
- Testing
- light cured low viscosity resin infiltration
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions, Dental Plaque
AI-Generated WhatsApp Reminders vs. No Reminders: Impact on Oral Health in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of artificial intelligence-generated WhatsApp reminders on improving oral hygiene practices among individuals aged 20-40 years visiting the periodontal clinic at…
- Conditions
- White Spot Lesions, Dental Plaque, Oral Hygiene, Oral Health
- Trial name
- NCT06897033
- Testing
- Health education followed by AI-generated Whatsapp reminders, Oral Health Education
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Malaligned Teeth, Crowding of Teeth
Effect of Different Adhesive Systems on White Spot Lesions During Fixed Orthodontic Treatment
The primary goal of this study is to compare the number of white spot lesions during fixed appliance therapy between self-etch and one-step bonding systems.
- Trial name
- NCT07753512
- Testing
- Self-etch adhesive, One-Step Adhesive, Conventional Bonding Technique
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Tooth; Lesion, White Spot Lesions
Resin Infiltratration on the Sealing of Proximal Early Caries
Material for caries prevention dont have better results compared with non-operatory interventions.
- Trial name
- NCT01659463
- Testing
- ICON, instruction oral hygiene
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Dental Caries Tooth Demineralization, Post-Orthodontic Esthetic Defects
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth.
- Trial name
- NCT07146464
- Testing
- Self-Assembling Peptide P11-4 Self-Assembling Peptide P11-4 is a biomimetic material applied topically to white spot lesions on the enamel. It diffuses into the lesion body and forms a three-dimension
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Ain Shams University
White Spot Lesions
One Year Clinical Evaluation of White Spot Lesions Treated With Newly Introduced Resin Modified Glass Ionomer in Comparison to Resin Infiltration in Anterior Teeth Split Mouth Technique
The aim of this study is to evaluate the addition of new technology of resin modified glass-ionomer in comparison to resin infiltration in treating post-orthodontic white spot lesions; both applies into the same patient's mouth…
- Trial name
- NCT02912741
- Testing
- Vanish xt Extended Contact Varnish, resin infiltration
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Cairo University
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Caries,Dental, Remineralization
Remineralization Efficacy of Gum Arabic Varnish.
The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.
- Conditions
- Caries,Dental, Remineralization, White Spot Lesion
- Trial name
- NCT04422860
- Testing
- Gum Arabic varnish, Proflourid Varnish,VOCO, MI Varnish,GC Japan Inc.
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions
Remineralization Potential of Ginger and Rosemary Herbals Versus Sodium Fluoride in Treatment of White Spot Lesions
To evaluate the effectiveness of ginger and rosemary herbals versus sodium fluoride in remineralization of incipient enamel caries.
- Trial name
- NCT03990935
- Testing
- ginger and rosemary gel
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Tooth Demineralization
Study of Treatments Used for White Spot Lesions After Orthodontic Treatment.
The purpose of this study is to learn more about the management of white spot lesions that occur after orthodontic treatment. White spot lesions generally improve slightly with time.
- Trial name
- NCT01059058
- Testing
- MI Paste Plus, PreviDent Fluoride Varnish, Normal Home Care
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Washington
Prevention of White Spot Lesions
the Remineralizing Self-Assembling Peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride White Spot Lesions
The aim of the current study is to compare the remineralizing ability of Self-assembling peptide P11-4, 2% Arginine Enriched Sodium Fluoride and Functionalized Tri Calcium Phosphate Fluoride varnishes in treatment of white spot…
- Trial name
- NCT05127889
- Testing
- curodont
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
White Spot Lesion
Remineralization Potential of Bioactive Varnish
This randomized controlled trial is held to investigate the effectiveness of two remineralizing agents surface pre-reacted glass-ionomer (S-PRG) filler and fluoride in management of white spot lesions.
- Trial name
- NCT07602660
- Testing
- S-PRG barrier coat, Profluorid Varnish
- Volunteers
- 60 people
- Sponsor
- Future University in Egypt
White Spot Lesion
White Spot Lesions Treatment in Orthodontic
The study aims to investigate the effectiveness of a new treatment for demineralized white spot lesions (WSLs) after fixed appliance therapy.
- Trial name
- WSL (NCT06051981)
- Testing
- 5% sodium fluoride, Intensive 5% sodium fluoride, Casein Phosphopeptide-Amorphous Calcium Phosphate
- Volunteers
- 88 people
- Sponsor
- Riyadh Elm University
Demineralisation, White Spot Lesions
A Trial of Tooth Mousse to Remineralise Post-orthodontic Treatment White Spot Lesions
Fixed dental braces are associated with the risk of developing White Spot Lesions (WSLs), which appear as white chalky marks on the teeth.
- Conditions
- Demineralisation, White Spot Lesions, Orthodontic Treatment
- Trial name
- NCT01344473
- Testing
- Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
- Where
- 2 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- University of Dundee
Dental Caries
Remineralizing Efficacy of Grape Seed Extract in Management of White Spot Lesion in Post Orthodontic Treated Patients.
This clinical trial will be conducted to compare the efficacy of grape seed extract oil versus sodium fluoride mouth wash in the management of remineralization in adult patients with white spot lesion over six months.
- Trial name
- NCT04357093
- Testing
- Grape seed extract mouthwash, Sodium fluoride mouthwash
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University