Clinical trials: Wound Infections
Sepsis, Septic Shock
The Role of Serotonin in Intensive Care Patients
Sepsis, cardiac arrest and multiple trauma are potentially life-threatening conditions and common reasons for intensive care unit (ICU) admission.
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest With Successful Resuscitation, Multiple Trauma
- Trial name
- SERO-22 (NCT05386199)
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Shock, Septic, Echocardiography
Strain Echocardiography During Septic Shock : an Observational Pilot Study
The mortality of septic shock remains high nowadays despite a trend toward improvement.Septic cardiomyopathy has been reported in most experimental models of sepsis shock. Its relationship with mortality is unclear.
- Trial name
- Sepsistrain (NCT03663192)
- Testing
- strain echocardiography
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Bacterial Infections
The Value of the Neutrophil to Lymphocyte Ratio in the Diagnosis of Bacterial Infections
The "gold standard" for diagnosing a bacterial infection is isolation of the pathogenic germ, which is not easy in routine clinical practice.
- Trial name
- RNL-MI (NCT02848534)
- Testing
- neutrophil to lymphocyte ratio
- Where
- France
- Volunteers
- 479 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Wound Infection, Complication
Abdomen CT and Open Appendicectomy：New Diagnostic and Surgical Procedures
The traditional open appendectomy in the clinical effect is not prefect, and for a long time there is no measurable improvement.
- Conditions
- Wound Infection, Complication, Scar
- Trial name
- ACAOA (NCT02574364)
- Testing
- The application of abdomen CT, traditional incision
- Volunteers
- 730 people
- Sponsor
- Ningbo Municipal No.4 Hospital
Infection-Associated Acute Kidney Injury
Folate Treatment to Reduce Death Risk in the Year After Infection-Related Acute Kidney Injury
The goal of this clinical trial is to evaluate if taking folic acid (a form of vitamin B9) can help reduce the risk of death and improve kidney recovery in adults with acute kidney injury (AKI) caused by infections or sepsis.
- Trial name
- FOL-AKI (NCT07377071)
- Testing
- Folic Acid 5 MG
- Where
- Hong Kong
- Volunteers
- 382 people
- Sponsor
- The University of Hong Kong
Complicated Skin and Soft Tissue Infection
Evaluation of Ceftaroline Fosamil Versus Vancomycin Plus Aztreonam in the Treatment of Patients With Skin Infections
The purpose of this study is to evaluate the effects of Ceftaroline Fosamil versus Vancomycin plus Aztreonam in treatment of patients with complicated bacterial skin and soft tissue infections.
- Trial name
- NCT01499277
- Testing
- Ceftaroline fosamil, Vancomycin, Aztreonam
- Where
- 91 sites in United States, Argentina and 26 more
- Volunteers
- 802 people
- Sponsor
- Pfizer
Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans
Etanercept for Non-Infectious Lung Injury Following Bone Marrow Transplantation
The purpose of this study is to determine the effects of etanercept, and define the toxicity, when administered to patients with acute non-infectious lung injury (idiopathic pneumonia syndrome, IPS) and with subacute pulmonary…
- Conditions
- Respiratory Distress Syndrome, Adult, Bronchiolitis Obliterans, Pneumonia
- Trial name
- NCT00029328
- Testing
- etanercept
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- FDA Office of Orphan Products Development
Corneal Diseases, Keratoconus
Keratoconus, Corneal Diseases and Transplant Registry
The cornea is the clear layer in front of the iris and pupil. It protects the iris and lens and helps focus light on the retina.
- Conditions
- Corneal Diseases, Keratoconus, Corneal Ulcer, Corneal Trauma
- Trial name
- KCDTR (NCT04164407)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Infection, Hand Injury Wrist
Vancomycin Tissue Concentrations by Bier Block or Intravenous Administration
The purpose of this study is to determine whether or not giving a lower dose of antibiotics (Vancomycin) in the area where it is needed (upper extremity) is more effective at preventing infection than the current standard dose…
- Conditions
- Infection, Hand Injury Wrist, Hand Injuries, Hand Injuries and Disorders
- Trial name
- NCT04673877
- Testing
- Systemic IV Vancomycin, Bier Block, Vancomycin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Surgical Wound Infection
Vacuum Assisted Closure for Cesarean Section
To study if incisional vacuum-assisted closure can decrease the risk of infection in cesarean section incisions in the obese compared with standard sterile dressing.
- Trial name
- VACCS (NCT02390401)
- Testing
- Vacuum-assisted closure, Standard sterile dressing
- Where
- 4 sites in United States
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Trauma, Spinal Cord, SPINAL Fracture
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.
The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI).
- Trial name
- NCT03253952
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Knowledge, Attitude
Knowledge, Attitude, Practice Survey
This study aimed to assess the knowledge, attitude, and practice(KAP) towards infection-control guidelines among undergraduate and postgraduate dental students in Haryana, and to evaluate the incidence of needlestick/sharp…
- Conditions
- Knowledge, Attitude, Practice
- Trial name
- NCT07614750
- Testing
- Questionnaire
- Where
- India
- Volunteers
- 347 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Sepsis
Preclinical Detection of Sepsis Early in Hospitalized Patients Following Surgery, Injury or Severe Illness
This clinical study is to evaluate a novel biomarker - CNA Rapid Sepsis Dx - to predict the development of sepsis in patients admitted to the hospital with non-sepsis conditions.
- Trial name
- Pre-SEPSIS (NCT04189549)
- Testing
- CNA Rapid Sepsis Dx
- Where
- 5 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Robert Ehrman
Trauma, Urinary Tract Infections
Does a Nitrofurazone Coated Bladder Catheter Reduce the Number of Urinary Tract Infections in Trauma
Urinary tract infections occurs in trauma. We investigate whether a nitrofurazone coated can reduce the number of urinary tract infections.
- Trial name
- NCT00192985
- Testing
- Nitrofuranzone coated bladder catheter
- Where
- Denmark
- Volunteers
- 216 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cesarean Section, Surgical Wound
To Explore the Effectiveness and Feasibility of HERADERM Hydrogel Wound Dressing on Caesarean Section Surgical Site
The wound of cesarean section involves multiple layers of tissue and often cause significant postoperative pain. The epidermal wound typically heals within 1 to 2 weeks after surgery.
- Conditions
- Cesarean Section, Surgical Wound, Surgical Wound Infection, Wounds and Injuries
- Trial name
- NCT06558240
- Testing
- HERADERM Hydrogel Wound Dressing (Sterile)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Postoperative Wound Infection
Effects of Triclosan-coated Sutures in Cardiac Surgery
The purpose of this study is to assess if triclosan-coated sutures reduces wound infections after saphenous vein harvesting in CABG patients.
- Trial name
- NCT01212315
- Testing
- Triclosan coated sutures
- Where
- Sweden
- Volunteers
- 392 people
- Sponsor
- Sahlgrenska University Hospital
Burns
A Randomized Comparison Study of Aquacel Ag and Glucan II as Donor Site Dressings
The research will be looking at patient outcomes for healing of donor sites after a split-thickness skin graft procedure for a burn or skin tissue loss.
- Trial name
- NCT00581217
- Testing
- Aquacel Ag, Glucan II
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Fracture, Dislocation
Pre-drilling or Self Drilling External Fixation Pins
Hypothesis There is no difference in the incidence of pin tract infection and pin loosening in case of lower extremity external fixators when self-drilling schanz pins are used with or without pre-drilling.
- Trial name
- NCT01046747
- Testing
- Placement of external fixation pins
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Temple University
Tuberculosis, Tuberculous Meningitis
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults.
- Conditions
- Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV
- Trial name
- NCT03092817
- Testing
- Dexamethasone
- Where
- 6 sites in Indonesia, Vietnam
- Volunteers
- 520 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Gastrointestinal Tumors, Surgical Wound Infection
Non-Dressing vs. Routine Dressing Change After Gastrointestinal Cancer Surgery
The goal of this randomized non-inferiority trial is to evaluate whether omitting postoperative wound dressings is noninferior to routine dressing changes in patients undergoing gastrointestinal cancer surgery.
- Conditions
- Gastrointestinal Tumors, Surgical Wound Infection, Pain, Postoperative
- Trial name
- Dressing (NCT06263205)
- Testing
- Non-Dressing of Surgical Wound, Regular Dressing Change of Surgical Wound
- Where
- 4 sites in China
- Volunteers
- 1,138 people
- Sponsor
- Fudan University
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