Clinical trials: Wound Sepsis
Critical Illness, Sepsis
Role of Active Deresuscitation After Resuscitation-2
RADAR-2 will be a randomised, open-label, allocation concealed, pilot trial of conservative fluid administration and deresuscitation compared with usual care in patients who are critically ill.
- Conditions
- Critical Illness, Sepsis, Trauma
- Trial name
- RADAR-2 (NCT03512392)
- Testing
- Conservative fluid and deresuscitation strategy, Usual care strategy
- Where
- 8 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- Belfast Health and Social Care Trust
Abdominal Trauma, Abdominal Injury
A Non-Traumatic Binder for Temporary Abdominal Wall Closure
At the end of most abdominal operations, the fascial layer is closed by stitching edges of the wound together. However, because of logistic and/or technical reasons or the patient's critical condition, the surgeon is forced to…
- Conditions
- Abdominal Trauma, Abdominal Injury, Abdominal Infection, Abdominal Sepsis
- Trial name
- ABRO (NCT03815370)
- Testing
- Experimental: ABRO™ Binder Arm
- Where
- 4 sites in Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Failure, COVID-19
REmimazolam Infusion in the Context of Hypnotic Shortage in the Critical Care Unit During the Pandemic of COVID-19: REHSCU Study
The worldwide COVID-19 pandemic has led to a dramatic increase in the number of patients hospitalized in intensive care units for an acute respiratory failure in all countries.
- Conditions
- Acute Respiratory Failure, COVID-19, Trauma, Stroke
- Trial name
- REHSCU (NCT04611425)
- Testing
- Remimazolam
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Nantes University Hospital
Surgical Site Infection, Thrombosis
Tumescent Anesthesia Antibiotic Delivery (TAAD)
This is a multicenter randomized clinical trial (RCT) comparing two modes of antibiotic delivery: Control: Intravenous Antibiotic Delivery (IVAD) Treatment: IVAD + TAAD The Food \& Drug Administration (FDA) has approved our…
- Conditions
- Surgical Site Infection, Thrombosis, Sepsis
- Trial name
- TAAD (NCT03226626)
- Testing
- Tumescent Anesthesia and antibiotic delivery (TAAD) plus IVAD, SubQKath
- Volunteers
- 330 people
- Sponsor
- HK Surgical, Inc.
Sarcopenia, Critical Illness
ICU Sarcopenia Rates by Abdominal CT: Sepsis vs. Trauma
Using abdominal computed tomography (CT) imaging, the investigators will estimate total body muscle mass at two time points in Intensive Care Unit (ICU) by assessing cross-sectional muscle areas at the L3 vertebral body level.
- Conditions
- Sarcopenia, Critical Illness, Sepsis, Trauma
- Trial name
- NCT03982628
- Testing
- Abdominal CT imaging
- Where
- Canada
- Volunteers
- 146 people
- Sponsor
- University of Calgary
Cardiac Arrest, Sepsis
Improving Outcomes After Time Sensitive Prehospital Interventions: Rescu Epistry
Rescu Epistry includes data points pertaining to prehospital and in-hospital clinical treatments and responses to therapy, survival to discharge and functional outcome data for all cases.
- Conditions
- Cardiac Arrest, Sepsis, Trauma, Stroke
- Trial name
- NCT04110912
- Testing
- This is a registry and no interventions are taking place.
- Where
- 3 sites in Canada
- Sponsor
- Unity Health Toronto
Wound Sepsis
Efficacy of Adding Azithromycin to Cephalosporin Before Cesarean Delivery
efficacy of adding azithromycin to cephalosporin before cesarean delivery
- Trial name
- NCT04062175
- Testing
- cephalosporin, Azithromycin Tablets
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Sepsis, Trauma
Longitudinal Gene Expression Profiling in Adults After Traumatic Injury
The purpose of this study is to examine the immune response to traumatic injury and subsequent infections in critically ill adults.
- Conditions
- Sepsis, Trauma, Infection
- Trial name
- NCT02656459
- Testing
- 11-gene set
- Where
- 3 sites in United States, Germany
- Volunteers
- 52 people
- Sponsor
- Stanford University
Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery
Our Aim is to identify patient risk factors and clinical practices associated with healthcare-acquired infections (HAIs) after cardiac surgery.
- Conditions
- Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Sepsis, Pneumonia
- Trial name
- HAI (NCT02068716)
- Where
- United States
- Volunteers
- 911,754 people
- Sponsor
- Dr. Donald Likosky
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Critical Illness, Sepsis
The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
The purpose of the study is to test whether the health care provider access and training in CERTAIN (Checklist for Early Recognition and Treatment of Acute Illness), would facilitate timely and error free best-practice delivery…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- NCT01973829
- Testing
- Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN)
- Where
- 30 sites in Belarus, Bosnia and Herzegovina and 15 more
- Volunteers
- 5,215 people
- Sponsor
- Mayo Clinic
Disseminated Intravascular Coagulation
International Prospective Registry of Disseminated Intravascular Coagulation
Objectives: to evaluate the current diagnostic and therapeutic approaches for sepis-associated disseminated intravascular coagulation (DIC) in a large prospective registry.
- Trial name
- NCT03577015
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Marcella Muller
Sepsis, Trauma
Critical Care Excellence in Sepsis and Trauma
The care of patients with sepsis and trauma requires the delivery of appropriate definitive care in the early stages of the illness.
- Trial name
- CREST (NCT01426711)
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Medical University of South Carolina
Multiple Trauma, Sepsis
The Role of Post-traumatic Inhibition of the Innate and Adaptive Immune System in the Development of Infectious Complications in Severely Injured Patients
Patients admitted to the Intensive Care Unit after severe injury are prone to suffer from infectious complications and even sepsis.
- Conditions
- Multiple Trauma, Sepsis, Innate Immune Response, Disorder of Neutrophils
- Trial name
- POSEIDON (NCT03489577)
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- UMC Utrecht
Critical Illness, Sepsis
Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE)
In this multicenter project, we will introduce AWARE (electronic interface) Using a cloud-based technology . The goal of this project is to improve compliance with best practice through the use of a new acute care interface with…
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- AWARE (NCT02039297)
- Testing
- Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation
- Where
- 6 sites in United States
- Volunteers
- 7,813 people
- Sponsor
- Mayo Clinic
Sepsis, Shock
Studies of Blood DNA in Patients With Severe Infection DYNAMICS
Severe sepsis (ie. life-threatening infections) is triggered by harmful microorganisms or their toxins in the blood or tissues. These harmful agents damage the lining of blood vessels which can lead to inflammation, blood clot…
- Conditions
- Sepsis, Shock, Trauma
- Trial name
- DYNAMICS (NCT01355042)
- Where
- 6 sites in Canada
- Volunteers
- 792 people
- Sponsor
- Alison Fox-Robichaud
Multiple Organ Failure, Sepsis
Pharmacokinetics of Two Different High-dose Regimens of Intravenous Vitamin C in Critically Ill Patients
The purpose of this study is to determine the pharmacokinetic properties of two different dosage regimens of intravenous vitamin C in patients admitted to the Intensive Care Unit with life-threatening illness.
- Conditions
- Multiple Organ Failure, Sepsis, Systemic Inflammatory Response Syndrome, Trauma
- Trial name
- NCT02455180
- Testing
- Ascorbic Acid
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Amsterdam UMC, location VUmc
Brain Injuries, Dementia
ACT-ICU Study: Activity and Cognitive Therapy in the Intensive Care Unit
Intensive care unit (ICU) hospitalization saves lives but often does so at a high personal cost to ICU survivors who frequently experience significant cognitive impairment and an array of physical and functional disabilities that…
- Conditions
- Brain Injuries, Dementia, Myopathies, Muscle Disorders
- Trial name
- ACT-ICU (NCT01270269)
- Testing
- Behavioral: Physical and functional rehabilitation, Behavioral: Cognitive, physical, & functional rehabilitation
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Vanderbilt University
Sepsis
The Effect of Rhubarb on Sepsis and Post-traumatic Gastrointestinal Function Failure
Random grouping by computer, divided into two groups, a group of rhubarb treatment group, another group for the placebo group.
- Trial name
- NCT03048903
- Testing
- Rheum Palmatum Root, Starch Corn
- Where
- China
- Volunteers
- 400 people
- Sponsor
- CHEN De-chang
Respiratory Failure, Cardiovascular Failure
Strict Glucose Control of Pediatric Intensive Care Unit (ICU) Patients
The study objective is to improve morbidity and mortality of high-risk critically ill children. Our hypothesis is that a strict ICU glucose control protocol will decrease morbidity and mortality associated with hyperglycemia in a…
- Conditions
- Respiratory Failure, Cardiovascular Failure, Sepsis, Trauma
- Trial name
- NCT00247468
- Testing
- Strict Glucose Control
- Sponsor
- Children's Hospital of Philadelphia