Clinical trials: Worm Infestation
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Mansonelliasis, Pruritus
Epidemiology and Control of Mansonella Perstans Infection in Uganda
Mansonella perstans (M. perstans) infection is widespread in Uganda. Knowledge about the epidemiology of this infection, and of the morbidity it induces is poor, and no effective treatment is available.
- Conditions
- Mansonelliasis, Pruritus, Lymphoedema, Abdominal Pains
- Trial name
- NCT00215280
- Testing
- ivermectin and albendazole
- Where
- Uganda
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Cholangiocarcinoma, Liver Fluke-Related Cholangiocarcinoma
Evaluating a Community-Based Behaviour Change Communication Model to Prevent Cholangiocarcinoma in Khon Kaen, Thailand
Liver cancer, specifically cholangiocarcinoma (CCA), is very common in different areas in Thailand. Many factors make this cancer more common, such as liver fluke infection, older age, eating raw fish, family history of cancer…
- Conditions
- Cholangiocarcinoma, Liver Fluke-Related Cholangiocarcinoma, Opisthorchiasis
- Trial name
- eCHEC (NCT05321992)
- Testing
- eCHEC program
- Where
- Thailand
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- McMaster University
Schistosomiasis, Anaemia
Schistosomiasis in Women of Reproductive Age in Burkina Faso: Implications for Control
Cross-sectional study of prevalence and intensity of schistosome infection in pregnant women, follow-up into postpartum, and the association of schistosome infection with haemoglobin concentration, compared to a group of…
- Conditions
- Schistosomiasis, Anaemia, Pregnancy
- Trial name
- NCT00463632
- Where
- 2 sites in Burkina Faso
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DBL -Institute for Health Research and Development
Ulcerative Colitis, Ulcerative Colitis Exacerbation
Role of Intestinal Protozoa and Helminths in the Course of Ulcerative Colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract of unknown etiology. UC is characterized by recurring episodes of inflammation limited to mucosal and submucosal layers of the colon.
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Exacerbation, Protozoan Infections, Helminth Infection
- Trial name
- NCT03441893
- Testing
- parasitological diagnostics (coproscopy), Nitazoxanide 500Mg Oral Tablet, Mesalazine 250Mg Tablet and nitazoxanide 500Mg Oral Tablet
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Diarrhoea, Soil-transmitted Helminth Infection
Cluster Randomised Trial of Improved Sanitation in Rural Orissa, India
The study is a cluster-randomized, controlled trial conducted among 100 villages (including approximately 3500 households and 20,000 people) in Puri district, State of Orissa, India.
- Conditions
- Diarrhoea, Soil-transmitted Helminth Infection, Nutritional Status
- Trial name
- NCT01214785
- Testing
- Provision of household latrines
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Helminthiasis, Diarrhea
Spillover Effects of Water, Sanitation, and Hygiene Interventions on Child Health
The purpose of this study is to measure whether a combined water, sanitation, and hygiene intervention leads to improved health of children who did not receive the intervention themselves and who live within a close vicinity of…
- Conditions
- Helminthiasis, Diarrhea, Respiratory Infection
- Trial name
- NCT02396407
- Testing
- Combined water, sanitation, and hygiene
- Where
- Bangladesh
- Volunteers
- 1,789 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Schistosomiasis, Bilharziasis
Clinical Trial of Bilhvax,a Vaccine Candidate Against Schistosomiasis
The purpose of this clinical study is to evaluate safety and immunogenicity in adult healthy volunteers of the vaccine candidate against schistosomiasis named Bilhvax.
- Conditions
- Schistosomiasis, Bilharziasis, Urinary Schistosomiasis
- Trial name
- Bilhvax1a (NCT01512277)
- Testing
- rSh28GST
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Schistosoma Haematobium
Performance of Tests for Schistosoma Haematobium Diagnosis
Urogenital schistosomiasis caused by infection with the blood fluke Schistosoma haematobium is a debilitating disease. The World Health Organization (WHO) has set the goal to eliminate schistosomiasis as a public health problem…
- Trial name
- SchistoBreak-D (NCT06808750)
- Testing
- S. haematobium egg detection by single urine filtration, S. haematobium egg detection by quintuple urine filtration, S. haematobium egg detection by artificial intelligence (AI) microscopy
- Where
- Tanzania
- Volunteers
- 801 people, healthy volunteers welcome
- Sponsor
- Stefanie Knopp
Onchocerciasis
Safety of a Single Dose of Moxidectin Compared With Ivermectin in Individuals Living in Onchocerciasis Endemic Areas and in Individuals Living in Onchocerciasis Endemic Areas With High Levels of Lymphatic Filariasis Co-endemicity Receiving Concomitant Albendazole
The purpose of this phase 3b study is to determine the safety of a single dose of moxidectin, compared to a single dose of ivermectin, in individuals living in onchocerciasis endemic areas and in individuals living in…
- Trial name
- NCT04311671
- Testing
- Moxidectin, Ivermectin, Albendazole
- Where
- 2 sites in Côte d’Ivoire, Democratic Republic of the Congo
- Volunteers
- 12,979 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
Wuchereria Bancrofti Infection
Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE)
The study will be an open label cohort study with 2 two-treatment groups 2). Both groups will be treated with a single oral administration of Diethylcarbamazine (DEC) 6 mg/kg + Albendazole (ALB) 400 mg + Ivermectin (IVR) 200…
- Trial name
- NCT02845713
- Testing
- Ivermectin, Diethylcarbamazine Albendazole (IDA)
- Where
- Côte d’Ivoire
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Schistosomiasis
Study to Evaluate the Safety of the Vaccine Prepared sm14 Against Schistosomiasis
This is a phase I, open-label, single arm trial, which aims to assess the safety of the vaccine prepared sm14 in healthy subjects.
- Trial name
- NCT01154049
- Testing
- sm14 antigen plus adjuvant GLA
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Whipworm, Trichuriasis
Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults
A Controlled Human Infection Model (CHIM) is being developed to provide early proof-of-concept that experimental infection with the intestinal nematode, Trichuris trichiura, is feasible and safe.
- Conditions
- Whipworm, Trichuriasis, Controlled Human Infection
- Trial name
- NCT05706116
- Testing
- Trichuris trichiura Egg Inoculum
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- George Washington University
Hookworm Infection, Hookworm Disease
Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With Different Doses of a Novel Adjuvant
This study is designed to evaluate the safety, reactogenicity, and immunogenicity of Na-GST-1 adsorbed to Alhydrogel® with or without two different dose concentrations of a novel adjuvant, GLA-AF (1 µg or 5 μg) among healthy…
- Trial name
- NCT01385189
- Testing
- 10 μg Na-GST-1/Alhydrogel, 30 μg Na-GST-1/Alhydrogel, 100 μg Na-GST-1/Alhydrogel
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Schistosomiasis
Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Children
The clinical trial phase 2b is designed to assess the safety and the specific immune response of the active ingredient (protein + adjuvant) in healthy and then in infected school children from 8 to 11 years of age with intestinal…
- Trial name
- NCT03799510
- Testing
- Sm14, GLA-SE solution
- Where
- Senegal
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Schistosoma Haematobium
Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.
Schistosomiasis is the second most common parasitic infection affecting humans, endemic in the Middle East, especially Egypt (1), and in 42 African countries (2). There are 5 main species infecting humans: S. mansoni, S.
- Trial name
- NCT05941884
- Testing
- Immunohistochemistry staining,, microscopic examination of urine
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Malnutrition, Child, Intestinal Worms
Reducing Malnutrition and Helminthic Infectious Disease Among Primary School Children by the School Nurses
Title: Reducing malnutrition and helminthic infectious disease among primary school children by the school nurses: School-based non-randomized study in a developing country Introduction: Globally, malnutrition alone with the…
- Trial name
- NCT05012592
- Testing
- Health Awareness Program TO Reduce Malnutrition and Helminth Infestation among Primary School children
- Where
- Bangladesh
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Hiroshima University
Intestinal Helminthiasis, Diarrhea
The Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in Vietnamese School Children
Cheap and effective drugs called 'anthelmintics' are routinely administered to children in developing countries to eliminate infections by parasitic helminths.
- Trial name
- NCT02597556
- Testing
- Albendazole
- Where
- Vietnam
- Volunteers
- healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Nodding Syndrome, Epilepsy
Clinical Features and Potential Etiology of Epilepsy and Nodding Syndrome in the Mahenge Area, Ulanga District
Background: Childhood epilepsy disorders are particular frequent in the area around Mahenge, southern Tanzania and recent studies have described a novel type of epilepsy with repetitive head nodding episodes and often progressive…
- Conditions
- Nodding Syndrome, Epilepsy, Onchocerciasis, Cognitive Impairment
- Trial name
- NSEC (NCT03653975)
- Testing
- no intervention
- Where
- Tanzania
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Necator Americanus Infection
Repeated Controlled Human Hookworm Infection
Twenty-four healthy hookworm-naive volunteers will be exposed to 50 L3 Necator americanus larvae for a maximum of three times.
- Trial name
- ReCHHI1 (NCT03257072)
- Testing
- 50 Necator americanus L3 larvae, 100 Necator americanus L3 larvae, 150 Necator americanus L3 larvae
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Meta Roestenberg