Clinical trials: Wrinkles and Rhytides
Correction of Nasolabial Folds and Lip Augmentation
PREVELLE Shape (CX002) Dermal Filler Protocol
The purpose of this study was to assess PREVELLE Shape (CX002), with respect to safety and efficacy for one year following treatment, for correction of facial nasolabial folds and when applied as an intradermal implant for lip…
- Trial name
- NCT00764257
- Testing
- PREVELLE Shape, Restylane
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mentor Worldwide, LLC
Wrinkle
The Effect of Almonds on Facial Aesthetics and Modulation of the Microbiome and Lipidome
The investigator hypothesizes that regular consumption of almonds will 1) improve the facial wrinkle severity in post-menopausal women, 2) improve the evenness of facial skin pigmentation, 3) diversify the gut microbiome and…
- Trial name
- NCT03729700
- Testing
- Almond
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Wrinkle Reduction
Assessment of the Safety and Effectiveness of a Micro-RF Skin Treatment Device (nebulyft）
The objective of the study is to evaluate the safety, efficacy and usage compliance of the home-use device nebulyft for self-treatment of wrinkles appearance. The participants do treatment 5 time /week and last 4 weeks.
- Trial name
- ASEMRSTD (NCT06623214)
- Testing
- nebulyft
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Hangzhou Rebecca Medical Science and Technology Ltd.
Skin Ageing, Facial Wrinkles - Rough Texture - Hyperpigmentation
Clinical Effects of Two Oral Bioactive Collagen Peptides On Skin Properties and Aging Hallmarks
This randomized, controlled clinical trial evaluated whether daily oral intake of a collagen peptides supplement improved age-associated skin beauty parameters in healthy women with visible facial wrinkles.
- Conditions
- Skin Ageing, Facial Wrinkles - Rough Texture - Hyperpigmentation, Skin Hydration in Healthy Volunteers
- Trial name
- NCT07302789
- Testing
- Dietary Supplement: Collagen Peptides Supplement, Dietary Supplement: Competitor's Collagen Supplement
- Where
- Spain
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Bionos Biotech S.L.
Wrinkle, Skin Pigmentation
Prospective Study of Topical Vitamin C (THDA) Versus Topical Vitamin C (THDA) With Acetyl Zingerone
The purpose of this study is to asses the impact of topically applying a form of vitamin C known as tetrahexyldecyl Ascorbate (THDA) along with a novel anti-aging ingredient, acetyl zingerone, compared against applying THDA alone.
- Trial name
- NCT05779280
- Testing
- THDA + Acetyl Zingerone Topical Product, THDA
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Aging, Wrinkles
Effects of Application LED Therapy and Laser Therapy in Facial Rejuvenation
In today's society, the search for keeping up with the appearance with no visible signs of aging has become common. Therefore, many therapies to try to mitigate these senility markers are present in specialized clinics.
- Trial name
- NCT02513680
- Testing
- Infrared Laser + Amber LED, Amber LED
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Facial Aging, Skin Aging
Hyaluronic Acid Crosslinking Clinical Study
This prospective observational case series aims to evaluate the clinical efficacy, safety, and patient satisfaction associated with hyaluronic acid dermal fillers with different degrees of divinyl sulfone (DVS) crosslinking.
- Conditions
- Facial Aging, Skin Aging, Facial Volume Loss, Facial Rhytides
- Trial name
- HACS (NCT07744464)
- Testing
- Hyaluronic Acid Dermal Fillers
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Antony de Paula Barbosa
Dermal Fillers, Nasolabial Folds, Wrinkles
Purpose of This Study is the Demonstration of Safety and Efficacy of the Dermal Fillers DXP01 Temporary Improvement of Moderate to Severe Nasolabial Folds
Purpose of this study is the demonstration of safety and efficacy of the dermal fillers DXP01 Face for restoration of moderate to severe nasolabial folds
- Trial name
- DXP01 (NCT06885775)
- Testing
- DXP01, Juvederm ULTRA 3
- Where
- Romania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- DEXLEVO
Wrinkles, Fine Lines
Clinical Study to Assess Safety, Effectiveness and In-Use Tolerability of Saffron Extract Capsules for Improving Skin Health and Reducing Signs of Aging on Healthy Adult Male and Female Subjects.
This is a randomized, double-blind, comparative, two-arm, prospective, interventional, multi-centre clinical study to evaluate the safety, efficacy, and in-use tolerability of test products, standardized saffron extract capsules…
- Conditions
- Wrinkles, Fine Lines, Hyperpigmentation, Dark Spots
- Trial name
- GLOW (NCT07324759)
- Testing
- Standardized Saffron Extract (Crocus Sativus L) 10 mg Capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Wrinkle
Study to Evaluate the Performance and Safety of the Medical Device Plenhyage®
The Research Question of the present study is the following: in a population of men and women affected by face wrinkles and skin tones and irregularities (atrophies) of the skin surface in neck, abdomen, thighs and buttocks, will…
- Trial name
- Plenhyage (NCT04650620)
- Testing
- Plenhyage® thin, Plenhyage® medium, Plenhyage® strong
- Where
- Romania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- I.R.A. Istituto Ricerche Applicate S.p.A.
Skin Ageing, Facial Wrinkles
Clinical Study Evaluating the Safety and Effectiveness of the NIRA Laser M2.1 for the Treatment of Full-Face Wrinkles
This clinical trial evaluated the safety and effectiveness of the NIRA Laser M2.1, with or without a topical treatment, for the treatment of full-face wrinkles in adults.
- Conditions
- Skin Ageing, Facial Wrinkles, Acne, Skin Elasticity
- Trial name
- NCT07572331
- Testing
- NIRA Laser M2.1, Topical
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NIRA Innovations Inc.
Wrinkle Reduction
A Prospective Pilot Study to Evaluate Safety and Effectiveness of GP0122 and GP0124 for Correction of Lines and Wrinkles in the Cheek Area
The primary objective of the study is to evaluate the safety of GP0122 and GP0124 for the correction of lines and wrinkles in the cheek area.
- Trial name
- NCT07344584
- Testing
- GP0122, GP0124
- Where
- 5 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Wrinkle
A Study on the Effectiveness and Safety Evaluation of Combination Therapy With 1,927nm Thulium Laser and Fractional Microneedle Radiofrequency Equipment for Improvement of Skin Aging
Fractional Microneedle Radiofrequency (FMR) equipment is a device that penetrates the epidermis and irradiates the high frequency by entering the dermis.
- Trial name
- NCT03739398
- Testing
- LUTRONIC GENUS laser(Fractional Microneedle Radiofrequency(FMR)), LASEMED laser(The Thulium laser with 1,927nm wavelength)
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Nasolabial Fold
Post Market Clinical Follow up Evaluating the Performance and Safety of Juläine(TM) on Nasolabial Fold Wrinkles
The goal of this post marketing study is to verify clincal performance and safety of CE-marked device Juläine. The main objective is to evaluate device performance when used as intended for augmentation of shallow to deep…
- Trial name
- NCT06471933
- Testing
- Juläine
- Where
- 2 sites in Spain, Sweden
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Nordberg Medical AB
Skin Laxity, Skin Aging
Cucurbita Pepo Flowers Extract to Promote Skin Health
The aim of this cosmetic clinical trial is to learn if an extract of Cucurbita pepo flower (CpLfe) works to enhance skin health and resilience in adult women with photo-damage.
- Conditions
- Skin Laxity, Skin Aging, Skin Wrinkling
- Trial name
- EACpLfe22S01 (NCT06674005)
- Testing
- Cucurbita pepo L. Flowers Extract
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ritamaria Di Lorenzo
Wrinkle
BTL-785F Device for Non-invasive Facial Rejuvenation in Patients Injected With Botulinum Toxin
This study will evaluate the clinical safety and the efficacy of the BTL-785F system equipped with the BTL-785-7 applicator for non-invasive facial treatment in patients injected with botulinum toxin.
- Trial name
- NCT05524766
- Testing
- BTL-785-7 Treatment
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- BTL Industries Ltd.
Rosacea, Wrinkles
Safety and Efficacy of the Luxe Device to Treat Facial Wrinkles and Rosacea
This study is designed to evaluate the efficacy and safety of the Luxe™ device for use in wrinkle and rosacea treatment. Up to 60 subjects will treat their periorbital and cheek areas daily for 4 weeks and then twice a week for…
- Trial name
- NCT01618864
- Testing
- Luxe
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Syneron Medical
Subjects Displaying Facial Ageing
Evaluation of Efficacy and Safety of the Skinstylus Sterilock Microneedling System for the Treatment of Facial Wrinkles
To assess the efficacy and safety of the Skin stylus Sterilock microneedling system in reducing the appearance of facial wrinkles.This study is intended to be a single arm study.
- Trial name
- NCT06032286
- Testing
- Skinstylus microneedling device
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Beauty Health
Peri-orbital Wrinkles, Dry Eye
Tixel Treatment for Dry Eye Symptoms
Dry eye syndrome is caused by a chronic lack of sufficient lubrication and moisture on the surface of the eye. Consequences of dry eyes range from subtle but constant eye irritation to significant inflammation and even scarring…
- Trial name
- NCT05299619
- Testing
- Tixel
- Where
- Andorra
- Volunteers
- 40 people
- Sponsor
- Dr Ludger Hanneken
Jowls
Jowl Improvement With Injectable Fillers
This is a prospective clinical study to demonstrate a reduction in jowling and laxity of the jawline that can be achieved following facial volume enhancement using JUVÉDERM VOLUMA™ XC (0.3% w/w lidocaine).
- Trial name
- NCT04389866
- Testing
- JUVÉDERM VOLUMA™ XC
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Advanced Dermatology