Clinical trials: Wound; Knee
Lateral Patellar Compression Syndrome, Patellar Dislocation
Tactile Guided Lateral Patellar Release
The lateral edge of the patella is identified by the surgeon's finger and the lateral ligament incision is performed with a blade through the skin.
- Conditions
- Lateral Patellar Compression Syndrome, Patellar Dislocation, Patellar (or Kneecap) Instability and Mal-alignment, Patella Alta
- Trial name
- TGLPR (NCT07637344)
- Testing
- Percutaneous lateral retinacular release of the patella
- Volunteers
- 23 people
- Sponsor
- Issa, Abdulhamid Sayed, M.D.
Tendinopathy
Is There a Mechanistic Reason for the Response or Non-response to Isometric Exercise in Tendinopathy?
In early phase tendinopathy, isometric exercises are seen as ideal to provide pain relief to patients. This approach is mainly based on a paper by Rio et al (2016), where they found that isometric exercises of a certain load…
- Trial name
- NCT03848598
- Testing
- Evaluation of local tendon deformation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Patellar Dislocation, ACL Injury
The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations.
The investigators intend to establish a national cohort including all persons in the ages from 15-20 years old with patellar instability (PI) or a prior knee injury (ACL-ruptur or meniscus damage) .
- Conditions
- Patellar Dislocation, ACL Injury, Meniscus Lesion, Trochlear Dysplasia
- Trial name
- FKC (NCT04607538)
- Testing
- No intervention is made
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Anterior Cruciate Ligament Injuries
Cartilage Injury and Remodeling After ACL Rupture and Reconstruction: Functional Imaging and Biomarkers
The proposed study will establish novel relationships between intra-articular MSC recruitment, synovial inflammation, biomarkers of cartilage degeneration and joint inflammation, clinical patient factors, and downstream…
- Trial name
- NCT04970706
- Testing
- ACL reconstruction
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
ACL Injury
Low-Intensity Blood Flow Restriction Training as a Pre-Operative Rehabilitative Modality to Improve Post-Operative Outcomes for ACL Reconstruction
Researchers are trying to find out whether the use of low-intensity strength exercises during the 2 weeks before surgery, and while the blood flow to the leg is reduced, will improve the outcomes after surgery to repair an…
- Trial name
- NCT04302558
- Testing
- Exercise Blood Flow Restriction training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Cartilage Injuries in the Human Knee
Reparation of Cartilage Injuries in the Human Knee by Implantation of Fresh Human Allogenic Chondrocytes
Implantation of fresh human allogenic chondrocytes in human knee cartilage injuries to obtain a repair and prevention of secondary osteoarthritis
- Trial name
- NCT00263432
- Testing
- Human allogenic chondrocytes
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- University Hospital, Ghent
Cartilage Injury of Knee
A Multicenter Trial of Sprifermin (AS902330 [Recombinant Human Fibroblast Growth Factor-18]) or Placebo After Microfracture Surgery for Cartilage Injury of the Knee
This is a Phase 2, double-blind, multicenter, randomized, placebo-controlled trial to evaluate the efficacy and safety of Sprifermin (AS902330) (recombinant human fibroblast growth factor-18 [rhFGF-18]) as an adjunct treatment to…
- Trial name
- NCT01689337
- Testing
- Sprifermin (AS902330)
- Volunteers
- 1 people
- Sponsor
- EMD Serono
Knee Injury
Preventing Knee Injuries in Adolescent Female Football Players
Football-related knee injuries are common and especially the anterior cruciate ligament (ACL) injury constitute a serious problem in football regardless of the playing level.
- Trial name
- NCT00894595
- Testing
- Knäkontroll, SISU Idrottsböcker©, Sweden, 2005
- Where
- Sweden
- Volunteers
- 4,564 people, healthy volunteers welcome
- Sponsor
- Region Skane
Osteoarthritis of the Knee, Degenerative Osteoarthritis
Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis
The primary research purpose is to determine if the use of a drug therapy intervention (each study participant will be randomly assigned to receive one of 3 study medications which will be blinded from everyone, including the…
- Conditions
- Osteoarthritis of the Knee, Degenerative Osteoarthritis, Knee Pain Chronic
- Trial name
- PRPNSAIDsKOA (NCT05742763)
- Testing
- Ibuprofen and PRP, Acetaminophen and PRP
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- QC Kinetix LLC
Wound, Diabetes
Pathology of Skin, Nerve and Vasculature in the Amputated Limb of Diabetes
1. To explore the pathology of nerve, vascular, and skin in the amputated leg 2. To diagnose small-fiber sensory neuropathy of the contralateral leg by investigating the skin intervention 3.
- Conditions
- Wound, Diabetes, Amputation
- Trial name
- NCT00840164
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear
Effects of Whole Body Vibration on Quadriceps Function, Landing Biomechanics, and Performance in Individuals With ACL Reconstruction
Individuals who undergo anterior cruciate ligament reconstruction (ACLR) are at heightened risk of secondary anterior cruciate ligament (ACL) injury (e.g. additional injury to the ACL in either knee).
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Tear, ACL Injury, ACL Tear
- Trial name
- NCT07681193
- Testing
- Whole body vibration (WBV)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of North Carolina, Chapel Hill
ACL Injury, ACL Reconstruction
Study to Use Oral Losartan to Decrease the Risk of Postoperative Scarring Following (ACL) Reconstruction
The purpose of this study to investigate the effect of using losartan (a blood pressure lowering drug with anti-scarring properties) on preventing primary postoperative arthrofibrosis (formation of abnormal scar tissue) in the…
- Conditions
- ACL Injury, ACL Reconstruction, Scar Formation
- Trial name
- NCT07135687
- Testing
- Losartan
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Rush University Medical Center
Anterior Cruciate Ligament Injuries, Atrophy
Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction
This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and…
- Conditions
- Anterior Cruciate Ligament Injuries, Atrophy, Muscle Weakness
- Trial name
- NCT04284748
- Testing
- Plyometric exercise with blood flow restriction, Plyometric exercise, Routine physiotherapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Pain, Postoperative, ACL Injury
Effectiveness of iPACK on Postoperative Pain From Hamstring Autograft Following ACL Repair
Patients undergoing ACL repair with hamstring autograft frequently develop significant post operative pain at the hamstring grafting site.
- Conditions
- Pain, Postoperative, ACL Injury, Anesthesia, Local, Opioid Use
- Trial name
- NCT05080348
- Testing
- Ropivacaine iPACK Injection, Normal Saline iPACK Injection
- Volunteers
- 40 people
- Sponsor
- Brenton Alexander
Knee Injuries
Nalbuphine With Remimazolam Versus Nalbuphine With Propofol for Knee Arthroscopy
This study compared two combinations of medicines used for sedation and pain relief in adults undergoing knee arthroscopy for knee joint injuries.
- Trial name
- NCT07838948
- Testing
- Nalbuphine, Remimazolam, Propofol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Wuhan Fourth Hospital
ACL-injury
Comparison of Low-Level Laser Therapy Versus Infrared Therapy in Grade II ACL Injury Rehabilitation
This study is being conducted to compare two commonly used physical therapy treatments, low-level laser therapy (LLLT) and infrared therapy, for people with a Grade II anterior cruciate ligament (ACL) injury of the knee.
- Trial name
- NCT07829835
- Testing
- Low-Level Laser Therapy (LLLT), Infrared Therapy (IRT), Standard Physiotherapy
- Where
- 3 sites in Pakistan
- Volunteers
- 30 people
- Sponsor
- Superior University
ACL Injury, ACL Tear
Comparison of Six-Month Functional Outcomes Following Anterior Cruciate Ligament (ACL) Reconstruction Using Peroneus Longus Tendon Grafts With Adjunctive Secretome Injection Versus Without Secretome Injection
Anterior cruciate ligament (ACL) reconstruction is commonly performed to restore knee stability after ACL injury; however, graft healing remains a critical determinant of successful outcomes.
- Trial name
- Secretome ACL (NCT07723625)
- Testing
- Secretome
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Intraarticular Fracture and Post-traumatic Osteoarthritis
Inflammatory Response Following Intraarticular Fracture
The purpose of the study is to investigate a relationship between the inflammatory response following intraarticular fracture and post-traumatic osteoarthritis.
- Trial name
- PTOA (NCT01514643)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Utah
Infection, Surgical Site
IO vs IV Vancomycin in Tourniquetless TKA
Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.
- Trial name
- NCT05705843
- Testing
- Intraosseous Vancomycin Injection, Intravenous Vancomycin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The Methodist Hospital Research Institute
ACL Injury, ACL Sprain
Isoinertial Rehabilitation in Recovering Hamstring Strength Following Surgical Anterior Cruciate Ligament Reconstruction
The present experimental study aims to evaluate the effectiveness and tolerability of isoinertial strength training of the hamstrings using machines in patients with ACL-R during the intermediate post-intervention phases.
- Conditions
- ACL Injury, ACL Sprain, ACL Tear, Anterior Cruciate Ligament Rupture
- Trial name
- NCT06063915
- Testing
- Isoinertial training, Strength Training
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Università degli studi di Roma Foro Italico
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