Clinical trials: Withdrawal
Infant Social Withdrawal, Maternal Postnatal Depression
Copenhagen Infant Mental Health Project: Enhancing Parental Sensitivity and Attachment (CIMHP)
Infant mental health is a significant public health issue as early adversity and expose to childhood stress has life-long consequences for the affected children.
- Trial name
- CIMHP (NCT02497677)
- Testing
- Circle of Security -Parenting, Care as Usual
- Where
- Denmark
- Volunteers
- 314 people
- Sponsor
- University of Copenhagen
Idiopathic Hypersomnia
A Phase 3 Study to Assess the Safety and Efficacy of Pitolisant in Adult Patients With Idiopathic Hypersomnia
The primary objective of this study is to evaluate the safety and efficacy of pitolisant compared with placebo in treating excessive daytime sleepiness (EDS) in participants with idiopathic hypersomnia (IH) age ≥18 years.
- Trial name
- NCT05156047
- Testing
- Open-label Pitolisant, Double-blind Pitolisant
- Where
- 58 sites in United States
- Volunteers
- 214 people
- Sponsor
- Harmony Biosciences Management, Inc.
Major Depressive Disorder
Ovarian Hormone Withdrawal, Anhedonia, and Reward Sensitivity in Women With Premenstrual Exacerbations of Depression
The goal of this clinical trial is to learn how hormonal changes over the menstrual cycle affect mood symptoms in reproductive-aged women with depression that worsens during the premenstrual period.
- Trial name
- PEAR (NCT06610305)
- Testing
- Transdermal estradiol, Progesterone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of North Carolina, Chapel Hill
Cannabis Dependence
Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal
Cannabis dependence is associated with changes in the brain's cannabinoid system. When cannabis dependent individuals try to quit using cannabis, some of them experience problems that make it difficult for them to achieve and…
- Trial name
- NCT01618656
- Testing
- PF-04457845
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Yale University
Type 1 Diabetes, Diabetic Ketoacidosis
Study to Explore the Effect of Dapagliflozin and Stress in Adolescent and Adult Subjects With Type 1 Diabetes (T1D)
Type 1 Diabetes is characterized by an absolute lack of insulin caused by autoimmune ß-cell destruction. Looking for different therapeutic approaches, beyond the administration of Insulin SGLT-Inhibitors (SGLT=sodium-glucose…
- Trial name
- Dapa-Stress (NCT04234867)
- Testing
- Dapagliflozin, Stress
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Kinderkrankenhaus auf der Bult
Cystic Fibrosis, Drug Withdrawal
Qualitative Understanding of Experiences With the SIMPLIFY Trial
This qualitative longitudinal study is designed to elicit and thematically analyze the perspectives of SIMPLIFY subjects about treatment withdrawal research and treatment burden in the context of triple combination CFTR (Cystic…
- Trial name
- QUEST (NCT04320381)
- Testing
- Qualitative Interview
- Where
- 2 sites in United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Tobacco Use Disorder
Tobacco Cessation in Postmenopausal Women (Part I) - 1
The purpose of this study is to evaluate the effects of ERT on appetitive behavior and withdrawal in short-term smoking cessation compared to smoking ad lib in postmenopausal female smokers.
- Trial name
- NCT00061061
- Testing
- Behavior Therapy
- Where
- United States
- Sponsor
- University of Minnesota
Impaction of Tooth
The Effect of Surgical Interventions to Assist Orthodontic Movement of Impacted Maxillary Canines
Impacted canine causes many problems for patients, such as absorption and damages to the adjacent teeth roots, as well as aesthetic problems. Correction of this problem requires a lengthy time.
- Trial name
- NCT03678805
- Testing
- Corticotomy, Traditional withdrawal techniques
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Obstructive Sleep Apnea, Cardiovascular Disease
Cardiovascular Effects After CPAP Withdrawal for Obstructive Sleep Apnea
Background: Patients with obstructive sleep apnea run an increased risk of cardiovascular disease including hypertension. Continuous positive airway pressure (CPAP) is the first line of treatment.
- Trial name
- NCT02329470
- Testing
- Withdrawal of continuous positive airway pressure treatment
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Umeå University
Advanced Prostate Cancer
Prostate Cancer, Androgen Deprivation Withdrawal and Intermittent Chemotherapy
The study includes the recruitment of patients with advanced prostate cancer resistant to chemical castration This is a multicenter prospective trial randomized phase III
- Trial name
- PON-PC-02 (NCT01224405)
- Testing
- Docetaxel + LH-RH analogues, Docetaxel, Continuous Docetaxel
- Where
- 32 sites in Italy
- Volunteers
- 600 people
- Sponsor
- University of Turin, Italy
Tumor, Pain
A Study to Evaluate Tapentadol (CG5503) in the Treatment of Chronic Tumor-Related Pain Compared With Placebo and Morphine
The purpose of this study will be to determine whether tapentadol (CG5503) is effective and safe in the treatment of chronic tumor related pain compared to placebo.
- Trial name
- NCT00472303
- Testing
- Tapentadol Extended Release, Morphine Sulphate Controlled Release
- Where
- 71 sites in Austria, Bulgaria and 14 more
- Volunteers
- 622 people
- Sponsor
- Grünenthal GmbH
Monocarboxylate Transporter 8 Deficiency, Allan-Herndon-Dudley Syndrome
Withdrawal of Tiratricol Treatment in Males With Monocarboxylate Transporter 8 Deficiency (MCT8 Deficiency)
This is a double-blind, randomized phase 3 multicenter placebo-controlled study in at least 16 evaluable male participants diagnosed with MCT8 deficiency.
- Trial name
- ReTRIACt (NCT05579327)
- Testing
- Tiratricol
- Where
- 8 sites in United States, Netherlands and 1 more
- Volunteers
- 20 people
- Sponsor
- Rare Thyroid Therapeutics International AB
Irritable Bowel Syndrome Characterized by Constipation
Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With Constipation
The objective of this trial is to determine the efficacy and safety of linaclotide administered to patients with irritable bowel syndrome with constipation (IBS-C).
- Trial name
- NCT00948818
- Testing
- Linaclotide 290 micrograms
- Where
- 118 sites in United States, Canada
- Volunteers
- 803 people
- Sponsor
- Forest Laboratories
Pelvic Pain, Headaches
Study of Loestrin 24(24 Days of "Real" Pills) Fe Versus Loestrin 1/20 (21 "Real" Pills)
The purpose of this research study is to assess hormone withdrawal symptoms in women while taking an oral contraceptive in the novel 24/4 (24 days of "real" pills) manner in comparison to taking pills in the standard 21/7 (21…
- Conditions
- Pelvic Pain, Headaches, Emotional
- Trial name
- NCT00475189
- Testing
- loestrin 24/4 vs loestrin 1/20, loestrin 1/20
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Scott and White Hospital & Clinic
Amenorrhea
A Trial to Evaluate DR-2021 in Women With Secondary Amenorrhea
This is a multicenter trial to compare the effectiveness of 4 doses of DR-2021 with placebo and oral micronized progesterone in inducing withdrawal bleeding in women with secondary amenorrhea.
- Trial name
- NCT00196391
- Testing
- DR-2021a, DR-2021b, DR-2021c
- Where
- 27 sites in United States
- Volunteers
- 180 people
- Sponsor
- Duramed Research
Oral Contraceptive, Headache
Effect of a New Oral Contraceptive Pill on Hormone Related Symptoms Such as Pelvic Pain and Headache
The aim of the present study is to investigate whether women taking a new combined oral contraceptive pill (SH T00658ID, estradiol valerate/dienogest) experience fewer hormone withdrawal-associated symptoms such as pelvic pain or…
- Conditions
- Oral Contraceptive, Headache, Pelvic Pain
- Trial name
- NCT00778609
- Testing
- EV/DNG (Qlaira, BAY86-5027)
- Where
- 63 sites in Australia, Finland and 7 more
- Volunteers
- 449 people
- Sponsor
- Bayer
Ovulation Disorder
"Stair Step Study"
Rationale: There is some information suggesting that a progesterone-induced withdrawal bleeding before the start of ovulation induction in women suffering from oligo- or amenorrhea reduces pregnancy and live birth rate.
- Trial name
- NCT03309176
- Testing
- Medroxyprogesterone Acetate 10 MG, Stair step protocol without Medroxyprogesterone Acetate
- Where
- 3 sites in Netherlands
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Schizophrenia
Randomized Withdrawal Study in Patients With Schizophrenia
The purpose of this research is to evaluate the efficacy of dosing iloperidone long-acting injection (LAI) compared to placebo in preventing the exacerbation of symptoms in patients with schizophrenia.
- Trial name
- NCT06961968
- Testing
- iloperidone
- Where
- 22 sites in United States
- Volunteers
- 400 people
- Sponsor
- Vanda Pharmaceuticals
Sedative Withdrawal Delirium
The Psychological Effects of Different Sedation Protocol on Mechanically Ventilated Critically Ill Adults.
The study was designed to explore the effects of different sedation protocol on incidence rates of delirium and PTSD in severe patients with mechanically ventilation.
- Trial name
- NCT02123589
- Testing
- Deep sedation(midazolam and fentanyl ), Deep and daily interruption of sedation(midazolam and fentanyl ), Light sedation(midazolam and fentanyl )
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Psoriasis
An Investigational Study to Evaluate Experimental Medication BMS-986165 Compared to Placebo and a Currently Available Treatment in Participants With Moderate-to-Severe Plaque Psoriasis
The purpose of this study is to investigate the experimental medication BMS-986165 compared to placebo and a currently available treatment in participants with moderate to severe plaque psoriasis.
- Trial name
- POETYK-PSO-2 (NCT03611751)
- Testing
- BMS-986165, Apremilast
- Where
- 205 sites in United States, Australia and 14 more
- Volunteers
- 1,020 people
- Sponsor
- Bristol-Myers Squibb
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